期刊
CELL CYCLE
卷 10, 期 6, 页码 951-955出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/cc.10.6.15032
关键词
meiosis; chromosome segregation; recombination; kinetochore; Sgo1; fission yeast
类别
资金
- Austrian Science Fund [P18955, P20444, F3403]
- HFSP [RGY0069/2010]
- FWF [M1145]
- Austrian Science Fund (FWF) [P20444, M1145, P18955] Funding Source: Austrian Science Fund (FWF)
The reduction of chromosome number during meiosis is achieved by two successive rounds of chromosome segregation, called meiosis I and meiosis II. While meiosis II is similar to mitosis in that sister kinetochores are bi-oriented and segregate to opposite poles, recombined homologous chromosomes segregate during the first meiotic division. Formation of chiasmata, mono-orientation of sister kinetochores and protection of centromeric cohesion are three major features of meiosis I chromosomes which ensure the reductional nature of chromosome segregation. Here we show that sister chromatids frequently segregate to opposite poles during meiosis I in fission yeast cells that lack both chiasmata and the protector of centromeric cohesion Sgo1. Our data are consistent with the notion that sister kinetochores are frequently bi-oriented in the absence of chiasmata and that Sgo1 prevents equational segregation of sister chromatids during achiasmate meiosis I.
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