Article
Oncology
Sami Shoucair, Joseph R. Habib, Ning Pu, Benedict Kinny-Koster, A. Floortje van Ooston, Ammar A. Javed, Kelly J. Lafaro, Jin He, Christopher L. Wolfgang, Jun Yu
Summary: The study revealed that combinations of mutations in the four driver genes are associated with prognosis in resected PDAC patients. Patients with combined mtKRAS and mtTP53 had a better overall survival and recurrence-free survival when the KRAS p.G12D variant was present.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Medicine, Research & Experimental
Thomas Wilson, Giacomo Pirovano, Gu Xiao, Zachary Samuels, Sheryl Roberts, Tara Viray, Navjot Guru, Pat Zanzonico, Marc Gollub, Naga Vara Kishore Pillarsetty, Thomas Reiner, Jill Bargonetti
Summary: The PARP inhibitor 123I-MAPi shows promise for the systemic treatment of p53 mutant cancers, delivering therapeutic levels of Auger radiation without significant off-site toxicity. Studies also demonstrate that its stable isotopologue, I-127-PARPi, has minimal off-site toxicity when administered systemically.
MOLECULAR PHARMACEUTICS
(2021)
Article
Cell Biology
Gautier Tejedor, Patricia Luz-Crawford, Audrey Barthelaix, Karine Toupet, Sebastien Roudieres, Francois Autelitano, Christian Jorgensen, Farida Djouad
Summary: The research demonstrates that MSC derived from MRL mice have a higher migration potential and produce higher levels of MANF, which plays a significant role in regenerative medicine and OA treatment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Craig E. Higgins, Jiaqi Tang, Stephen P. Higgins, Cody C. Gifford, Badar M. Mian, David M. Jones, Wenzheng Zhang, Angelica Costello, David J. Conti, Rohan Samarakoon, Paul J. Higgins
Summary: Tubulointerstitial fibrosis is a common feature in chronic renal disorders, driven by persistent TGF-beta 1 signaling. The transcriptional co-regulator p53 plays a key role in the fibrotic response induced by TGF-beta 1.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Han Thi Ngoc To, Ji-Hong Park, Jeong Won Kim, Dongchul Kang
Summary: Upregulation of DNER expression is associated with advanced gastric cancer and poor prognosis. DNER regulates cell proliferation, survival, and invasive capacity through activation of Notch signaling, suggesting it could be a potential prognostic marker and therapeutic target.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Di Huang, Dan Zhao, Ming Li, Si-Yu Chang, Ya-Dong Xue, Ning Xu, Si-Jia Li, Nan-Nan Tang, Li-Ling Gong, Yi-Ning Liu, Hang Yu, Qing-Sui Li, Peng-Yu Li, Jia-Li Liu, Hai-Xin Chen, Ming-Bin Liu, Wan-Yu Zhang, Xing-Miao Zhao, Xian-Zhi Lang, Zhen-Dong Li, Yu Liu, Zhi-Yong Ma, Jia-Min Li, Ning Wang, Hai Tian, Ben-Zhi Cai
Summary: This study reveals that PML is upregulated in cardiac fibrotic tissue and activated cardiac fibroblasts treated with TGF-beta 1. The interaction between PML and p53 regulates the activation of cardiac fibroblasts and has a significant role in cardiac fibrosis.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Cell Biology
Gautier Tejedor, Rafael Contreras-Lopez, Audrey Barthelaix, Maxime Ruiz, Daniele Noel, Frederic De Ceuninck, Philippe Pastoureau, Patricia Luz-Crawford, Christian Jorgensen, Farida Djouad
Summary: The study revealed that MSCs from MRL mice have a superior chondrogenic potential compared to those from BL6 mice, which is associated with a higher expression of PYCR1.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
David E. Ebeid, Farid G. Khalafalla, Kathleen M. Broughton, Megan M. Monsanto, Carolina Y. Esquer, Veronica Sacchi, Nirmala Hariharan, Kelli Korski, Maryam Moshref, Jacqueline Emathinger, Christopher T. Cottage, Pearl J. Quijada, Jonathan H. Nguyen, Roberto Alvarez, Mirko Volkers, Mathias H. Konstandin, Bingyan J. Wang, Fareheh Firouzi, Julian M. Navarrete, Natalie A. Gude, Marie-Jose Goumans, Mark A. Sussman
Summary: Pim1 maintains telomere lengths in cardiomyocytes by inhibiting phosphorylation of the TGF beta pathway downstream effectors Smad2 and Smad3, which prevents repression of telomerase reverse transcriptase.
CARDIOVASCULAR RESEARCH
(2021)
Article
Oncology
Wafaa S. Ramadan, Saleh Alkarim, Mohammed Moulay, Ghadeer Alrefeai, Fatma Alkudsy, Khalid Rehman Hakeem, Ashwaq Iskander
Summary: The challenges in treating hepatocellular carcinoma (HCC) are largely due to drug resistance or relapse, which is attributed to the presence of hepatic cancer stem cells (HCSCs). In this study, the therapeutic effect of ellagic acid (EA) on HCC and the reaction of the HCC microenvironment and HCSCs to EA therapy were evaluated.
Article
Biochemistry & Molecular Biology
Ukjin Kim, Kwang Seok Kim, Jong-Kuk Park, Hong -Duck Um
Summary: Based on previous findings, the interaction between p53 and p21 is essential for the tumor-suppressing functions of p53, and the acetylation of the C-terminal domain of p53 can affect this interaction. In this study, it was found that inhibiting the deacetylase SIRT1 or increasing the acetylation levels of lysine residues in the C-terminal domain reduced the interaction between p53 and p21. Additionally, substituting acetylation mimetics for the lysine residues in the C-terminal domain weakened the interaction. The degree of acetylation correlated with the extent of the inhibitory effect. Overall, these results suggest that cellular components involved in the acetylation or deacetylation of the C-terminal domain of p53 play a critical role in regulating the formation of the p53/p21 complex.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Developmental Biology
Emilie Lamarche, Hamood AlSudais, Rashida Rajgara, Dechen Fu, Saadeddine Omaiche, Nadine Wiper-Bergeron
Summary: SMAD2 acts as an important positive regulator of myogenic differentiation, promoting terminal myogenic differentiation independently of TGF beta receptor complex activation. Loss of Smad2 in muscle cells leads to decreased muscle fiber caliber and impaired regeneration.
Article
Biochemistry & Molecular Biology
Bagher Pourheydar, Mahrokh Samadi, Parisa Habibi, Ahmad Ali Nikibakhsh, Roya Naderi
Summary: Treatment with tropisetron in diabetic rats led to significant improvements in blood glucose, serum cystatin C, and urinary total protein levels, indicating enhanced kidney function and reduced renal fibrosis. The expression of TGF-beta 1, p53, MMP-9, and MMP-2 in the kidneys of diabetic rats was regulated by tropisetron, suggesting its potential as a therapeutic agent for diabetic nephropathy.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Multidisciplinary Sciences
Borys Frankewycz, Rebecca Bell, Monideepa Chatterjee, Nelly Andarawis-Puri
Summary: MRL mice have improved tendon healing capacity, with the innate tendon environment playing a driving role in the enhanced healing ability, and MRL also exhibits a systemic protective effect that reduces joint adhesions.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
M. Herranz-Iturbide, J. Lopez-Luque, E. Gonzalez-Sanchez, D. Caballero-Diaz, E. Crosas-Molist, B. Martin-Mur, M. Gut, A. Esteve-Codina, V Jaquet, J. X. Jiang, N. J. Torok, I Fabregat
Summary: NOX4 plays a role in promoting hepatocyte proliferation and repair during liver regeneration, with its deletion leading to accelerated liver recovery. NOX4-deleted mice show faster cell proliferation and better liver weight restoration, suggesting the potential of NOX4 as a therapeutic target for improving liver regeneration.
Review
Oncology
Lidia Rodriguez Calleja, Melanie Lavaud, Robel Tesfaye, Benedicte Brounais-Le-Royer, Marc Baud'huin, Steven Georges, Francois Lamoureux, Franck Verrecchia, Benjamin Ory
Summary: The p53 protein family and the TGFb pathway play important roles in tumor growth and metastatic spread. Various isoforms of the p53 protein family, as well as interactions between the p53 protein family and the TGFb pathway, have been found to contribute to the complexity of tumor development.
Article
Environmental Sciences
Emily F. Winterbottom, Devin C. Koestler, Dennis Liang Fei, Eric Wika, Anthony J. Capobianco, Carmen J. Marsit, Margaret R. Karagas, David J. Robbins
ENVIRONMENTAL HEALTH
(2017)
Article
Oncology
Xiaoqing Han, Prathibha Ranganathan, Christos Tzimas, Kelly L. Weaver, Ke Jin, Luisana Astudillo, Wen Zhou, Xiaoxia Zhu, Bin Li, David J. Robbins, Anthony J. Capobianco
MOLECULAR CANCER RESEARCH
(2017)
Article
Biochemistry & Molecular Biology
J. Rodriguez-Blanco, L. Pednekar, C. Penas, B. Li, V. Martin, J. Long, E. Lee, W. A. Weiss, C. Rodriguez, N. Mehrdad, D. M. Nguyen, N. G. Ayad, P. Rai, A. J. Capobianco, D. J. Robbins
Article
Biochemistry & Molecular Biology
Bin Li, Darren Orton, Leif R. Neitzel, Luisana Astudillo, Chen Shen, Jun Long, Xi Chen, Kellye C. Kirkbride, Thomas Doundoulakis, Marcy L. Guerra, Julia Zaias, Dennis Liang Fei, Jezabel Rodriguez-Blanco, Curtis Thorne, Zhiqiang Wang, Ke Jin, Dao M. Nguyen, Laurence R. Sands, Floriano Marchetti, Maria T. Abreu, Melanie H. Cobb, Anthony J. Capobianco, Ethan Lee, David J. Robbins
Article
Biochemistry & Molecular Biology
Bin Li, Darren Orton, Leif R. Neitzel, Luisana Astudillo, Chen Shen, Jun Long, Xi Chen, Kellye C. Kirkbride, Thomas Doundoulakis, Marcy L. Guerra, Julia Zaias, Dennis Liang Fei, Jezabel Rodriguez-Blanco, Curtis Thorne, Zhiqiang Wang, Ke Jin, Dao M. Nguyen, Laurence R. Sands, Floriano Marchetti, Maria T. Abreu, Melanie H. Cobb, Anthony J. Capobianco, Ethan Lee, David J. Robbins
Article
Multidisciplinary Sciences
Ines Lohse, Hassan Al-Ali, Claude-Henry Volmar, Annamil D. Alvarez Trotta, Shaun P. Brothers, Anthony J. Capobianco, Claes Wahlestedt
Article
Oncology
Jezabel Rodriguez-Blanco, Bin Li, Jun Long, Chen Shen, Fan Yang, Darren Orton, Sara Collins, Noriyuki Kasahara, Nagi G. Ayad, Heather J. McCrea, Martine F. Roussel, William A. Weiss, Anthony J. Capobianco, David J. Robbins
CLINICAL CANCER RESEARCH
(2019)
Article
Environmental Sciences
Emily F. Winterbottom, Yuka Moroishi, Yuliya Halchenko, David A. Armstrong, Paul J. Beach, Quang P. Nguyen, Anthony J. Capobianco, Nagi G. Ayad, Carmen J. Marsit, Zhigang Li, Margaret R. Karagas, David J. Robbins
ENVIRONMENTAL HEALTH
(2019)
Article
Environmental Sciences
Emily F. Winterbottom, Yuguang Ban, Xiaodian Sun, Anthony J. Capobianco, Carmen J. Marsit, Xi Chen, Lily Wang, Margaret R. Karagas, David J. Robbins
ENVIRONMENTAL HEALTH
(2019)
Article
Biochemistry & Molecular Biology
Chen Shen, Bin Li, Luisana Astudillo, Murray P. Deutscher, Melanie H. Cobb, Anthony J. Capobianco, Ethan Lee, David J. Robbins
Article
Oncology
Annamil Alvarez-Trotta, William Guerrant, Luisana Astudillo, Mohini Lahiry, Giulia Diluvio, Elena Shersher, Hugo Kaneku, David J. Robbins, Darren Orton, Anthony J. Capobianco
Summary: NADI-351 is the first specific small-molecule inhibitor that selectively disrupts Notch1 transcriptional complexes, demonstrating robust antitumor activity without inducing intestinal toxicity, providing a potential therapeutic approach for improved cancer treatment.
Article
Cell Biology
Elena Shersher, Mohini Lahiry, Annamil Alvarez-Trotta, Giulia Diluvio, David J. Robbins, Ramin Shiekhattar, Anthony J. Capobianco
Summary: This study identifies the INT complex as a novel co-factor in Notch-mediated transcription that together with NACK activates Notch target genes and leads to cancer cell proliferation.
CELL COMMUNICATION AND SIGNALING
(2021)
Article
Multidisciplinary Sciences
Chen Shen, Anmada Nayak, Leif R. Neitzel, Amber A. Adams, Maya Silver-Isenstadt, Leah M. Sawyer, Hassina Benchabane, Huilan Wang, Nawat Bunnag, Bin Li, Daniel T. Wynn, Fan Yang, Marta Garcia-Contreras, Charles H. Williams, Sivanesan Dakshanamurthy, Charles C. Hong, Nagi G. Ayad, Anthony J. Capobianco, Yashi Ahmed, Ethan Lee, David J. Robbins
Summary: This study reveals how the Wnt ligand can enhance CRBN-dependent protein degradation and highlights the importance of CRBN in physiological Wnt signaling.
NATURE COMMUNICATIONS
(2021)
Article
Oncology
Ke Jin, Wen Zhou, Xiaoqing Han, Zhiqiang Wang, Bin Li, Shawn Jeffries, Wensi Tao, David J. Robbins, Anthony J. Capobianco
Article
Cell Biology
Alexandria Scott, Feng Bai, Ho Lam Chan, Shiqin Liu, Joyce M. Slingerland, David J. Robbins, Anthony J. Capobianco, Xin-Hai Pei