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The DNA-dependent protein kinase (DNA-PK) More than just a case of making ends meet?

CELL CYCLE (2010)

期刊

CELL CYCLE

卷 9, 期 17, 页码 3460-3469

出版社

TAYLOR & FRANCIS INC

DOI: 10.4161/cc.9.17.13043

关键词

DNA-PK; p53; apoptosis; transcription

类别

Cell Biology

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Reagent

摘要

The DNA-dependent protein kinase (DNA-PK) has a vital role in DNA double strand break repair and in mediating V(D) J recombination events. Over the years a body of data has implicated DNA-PK playing a significant role in mediating a p53-dependent apoptotic response under a range of cellular conditions including exposure to ionizing radiation (IR), environmental carcinogens and chemotherapeutic agents or in cells that have critically shortened telomeres. These findings raise the hypothesis that DNA-PK acts as both a sensor and transmitter of DNA damage signals that directly impact cell fate. These many overlapping roles are discussed and considered in this review article.

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