期刊
CELL CYCLE
卷 9, 期 12, 页码 2292-2299出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/cc.9.12.11919
关键词
hippo pathway; YAP; cell growth; apoptosis; cancer
类别
资金
- Alex's Lemonade Stand Foundation
- National Brain Tumor Society
- Spanish Ministry of Education
During development and in cancer, tissue and cell growth control requires coordinated regulation of cell proliferation and apoptosis. The tumor suppressive Hippo pathway plays a key role in size regulation and cell-contact inhibition. During the past decade, this pathway has been delineated in Drosophila and now is starting to be better understood in mammals, where an increasing level of complexity and cell context specificity is becoming evident. As we discuss, dys-regulation of this pathway at any step can lead to uncontrolled growth and tumor formation. Indeed, a majority of the pathway components have been implicated in human cancers.
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