Review
Biochemistry & Molecular Biology
Robert H. Whitaker, Jeanette Gowen Cook
Summary: Protein signaling networks are formed by diverse and interconnected cell signaling pathways, with the mitogen activated protein kinases (MAPKs) being important components in transmitting signals through phosphorylation. The p38 family, a subfamily of MAPKs, plays a crucial role in regulating various cellular functions such as DNA repair and cell survival. Additionally, the balance of the BCL2 family members determines cell survival by controlling apoptosis signaling pathways.
Article
Medicine, Research & Experimental
Qun Long, Xiao Xiao, Ping Yi, Yuancui Liu, Krishnapriya M. Varier, Qing Rao, Jingrui Song, Jianfei Qiu, Chunlin Wang, Wuling Liu, Babu Gajendran, Zhixu He, Sheng Liu, Yanmei Li
Summary: This study investigated the anti-leukemic effect of a new Calothrixin B derivative, L20, which showed significant cytotoxicity in HEL cells and induced apoptosis and G(2)/M arrest. The mechanism involved DNA damage, modulation of p38 MAPK pathways, and mitochondrial-mediated apoptosis.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Genetics & Heredity
Yongxin Li, Yan Tong, Jiaqi Liu, Jianlin Lou
Summary: DNA is crucial for organism development and function. MiRNA, a type of non-coding RNA, may play an important role in the DNA damage response by influencing processes like cell cycle, DNA repair, and apoptosis, thereby impacting genomic stability and tumorigenesis.
FRONTIERS IN GENETICS
(2022)
Article
Oncology
Kyle H. Bond, Jennifer L. Fetting, Christine W. Lary, Ivette F. Emery, Leif Oxburgh
Summary: The study reveals that FOXD1 regulates the cell cycle in ccRCC cells by controlling histone H3 phosphorylation and governs tumor formation and growth. Transcriptome analysis supports this role for FOXD1 in ccRCC patient tumors and explains the inverse correlation between FOXD1 expression and patient survival.
Review
Biochemistry & Molecular Biology
Naomie Gentric, Pascal Genschik, Sandra Noir
Summary: The article discusses the response of plants to DNA damage, summarizing important regulatory steps of the plant cell cycle and DNA damage response mechanisms. Furthermore, it specifically examines the role played by some cell cycle regulators at the interface between the cell cycle and DNA damage responses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Hai-bin Nong, Ya-nan Zhang, Yi-guang Bai, Qiong Zhang, Ming-fu Liu, Quan Zhou, Zhuo-hua Shi, Gao-feng Zeng, Shao-Hui Zong
Summary: The study demonstrated that ADA significantly inhibited cell proliferation, migration, invasiveness, induced S-phase arrest and apoptosis in prostate cancer cells. ADA also regulated the expression of S-phase associated proteins and DNA damage markers, suggesting its potential anti-tumor effect through the DNA damage/p53 pathway. Additionally, ADA effectively inhibited tumor growth and bone destruction in mice models.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Vartika Srivastava, Mohmmad Younus Wani, Abdullah Saad Al-Bogami, Aijaz Ahmad
Summary: The study synthesized six novel piperidine derivatives and tested their antifungal activity and mechanism of action against clinical isolates of C. auris. Among them, pta1, pta2, and pta3 demonstrated the highest activity, lower toxicity, and the ability to induce apoptotic cell death and cell cycle arrest in C. auris.
JOURNAL OF ADVANCED RESEARCH
(2021)
Article
Genetics & Heredity
Delisa E. Clay, Donald T. Fox
Summary: Genome damage is a common threat to all organisms, and DNA damage responses (DDRs) play a crucial role in initiating cell cycle arrest, repair, and cell death. While many DDR components are conserved across different organisms, there are also adaptations to specific needs. Research on model genetic organisms has greatly advanced our understanding of DDR mechanisms and how they are influenced by the cell cycle stage. Future studies expanding beyond traditional model organisms will further enhance our knowledge of genome protection mechanisms.
Review
Plant Sciences
Jose Antonio Pedroza-Garcia, Yanli Xiang, Lieven De Veylder
Summary: Plants utilize DNA damage response pathways to cope with various stresses, involving cell cycle checkpoint mechanisms that either pause the cell cycle for DNA repair or direct cells into differentiation or programmed cell death. Different checkpoint mechanisms control replication processes and G2/M transition, with plant-specific elements such as SOG1 playing a key role. These mechanisms are called upon during development, signaling pathways, and in response to stresses, contributing to plant adaptation to changing environments.
Article
Cell Biology
Antoine Simoneau, Rosalinda Xiong, Lee Zou
Summary: PARP inhibitor (PARPi) generates DNA double-strand breaks (DSBs) predominantly in a trans cell cycle manner by inducing single-stranded DNA (ssDNA) gaps during the first S phase after exposure. BRCA1/2-deficient cells are unable to effectively repair DSBs, resulting in the unique efficacy of PARPi in these cells.
GENES & DEVELOPMENT
(2021)
Article
Biochemistry & Molecular Biology
Jia-feng Tang, Guo-li Li, Tao Zhang, Yu-mei Du, Shi-ying Huang, Jian-hua Ran, Jing Li, Di-long Chen
Summary: In this study, it was found that HHT effectively inhibits the proliferation of melanoma cells by inducing DNA damage, apoptosis, and cell cycle arrest. Both in vitro and in vivo experiments confirmed the inhibitory effect of HHT on melanoma, providing evidence for its potential as an anti-melanoma agent.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Oncology
Chunmei Wen, Qingqing Ruan, Zhaofeng Li, Xiang Zhou, Xuezhi Yang, Pingwei Xu, Percy David Papa Akuetteh, Zheng Xu, Jie Deng
Summary: This study found that Cory inhibited the proliferation of pancreatic cancer cells, induced apoptosis, and promoted cell death by generating intracellular reactive oxygen species (ROS) and activating the p38 signaling pathway. Cory also exerted an anti-tumor effect by inducing endoplasmic reticulum stress.
BRITISH JOURNAL OF CANCER
(2022)
Article
Multidisciplinary Sciences
Najmeh Soltanmohammadi, Siyao Wang, Bjoern Schumacher
Summary: This study reveals that stress signaling from intestinal cells regulates elimination of germ cells carrying damaged genomes, which in turn impacts inheritance. Failure of intestinal signaling results in stress-induced aneuploidy.
NATURE COMMUNICATIONS
(2022)
Article
Pharmacology & Pharmacy
Sara Cimini, Giorgio Giaccone, Fabrizio Tagliavini, Matteo Costantino, Paola Perego, Giacomina Rossi
Summary: Tau protein, which plays a key role in neurons, is associated with neurodegenerative diseases and has been found to be linked to cancer. Mutations in the MAPT gene, which codes for tau, lead to dysregulation of cancer-relevant processes and decreased sensitivity to microtubule and DNA perturbation.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Qinqin Xu, Ryan P. Mackay, Adam Y. Xiao, John A. Copland, Paul M. Weinberger
Summary: ATC is a highly lethal malignancy with no effective treatment currently available. YM155, identified as a promising candidate in a high-throughput screen, shows potential as a targeted therapy for ATC by inhibiting proliferation of cancer cells while sparing normal cells, inducing DNA damage, cell cycle arrest, and apoptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Ian G. Canne, Karl A. Merrick, Sandra Morandell, Chang-Qi Zhu, Christian J. Braun, Robert A. Grant, Eleanor R. Cameron, Ming-Sound Tsao, Michael T. Hemann, Michael B. Yaffe
Correction
Oncology
Ian G. Cannell, Karl A. Merrick, Sandra Morandell, Chang-Qi Zhu, Christian J. Braun, Robert A. Grant, Eleanor R. Cameron, Ming-Sound Tsao, Michael T. Hemann, Michael B. Yaffe
Article
Cell Biology
Joanna Somers, Lindsay A. Wilson, John-Paul Kilday, Emilie Horvilleur, Ian G. Cannell, Tuija A. A. Poeyry, Laura C. Cobbold, Alexander Kondrashov, John R. P. Knight, Stephanie Puget, Jacques Grill, Richard G. Grundy, Martin Bushell, Anne E. Willis
GENES & DEVELOPMENT
(2015)
Article
Cell Biology
H. Christian Reinhardt, Ian G. Cannell, Sandra Morandell, Michael B. Yaffe
Article
Biochemistry & Molecular Biology
D. Ferland-McCollough, D. S. Fernandez-Twinn, I. G. Cannell, H. David, M. Warner, A. A. Vaag, J. Bork-Jensen, C. Brons, T. W. Gant, A. E. Willis, K. Siddle, M. Bushell, S. E. Ozanne
CELL DEATH AND DIFFERENTIATION
(2012)
Editorial Material
Critical Care Medicine
Ian G. Cannell, Michael B. Yaffe
CRITICAL CARE MEDICINE
(2011)
Article
Biochemistry & Molecular Biology
Theresia R. Kress, Ian G. Cannell, Arjan B. Brenkman, Birgit Samans, Matthias Gaestel, Paul Roepman, Boudewijn M. Burgering, Martin Bushell, Andreas Rosenwald, Martin Eilers
Article
Multidisciplinary Sciences
Scott R. Floyd, Michael E. Pacold, Qiuying Huang, Scott M. Clarke, Fred C. Lam, Ian G. Cannell, Bryan D. Bryson, Jonathan Rameseder, Michael J. Lee, Emily J. Blake, Anna Fydrych, Richard Ho, Benjamin A. Greenberger, Grace C. Chen, Amanda Maffa, Amanda M. Del Rosario, David E. Root, Anne E. Carpenter, William C. Hahn, David M. Sabatini, Clark C. Chen, Forest M. White, James E. Bradner, Michael B. Yaffe
Article
Cell Biology
Sandra Morandell, H. Christian Reinhardt, Ian G. Cannell, Jacob S. Kim, Daniela M. Ruf, Tanya Mitra, Anthony D. Couvillon, Tyler Jacks, Michael B. Yaffe
Article
Biochemistry & Molecular Biology
Emma Laks, Andrew McPherson, Hans Zahn, Daniel Lai, Adi Steif, Jazmine Brimhall, Justina Biele, Beixi Wang, Tehmina Masud, Jerome Ting, Diljot Grewal, Cydney Nielsen, Samantha Leung, Viktoria Bojilova, Maia Smith, Oleg Golovko, Steven Poon, Peter Eirew, Farhia Kabeer, Teresa Ruiz de Algara, So Ra Lee, M. Jafar Taghiyar, Curtis Huebner, Jessica Ngo, Tim Chan, Spencer Vatrt-Watts, Pascale Walters, Nafis Abrar, Sophia Chan, Matt Wiens, Lauren Martin, R. Wilder Scott, T. Michael Underhill, Elizabeth Chavez, Christian Steidl, Daniel Da Costa, Yussanne Ma, Robin J. N. Coope, Richard Corbett, Stephen Pleasance, Richard Moore, Andrew J. Mungall, Colin Mar, Fergus Cafferty, Karen Gelmon, Stephen Chia, Marco A. Marra, Carl Hansen, Sohrab P. Shah, Samuel Aparicio
Article
Cell Biology
Konstantin Krismer, Molly A. Bird, Shohreh Varmeh, Erika D. Handly, Anna Gattinger, Thomas Bernwinkler, Daniel A. Anderson, Andreas Heinzel, Brian A. Joughin, Yi Wen Kong, Ian G. Cannell, Michael B. Yaffe
Article
Multidisciplinary Sciences
Dimitra Georgopoulou, Maurizio Callari, Oscar M. Rueda, Abigail Shea, Alistair Martin, Agnese Giovannetti, Fatime Qosaj, Ali Dariush, Suet-Feung Chin, Larissa S. Carnevalli, Elena Provenzano, Wendy Greenwood, Giulia Lerda, Elham Esmaeilishirazifard, Martin O'Reilly, Violeta Serra, Dario Bressan, Gordon B. Mills, H. R. Ali, Sabina S. Cosulich, Gregory J. Hannon, Alejandra Bruna, Carlos Caldas, S. Alon, M. Al Sa'd, S. Aparicio, G. Battistoni, S. Balasubramanian, R. Becker, B. Bodenmiller, E. S. Boyden, Marcel Burger, I. G. Cannell, H. Casbolt, N. Chornay, Y. Cui, A. Dariush, K. Dinh, A. Emenari, Y. Eyal-Lubling, J. Fan, A. Fatemi, E. Fisher, E. A. Gonzalez-Solares, C. Gonzalez-Fernandez, D. Goodwin, W. Greenwood, F. Grimaldi, G. J. Hannon, O. Harris, S. Harris, C. Jauset, J. A. Joyce, E. D. Karagiannis, T. Kovacevic, L. Kuett, R. Kunes, Yoldas A. Kupcu, D. Lai, E. Laks, H. Lee, M. Lee, G. Lerda, Y. Li, A. McPherson, N. Millar, C. M. Mulvey, F. Nugent, C. H. O'Flanagan, M. Paez-Ribes, I. Pearsall, F. Qosaj, A. J. Roth, O. M. Rueda, T. Ruiz, K. Sawicka, L. A. Sepulveda, S. P. Shah, A. Shea, A. Sinha, A. Smith, S. Tavare, S. Tietscher, I. Vazquez-Garcia, S. L. Vogl, N. A. Walton, A. T. Wassie, S. S. Watson, J. Weselak, S. A. Wild, E. Williams, J. Windhager, T. Whitmarsh, C. Xia, P. Zheng, X. Zhuang
Summary: Breast cancer heterogeneity plays a significant role in drug response and resistance. This study utilizes patient-derived tumor xenografts for drug testing and correlation with single-cell proteomic phenotypes revealed by mass cytometry, shedding light on the association between cellular heterogeneity and drug response and resistance.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Sohrab Salehi, Farhia Kabeer, Nicholas Ceglia, Mirela Andronescu, Marc J. Williams, Kieran R. Campbell, Tehmina Masud, Beixi Wang, Justina Biele, Jazmine Brimhall, David Gee, Hakwoo Lee, Jerome Ting, Allen W. Zhang, Hoa Tran, Ciara O'Flanagan, Fatemeh Dorri, Nicole Rusk, Teresa Ruiz de Algara, So Ra Lee, Brian Yu Chieh Cheng, Peter Eirew, Takako Kono, Jenifer Pham, Diljot Grewal, Daniel Lai, Richard Moore, Andrew J. Mungall, Marco A. Marra, Andrew McPherson, Alexandre Bouchard-Cote, Samuel Aparicio, Sohrab P. Shah
Summary: Progress in defining genomic fitness landscapes in cancer, particularly those associated with copy number alterations (CNAs), has been hindered by the absence of time-series single-cell sampling and temporal statistical models. This study generated a large number of genomes from long-term time-series single-cell whole-genome sequencing of breast epithelium and primary triple-negative breast cancer (TNBC) patient-derived xenografts, revealing the impact of TP53 mutation and cisplatin chemotherapy on clonal fitness dynamics defined by CNAs. The findings show that TP53 mutation alters the fitness landscape, redistributing fitness across different clones associated with distinct CNAs, and that drug treatment can lead to the emergence of drug-resistant clones while eradicating high-fitness clones in untreated settings.
Article
Biology
Sophia A. Wild, Ian G. Cannell, Ashley Nicholls, Katarzyna Kania, Dario Bressan, Gregory J. Hannon, Kirsty Sawicka
Summary: This study utilizes clonal transcriptomics with WILD-seq to analyze mouse models of TNBC and identifies NRF2 as a major mechanism of taxane resistance. It also discovers the collateral sensitivity of tumor models to asparagine deprivation therapy using L-asparaginase after docetaxel treatment.
Article
Oncology
Laura Kuett, Raul Catena, Alaz Ozcan, Alex Pluss, Peter Schraml, Holger Moch, Natalie de Souza, Bernd Bodenmiller
Summary: The article introduces a new imaging mass cytometry technology that allows for multiplexed tissue analysis in three dimensions. The study shows that this technology can reveal the complexity of cells and microenvironments, as well as phenomena occurring in three-dimensional space, such as tumor cell invasion.
