Article
Oncology
Mackenzie L. Davenport, John B. Echols, Austin D. Silva, Joshua C. Anderson, Philip Owens, Clayton Yates, Qing Wei, Shuko Harada, Douglas R. Hurst, Mick D. Edmonds
Summary: miR-31 demonstrates oncogenic properties in specific subtypes of lung cancer, highlighting its potential as a therapeutic target in these subtypes.
Editorial Material
Microbiology
Rik L. de Swart
Summary: In this study, Zohar et al. examined the immunization of non-human primates with six different candidate vaccines for respiratory syncytial virus, revealing distinct antibody profiles and varying levels of protection. Using a systems serology approach, they identified compartment-specific antibody mediated correlates of protection.
CELL HOST & MICROBE
(2022)
Editorial Material
Multidisciplinary Sciences
Lauren Gravitz
Summary: A special package that delves into the issues of unjust geography and offers potential solutions.
Article
Biochemistry & Molecular Biology
Anna Polz, Kamal Morshed, Robert Bibik, Bartlomiej Drop, Andrzej Drop, Malgorzata Polz-Dacewicz
Summary: This study aimed to investigate the importance of miR-31-5p and miR-let 7a in the pathogenesis of EBV-associated oropharyngeal cancer. The results showed a significantly increased serum level of miR-31-5p but decreased level of miR-let 7a in EBV positive oropharyngeal cancer patients. The study also found an association between the levels of these miRs and clinical stage, suggesting their potential as important biomarkers for the diagnosis of EBV-associated oropharyngeal cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Yuan Chen, Shiben Ji, Jianxin Ying, Yongchang Sun, Jun Liu, Guohong Yin
Summary: This study identifies a novel biomarker, KRT6A, for early diagnosis of bladder tumors and reveals its role in promoting bladder tumor progression. Additionally, it uncovers the regulatory axis of KRT6A/miR-31-5p in bladder tumor growth.
Editorial Material
Oncology
Huocong Huang, Rolf A. Brekken
Summary: Spatial single-cell transcriptomics of primary diffuse type gastric cancer revealed distinct cancer and stromal cell differences based on location. The expression of CCL2 by stromal cells in deep tumor regions may drive the immunosuppressive microenvironment and enhance the invasive capacity of tumor cells.
CLINICAL CANCER RESEARCH
(2021)
Editorial Material
Oncology
Andres Felipe Cardona, Maria Gonzalez-Cao, Oscar Arrieta, Rafael Rosell
Summary: This study reveals the therapy dilemma faced by EGFR exon 20 insertions subgroup in NSCLC and the effectiveness of poziotinib in treating this subgroup. The study also finds that tumor growth in poziotinib-resistant exon 20 insertions can be inhibited by pharmacological inhibition of spindle assembly checkpoint components.
Article
Biochemistry & Molecular Biology
Sachi Oshima, Shunichi Asai, Naohiko Seki, Chikashi Minemura, Takashi Kinoshita, Yusuke Goto, Naoko Kikkawa, Shogo Moriya, Atsushi Kasamatsu, Toyoyuki Hanazawa, Katsuhiro Uzawa
Summary: The miRNAs miR-31-5p and miR-31-3p play important roles in regulating the oncogenic properties of HNSCC cells, affecting patient prognosis by controlling a series of genes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Sujin Choi, Soonchul Lee, Young-Hoon Han, Junwon Choi, Isaac Kim, Jusung Lee, Hyun-Ju An
Summary: miR-31-3p is expressed at lower levels in prostate cancer tissues compared to adjacent normal tissues, and it plays a tumor-suppressive role by inducing apoptosis and decreasing cell proliferation, migration, invasiveness. GABBR2 is identified as a direct target of miR-31-3p.
FRONTIERS IN ONCOLOGY
(2022)
Article
Urban Studies
Becky P. Y. Loo, Zhiran Huang
Summary: This study examines the relationship between high-speed rail (HSR) stations and city evolution from an urban science perspective. The analysis of 1627 HSR stations in 533 Chinese and European cities reveals that European cities have more contiguous and clustered activity clusters, indicating a clear downtown. In contrast, Chinese cities have more scattered clusters, suggesting polycentric urban development. The study also shows that it takes approximately two decades for an HSR station to mature and attract related development in the city.
Article
Multidisciplinary Sciences
Guoqiang Yan, Wang Lei
Summary: This study investigated the role of ELK1 and its downstream pathway in colorectal cancer (CRC). The findings suggest that ELK1 regulates the progression of CRC through the miR-31-5p/CDIP1 axis, which could be a potential therapeutic target for CRC.
Editorial Material
Endocrinology & Metabolism
Sivaraj M. Sundaram, Luke A. Doughty, Michael W. Sereda
Summary: The mitochondrial-binding mechanisms of Hexokinase (HK) -1 and its physiological relevance are still unclear. Recent studies suggest that the localization of HK1 controls glucose metabolic fate in myeloid cells, potentially contributing to inflammation associated with diabetes and aging.
TRENDS IN ENDOCRINOLOGY AND METABOLISM
(2022)
Article
Biochemistry & Molecular Biology
Maria Szubert, Anna Nowak-Gluck, Daria Domanska-Senderowska, Bozena Szymanska, Piotr Sowa, Aleksander Rycerz, Jacek R. Wilczynski
Summary: This study found that miR-31-3p was upregulated and miR-125b-1-3p was downregulated in cesarean scar endometriosis. These findings demonstrate the potential of using miRNA to monitor the risk of malignant transformation in endometriosis tissue.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Editorial Material
Immunology
Hadeesha Piyadasa, Michael Angelo, Sean C. Bendall
Summary: Capturing cell organization in the tumor microenvironment using spatial proteomics can provide insight into the disease. A pair of studies applying this to advanced lung and brain tumors identifies organizational immune hallmarks that are associated with patient outcomes.
Article
Economics
Christopher James Day
Summary: Reductions in freight transportation costs have led to agglomeration, reducing the need for production activities to be located near natural resources. However, as the world moves towards a low carbon economy, transport costs of renewable energy become a significant factor. Regions with surplus clean energy resources, strong institutions, and developed capital markets have a competitive advantage. The distribution of renewable energy and its transport costs significantly affect the price of industrial activities, impacting global value chains. Future models of industrial location should consider these dynamics.
STRUCTURAL CHANGE AND ECONOMIC DYNAMICS
(2022)
Article
Cell Biology
Christina H. Stuelten, Rachel M. Lee, Wolfgang Losert, Carole A. Parent
CELLULAR SIGNALLING
(2018)
Article
Biochemical Research Methods
Joe Chalfoun, Michael Majurski, Alden Dima, Christina Stuelten, Adele Peskin, Mary Brady
BMC BIOINFORMATICS
(2014)
Article
Oncology
Christina H. Stuelten, Adrian Barbul, Johanna I. Busch, Emily Sutton, Ryan Katz, Misako Sato, Lalage M. Wakefield, Anita B. Roberts, John E. Niederhuber
Article
Immunology
Lili Xu, Atsushi Kitani, Christina Stuelten, George McGrady, Ivan Fuss, Warren Strober
Article
Immunology
Jens Nolting, Carolin Daniel, Sabine Reuter, Christina Stuelten, Peng Li, Henry Sucov, Byung-Gyu Kim, John J. Letterio, Karsten Kretschmer, Hye-Jung Kim, Harald von Boehmer
JOURNAL OF EXPERIMENTAL MEDICINE
(2009)
Article
Oncology
Ethan A. Kohn, Yu-an Yang, Zhijun Du, Yoshiko Nagano, Catherine M. H. Van Schyndle, Michelle A. Herrmann, Madeleine Heldman, Jin-Qiu Chen, Christina H. Stuelten, Kathleen C. Flanders, Lalage M. Wakefield
MOLECULAR CANCER RESEARCH
(2012)
Article
Multidisciplinary Sciences
Christina H. Stuelten, Johanna I. Busch, Binwu Tang, Kathleen C. Flanders, Akira Oshima, Emily Sutton, Tatiana S. Karpova, Anita B. Roberts, Lalage M. Wakefield, John E. Niederhuber
Article
Multidisciplinary Sciences
Michael C. Weiger, Vidya Vedham, Christina H. Stuelten, Karen Shou, Mark Herrera, Misako Sato, Wolfgang Losert, Carole A. Parent
Article
Multidisciplinary Sciences
Christina H. Stuelten, Frances N. Cervoni-Curet, Johanna I. Busch, Emily Sutton, Joshua D. Webster, Sandra L. Kavalukas, Lalage M. Wakefield, Adrian Barbul, John E. Niederhuber
Article
Cell & Tissue Engineering
Christina H. Stuelten, Susan D. Mertins, Johanna I. Busch, Meghan Gowens, Dominic A. Scudiero, Mark W. Burkett, Karen M. Hite, Mike Alley, Melinda Hollingshead, Robert H. Shoemaker, John E. Niederhuber
Article
Chemistry, Multidisciplinary
Alex C. Szatmary, Christina H. Stuelten, Ralph Nossal
Review
Oncology
Christina H. Stuelten, Carole A. Parent, Denise J. Montell
NATURE REVIEWS CANCER
(2018)
Article
Oncology
R. M. Lee, C. H. Stuelten, C. A. Parent, W. Losert
CONVERGENT SCIENCE PHYSICAL ONCOLOGY
(2016)
Article
Oncology
Ethan A. Kohn, Zhijun Du, Misako Sato, Catherine M. H. van Schyndle, Michael A. Welsh, Yu-an Yang, Christina H. Stuelten, Binwu Tang, Wenjun Ju, Erwin P. Bottinger, Lalage M. Wakefield
BREAST CANCER RESEARCH
(2010)
