期刊
CELL CYCLE
卷 8, 期 8, 页码 1158-1160出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/cc.8.8.8139
关键词
hematopoietic stem cells; mitochondria; mTOR; reactive oxygen species; quiescence
类别
资金
- NIA NIH HHS [R01 AG036690] Funding Source: Medline
- NIGMS NIH HHS [RC1 GM091648] Funding Source: Medline
It has been hypothesized that adult hematopoietic stem cells (HSCs) need to remain quiescent to retain their long-term self-renewal activity and multipotency. However, it is still unclear how lack of quiescence is detrimental to HSC. We identified that the mTOR pathway is the key to HSCs quiescence. mTOR overactivation caused increased mitochondrial biogenesis and accumulation of much higher level of reactive oxygen species (ROS). Removal of ROS rescued HSC defects associated with hyperactivated mTOR. We propose susceptibility to ROS as the underlying cause for HSC's general requirement for quiescence.
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