期刊
CELL CYCLE
卷 8, 期 22, 页码 3695-3701出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/cc.8.22.9937
关键词
breast cancer; ATX; LPA; G protein-coupled receptor; inflammation; cytokines; target therapy
类别
资金
- DOD Breast Cancer Research Program [DAMD17-03-1-0409]
- National Institute of Health [CA82716, CA64602, CA099031]
Lysophosphatidic acid (LPA, 1- or 2-acyl-sn-glycerol 3-phosphate) mediates a plethora of physiological and pathological activities via interactions with a series of high affinity G protein-coupled receptors (GPCR). Both LPA receptor family members and autotaxin (ATX/LysoPLD), the primary LPA-producing enzyme, are aberrantly expressed in many human breast cancers and several other cancer lineages. Using transgenic mice expressing either an LPA receptor or ATX, we recently demonstrated that the ATX-LPA receptor axis plays a causal role in breast tumorigenesis and cancer-related inflammation, further validating the ATX-LPA receptor axis as a rich therapeutic target in cancer.
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