期刊
CELL CYCLE
卷 7, 期 12, 页码 1745-1762出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/cc.7.12.6166
关键词
radiosensitization; prostate cancer; p53; MDM-2; MDM-2 antagonists; senescence; PTEN; Akt
类别
资金
- NCI NIH HHS [R01 CA098195-05] Funding Source: Medline
- PHS HHS [R01098195] Funding Source: Medline
Prostate cancer remains a leading cause of death in men despite increased capacity to diagnose at earlier stages. After prostate cancer has become hormone independent, which often occurs after hormonal ablation therapies, it is difficult to effectively treat. Prostate cancer may arise from mutations and dysregulation of various genes involved in regulation signal transduction (e.g., PTEN, Akt, etc.,) and the cell cycle (e. g., p53, p21(Cip1), p27(Kip1), Rb, etc.,). This review focuses on the aberrant interactions of signal transduction and cell cycle genes products and how they can contribute to prostate cancer and alter therapeutic effectiveness.
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