Review
Cell Biology
T. Ferreira Luisa, Helder Maiato
Summary: Accurate chromosome segregation during mitosis requires a complete restructuring of cellular organization, including the remodeling of microtubules and actin cytoskeleton. These cytoplasmic events must be coordinated with mitotic chromosome condensation and nuclear envelope permeabilization to ensure mitotic timing and fidelity. Recent progress has been made in understanding the regulatory biochemical and mechanical pathways involved in these processes.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2021)
Article
Microbiology
Ramiro Tomasina, Fabiana C. Gonzalez, Erica S. Martins-Duarte, Philippe Bastin, Mathieu Gissot, Maria E. Francia
Summary: Centrosomes are crucial for cell division and formation of the mitotic spindle. This study reveals the important role of the inner core protein TgCep250L1 in Toxoplasma gondii cell division, as its absence leads to nuclear segregation defects and failure to assemble the mitotic spindle.
Review
Biochemistry & Molecular Biology
Yuri Prozzillo, Maria Virginia Santopietro, Giovanni Messina, Patrizio Dimitri
Summary: This review article focuses on the unconventional roles of epigenetic players, including chromatin remodelers and long non-coding RNAs, in cell division. The study highlights their impact on differentiation, development, and diseases.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Review
Cell Biology
Imge Ozugergin, Alisa Piekny
Summary: Cytokinesis, the process of physically dividing a cell into two daughters, has been extensively studied in vitro and early embryos, but its regulation in different animal cell types and developmental contexts remains poorly understood. Recent studies have revealed striking differences in the regulation of cytokinesis between different cell types and organisms, including diverse threshold requirements for structural components and different mechanisms of regulation. This review focuses on these differences, particularly in pathways independent of the mitotic spindle, and associated with the cortex, kinetochores, or chromatin.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Tenghan Zhuang, Boyan Zhang, Yihong Song, Fan Huang, Wangfei Chi, Guangwei Xin, Ziyu Zhang, Steven Y. Cheng, Qing Jiang, Chuanmao Zhang
Summary: Sufu, as a negative regulator, plays a critical role in both centrosome and nuclear localization, regulating centrosome duplication and DNA replication by facilitating CP110 phosphorylation and Cdt1 degradation. Serum stimulation leads to the removal of Sufu from the centrosome and nucleus, promoting cell cycle progression.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Cell Biology
Patrick Partscht, Borhan Uddin, Elmar Schiebel
Summary: This study reveals that there is redundancy among the three human CDC14 paralogues, CDC14A, CDC14B, and CDC14C, and their specific roles in cell cycle control are not clear. The functions of CDC14 proteins in the cell cycle are not conserved between yeast and human cells.
JOURNAL OF CELL SCIENCE
(2021)
Article
Biology
Tomoki Harada, Shoji Hata, Rioka Takagi, Takuma Komori, Masamitsu Fukuyama, Takumi Chinen, Daiju Kitagawa
Summary: This study analyzes the impact of phototoxicity on mitosis and identifies ascorbic acid as an efficient agent to alleviate these effects. The addition of ascorbic acid to the media allows for high temporal resolution imaging of mitotic events without photodamage.
COMMUNICATIONS BIOLOGY
(2023)
Article
Cell Biology
Wonkyung Oh, Ting Ting Wu, Seo-Yeon Jeong, Ho Jin You, Jung-Hee Lee
Summary: CtIP plays a critical role in regulating mitosis by interacting with TPX2 to control spindle dynamics and regulate the concentration of Aurora A and microtubule intensity at the spindle poles. Depletion of CtIP may lead to improper execution of mitosis and result in chromosomal instability.
Article
Multidisciplinary Sciences
Osama Garwain, Xiaoming Sun, Divya Ramalingam Iyer, Rui Li, Lihua Julie Zhu, Paul D. Kaufman
Summary: The depletion of Ki-67 in vertebrate mammals can cause DNA damage, particularly in mitotic cells. The C-terminal chromatin-binding domain of Ki-67 plays a crucial role in protecting cells from this damage. Simultaneous depletion of Ki-67 and p53 results in increased chromosome bridges and micronuclei, highlighting the importance of Ki-67 in maintaining genome stability.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Cell Biology
Fabiola Mascanzoni, Roberta Iannitti, Antonino Colanzi
Summary: The dynamic association between the Golgi complex and the centrosome plays a crucial role in cellular processes such as cell polarization and division.
Article
Oncology
Jose Thaiparambil, Chandra S. Amara, Subrata Sen, Nagireddy Putluri, Randa El-Zein
Summary: The exposure to cigarette smoke can induce centrosome amplification and clustering in lung epithelial cells, which may contribute to lung carcinogenesis. The cyclin D2-mediated centrosome clustering pathway is critical for mitosis and its inhibition can lead to cell death.
Article
Multidisciplinary Sciences
Georgios N. Hatzopoulos, Tim Kuekenshoener, Niccolo Banterle, Tatiana Favez, Isabelle Flueckiger, Virginie Hamel, Santiago Andany, Georg E. Fantner, Oliver Hantschel, Pierre Goenczy
Summary: The study presents the development of monobodies against Chlamydomonas reinhardtii SAS-6 and their effects on ring assembly and stacking, using X-ray crystallography, atomic force microscopy, and cryo-electron microscopy.
NATURE COMMUNICATIONS
(2021)
Review
Cell Biology
Fernando Luna-Maldonado, Marco A. Andonegui-Elguera, Jose Diaz-Chavez, Luis A. Herrera
Summary: This review highlights the importance of genomic stability for cellular function, and discusses the crosstalk between SAC and DDR proteins throughout the cell cycle, providing new insights into maintaining genome stability.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Sylvia Fenosoa Rasamizafy, Claude Delsert, Gabriel Rabeharivelo, Julien Cau, Nathalie Morin, Juliette van Dijk
Summary: Tubulin post-translational modifications play a crucial role in regulating microtubule properties and functions, with depletion of the acetyltransferase ATAT1 causing defects in mitotic progression. This study highlights the importance of tubulin acetylation in maintaining spindle bipolarity and proper recruitment of proteins essential for mitosis.
Article
Cell Biology
Amanda Guerreiro, Filipe De Sousa, Nicolas Liaudet, Daria Ivanova, Anja Eskat, Patrick Meraldi
Summary: In cells, WDR62 localizes at spindle poles, promoting the recruitment of the microtubule-severing enzyme katanin. This protein helps in efficient poleward microtubule flux during chromosome segregation, ultimately preventing lagging chromosomes during anaphase.
JOURNAL OF CELL BIOLOGY
(2021)