Article
Microbiology
Courtney M. Klappenbach, Nicholas M. Negretti, Jesse Aaron, Teng-Leong Chew, Michael E. Konkel
Summary: Our study reveals that C. jejuni infection alters the size and topology of focal adhesions in epithelial cells, leading to changes in cell adhesion strength and motility. The increased phosphorylation of paxillin and altered turnover at focal adhesions may contribute to the effects on cell behavior. Additionally, inhibiting protein synthesis or using specific mutants of C. jejuni can partially reverse these effects, suggesting a potential mechanism for the observed restricted intestinal repair in infected animals.
Article
Multidisciplinary Sciences
Guillaume Rapin, Nirvana Caballero, Iaroslav Gaponenko, Benedikt Ziegler, Audrey Rawleigh, Ermanno Moriggi, Thierry Giamarchi, Steven A. Brown, Patrycja Paruch
Summary: Cell-cell interactions play a crucial role in both normal tissue development and tumor invasion, affecting the geometry and dynamics of biological interfaces. Pharmacological modulation significantly influences the proliferation speed and roughness evolution of cell fronts. Interactions at different cell length scales exhibit distinct hierarchies of effects on cell front roughness.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Li-Juan Zhou, Jiao Peng, Min Chen, Li-Jie Yao, Wei-Hao Zou, Cynthia Y. He, Hong-Juan Peng
Summary: TgSAG1 is a crucial surface protein of tachyzoites that plays a role in parasite invasion and host immune regulation by interacting with S100A6. This interaction affects the invasion process and host cell response, ultimately leading to the secretion of TNF-alpha through specific signaling pathways.
Review
Developmental Biology
Naoya Yamaguchi, Holger Knaut
Summary: Cell-extracellular matrix interactions are essential for cell anchoring and migration, with focal adhesions (FAs) playing a key role. However, the role of FAs in vivo is still not well understood.
Article
Oncology
Yunjian Wang, Ahamad Imran, Ashwag Shami, Anis Ahmad Chaudhary, Shahanavaj Khan
Summary: Gallbladder cancer (GBC) is a major cause of cancer deaths worldwide, and research suggests that proteins from H. pylori may affect the growth of GBC by targeting the nucleus of host cells, potentially serving as targets or biomarkers for early treatment or diagnosis.
Article
Biochemistry & Molecular Biology
Yu-Shan Lin, Yi-Hsin Lin, MyHang Nguyen Thi, Shih-Chuan Hsiao, Wen-Tai Chiu
Summary: The dysregulation of store-operated Ca2+ entry (SOCE) is associated with cancer progression. Upregulation of stromal interaction molecule 1 (STIM1) promotes cancer cell migration, invasion, and metastasis, while excessive Ca2+ can have a negative impact on cancer metastasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Siew Pheng Lim
Summary: Despite the availability of vaccines and therapeutics, continuous genetic alterations in the SARS-CoV-2 virus pose a persistent threat, especially to immunocompromised and elderly individuals. The virus enters host cells via the interaction of its spike protein (S protein) with different receptors on the cell surface, such as angiotensin-converting enzyme 2 (ACE2). This review discusses therapeutic approaches to block the interaction between SARS-CoV-2 and host cell receptors, as well as the identification of auxiliary entry receptors.
ANTIVIRAL RESEARCH
(2023)
Article
Oncology
Xuan Yi, Linlin Luo, Yanzhen Zhu, Hong Deng, Huitian Liao, Yang Shen, Yan Zheng
Summary: SPP1 plays a critical role in promoting cell migration and invasion in lung adenocarcinoma by upregulating COL11A1 expression.
CANCER CELL INTERNATIONAL
(2022)
Article
Medicine, Research & Experimental
Hyuk-Kwon Kwon, Kristin E. Yu, Sean Cahill, Kareme D. Alder, Christopher M. Dussik, Sang-Hun Kim, Lokesh Sharma, Jungho Back, Irvin Oh, Francis Y. Lee
Summary: Intracellular infiltration of bacteria in bacterial joint infections complicates treatment and destroys cartilage. Glycolytic pathways play a crucial role in the proliferation of bacteria and the host inflammatory response. By targeting glycolysis, the drug DMF can inhibit bacterial growth and reduce inflammation, protecting the joint.
EMBO MOLECULAR MEDICINE
(2022)
Review
Nanoscience & Nanotechnology
Min Jun Shin, Jun Young Park, Dae Ho Lee, Dongwoo Khang
Summary: Mesenchymal stem cells (MSCs) possess homing ability and show potential in treating malignant diseases and rheumatoid arthritis. The migration and targeting capabilities of MSCs can be enhanced through genetic engineering or modification. MSC mimicking nanoencapsulations, as an alternative strategy, have targeting and drug delivery advantages, especially in combination with genetic engineering in clinical settings.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Judeng Zeng, Chuan Xie, Lin Zhang, Xiaodong Liu, Matthew Tak Vai Chan, William Ka Kei Wu, Huarong Chen
Summary: This article focuses on the virulence factors necessary for the colonization and survival of H. pylori in the host gastric mucosa, as well as the host's antimicrobial responses to H. pylori infection. Additionally, the current treatments for H. pylori eradication are described, along with insights into new therapeutic strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Cairong Zhu, Zhiquan Song, Zhen Chen, Tianqi Lin, Haili Lin, Zhenqiang Xu, Fen Ai, Shijiao Zheng
Summary: miR-4735-3p expression is reduced in ccRCC, but elevated upon ferroptotic stimulation. miR-4735-3p promotes ferroptosis and tumor suppression in ccRCC by targeting SLC40A1.
ANALYTICAL CELLULAR PATHOLOGY
(2022)
Article
Multidisciplinary Sciences
W. Tucker Shelton, S. Madison Thomas, Hunter R. Alexander, C. Evan Thomes, Daniel E. Conway, Adi D. Dubash
Summary: Desmosomes play a central role in cell-cell extracellular adhesion and also regulate biological processes such as proliferation, differentiation, apoptosis, and migration. The study found that the desmosomal protein Dsg2 controls cell-matrix adhesion through Rap1 GTPase, influencing cell spreading and focal adhesion protein phosphorylation. These findings provide insight into non-canonical effects of cadherins on cell spreading mechanisms.
SCIENTIFIC REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Natalia Diaz-Garrido, Cecilia Cordero, Yenifer Olivo-Martinez, Josefa Badia, Laura Baldoma
Summary: Cell-cell communication is crucial for maintaining body homeostasis and health, and extracellular vesicles (EVs) play a significant role in mediating this communication by transferring bioactive molecules between cells. The specific functions of EVs depend on their cargo, which can be influenced by genetic, pathological, and environmental factors. EVs released by cells in the gut have a significant impact on intestinal homeostasis, influencing epithelial barrier integrity, wound healing, immunity, and microbiota shaping.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Chuanjie Zhang, Yan Shen, Lili Gao, Xiaojing Wang, Da Huang, Xin Xie, Danfeng Xu, Hongchao He
Summary: This study investigated the biological functions and mechanisms of DNA polymerase epsilon subunit 2 (POLE2) in renal cell carcinoma (RCC). Results showed that high POLE2 expression in RCC tissues was correlated with poor prognosis. Knockdown of POLE2 inhibited cell proliferation, migration and promoted apoptosis, and its regulation of STC1 suggested potential as a target for RCC therapy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)