期刊
CELL CALCIUM
卷 49, 期 5, 页码 350-356出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ceca.2010.12.003
关键词
Calcium signaling; Placenta; Placental pathology; Placental development; Transcriptional regulation
类别
资金
- Canadian Institute of Health Research [64302]
- Department of Obstetrics & Gynecology and Rose Tomb Chair at Mount Sinai Hospital
- Swedish Research Council [2005-6682, 2009-3364, 2010-4392, DBRM]
- Foundation for Strategic Research (CEDB)
- Knut and Alice Wallenberg Foundation
- Royal Swedish Academy of Sciences
- Fredrik and Ingrid Thuring's Foundation
- Ake Wiberg's Foundation
- Magnus Bergvall's Foundation
- Swedish Society for Medical Research
The placenta sustains the developing fetus throughout gestation and its major functions include nutrition, gas and waste exchange via a variety of passive or active mechanisms. Up to 30 g of calcium (Ca2+) actively crosses the trophoblast layer during human pregnancy. The Ca2+ ion not only plays an important role for skeletal development but is also an essential second messenger. This review is intended to highlight the implications of Ca2+ signaling during reproduction and specifically placentation. Initially, a Ca2+ wave induces fertilization of the oocyte. The intracellular Ca2+ concentration is key for the blastocyst implantation, proper placental development and function. Current knowledge of many proteins involved in placental Ca2+ regulation and their function in pathologic conditions is largely limited. Recent studies, however, point to alterations in Ca2+ homeostasis in placental pathologies such as pre-eclampsia (PE) and intrauterine growth restriction (IUGR). A broader understanding of the role of Ca2+ signaling during human reproduction may offer insight into impaired pregnancy outcomes. (C) 2010 Elsevier Ltd. All rights reserved.
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