Article
Neurosciences
Sandra Blaess, Sabine Krabbe
Summary: In this article, recent studies investigating various aspects of dopaminergic heterogeneity are reviewed, including how development, behavior, and disease influence subtype characteristics. The potential future approaches to gain a more inclusive picture of dopaminergic diversity are outlined, which could be crucial for understanding the functional architecture of this system.
CURRENT OPINION IN NEUROBIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Walaa F. Alsanie, Sherin Abdelrahman, Majid Alhomrani, Ahmed Gaber, Hamza Habeeballah, Heba A. Alkhatabi, Raed I. Felimban, Charlotte A. E. Hauser, Hossam H. Tayeb, Abdulhakeem S. Alamri, Bassem M. Raafat, Sirajudheen Anwar, Khaled A. Alswat, Yusuf S. Althobaiti, Yousif A. Asiri
Summary: Research has shown that gabapentin interferes with the development of fetal ventral midbrain dopaminergic neurons, affecting morphology and expression of key developmental genes. This suggests that the use of gabapentin may lead to serious complications for pregnant women and their babies, warranting caution in prescription decisions.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Vladislav Chubinskiy-Nadezhdin, Svetlana Semenova, Valeria Vasileva, Alla Shatrova, Natalia Pugovkina, Yuri Negulyaev
Summary: Endometrial mesenchymal stem cells (eMSCs) have the ability to differentiate into different cell types and are influenced by mechanical forces in their microenvironment. This study identified Piezo1 proteins as mechanosensitive channels in the plasma membrane of eMSCs, which transduce mechanical stimuli into intracellular signaling pathways. The influx of Ca2+ triggered by Piezo1 activity is regulated by store-operated Ca2+ entry (SOCE) through the ORAI1 channel and STIM1/STIM2 Ca2+ sensors. Activation of Piezo1 or SOCE does not cause cytotoxicity in eMSCs but affects their migratory capacity and cell proliferation. This finding suggests that Piezo1 and SOCE play important roles in the regulation of intracellular calcium, which influences the migratory activity and regenerative potential of eMSCs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Jia Shang, Bin Li, Han Fan, Peidi Liu, Wen Zhao, Tao Chen, Pu Chen, Longqiu Yang
Summary: This study investigated the effects of sevoflurane on the midbrain's development using human physiologically-relevant midbrain organoids. The results showed that long-term exposure to sevoflurane could promote premature differentiation of midbrain organoids and inhibit cell proliferation, indicating a potential adverse effect on the midbrain development in fetuses.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Physiology
Declan Manning, Richard Barrett-Jolley, Richard L. Evans, Caroline Dart
Summary: Skin is the largest organ in the human body, mainly composed of keratinocytes which maintain a healthy skin barrier through regulated differentiation driven by Ca2+-transcriptional coupling. Disruption of this process leads to various skin conditions. Our study suggests that TRPC2 and Orai1 channels do not insert into the plasma membrane during store-operated Ca2+ entry.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Neurosciences
Amanda R. Burmeister, Juozas Gordevicius, Emmanuel N. Paul, Christina Houck, Sonia George, Martha L. Escobar Galvis, Qiong Sha, Patrik Brundin, J. Andrew Pospisilik, Karen Racicot, Lena Brundin
Summary: In this study, a mouse maternal infection model was used to investigate the impact of maternal herpesvirus infection on the development and physiology of midbrain dopaminergic neurons in adult offspring. The results suggested that maternal infection with Herpesviridae, specifically MHV68, can trigger changes in midbrain development that affect dopamine neuron physiology in adulthood. This study is important for understanding the neuronal susceptibility underlying neurodegenerative diseases, particularly Parkinson's disease.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Cell Biology
Marianna Tolve, Ayse Ulusoy, Nikolaos Patikas, K. Ushna S. Islam, Gabriela O. Bodea, Ece Oeztuerk, Bianca Broske, Astrid Mentani, Antonia Wagener, Karen M. J. van Loo, Stefan Britsch, Pengtao Liu, Walid T. Khaled, Emmanouil Metzakopian, Stephan L. Baader, Donato A. Di Monte, Sandra Blaess
Summary: The transcription factor BCL11A is expressed in subsets of murine and human dopamine neurons, forming specific subcircuits within the dopamine system. These Bcl11a-expressing neurons are vulnerable to neurodegeneration, as inactivation of Bcl11a increases susceptibility and results in motor behavior deficits. BCL11A is crucial for establishing and maintaining the physiological characteristics of dopamine neuron subpopulations.
Article
Neurosciences
Laetitia Etchepare, Helene Grea, Pauline Durand, Delphine Bouchet, Laurent Groc
Summary: Key points: NMDA receptors expressed by dopamine neurons in the midbrain have highly diffusive surface dynamics, which regulate the firing pattern of VTA dopaminergic neurons through a functional interplay with SK channels. This surface dynamics of NMDAR, rather than just its ionotropic function, tunes the firing pattern of midbrain DA neurons.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Cell Biology
Walaa F. Alsanie, Majid Alhomrani, Ahmed Gaber, Hamza Habeeballah, Heba A. Alkhatabi, Raed I. Felimban, Sherin Abdelrahman, Charlotte A. E. Hauser, Adeel G. Chaudhary, Abdulhakeem S. Alamri, Bassem M. Raafat, Abdulwahab Alamri, Sirajudheen Anwar, Khaled A. Alswat, Yusuf S. Althobaiti, Yousif A. Asiri
Summary: This study found that early exposure to pregabalin could interfere with the development of ventral midbrain dopaminergic neurons, which is crucial for clinical consideration of its use during pregnancy.
Article
Neurosciences
Mengjiao Chen, Fangqing Liu, Longying Wen, Xia Hu
Summary: This study used a mathematical model to analyze the mechanisms and synergy between muscarinic receptors (mAChRs) and NMDA receptors (NMDARs) in bursting induction of dopamine (DA) neurons. The findings provide new insights into the specific afferents and their synergy, contributing to a better understanding of dopamine signals and neuropsychiatric disorders.
COGNITIVE NEURODYNAMICS
(2022)
Review
Cell Biology
Ting Lu, Yihua Zhang, Yong Su, Dayan Zhou, Qiang Xu
Summary: Store-operated channels (SOCs) are highly selective Ca2+ channels that mediate Ca2+ influx in various cells. These channels are activated by Ca2+ depletion of the endoplasmic reticulum and sarcoplasmic reticulum, independently of inositol 1,4,5-trisphosphate (InsP3). SOC plays critical roles in endothelial dysfunction and vascular smooth muscle proliferation, contributing to the progression of cardiovascular disease.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Biochemistry & Molecular Biology
Egor A. Turovsky, Maria V. Turovskaya, Evgeniya I. Fedotova, Alexey A. Babaev, Victor S. Tarabykin, Elena G. Varlamova
Summary: Transcription factors Satb1 and Satb2 are involved in regulating genes encoding NMDA, AMPA, and KA receptor subunits, impacting neurotransmission and neuronal network inhibition. Their deletion alters gene expression and calcium signaling, affecting neuron maturation processes and switching GABAergic responses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Willy Carrasquel-Ursulaez, Ignacio Segura, Ignacio Diaz-Franulic, Felipe Echeverria, Yenisleidy Lorenzo-Ceballos, Nicolas Espinoza, Maximiliano Rojas, Jose Antonio Garate, Eduardo Perozo, Osvaldo Alvarez, Fernando D. Gonzalez-Nilo, Ramon Latorre
Summary: This study demonstrates that two arginines in the transmembrane segment S4 function as the gating charges of BK channels, and the energy landscape of gating particles is tuned by a network of salt bridges in the voltage sensor domain (VSD). Unlike Kv channels, the charge movement in BK seems limited to a small displacement of the guanidinium moieties of R210 and R213.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Cell Biology
Yuria Hori, Reiho Tsutsumi, Kento Nasu, Alex Boateng, Yasuhiko Ashikari, Masaharu Sugiura, Makoto Nakajima, Yuki Kurauchi, Akinori Hisatsune, Hiroshi Katsuki, Takahiro Seki
Summary: The study identified ar-turmerone analogs that directly and potently protected dopaminergic neurons, even independently of microglial activation inhibition, possibly involving nuclear factor erythroid 2-related factor 2.
Article
Neurosciences
Estelle Moubarak, Yanis Inglebert, Fabien Tell, Jean -Marc Goaillard
Summary: The shape of action potential (AP) is crucial in regulating neurotransmitter release and distinguishing neuronal populations. While variations in AP shape between different neuronal types are mainly attributed to differences in ion channel expression, the influence of dendritic morphology on AP shape has been suggested. This study investigates the relationship between dendritic morphology and AP shape in rat SNc DA neurons. The results demonstrate that dendritic morphology plays a significant role in defining the electrophysiological properties of SNc DA neurons.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Miae Jang, Ki Bum Um, Jinyoung Jang, Hyun Jin Kim, Hana Cho, Sungkwon Chung, Myoung Kyu Park
SCIENTIFIC REPORTS
(2015)
Article
Cell Biology
Shin Hye Kim, Jin Young Jang, Miae Jang, Ki Bum Um, Sungkwon Chung, Hyun Jin Kim, Myoung Kyu Park
Article
Biochemistry & Molecular Biology
Jin Young Jang, Miae Jang, Shin Hye Kim, Ki Bum Um, Yun Kyung Kang, Hyun Jin Kim, Sungkwon Chung, Myoung Kyu Park
JOURNAL OF NEUROCHEMISTRY
(2011)
Article
Neurosciences
Jinyoung Jang, Ki Bumum, Miae Jang, Shin Hye Kim, Hana Cho, Sungkwon Chung, Hyun Jin Kim, Myoung Kyu Park
JOURNAL OF PHYSIOLOGY-LONDON
(2014)
Article
Pharmacology & Pharmacy
Suyun Hahn, So Woon Kim, Ki Bum Um, Hyun Jin Kim, Myoung Kyu Park
BRITISH JOURNAL OF PHARMACOLOGY
(2020)
Article
Biology
Ki Bum Um, Suyun Hahn, So Woon Kim, Yoon Je Lee, Lutz Birnbaumer, Hyun Jin Kim, Myoung Kyu Park
Summary: The research shows that TRPC3 and NALCN channels together form sustained inward currents responsible for the slow depolarization of nigral DA neurons. Blocking TRPC3 channels completely halts dopamine neuron pacemaking, while blocking NALCN channels stops pacemaking altogether.
Article
Neurosciences
Suyun Hahn, Ki Bum Um, So Woon Kim, Hyun Jin Kim, Myoung Kyu Park
Summary: The proximal dendritic localization of NALCN channels determines the characteristics of pacemaking and burst firing in multipolar nigral dopamine neurons.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Cell Biology
Dominic Tscherrig, Rajesh Bhardwaj, Daniel Biner, Jan Dernic, Daniela Ross-Kaschitza, Christine Peinelt, Matthias A. Hediger, Martin Lochner
Summary: Changes in Ca2+ levels regulate many physiological functions, and the endoplasmic reticulum is the major Ca2+ store in cells. Store-operated calcium entry (SOCE) is a refilling process that involves protein-protein interactions between Ca2+ sensing STIM in the ER and Orai proteins in the plasma membrane, forming selective Ca2+ channels. Abnormal SOCE is associated with diseases and cancers, making STIM and Orai important therapeutic targets. Novel GSK-7975A-based molecular probes have been developed for studying SOCE in different cells and settings.
Article
Cell Biology
Nicola Fameli, Cornelis van Breemen, Klaus Groschner
Summary: The study provides evidence for the importance of junctional membrane architecture in cellular function. Through modeling and prediction, it is shown that nano-scale membrane spacing plays a crucial role in junctional ER Ca2+ refilling and signaling efficiency. Additionally, interactions between Ca2+ and the phospholipid membrane surface are suggested to support interfacial Ca2+ transport and receptor targeting. This research introduces a new concept in pathophysiology.
Article
Cell Biology
Satomi Ohtsuka, Yumi Miyai, Hiroyuki Mima, Masaki Magari, Yoichi Chiba, Futoshi Suizu, Hiroyuki Sakagami, Masaki Ueno, Hiroshi Tokumitsu
Summary: This study characterized the splice variants of mouse CaMKKI3/2 and found that CaMKKI3-3 and I3-3x were functionally active and likely to be bona fide CaMKIV kinases involved in the regulation of spermiogenesis.