Article
Oncology
Soon A. Park, Hye Rim Han, Stephen Ahn, Chung Heon Ryu, Sin-Soo Jeun
Summary: This study examined the synergistic effect of valproic acid (VPA) in enhancing MSC-delivered TRAIL efficacy, as well as the induced tumor tropism of MSCs. Combination treatment with VPA and MSCs-TRAIL increased therapeutic effect against glioma by enhancing death receptor 5 and caspase activation. Migration assays showed increased MSC migration in glioma cells and tumor site in glioma-bearing mice when treated with VPA and MSCs-TRAIL. In vivo experiments demonstrated greater therapeutic efficacy when MSC-based TRAIL gene delivery was used in VPA-treated tumors compared to each agent alone.
Review
Biochemistry & Molecular Biology
Farzad Sadri, Zohreh Rezaei, Mohammad Fereidouni
Summary: This review summarizes the molecular signature of the SDF-1/CXCR4 pathway and explains how this axis is involved in normal events.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Cell Biology
Ekaterina Kiseleva, Olesya Serbina, Anna Karpukhina, Vincent Mouly, Yegor S. Vassetzky
Summary: Facioscapulohumeral muscular dystrophy (FSHD) is a genetic disease caused by the ectopic expression of the DUX4 gene in skeletal muscle, leading to muscle degeneration and replacement by fat and connective tissue. This study demonstrates that the interaction between FSHD myoblasts and MSCs plays a crucial role in the pathophysiology of FSHD, including stimulation of MSC migration, proliferation, and collagen secretion.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Engineering, Biomedical
Fan An, Zhijie Hou, Xiaochao Wang, Zhongmin Wang, Chenying Jing, Ran Sui, Yameng Wu, Yunfeng Ma, Cheng Chang, Shuai Liu, Manman Li, Lijie Sun, Ziqi Gao, Wenjuan Zhang, Zhenghui Lang, Jiaqi Zhao, Yueyang Qu, Lingzhi Xu, Yong Luo, Jinsong Yan, Yuesheng Wang, Jie Xu, Quentin Liu
Summary: Mesenchymal stem cells (MSCs) play a critical role in promoting tumor metastasis, particularly in breast cancer. Through the use of a microfluidic-based 3D co-culture device, it was observed that MSCs guide cancer cell migration and accelerate invasion in a hypoxic microenvironment. The upregulation of H19 under hypoxic conditions was found to be important in MSCs-mediated cancer cell invasion. Aspirin was shown to suppress H19 expression and inhibit MSCs infiltration, leading to reduced breast cancer cell invasion.
Article
Oncology
Solmaz Khalighfard, Vahid Khori, Ebrahim Esmati, Farahnazsadat Ahmadi, Taghi Amiriani, Amirhoushang Poorkhani, Somayeh Sadani, Saeed Khodayari, Hamid Khodayari, Mohammad Reza Kalhori, Pedram Keshavarz, Ali Mohammad Alizadeh
Summary: Filgrastim, a recombinant G-CSF, can stimulate the migration of bone marrow-derived stem/progenitor cells to the bloodstream, which helps manage chemotherapy-induced leukopenia. However, our in vitro and in vivo experiments on 4T1 cells suggest that Filgrastim may increase cell migration, invasion, and metastasis, potentially increasing the risk of cancer cell metastasis in patients continuously receiving Filgrastim treatment.
Article
Medicine, Research & Experimental
Omaima A. Ahmedy, Marwa W. Kamel, Dalia M. Abouelfadl, Marwa E. Shabana, Rabab H. Sayed
Summary: This study discovered the protective effects of berberine in bleomycin-induced pulmonary fibrosis in mice, and its mechanism involved the activation of adenosine A2a receptor and suppression of SDF-1/CXCR4 signaling pathway. Berberine improved lung fibrosis by modulating the purinergic system, inhibiting epithelial mesenchymal transition, and effectively suppressing inflammation and oxidative stress.
Article
Cell & Tissue Engineering
Mingxing Sui, Tuo Li, Hanlan Lu, Yanhua Li, Juan Huang, Pei Zhang, Shusen Wang, Li Zeng
Summary: A recent study found that SDF-1 secreted by mesenchymal stromal cells can improve the function of islet grafts, but the presence of SOCS3 reverses the protective effect of SDF-1 on islet grafts. This study reveals a molecular pathway that can elicit localized immunosuppression and delay graft destruction in transplanted islets.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Oncology
Chunyan Ma
Summary: Adding bevacizumab to chemotherapy may have a positive impact on the treatment and prognosis of patients with epithelial ovarian cancer. It can significantly decrease the expression of related cancer markers and lower the recurrence rate, without significant safety concerns.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Biology
Shady G. El-Sawah, Hanan M. Rashwan, Fayez Althobaiti, Adil Aldhahrani, Eman Fayad, El-Shaimaa Shabana, Ehab El-Hallous, Rehab M. Amen
Summary: This study aimed to investigate the potential benefits of adult mesenchymal stem cells (MSCs) on metabolic disturbances and tissue function defects in diabetic rats. The results showed that MSCs treatment significantly reduced hyperglycemia, normalized lipid fractions levels, and had hepato-renal protective effects in diabetic rats.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Multidisciplinary Sciences
Jose Mario Gonzalez-Meljem, Sarah Ivins, Cynthia Lilian Andoniadou, Paul Le Tissier, Peter Scambler, Juan Pedro Martinez-Barbera
Summary: The role of the chemokine SDF-1 and its receptor CXCR4 in pituitary gland development was investigated. The expression patterns of CXCR4, SDF-1, and CXCR7 were characterized, and it was found that SDF-1 is expressed in progenitor-rich regions of the pituitary gland. Conditional deletion of CXCR4 in embryonic pituitary progenitors did not lead to observable defects, suggesting that CXCR4 expression in HESX1+ cells and their descendants is not essential for normal pituitary development in mice.
Article
Oncology
Chi Shang, Xuehai Ou, Hongxing Zhang, Dengke Wei, Qiang Wang, Gang Li
Summary: This study found that the aberrantly high expression of Progranulin (PGRN) in osteosarcoma (OS) was associated with poor prognosis. Inhibiting PGRN expression could repress the proliferation and migration of OS cells, and activating the MAPK signaling pathway reversed these effects. In addition, mesenchymal stem cells (MSCs) regulated PGRN to mediate the malignant behavior of OS cells. Hypoxia enhanced HIF-1α expression in MSCs, and silencing HIF-1α suppressed the oncogenic effects of MSCs and reduced PGRN expression in OS cells.
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Cell Biology
Yi Li, Ziqian Feng, Luochen Zhu, Ni Chen, Qin Wan, Jianbo Wu
Summary: Research has shown that SDF-1 and CXCR4 play important roles in regulating platelet activation, mitochondrial respiration, glucose uptake, and ATP production.
Article
Pathology
Hailing Tang, Qianfa Long, Kun Zhuang, Kun Han, Xin Zhang, Hanqing Guo, Xiaolan Lu
Summary: RB1 was downregulated in gastric cancer cell lines, and overexpression of RB1 enhanced chemosensitivity to 5-FU in gastric cancer cells by regulating cell autophagy via the SDF-1/CXCR4 pathway. RB1 may serve as a promising therapeutic target in gastric cancer.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Article
Biochemistry & Molecular Biology
Jiazhou Li, Hao Chen, Lang Cai, Daimo Guo, Demao Zhang, Xuedong Zhou, Jing Xie
Summary: This study reveals that SDF-1 alpha promotes chondrocyte autophagy through the CXCR4/mTOR signaling axis, highlighting the importance of autophagy in the survival of chondrocytes in harsh environments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell & Tissue Engineering
Yuyan Xiong, Ruijie Tang, Junyan Xu, Wenyang Jiang, Zhaoting Gong, Lili Zhang, Xiaosong Li, Yu Ning, Peisen Huang, Jun Xu, Guihao Chen, Chen Jin, Xiangdong Li, Haiyan Qian, Yuejin Yang
Summary: Sequential transplantation of exosomes and pretreated MSCs can effectively promote cardiac repair post-AMI. Among them, the combination of pretreatment with hypoxia and TXL significantly enhances the CXCR4 level of MSCs, promotes recruitment, improves cardiac function, reduces infarct size, and enhances angiogenesis.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Materials Science, Multidisciplinary
Yong Liu, Yinchuan Wang, Jialiang Lin, Meng Zhou, Fei Yu, Yongcan Huang, Bin Kang, Deli Wang, Tianbing Wang, Hui Zeng
Summary: The study found that brushite coated JDBM had the highest corrosion resistance, followed by uncoated JDBM, and then pure Mg. The main corrosion product of the Mg alloys in the cell culture medium was MgCO3 center dot 3H(2)O. The corrosion form of the JDBM alloys was uniform corrosion, while that of pure Mg was not uniform.
MATERIALS TODAY COMMUNICATIONS
(2021)
Article
Clinical Neurology
Jun-Xin Chen, Yun-He Li, Jian Wen, Zhen Li, Bin-Sheng Yu, Yong-Can Huang
Summary: This biomechanical study investigated the effects of cruciform and square incisions on the mechanical stability of bovine intervertebral discs. The results showed that both incisions reduced axial compressive and torsional stiffness, but did not affect flexion-extension and lateral-bending stiffness. This study is important for the development of new approaches to disc repair and patient rehabilitation after discectomy.
GLOBAL SPINE JOURNAL
(2023)
Article
Materials Science, Multidisciplinary
Bo Chen, Zhengjie Lin, Qimanguli Saiding, Yongcan Huang, Yi Sun, Xinyun Zhai, Ziyu Ning, Hai Liang, Wei Qiao, Bingsheng Yu, W. K. Kelvin Yeung, Jie Shen
Summary: The use of three-dimensional (3D) printed biocomposite scaffolds, reinforced with magnesium oxide (MgO), has shown promising results in the treatment of critical-sized bone defects (CSD). The incorporation of magnesium ions (Mg2+) in the scaffold enhances mechanical performance and cytocompatibility, leading to improved bone regeneration and repair.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2023)
Article
Orthopedics
Yun-He Li, Hai-Long Wu, Zhen Li, Bin-Bin Li, Man Zhu, Di Chen, Fei-Hong Ye, Bin-Sheng Yu, Yong-Can Huang
Summary: This study compared the structure of cartilaginous endplate (CEP) in different species and revealed the integration pattern between CEP and bony endplate (BEP). The results showed significant differences in thickness, cellular density, and collagen characterization of CEPs from different species.
Article
Cell Biology
Rong Li, Han-Lei Li, Hong-Yan Cui, Yong-Can Huang, Yong Hu
Summary: This study investigated the electrophysiological and histopathological changes in contusion, distraction, and dislocation spinal cord injuries using a rat model. The results showed that different types of injuries caused different levels of damage to specific spinal cord regions, resulting in varying somatosensory and motor evoked potential responses. Additionally, the study found significant correlations between histological and electrophysiological findings and injury types. Intraoperative monitoring of somatosensory and motor evoked potentials has the potential to identify the type of iatrogenic spinal cord injury during surgery.
NEURAL REGENERATION RESEARCH
(2023)
Article
Cell & Tissue Engineering
Jiang-Tao Wan, Xian-Shuai Qiu, Zhuo-Hang Fu, Yong-Can Huang, Shao-Xiong Min
Summary: This study found that TNF-alpha inhibits the synthesis and secretion of cartilage matrix in ADSCs during chondrogenic differentiation. Blocking TNF-alpha can restore matrix formation. This study provides a new method to optimize the chondrogenesis of ADSCs.
WORLD JOURNAL OF STEM CELLS
(2022)
Article
Orthopedics
Fan Yang, Weijian Liu, Yongcan Huang, Shuhua Yang, Zengwu Shao, Xianyi Cai, Liming Xiong
Summary: This review addresses the role of regulated cell death (RCD) in intervertebral disc degeneration and provides preclinical strategies to alleviate disc degeneration and promote disc repair by regulating RCD.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2022)
Article
Neurosciences
Jing Guo, Weiming Jin, Yan Shi, Zhiping Guan, Jian Wen, Yongcan Huang, Binsheng Yu
Summary: This study compared the clinical and radiological outcomes of using Zero-P spacers versus a traditional plate and cage system for 3-level anterior cervical discectomy and fusion surgery. The results showed that patients who used Zero-P spacers had fewer postoperative dysphagia symptoms but inferior sagittal alignment reconstruction compared to the traditional plate and cage system for 3-level fixation.
Article
Engineering, Biomedical
Cheng Ma, Xin Qi, Yi-Fan Wei, Zhi Li, He-Long Zhang, He Li, Feng-Lei Yu, Ya-Nan Pu, Yong-Can Huang, Yong-Xin Ren
Summary: This study introduced human umbilical cord mesenchymal stromal cell-derived extracellular vesicles (hUCMSC-EVs) as promising vehicles for the treatment of ligamentum flavum hypertrophy (LFH). By delivering miR-146a-5p and miR-221-3p, the hUCMSC-EVs significantly suppressed LFH and inhibited the activity of the TGF-beta/SMAD4 signaling pathway.
BIOACTIVE MATERIALS
(2023)
Review
Materials Science, Multidisciplinary
Zhiyu Zhou, Wentao Wang, Jianmin Wang, Hongshui Wang, Yi Xia, Wei Zhang, Yuxiao Lai, Xiao Lin, Yongcan Huang, Xuenong Zou, Martin J. Stoddart, Zhen Li, Wei Tian, Shaoyu Liu, Xinbao Wu, Manman Gao, Junhong Li, Lei Yang, Dafu Chen
Summary: Tissue engineering is a milestone in the developmental history of life science, but tissue-engineered biomaterials have not been widely used clinically. To overcome these challenges, a new approach has been proposed, focusing on the construction of organoid structures and function-oriented design.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Hanlei Li, Songkun Gao, Rong Li, Hongyan Cui, Wei Huang, Yongcan Huang, Yong Hu
Summary: By collecting the time-frequency components of somatosensory evoked potentials in rat models, this study successfully diagnosed spinal cord injuries at different levels using k-medoid clustering and naive Bayes methods.
BIOENGINEERING-BASEL
(2023)
Article
Biotechnology & Applied Microbiology
Yu-Dong Zhao, Yong-Can Huang, Jia-Liang Lin, Wei-Shi Li
Summary: The worldwide burden of low back pain (LBP) caused by intervertebral disc degeneration (IVDD) has been increasing in recent years. Current treatments mainly focus on relieving symptoms rather than reversing the cause of IVDD, but stem/progenitor cell therapy shows potential for IVD regeneration. Single-cell RNA sequencing results provide insights into IVD progenitors, aiding in the development of effective stem/progenitor cell therapy for LBP.
BIOENGINEERING-BASEL
(2023)
Article
Biotechnology & Applied Microbiology
Cheng-Hao Jiang, Yan Shi, Yong-Mei Sun, Ming-Jun Cai, Hai-Long Wu, Li-Sheng Hu, Li-Min Yu, Peng Wang, Jie Shen, Yong-Can Huang, Bin-Sheng Yu
Summary: This study compares the accuracy and safety of pedicle screw placement using a 3D navigation template with the free-hand fluoroscopy technique in scoliotic patients. The results showed that both techniques achieved satisfactory safety of screw insertion, but the 3D navigation template had a higher accuracy in the thoracic region.
BIOENGINEERING-BASEL
(2023)
Article
Cell & Tissue Engineering
Ke Lu, Qingyun Wang, Hua Jiang, Jun Li, Zhou Yao, Yongcan Huang, Jianquan Chen, Yejia Zhang, Guozhi Xiao, Xueyu Hu, Zhuojing Luo, Liu Yang, Liping Tong, Di Chen
Summary: This study reveals the crucial role of beta-catenin signaling in spinal degeneration and its correlation with pain sensitivity in patients. The inhibition of beta-catenin can alleviate low back pain, suggesting its potential as a therapeutic target for spinal degeneration.
Article
Engineering, Biomedical
Hongyan Cui, Yazhou Wang, Guangsheng Li, Yongcan Huang, Yong Hu
Summary: This study proposes a new algorithm to differentiate between dual-level and single-level compressions in cervical myelopathy, and demonstrates its effectiveness in a rat model.
IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING
(2022)
