Review
Immunology
Yuhao Chen, Lihong Yang, Xihong Li
Summary: This review discusses the mechanisms and signaling pathways involved in the modulation of macrophage polarization by mesenchymal stem cells (MSCs), providing innovative directions for the treatment of sepsis-induced liver injury.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Cell & Tissue Engineering
Xiangling Li, Yanjun Guan, Chaochao Li, Tieyuan Zhang, Fanqi Meng, Jian Zhang, Junyang Li, Shengfeng Chen, Qi Wang, Yi Wang, Jiang Peng, Jinshu Tang
Summary: The article summarizes the interactions between MSCs, immune cells, and inflammatory cytokines following PNI, with a focus on the immunosuppressive role of MSCs. Additionally, the immunomodulatory potential of MSC-derived extracellular vesicles as a cell-free treatment for PNI is discussed.
STEM CELL RESEARCH & THERAPY
(2022)
Review
Cell Biology
Mohamad Mahjoor, Arshia Fakouri, Simin Farokhi, Hojjatollah Nazari, Hamed Afkhami, Fatemeh Heidari
Summary: The skin is essential for the innate and adaptive immune systems, but skin lesions can have undesirable consequences. Mesenchymal stromal cells (MSCs) are being increasingly used for skin wound treatment due to their advantages in promoting healing. The oxygen concentration has an impact on MSC biology, and expanding MSCs in a hypoxic environment can enhance their effectiveness.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Cell & Tissue Engineering
Rishi Man Chugh, Hang-soo Park, Abdeljabar El Andaloussi, Amro Elsharoud, Sahar Esfandyari, Mara Ulin, Lale Bakir, Alshimaa Aboalsoud, Mohamed Ali, Dalia Ashour, Prosper Igboeli, Nahed Ismail, Jan McAllister, Ayman Al-Hendy
Summary: The study showed that BM-hMSC and its secretome can effectively suppress androgen-producing gene expression, alleviate inflammation, and restore fertility in PCOS animal models.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Pharmacology & Pharmacy
Ravena P. do Nascimento, Livia B. de Jesus, Markley S. Oliveira-Junior, Aurea M. Almeida, Eduardo L. T. Moreira, Bruno D. Paredes, Jorge M. David, Bruno S. F. Souza, Maria de Fatima D. Costa, Arthur M. Butt, Victor Diogenes A. Silva, Silvia L. Costa
Summary: The study found that Agathisflavone can protect injured spinal cord tissue and exhibit therapeutic effects in a rat model of acute spinal cord injury. It also promotes neurogenesis and increases the expression of neurotrophins while reducing inflammation.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Narmadaa Raman, Siti A. M. Imran, Khairul Bariah Ahmad Amin Noordin, Wan Safwani Wan Kamarul Zaman, Fazlina Nordin
Summary: This review highlights the process of mechanotransduction, the effects of mechanical forces on cells and tissues, and the regulation of mesenchymal stem cell differentiation by mechanical factors. Research has shown that mechanical forces play a crucial role in cell sensing and adaptation to the environment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Yutong Huang, Qiang Wu, Paul Kwong Hang Tam
Summary: Mesenchymal stem cells (MSCs) have multiple properties, including self-renewal, immunomodulation, and regenerative medicine, making them a potential therapeutic strategy for immune disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Valentina Cocce, Mara Bonelli, Silvia La Monica, Roberta Alfieri, Luisa Doneda, Eleonora Martegani, Giulio Alessandri, Costanza Annamaria Lagrasta, Aldo Gianni, Valeria Sordi, Francesco Petrella, Leda Roncoroni, Francesca Paino, Augusto Pessina
Summary: Malignant pleural mesothelioma, an asbestos-related tumor, has poor response to chemotherapy. Adult mesenchymal stromal cells derived from bone marrow or adipose tissue can be a good model for cell-based therapy, and using Paclitaxel-loaded mesenchymal stromal cells inhibits mesothelioma cell proliferation more effectively than Paclitaxel alone. In vivo studies using a minimal amount of 106 mesenchymal stromal cells loaded with Paclitaxel showed the same efficacy as systemic administration of Paclitaxel, supporting the use of mesenchymal stromal cells as a drug delivery system for solid tumors.
BIOCHEMICAL PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Mahdi Ahmadi, Monireh Mahmoodi, Maryam Shoaran, Fereshteh Nazari-Khanamiri, Jafar Rezaie
Summary: New therapeutic approaches are urgently needed for combating metastatic cancers, which cause over 8 million deaths per year worldwide. Mesenchymal stem cells (MSCs) have shown potential as a novel treatment option for cancer, with their exosomes playing a crucial role in regulating tumor progression. However, there is still controversy surrounding the exact association between MSC-derived exosomes and tumors. Nevertheless, the use of MSC-derived exosomes as drug delivery systems and standalone therapeutics is actively being explored, and engineering these exosomes to target tumor cells shows promise in improving the efficacy of antitumor therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Agnieszka Krawczenko, Aleksandra Klimczak
Summary: MSCs, known for their regenerative and immunomodulatory properties, are typically isolated from bone marrow and adipose tissue. This review focuses on MSCs derived from adipose tissue and their secretome in regeneration processes, with a special emphasis on their contribution to angiogenic processes. Various clinical trials have been registered to explore the application of AT-MSCs and their secretome in treating different medical conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Qiuli Liu, Xiaoyong Chen, Chang Liu, Lijie Pan, Xinmei Kang, Yanli Li, Cong Du, Shuai Dong, Andy Peng Xiang, Yan Xu, Qi Zhang
Summary: CHI3L1 is a novel immunosuppressive factor secreted by MSCs, which plays a crucial role in inhibiting T cell activation and inflammatory responses in immune-mediated liver injury. Downregulating CHI3L1 in hUC-MSCs mitigates their therapeutic effects on liver injury by affecting T cell function. Additionally, CHI3L1 exerts its immunosuppressive effects by upregulating PPAR δ to inhibit the JAK/STAT signaling pathway in T cells.
CELL DEATH & DISEASE
(2021)
Article
Cell Biology
Maria Serena Piccinno, Tiziana Petrachi, Marco Pignatti, Alba Murgia, Giulia Grisendi, Olivia Candini, Elisa Resca, Valentina Bergamini, Francesco Ganzerli, Alberto Portone, Ilenia Mastrolia, Chiara Chiavelli, Ilaria Castelli, Daniela Bernabei, Mara Tagliazucchi, Elisa Bonetti, Francesca Lolli, Giorgio De Santis, Massimo Dominici, Elena Veronesi
Summary: This study investigates the use of adipose-derived mesenchymal stromal/stem cells (AD-MSCs) in autologous fat transfer (AFT) for tissue reconstruction. The results show that AD-MSCs can improve graft persistence and reduce tissue resorption after AFT. The implanted AD-MSCs can persist and differentiate into mature adipocytes, leading to better outcomes in terms of graft weight and reduced cyst formation. This suggests a long-term protective and anti-inflammatory/proangiogenic role of AD-MSCs in autologous AFT tissue resorption.
Article
Cell & Tissue Engineering
Anja Lena Thiebes, Franziska E. Uhl, Marie Hauser, Christian G. Cornelissen, Stefan Jockenhoevel, Daniel J. Weiss
Summary: The study evaluated the feasibility of spraying MSCs using endoscopic atomization devices and found high survival rates, as well as the ability to induce cell differentiation. This suggests that endoscopic atomization may have a potential role in pulmonary MSC-based cell therapies.
Review
Engineering, Biomedical
Xiao Xu, Limei Xu, Jiang Xia, Caining Wen, Yujie Liang, Yuanmin Zhang
Summary: Osteoarthritis (OA) is a common disease characterized by cartilage degeneration in middle-aged and elderly people. Currently, there is no effective treatment for OA apart from total joint replacement in advanced stages. Mesenchymal stem cells (MSCs) have shown great potential in regulating the cartilage microenvironment, promoting cartilage regeneration, and alleviating OA symptoms, making them a promising source of cells for OA therapy.
ACTA BIOMATERIALIA
(2023)
Review
Cell Biology
Ali Hassanzadeh, Nasim Vousooghi, Ramin Rahimnia, Ehsan Razeghian, Simin Rajaeian, Iman Seyhoun, Shiva Sharif, Javad Verdi
Summary: Recently, transplantation of mesenchymal stem/stromal cells (MSCs) has emerged as a promising treatment option for osteoarthritis (OA) patients, showing potential benefits in supporting cartilage structure and improving knee function. MSCs exert their effects by inhibiting inflammation and immunomodulation through the release of anti-inflammatory mediators. Additionally, they promote chondrocyte proliferation, maintain extracellular matrix homeostasis, and suppress matrix metalloproteinases activities, ultimately providing chondroprotection. Numerous studies have demonstrated that MSCs therapy can significantly reduce pain and restore knee function in OA patients. This review focuses on recent advances in MSCs-based therapeutics for inducing chondrogenic and chondroprotective effects in OA patients, with a specific emphasis on in vivo results from the past decade.
CELL BIOLOGY INTERNATIONAL
(2023)
Article
Psychology, Developmental
Ji Hye Park, Sun Jae Jung, YunJae Jung, Song Vogue Ahn, Eun Lee, Hyeon Chang Kim
Summary: Evidence suggests that changes in total cholesterol levels during adolescence may affect the development of depressive symptoms in early adulthood, with consistently low or increased cholesterol levels posing an increased risk. Different strategies should be considered for managing lipid risk factors based on age and sex.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2021)
Article
Pediatrics
Harpreet Singh, Satoshi Kusuda, Ryan M. McAdams, Shubham Gupta, Jayant Kalra, Ravneet Kaur, Ritu Das, Saket Anand, Ashish Kumar Pandey, Su Jin Cho, Satish Saluja, Justin J. Boutilier, Suchi Saria, Jonathan Palma, Avneet Kaur, Gautam Yadav, Yao Sun
Summary: This study aimed to use a deep learning system to classify neonatal manipulations and analyze their impact on physiological parameters, finding that diaper changes affect heart rate and oxygen saturation, while patting and tube feeding affect heart rate.
Article
Cell Biology
Han-Na Um, Jin-Ok Baek, Sohyeon Park, Eun-Hui Lee, Jinsun Jang, Woo-Jae Park, Joo-Young Roh, YunJae Jung
Summary: The study demonstrates that orally tolerized mice are protected from experimental atopic dermatitis induced by sensitization and epicutaneous challenge to ovalbumin. The findings suggest that the bidirectional interaction between the skin and the intestine plays a role in the pathogenesis of atopic dermatitis, and modulation of the intestinal microenvironments could be a therapeutic approach.
CELL DEATH & DISEASE
(2021)
Article
Chemistry, Multidisciplinary
Jun-Young Park, Sung Jean Park, Jun Young Park, Sang-Hyun Kim, Song Kwon, YunJae Jung, Dongwoo Khang
Summary: The protein corona surrounding nanoparticles significantly influences the subsequent immune response, with highly unfolded protein corona structures correlated with activation of proinflammatory cytokines and innate immune responses. This study clarified that the immune response mediated by the protein corona is greatly dependent on the type of plasma proteins surrounding the nanoparticles.
Article
Medicine, General & Internal
Yun-Hee Lee, Ka Hyun Lee, Ji-Won Han, Su Jin Cho
Summary: This case report describes a neonate with a patent omphalomesenteric duct fistula opening to the umbilicus, presenting with meconium sprouting from the umbilical stump. The patient underwent segmental resection of the ileum and end to end anastomosis, and was discharged without complications on the 8th postoperative day. Follow-up at the outpatient clinic up to 5 months after surgery showed no abnormalities.
EWHA MEDICAL JOURNAL
(2021)
Article
Nutrition & Dietetics
Seong-Hee Ko, YunJae Jung
Summary: Hormonal changes during menopause in women lead to body composition changes, muscle loss, and abdominal obesity, with increased visceral fat as a result. These changes in fat distribution also contribute to metabolic abnormalities, insulin resistance, and metabolic diseases, due to enhanced lipolysis of visceral fat.
Article
Nutrition & Dietetics
Hyo-Jung Kim, Yun-Shin Jung, Yun-Jae Jung, Ok-Hee Kim, Byung-Chul Oh
Summary: The study revealed that rats fed high-phytate diets showed A beta accumulation and increased neuronal cell death in the hippocampus, with the activation of the amyloidogenic pathway. Dysregulation of calcium and phosphate homeostasis mediated by phytate is a significant risk factor for elevated A beta accumulation and apoptotic neuronal cell death.
Review
Obstetrics & Gynecology
Ryan M. McAdams, Ravneet Kaur, Yao Sun, Harlieen Bindra, Su Jin Cho, Harpreet Singh
Summary: This study reviewed the use of artificial intelligence and machine learning techniques for predicting neonatal outcomes. The current predictor models, primarily built on supervised learning and regression models using retrospective data, have shown significant breakthroughs.
JOURNAL OF PERINATOLOGY
(2022)
Article
Chemistry, Medicinal
Seong-Hee Ko, YoonHee Lim, Eun Jae Kim, Young Wook Ko, In-Sun Hong, Sanghee Kim, YunJae Jung
Summary: Antarctic marine algae extracts have antioxidant activities, protect cells against inflammatory stimulation, and increase the barrier integrity of damaged cells.
Article
Peripheral Vascular Disease
Dai Sik Ko, Seung Eun Baek, Mihyang Ha, Jeong Jun Park, Changjin Lee, Hye Young Kim, YunJae Jung, Jin Mo Kang, Yun Hak Kim
Summary: This study identified OPN as a key factor associated with outflow vein stenosis in arteriovenous fistulas (AVFs) and demonstrated its increased expression in stenotic outflow veins of AVFs in patients. In vitro experiments showed that inhibiting OPN can reduce vascular smooth muscle cell proliferation, suggesting it as a potential therapeutic target to improve AVF patency.
MICROVASCULAR RESEARCH
(2023)
Article
Biology
YoonHee Lim, So-Hyun Park, Eun Jae Kim, HeeJun Lim, Jinsun Jang, In-Sun Hong, Sanghee Kim, YunJae Jung
Summary: This study analyzed compound profiles of polar microalgae extracts, evaluated their potential as skin protective agents, and examined the underlying mechanisms. Polar microalgae extracts showed strong free radical scavenging ability and enhanced the viability of human keratinocyte cells after UVB radiation or exposure to psoriatic cytokines. These extracts also reduced barrier integrity damage and decreased inflammatory cytokine levels in psoriatic cells. Polar microalgae extracts had a therapeutic effect in a mouse model of psoriasis.
BIOLOGICAL RESEARCH
(2023)
Article
Immunology
Hee Joo Kim, Eun-Hui Lee, Yoon Hee Lim, Dongil Jeong, Heung Sik Na, YunJae Jung
Summary: Inhibiting TLR4 can alleviate chronic itch and is associated with TLR4 signaling in mast cells and nerve fibers.
Article
Medicine, General & Internal
So-Yeon Shim, Su Jin Cho, Eun Ae Park
Summary: This study found a significant association between sepsis and cognitive delay in VLBWIs, while no association was observed with motor delay. Severe IVH, PVL, IUGR, and prolonged mechanical ventilation were linked to cognitive and motor delays in preterm infants.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2021)
Article
Public, Environmental & Occupational Health
Hye Ah Lee, Bohyun Park, Jungwon Min, Eun Jeong Choi, Ui Jeong Kim, Hyun Jin Park, Eun Ae Park, Su Jin Cho, Hae Soon Kim, Hwayoung Lee, Young Ju Kim, Young Sun Hong, Eui-Jung Kim, Eun Hee Ha, Hyesook Park
Summary: The study focuses on identifying early life risk factors for chronic diseases and developing interventions once these risk factors are identified.
EPIDEMIOLOGY AND HEALTH
(2021)
Article
Medicine, General & Internal
So-Yeon Shim, Ji Yun Yun, Su Jin Cho, Min Ho Kim, Eun Ae Park
Summary: This study developed a prediction model for bronchopulmonary dysplasia (BPD) using perinatal and neonatal factors in Korean very low birth weight infants. The model showed high predictability and could be helpful for early prediction of BPD.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2021)
