期刊
CELL BIOLOGY INTERNATIONAL
卷 33, 期 10, 页码 1087-1094出版社
WILEY
DOI: 10.1016/j.cellbi.2009.06.027
关键词
Dimethylfumarate; NF-kappa B; MMP; Metastasis; Invasion
类别
资金
- MEXT (Ministry of Education, Culture, Sports, Science and Technology) [2007-2011]
NF-kappa B acts as a signal transducer during tumor progression, cell invasion, and metastasis. Dimethylfumarate (DMF) is reported to inhibit tumor necrosis factor-alpha-induced nuclear entry of NF-kappa B/p65. However, only a few reports suggest that DMF inhibits tumor metastasis; also the molecular mechanisms underlying the inhibition of metastasis are poorly understood. We investigated the inhibition of tumor invasion and metastasis by DMF in a melanoma cell line, B16BL6. DMF inhibited B16BL6 cell invasion and metastasis by suppressing the expression and activities of MMPs. DMF also inhibited the nuclear entry of NF-kappa B/p65, thus inhibiting B16BL6 cell invasion and metastasis. These results suggest that DMF is potentially useful as an anti-metastatic agent for the treatment of malignant melanoma. (C) 2009 International Federation for Cell Biology. Published by Elsevier Ltd. All rights reserved.
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