期刊
CELL BIOLOGY INTERNATIONAL
卷 33, 期 10, 页码 1065-1072出版社
WILEY
DOI: 10.1016/j.cellbi.2009.06.026
关键词
Hypericin; Photodynamic therapy; Melanoma; Autophagy; Apoptosis
类别
资金
- National Research Foundation, South Africa
- NRF Thuthuka
Photodynamic therapy (PDT) as a regime for melanoma is of limited success due to factors such as the efficacy of the photosensitizer used, penetration depth and the presence of pigment. We characterised a pigmented and an unpigmented melanoma cell line with respect to their phenotypes. Cell viability was assessed after exposure to hypericin, a UVA-activated photosensitizer. Exposure to 3 mu M activated hypericin induced a cytoprotective (autophagic) response from both cell lines. However, the pigmented cells accumulated a large amount of glycogen in their cytoplasm. We hypothesise that the treatment induces an initial cytoprotective response through autophagy, but with increased stress results in a different mode of cell death in pigmented melanoma cells from unpigmented cells. These results indicate that hypericin-PDT could be an adjuvant therapy for melanoma. (C) 2009 International Federation for Cell Biology. Published by Elsevier Ltd. All rights reserved.
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