Article
Pharmacology & Pharmacy
Samar A. Salim, Samah A. Loutfy, Esmail M. El-Fakharany, Tarek H. Taha, Yasmen Hussien, Elbadawy A. Kamoun
Summary: The 3D scaffolds made of PVA/HA nanofiber mats, optimized with chitosan and hydroxyapatite, demonstrated improved biocompatibility and mechanical stability. The different compositions of nanofiber mats showed high cell viability and adhesion in cell evaluation and in vitro experiments.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Yuqing Niu, Florian J. Stadler, Xu Yang, Fuming Deng, Guochang Liu, Huimin Xia
Summary: This study demonstrates that hyaluronic acid functionalized collagen nanofibers can effectively modulate the pro-healing expression of macrophages, promoting urethral regeneration. The use of tubular HA-collagen nanofibers significantly facilitates urethral regeneration, with recruited anti-inflammatory M2 macrophages promoting angiogenesis and proliferation of urothelial progenitor cells in the regenerated urethra.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Antony Hoarau, Myriam Polette, Christelle Coraux
Summary: Hyaluronic acid (HA) is a major component of the extracellular matrix with anti-inflammatory and immunomodulatory functions in the lungs. The size of HA determines its pro-inflammatory or anti-inflammatory effects. The interactions between HA and hyaladherins play a role in HA activities. LMW-HA is involved in pulmonary innate immunity by activating various cells, making it a potential therapeutic target for inflammatory respiratory diseases.
Article
Chemistry, Physical
Yong Chen, Youping Gong, Lijun Shan, Chou Yong Tan, M. S. Al-Furjan, S. Ramesh, Huipeng Chen, Xiangjuan Bian, Yanda Chen, Yunfeng Liu, Rougang Zhou
Summary: In this study, the application of biological 3D printing in manufacturing new cartilage scaffolds for cartilage regeneration was explored. The addition of hydroxyapatite (HA) enhanced the mechanical properties of the hydrogel made from sodium alginate (SA) and gelatin (GA). Different concentrations of SA-GA-HA composite hydrogel cartilage scaffolds were prepared, and better formulations for printing and testing were obtained. The printed cartilage scaffold showed useful mechanical properties and higher cell survival rate after one week, suggesting that it provides a new scaffold strategy for cartilage tissue regeneration.
Article
Biotechnology & Applied Microbiology
Yi Liu, Yifan Zhang, Zexiang Zheng, Wenchao Zhong, Haiyang Wang, Zhen Lin, Lihua Li, Gang Wu
Summary: A thermoresponsive, injectable NGR1-HA/nHAp composite hydrogel was fabricated in this study, which showed potential for use in bone regeneration applications with controlled inflammation and excellent osteogenic effect.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Engineering, Biomedical
Min Wang, Zexing Deng, Yi Guo, Peng Xu
Summary: This review summarizes the recent progress and applications of hyaluronic acid-based hydrogels in cartilage tissue engineering. It investigates the multifunctional design of these hydrogels and discusses their potential for future research in cartilage tissue regeneration.
MATERIALS TODAY BIO
(2022)
Article
Biophysics
V. H. Giang Phan, Mohanapriya Murugesan, P. P. Thanh Nguyen, Cuong Hung Luu, Ngoc-Han Hoai Le, Huong Thi Nguyen, Panchanathan Manivasagan, Eue-Soon Jang, Yi Li, Thavasyappan Thambi
Summary: This study developed an injectable silk fibroin/hyaluronic acid hydrogel scaffold for repairing articular cartilage injuries. The hydrogel scaffold, similar to the natural extracellular microenvironment, had a highly porous network and controlled release of methylprednisolone for tissue regeneration and reducing inflammation. The results showed that the hydrogel scaffold did not affect angiogenesis and could form a gel in vivo, demonstrating its potential for cartilage regeneration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Engineering, Biomedical
Jiaqing Chen, Jiabei Yang, Li Wang, Xuewei Zhang, Boon Chin Heng, Dong-An Wang, Zigang Ge
Summary: The study developed a novel hydrogel, AHAMA hydrogel, with excellent adhesive strength and stability, capable of enhancing proliferation and migration of bone marrow stem cells. In experiments, AHAMA hydrogel demonstrated significant potential in promoting cartilage regeneration in a rat osteochondral defect model.
BIOACTIVE MATERIALS
(2021)
Article
Nanoscience & Nanotechnology
Xiangxiang Zhang, Huaen Chen, Yang Zhang, Qijing Huang, Jianjia Feng, Haoyu Xing, Xiaguo Fu, Xiufang Yan, Yingying Zhang, Qin Xu, Jianming Liang
Summary: The study developed a nano drug delivery system by combining HNK-loaded liposomes with HA-DOPE modification, which demonstrated effective antitumor abilities in both in vitro and in vivo studies.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Hui Wang, Tingting Peng, Haofeng Wu, Jintian Chen, Minglong Chen, Liling Mei, Feng Li, Wenhao Wang, Chuanbin Wu, Xin Pan
Summary: The study showed that HLC gel can improve the rheological properties of the gel, enhance joint protection by increasing mechanical strength, elasticity, and lubrication, prolong drug release and retention in the joint cavity for over 4 weeks, and provide a combined effect of kartogenin and hyaluronic acid for cartilage repair. Pharmacodynamic studies demonstrated that HLC gel was the most effective in promoting chondrogenesis and protecting subchondral bone.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Biotechnology & Applied Microbiology
Sandra Escalante, Gustavo Rico, Jose Becerra, Julio San Roman, Blanca Vazquez-Lasa, Maria Rosa Aguilar, Ivan Duran, Luis Garcia-Fernandez
Summary: Articular cartilage is an important avascular tissue that provides support, shock absorption, and facilitates joint motion. Current surgical treatments for cartilage damage have limitations in restoring fully functional cartilage. This study presents the development of hydrogels based on hyaluronic acid and chitosan loaded with chondroitin sulfate, which have the potential to improve the microfracture procedure and promote the colonization of articular cartilage by chondrocytes. These hydrogels act as delivery systems for chondroitin sulfate and have mucoadhesive properties, making them promising for next-generation therapies against articular cartilage damage.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Yuqing Niu, Massimiliano Galluzzi, Fuming Deng, Zhang Zhao, Ming Fu, Liang Su, Weitang Sun, Wei Jia, Huimin Xia
Summary: The study found that the hyaluronic acid-coating silk fibroin nanofiber scaffold can effectively regulate the epithelialization process of urethral regeneration, promoting luminal epithelialization, smooth muscle bundle structural remodeling, and capillary formation.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2022)
Article
Chemistry, Physical
Esteban Astudillo-Ortiz, Pedro S. Babo, Rui L. Reis, Manuela E. Gomes
Summary: The study investigated an injectable hyaluronic acid-based hydrogel system enriched with platelet lysate for endodontic regeneration. The hydrogels showed suitable working and setting times, a porous microstructure, and supportive properties for cell migration towards dentin surfaces, indicating great clinical potential for endodontic regenerative therapies.
Article
Chemistry, Multidisciplinary
X. Ma, R. Yang, P. Wang, S. Liu, H. Xu, Z. Ye, B. Chi
Summary: A facile strategy based on dynamic chemistry was presented to prepare injectable hydrogels using hyaluronic acid and poly(gamma-glutamic acid), enabling efficient stem cell delivery. The hydrogels showed stable structure, rapid self-healing ability, and injectability with dual dynamic networks. Remarkably, the hydrogels promoted stem cell viability, proliferation, and cartilage regeneration in preclinical models.
MATERIALS TODAY CHEMISTRY
(2022)
Review
Polymer Science
Hee Sook Hwang, Chung-Sung Lee
Summary: Hydrogel-based bone tissue engineering using hyaluronic acid (HA) has gained popularity as a potential strategy for treating bone abnormalities and fractures. HA-based hydrogels have the ability to mimic the natural extracellular matrix of bone tissue and provide a suitable microenvironment for cell support and tissue regeneration. The physical and chemical properties of HA can be modified to improve its mechanical strength, biocompatibility, and osteogenic potential, making it a promising material for bone tissue engineering.
Article
Anatomy & Morphology
E. Biasibetti, D. Bisanzio, S. Mioletti, S. Amedeo, A. Iuliano, P. Bianco, M. T. Capucchio
ANATOMIA HISTOLOGIA EMBRYOLOGIA
(2016)
Article
Veterinary Sciences
Gessica Giusto, Marco Gandini, Stefano Amedeo
AMERICAN JOURNAL OF VETERINARY RESEARCH
(2014)
Article
Agriculture, Dairy & Animal Science
E. Biasibetti, S. Amedeo, A. Brugiapaglia, G. Destefanis, L. Di Stasio, F. Valenza, M. T. Capucchio
Review
Biochemistry & Molecular Biology
Luisa Gennero, Maria Augusta Roos, Kirk Sperber, Tetyana Denysenko, Paola Bernabei, Gian Franco Calisti, Mauro Papotti, Susanna Cappia, Roberto Pagni, Giuseppe Aimo, Giulio Mengozzi, Giovanni Cavallo, Stefano Reguzzi, Gian Piero Pescarmona, Antonio Ponzetto
CELL BIOCHEMISTRY AND FUNCTION
(2010)
Review
Biochemistry & Molecular Biology
Maria Augusta Roos, Luisa Gennero, Tetyana Denysenko, Stefano Reguzzi, Giovanni Cavallo, Gian Piero Pescarmona, Antonio Ponzetto
CELL BIOCHEMISTRY AND FUNCTION
(2010)
Review
Biochemistry & Molecular Biology
Tetyana Denysenko, Luisa Gennero, Maria Augusta Roos, Antonio Melcarne, Carola Juenemann, Giuliano Faccani, Isabella Morra, Giovanni Cavallo, Stefano Reguzzi, Gianpiero Pescarmona, Antonio Ponzetto
CELL BIOCHEMISTRY AND FUNCTION
(2010)
Article
Biochemistry & Molecular Biology
Luisa Gennero, Rocco De Siena, Tetyana Denysenko, Maria Augusta Roos, Gian Franco Calisti, Manuela Martano, Simona Fiobellot, Michele Panzone, Stefano Reguzzi, Luisa Gabetti, Andrea Vercelli, Giovanni Cavallo, Elia Ricci, Gian Piero Pescarmona
CELL BIOCHEMISTRY AND FUNCTION
(2011)
Article
Virology
Cristina Costa, Massimiliano Garzaro, Valeria Boggio, Francesca Sidoti, Salvatore Simeone, Luca Raimondo, Giovanni Patrick Cavallo, Giancarlo Pecorari, Rossana Cavallo
Letter
Virology
Cristina Costa, Massimiliano Bergallo, Maria Elena Terlizzi, Giovanni P. Cavallo, Paola Cavalla, Rossana Cavallo
JOURNAL OF CLINICAL VIROLOGY
(2011)
Article
Surgery
G. Pecorari, C. Gramaglia, M. Garzaro, G. Abbate-Daga, G. P. Cavallo, C. Giordano, S. Fassino
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2010)
Article
Medicine, General & Internal
S. Astegiano, M. E. Terlizzi, M. Elia, G. P. Cavallo, C. Costa, R. Cavallo, M. Bergallo
Review
Biochemistry & Molecular Biology
Kumaresan Ramanathan, Minale Fekadie, Giri Padmanabhan, Henok Gulilat
Summary: Long noncoding RNAs (lncRNAs) play critical roles in kidney disease development and their dysregulation can lead to various disease processes. Understanding the function and potential application of lncRNAs in kidney disease may provide new diagnostic and therapeutic opportunities. This review provides an overview of lncRNA characteristics, function, and specific studies related to kidney disease treatment.
CELL BIOCHEMISTRY AND FUNCTION
(2024)