期刊
CELL BIOCHEMISTRY AND FUNCTION
卷 31, 期 5, 页码 395-399出版社
WILEY-BLACKWELL
DOI: 10.1002/cbf.2910
关键词
rheumatoid arthritis; E-NTPDase; E-ADA; nucleotides; lymphocytes
资金
- Conselho Nacional de Desen-volvimento Cientifico e Tecnologico (CNPq)
- Fundacao de Amparo a Pesquisa do Rio Grande do Sul (FAPERGS)
- Fundacao Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES), Brazil
The purpose of this study was to investigate the activities of ecto-nucleoside triphosphate diphosphohydrolase (E-NTPDase; EC 3.6.1.5; CD39) and adenosine deaminase (E-ADA; EC 3.5.4.4) in lymphocytes from patients with rheumatoid arthritis (RA). Thirty patients diagnosed with RA through American College of Rheumatology criteria as well as 30 healthy patients were selected. Peripheral blood lymphocytes were isolated, and E-NTPDase and E-ADA activities were assayed. The results demonstrated an increased E-NTPDase activity (both ATP and ADP as substrates) and a decreased E-ADA activity in RA patients. These data suggest an organic effort to preserve the adenosine level, which is known to have anti-inflammatory and analgesic properties, working as a potent suppressor of immune response. Copyright (c) 2012 John Wiley & Sons, Ltd.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据