Review
Chemistry, Medicinal
Chengyuan Liang, Guaiping Qiao, Yuzhi Liu, Lei Tian, Nan Hui, Juan Li, Yuling Ma, Han Li, Qianqian Zhao, Wenqiang Cao, Hong Liu, Xiaodong Ren
Summary: All-trans-retinoic acid (ATRA) is effective in preventing cancer and treating skin diseases and acute promyelocytic leukaemia (APL) by regulating differentiation-related gene transcription and autophagy through inhibiting mTOR. A total of 68 ATRA analogues show promising antitumour therapeutic potential for further development and research.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Oncology
Glenn J. Hanna, Anne ONeill, Jennifer M. Cutler, Michelle Flynn, Tushara Vijaykumar, John R. Clark, Lori J. Wirth, Jochen H. Lorch, Jong C. Park, Jeffrey K. Mito, Jens G. Lohr, Jeffrey Kaufman, Nicole Spardy Burr, Leonard Zon, Robert Haddad
Summary: While the trial did not meet its prespecified response endpoint, ATRA showed low toxicity and potential for stabilizing disease growth in a significant proportion of R/M ACC patients. Patients with prior VEGFR therapy had a higher rate of stable disease on ATRA. Low MYB protein expression correlated with longer stability on ATRA treatment.
Article
Oncology
Song Wang, Jingtao Liu, Hao Wu, Anna Jiang, Kun Zhao, Kun Yan, Wei Wu, Haibo Han, Yanhua Zhang, Wei Yang
Summary: The study revealed that ATRA improved the efficacy of RFA treatment for hepatocellular carcinoma by targeting tumor-initiating cells (TICs). This finding suggests the potential of ATRA as an alternative drug in developing better therapeutic strategies for use in combination with RFA.
CHINESE JOURNAL OF CANCER RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Takahisa Hirokawa, Taeko Horie, Yurie Fukiyama, Masashi Mimura, Shinji Takai, Teruyo Kida, Hidehiro Oku
Summary: The study identified that the overactivation of Cdk5 is associated with the development of tauopathies. Roscovitine, a Cdk5 inhibitor, reduces the phosphorylation level of tau protein and mitigates the pathologic phosphorylation of tau by inhibiting the calpain signaling pathway, thereby alleviating the degeneration of RGCs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Hyeyoun Kim, See-Hyoung Park, Sae Woong Oh, Kitae Kwon, Se Jung Park, Eunbi Yu, Seyoung Yang, Jung Yoen Park, Seoyoung Choi, Seoyoun Yang, Su Bin Han, Minkyung Song, Jae Youl Cho, Jongsung Lee
Summary: Olfactory receptor OR7A17 plays a role in the ATRA-induced suppression of human keratinocyte proliferation, regulated through retinoic acid receptor signaling. Overexpression of OR7A17 can reverse the ATRA-induced attenuation of Ca2+ entry.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Li Lin, Xiaodong Liu, Xuejun Cheng, Yujing Li, Marla Gearing, Allan Levey, Xiaoli Huang, Ying Li, Peng Jin, Xuekun Li
Summary: In this study, the altered expression and misregulation of miR-650 in Alzheimer's disease (AD) brains were observed. Bioinformatic analysis predicted that miR-650 targets three AD-associated genes, and experimental confirmation showed that miR-650 significantly reduces their expression levels in vitro. Overexpression of miR-650 was shown to alter CDK5 levels and ameliorate AD pathologies in transgenic mice. These findings suggest that miR-650 influences AD pathogenesis through regulation of CDK5.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Wenting Xie, Dong Guo, Jieyin Li, Lei Yue, Qi Kang, Guimiao Chen, Tingwen Zhou, Han Wang, Kai Zhuang, Lige Leng, Huifang Li, Zhenyi Chen, Weiwei Gao, Jie Zhang
Summary: Alzheimer's disease is a common neurodegenerative disease with unclear underlying mechanism. The neuronal specific protein CEND1 plays an important role in Alzheimer's disease by regulating mitochondrial function and affecting cognitive function.
CELL DEATH AND DIFFERENTIATION
(2022)
Article
Agriculture, Dairy & Animal Science
Qiushi Xu, Yunhui Fan, Juan J. Loor, Yusheng Liang, Xudong Sun, Hongdou Jia, Chenxu Zhao, Chuang Xu
Summary: This study evaluated the effects of all-trans retinoic acid (ATRA) on bovine adipocytes, showing that ATRA inhibited preadipocyte proliferation and postconfluent preadipocyte differentiation, while promoting basal lipolysis in mature adipocytes.
JOURNAL OF DAIRY SCIENCE
(2021)
Article
Virology
Xiaofei Niu, Hongyan Wang, Lihong Zhao, Pengjing Lian, Yu Bai, Jingyun Li, Jian Qiao
Summary: ATRA at therapeutic dose can increase the pathogenicity of H9N2 virus.
Article
Gastroenterology & Hepatology
Ferdinando Nicoletti, Laura Hammer, Stacia Furtado, Katia Mangano, Edith Mathiowitz, Benjamin Green, Dominick L. Auci
Summary: A poly(lactic-co-glycolic acid) (PLGA) microsphere encapsulated all-trans retinoic acid (ATRA) formulation was developed to target immune structures in the gut and limit systemic exposure, showing potential for attenuating inflammatory bowel disease (IBD).
INFLAMMATORY BOWEL DISEASES
(2022)
Article
Biotechnology & Applied Microbiology
Jichao Li, Zeng Zhang, Xiaohan Huang
Summary: The study developed Tripterine and all-trans retinoic acid loaded lipid-polymer hybrid nanoparticles for enhanced antiarthritic efficacy in arthritis conditions. The nanoparticles exhibited strong inhibitory effects on inflammatory markers and showed significant improvement in reducing inflammation compared to individual drugs. The co-delivery of drugs in nanoparticulate form could abolish the adverse effects of free drugs, indicating a promising therapeutic strategy for arthritis treatment.
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jiejie Cui, Mengjia Gong, Shuyu Fang, Chaoqun Hu, Yi Wang, Jingfang Zhang, Ni Tang, Yun He
Summary: All-trans retinoic acid (ATRA) can impact the proliferation, apoptosis, migration, and invasion abilities of hepal-6 hepatocarcinoma cell line by up-regulating specific miRNAs in the miR-200 family, as well as influencing the expression of related transcription factors, suggesting a potential role in suppressing epithelial-mesenchymal transition (EMT).
Article
Biology
Maximilian Lenz, Pia Kruse, Amelie Eichler, Jakob Straehle, Juergen Beck, Thomas Deller, Andreas Vlachos
Summary: A defining feature of the brain is its ability for synaptic contacts to adapt structurally and functionally, with atRA being identified as a potent mediator of synaptic plasticity in the adult human cortex. The coordinated structural and functional changes in excitatory synapses observed in cortical slices were accompanied by ultrastructural remodeling of the spine apparatus organelle and required mRNA translation for these synaptic adaptations. The absence of these changes in synaptopodin-deficient mice suggests the importance of this organelle in the process.
Article
Cell Biology
Yoko Hiyama, Emi Yamaoka, Takahiro Fukazawa, Masato Kojima, Yusuke Sotomaru, Eiso Hiyama
Summary: In this study, we investigated the association between the expression of DHRS3, NROB1, and CYP26A1 genes and the suppression of neuroblastoma cell growth. The overexpression of these genes led to a reduction in cell growth and induced morphological senescence, mainly through pathways related to cellular senescence and cell adhesion. DHRS3 and NROB1 also arrested the cell cycle and induced differentiation and senescence. These findings suggest that the induction of these genes could be a potential therapeutic strategy for suppressing high-risk neuroblastoma growth.
Article
Biochemistry & Molecular Biology
Zahra Azarifar, Razieh Amini, Hamid Tanzadehpanah, Saeid Afshar, Rezvan Najafi
Summary: This study evaluated the anticancer effect of all-trans retinoic acid (ATRA) and 5-Fluorouracil (5-FU) co-loaded in a composite liposomal nano-carrier in colorectal cancer (CRC) cells. The results showed that the dual drug loaded liposomal nano-carrier exhibited superior cytotoxicity, enhanced inhibition of cell proliferation, increased apoptotic potential, and decreased cancer stem cells (CSCs). Additionally, it also attenuated epithelial-mesenchymal transition (EMT)-associated biomarkers and beta-catenin gene expression.
MOLECULAR BIOLOGY REPORTS
(2023)