Article
Oncology
Baohua Lv, Xiaojuan Cheng, Yanling Cheng, Xue Kong, Erhu Jin
Summary: This study aimed to evaluate the predictive value of MRI-detected tumor deposits (mTDs) in rectal cancer. The results showed that mTDs were correlated with distant metastasis and lymph node metastasis. Two nomograms based on mTDs were established and demonstrated good performance in predicting the progression of the disease and lymph node involvement, which had certain clinical value.
FRONTIERS IN ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Daniela Bevanda Glibo, Danijel Bevanda, Katarina Vukojevic, Snjezana Tomic
Summary: The immunohistochemical level of IMP3 protein in rectal cancer patients in clinical stage II is correlated with various sociodemographic, pathohistological, and clinical indicators, as well as overall survival and progression-free survival duration. IMP3 positivity is associated with vascular invasion and is identified as an independent prognostic factor for clinical stage II rectal cancer. Patients with high IMP3 protein levels tend to have a shorter overall survival compared to those with low levels or without IMP3 expression.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, Research & Experimental
Lu Tang, Huifen Li, Jing Lv, Cantu Fang, Huatang Zhang, Jincheng Meng
Summary: This article reports a rare case of rectal metastasis in a patient with gastric cancer. Through surgery and pathological examination, it was confirmed that the rectal tumor and abdominal wall mass in the patient were both metastatic tumors from gastric cancer. Although metastasis of gastric cancer to the rectum is rare, it is important to differentiate between rectal metastasis and primary rectal cancer to avoid unnecessary treatment.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2023)
Article
Oncology
Hong Yang, Lei Chen, Xiuxiu Wu, Chenghai Zhang, Zhendan Yao, Jiadi Xing, Ming Cui, Beihai Jiang, Xiangqian Su
Summary: This study found that distant metastasis was more common than locoregional recurrence after laparoscopic resection of rectal cancer, and there were different clinicopathological factors associated with locoregional recurrence and distant metastasis. Involved circumferential resection margin and suboptimal lymph node yield were adverse surgery-related factors of tumor recurrence that should be paid more attention to during the operation.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Jung Kyong Shin, Yoon Ah Park, Jung Wook Huh, Seong Hyeon Yun, Hee Cheol Kim, Woo Yong Lee, Seok Hyung Kim, Sang Yun Ha, Yong Beom Cho
Summary: This study examined the impact of tumor budding on the prognosis of rectal cancer patients, finding that positive tumor budding is a predictive indicator of poor outcomes in rectal cancer patients, regardless of whether they received neoadjuvant chemoradiotherapy.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Cell Biology
Pengfei Qin, Huaxian Chen, Yuhang Wang, Liang Huang, Ke Huang, Guozhong Xiao, Changpeng Han, Jiancong Hu, Dezheng Lin, Xingyang Wan, Yihui Zheng, Yufeng Liu, Guiming Li, Haojie Yang, Shubiao Ye, Minyi Luo, Yuanji Fu, Hao Xu, Luping Wen, Zhiwei Guo, Xunan Shen, Zeyu Li, Chunqing Wang, Xi Chen, Linying Wang, Liuyong Sun, Donglin Ren, Liang Wu, Jufang Wang, Shiping Liu, Hongcheng Lin
Summary: Our study uses single-cell RNA sequencing and spatial transcriptome sequencing to examine the cell dynamics in RC patients before and after treatment. We find that NAC remodels the populations of cancer-associated fibroblasts, leading to improved therapeutic response and inhibition of tumor progression through modulation of the tumor microenvironment.
CELL REPORTS MEDICINE
(2023)
Review
Oncology
Wei Peng, Huimin Qiao, Linfeng Mo, You Guo
Summary: Historically, research on lymph node metastasis in rectal cancer has focused on a few key pathways and genes. Recent advancements in technology have led to a rapid accumulation of omics and imaging data, improving the accuracy of diagnosis and providing new insights for basic research. The integration of omics data, imaging data, clinical medicine, and diagnostic methods has led to notable advancements in our understanding and treatment of lymph node metastases. However, further progress will require collaboration between data scientists and clinicians.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Mohamed A. Abd El Aziz, Nicholas P. McKenna, James W. Jakub, Christopher L. Hallemeier, Scott R. Kelley, Zhaohui Jin, Kellie L. Mathis
Summary: This study aimed to compare the survival of patients with isolated inguinal lymph node metastases to patients with inguinal and additional synchronous distant metastases from rectal cancer who received curative therapy. The results showed that patients with isolated inguinal lymph node metastases had a longer survival period, and further research is needed.
Article
Multidisciplinary Sciences
Seung Ho Song, Jun Seok Park, Gyu-Seog Choi, An Na Seo, Soo Yeun Park, Hye Jin Kim, Sung-Min Lee, Ghilsuk Yoon
Summary: The study found a significant association between a short distal resection margin (< 1 cm) and local recurrence in patients with rectal cancer, especially in those with tumor stages ypT2-4.
SCIENTIFIC REPORTS
(2021)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Feiya Zeng, Feibi Zeng, Naoki Sugiyama, Munenobu Nogami, Takamichi Murakami
Summary: Metastatic rectal cancer was detected in a 79-year-old male patient with a rectal mass during postoperative follow-up of gastric cancer. F-18-FDG PET/MRI was performed, and the fused images showed lower FDG uptake around the mass compared to the rectal wall, indicating rectal dissemination of gastric cancer. PET/MRI was valuable for differentiating mass uptake from rectal wall uptake due to the high contrast resolution of MRI and precise image fusion enabled by simultaneous image acquisition.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Oncology
Wang Huang, Zheng-qiang Wei, Yu-hao Qiu, Gang Tang, Hao Sun
Summary: This study retrospectively evaluated the effects of perineal wound infection on survival after laparoscopic abdominoperineal resection (LAPR) of rectal cancer. The results showed that wound infection increased the postoperative hospital stay, prolonged the time to first postoperative treatment, and decreased disease-free survival (DFS) and overall survival (OS).
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Tzu-Ju Chen, Yu-Feng Tian, Chia-Lin Chou, Ti-Chun Chan, Hong-Lin He, Wan-Shan Li, Hsin-Hwa Tsai, Chien-Feng Li, Hong-Yue Lai
Summary: The study revealed that high SPINK4 expression is associated with advanced clinicopathological features and a poor therapeutic response in rectal cancer patients undergoing CCRT, validating the prospective prognostic value of SPINK4 for those patients.
Article
Oncology
Harufumi Maki, Reed I. I. Ayabe, Yujiro Nishioka, Tsuyoshi Konishi, Timothy E. E. Newhook, Hop S. Tran S. Cao, Yun Shin Chun, Ching-Wei D. Tzeng, Y. Nancy You, Jean-Nicolas Vauthey
Summary: For patients with synchronous liver metastases from rectal cancer, this study compares outcomes between the reverse, classic, and combined approaches. The reverse approach achieves similar survival rates as the combined and classic approaches, and may eliminate the need for primary rectal tumor resection and diversion.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Shishi Zhou, Wanfen Tang, Qinghua Wang, Xia Zhang, Xiayun Jin, Xifeng Xu, Jianfei Fu
Summary: Cutaneous metastasis of rectal cancer is rare and indicates poor prognosis. The reported case is a rare BRAF-mutated MSS rectal cancer with skin metastasis, showing limited response to chemotherapy and targeted therapy.
ONCOTARGETS AND THERAPY
(2021)
Article
Oncology
Binxu Qiu, Zixiong Shen, Song Wu, Xinxin Qin, Dongliang Yang, Quan Wang
Summary: The study developed and validated a machine-learning model based on clinicopathological information for predicting the risk of distant metastasis in patients with rectal cancer, and the model performed best in the internal test set and external validation set. A web calculator was developed to predict the risk of distant metastasis in rectal cancer patients. This study is of great importance in assisting physicians in making clinical decisions.
FRONTIERS IN ONCOLOGY
(2023)
