Review
Gastroenterology & Hepatology
Ana Petrovic, Sonja Vukadin, Renata Sikora, Kristina Bojanic, Robert Smolic, Davor Plavec, George Y. Wu, Martina Smolic
Summary: Anabolic androgenic steroids have therapeutic benefits but are commonly misused and have detrimental effects on various organs, particularly the liver. This article reviews the latest knowledge on the adverse effects of anabolic androgenic steroids on the liver and their mechanisms.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Review
Pharmacology & Pharmacy
Pragyan Acharya, Komal Chouhan, Sabine Weiskirchen, Ralf Weiskirchen
Summary: The liver, a central organ in the human body, is crucial for various metabolic functions and is susceptible to external agents that can lead to diseases like liver fibrosis. Understanding the cellular pathways of fibrosis is key in identifying potential therapeutic targets for liver-related diseases.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Maurizio Gabrielli, Laura Franza, Alessandra Esperide, Irene Gasparrini, Antonio Gasbarrini, Francesco Franceschi
Summary: Patients with COVID-19 often experience liver injury, but the specific mechanisms behind it are not fully understood. Possible factors include direct viral cytopathic effects, immune-mediated damage, and the impact of treatments.
Article
Cell Biology
Qiang Su, Wei Kuang, Weiyi Hao, Jing Liang, Liang Wu, Chunmei Tang, Yali Wang, Tao Liu
Summary: Patients treated for pulmonary tuberculosis often suffer liver injury due to the effects of anti-TB drugs, which induce inflammatory responses and oxidative stress by activating the NLRP3 inflammasome. Furthermore, drug treatment reduces the activity of drug-metabolizing enzymes, altering the antioxidant defense system in liver cells.
MEDIATORS OF INFLAMMATION
(2021)
Article
Pharmacology & Pharmacy
Yunjuan Gao, Chengzhao Wu, Xingran Zhai, Ming Niu, Zhaofang Bai, Haibo Song, Xu Zhao, Jiabo Wang, Xiaohe Xiao
Summary: This study analyzed and evaluated 452 cases of aripiprazole-induced liver injury reports collected from the China Adverse Drug Reaction Monitoring System. The results showed that 121 cases were classified as serious, accounting for 26.8% of the total. Male-to-female ratio was 1.24:1 and a high proportion of young adults were affected. Early and regular monitoring of liver function should be carried out in patients with potential risk factors to reduce adverse reactions.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Gastroenterology & Hepatology
A. Floreani, D. Bizzaro, S. Shalaby, G. Taliani, P. Burra
Summary: Drug-induced liver injury (DILI) is a serious clinical condition with varying incidences and a higher vulnerability in females. Sex differences in pharmacokinetics and pharmacodynamics, hormonal effects, immune response, and the use of herbal and dietary supplements contribute to the risk. A novel phenotype of autoimmune-mediated DILI has been described. Assessments of DILI and its associated factors are important for patient safety and drug development.
DIGESTIVE AND LIVER DISEASE
(2023)
Article
Chemistry, Multidisciplinary
Alaina M. Richard, Nathan R. Wong, Kurt Harris, Reethy Sundar, Emily E. Scott, Thomas C. Pochapsky
Summary: It has been shown that alkyl isonitriles can ligate the heme iron of cytochromes P450 in a stable manner, with the position and stereochemistry of the isonitrile affecting the binding ability. In this study, the interactions between four steroid-derived isonitriles and various P450s were investigated, revealing that the binding of isonitrile depends on the oxidation state of the heme iron. Furthermore, crystallographic analysis confirmed the interaction between alkyl isonitrile and CYP17A1 and identified the absolute stereochemistry of the bound species.
COMMUNICATIONS CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Yuanjie Wen, Guoqiang Zhang, Xin'an Wu
Summary: Short-term administration of HRZE may upregulate FXR and decrease hepatic bile acids, but prolonged treatment may downregulate FXR and lead to hepatic bile acid accumulation.
Article
Infectious Diseases
Yi-Hui Liu, Yan Guo, Hong Xu, Hui Feng, Dong-Ya Chen
Summary: This study retrospectively analyzed the impact of non-alcoholic simple fatty liver disease on drug-induced liver injury caused by tuberculosis. The results suggest that non-alcoholic simple fatty liver disease may increase the risk of antituberculosis drug-induced liver injury, with cholesterol identified as a high-risk factor for liver injury.
INFECTION AND DRUG RESISTANCE
(2021)
Article
Biology
Noha M. Elemam, Haifa Hannawi, Kashif Bin Naeem, Suad Hannawi
Summary: This study investigated the impact of liver injury on clinical and laboratory assessments in COVID-19 patients, revealing that patients with liver injury are at higher risk for serious outcomes, including higher mortality rates.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Cristina Vazquez-Carballo, Melania Guerrero-Hue, Cristina Garcia-Caballero, Sandra Rayego-Mateos, Lucas Opazo-Rios, Jose Luis Morgado-Pascual, Carmen Herencia-Bellido, Mercedes Vallejo-Mudarra, Isabel Cortegano, Maria Luisa Gaspar, Belen de Andres, Jesus Egido, Juan Antonio Moreno
Summary: Acute kidney injury (AKI) is a significant health issue, particularly in low- and middle-income countries. Studies suggest that inflammation plays a crucial role in the development of AKI, and anti-inflammatory agents targeting Toll-like receptors may help reduce kidney damage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Gastroenterology & Hepatology
Ankur Jindal, Shiv K. Sarin
Summary: The global burden of deaths caused by liver failure is substantial. The Asia-Pacific region accounted for more than half of the global population and a significant proportion of liver disease deaths in 2015. The causes of liver failure vary in different countries and include viruses, drugs, toxins, and autoimmune reactions. Rising alcohol misuse and metabolic syndrome pose a concern. Accurate estimates of the burden of liver failure are critical for determining clinical, research, and policy priorities.
LIVER INTERNATIONAL
(2022)
Review
Gastroenterology & Hepatology
Jiang Liu, Kwan Man
Summary: Ischemia/reperfusion injury is an inevitable process during liver transplantation, leading to high rates of dysfunction and failure. The mechanism involves microcirculation dysfunction, hypoxia, oxidative stress, and cell death. The immune response also plays a crucial role. Studies on living donor liver transplantation have identified specific mitochondrial and metabolic dysfunction in certain types of graft injury. These findings have paved the way for new biomarkers and potential therapeutics, but further validation and clinical trials are needed. This review emphasizes the importance of the spatiotemporal microenvironment resulting from various factors in liver ischemia/reperfusion injury.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Immunology
Mateus Eustaquio Lopes, Brenda Naemi Nakagaki, Matheus Silverio Mattos, Gabriel Henrique Campolina-Silva, Raquel de Oliveira Meira, Pierre Henrique de Menezes Paixao, Andre Gustavo Oliveira, Lucas D. Faustino, Ricardo Goncalves, Gustavo Batista Menezes
Summary: Kupffer cells are essential for liver immune function and their disruption during acute liver injury increases susceptibility to systemic infections. The study shows that disruption of the Kupffer cell niche leads to infiltration of immune cells and despite increased Kupffer cell numbers in injured livers, the mice remain susceptible to infections. Bone marrow-derived macrophage therapy effectively restores liver function and resistance.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Clinical Neurology
Pooria Namaei, Fereshteh Ghadiri, Raika Jamali, Amir Reza Azimi, Hamid Reza Farhadi Shabestari, Fahimeh Vahabizad
Summary: This study aimed to investigate the incidence, severity, and risk factors for liver injury in MS patients treated with pulsed methylprednisolone therapy. The study found a prevalence of liver injury of 2.86%, but all cases were not severe. Hyperlipidemia and history of alcohol abuse were significantly associated with liver injury.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2022)