Article
Oncology
Xinning Zhang, Yong Xu, Guodong Zhao, Rong Liu, Haisheng Yu
Summary: The study found that sorafenib suppressed the function of plasmacytoid dendritic cells (pDCs) and inhibited the production of interferon alpha (IFN-α) by peripheral blood mononuclear cells (PBMCs) or pDCs from healthy donors in a concentration-dependent manner. This suggests that the immunosuppressive effect of sorafenib on pDCs should be considered during cancer treatment.
Article
Food Science & Technology
Jinghe Sun, Shuang Song, Chunqing Ai, Beiwei Zhu, Jingfeng Yang
Summary: Sulfate-modified abalone polysaccharide (S-AGSP) effectively inhibits SARS-CoV-2 infection by weakening the binding affinity between the virus spike protein and ACE2. S-AGSP shows potential as a therapeutic candidate for COVID-19.
Article
Chemistry, Applied
Lihong Yang, Jun Liu, Xuewei Xia, Io Nam Wong, Sookja Kim Chung, Baojun Xu, Hesham R. El-Seedi, Bin Wang, Riming Huang
Summary: Investigation of polysaccharides from Undaria pinnatifida revealed the presence of three sulfated polysaccharides UPPs 1-3, which showed significant immunostimulatory effects. UPP-3 specifically activated the TLR4/NF-kappa B p65 signaling pathway.
Article
Oncology
Annabelle Vogt, Farsaneh Sadeghlar, Tiyasha H. Ayub, Carlo Schneider, Christian Moehring, Taotao Zhou, Robert Mahn, Alexandra Bartels, Michael Praktiknjo, Miroslaw T. Kornek, Marieta Toma, Ingo G. H. Schmidt-Wolf, Vittorio Branchi, Hanno Matthaei, Joerg C. Kalff, Christian P. Strassburg, Maria A. Gonzalez-Carmona
Summary: The combined strategy of subcutaneous vaccination with DCs transduced with AFP-coding adenoviruses and intratumoral treatment with DCs transduced with CD40L-coding adenoviruses showed promising results in inducing antitumoral immune response and leading to complete remissions and long-term survival in mice with HCC. This approach caused rapid and profound changes in the tumor environment, enhancing Th1-cytokine expression, tumor infiltration of cytotoxic T lymphocytes and DC, and tumor apoptosis, ultimately resulting in effective tumor regression of HCC.
Article
Biochemistry & Molecular Biology
Md. Akibul Hasan Bakky, Ngoc Tuan Tran, Ming Zhang, Yongsheng Zhang, Huifen Liang, Yilei Wang, Yueling Zhang, Hongyu Ma, Huaiping Zheng, Shengkang Li
Summary: This study characterized the polysaccharide from Gracilaria lemaneiformis and investigated its fermentation by rabbitfish intestinal microbes. The study found that the polysaccharide was mainly composed of galactose and anhydrogalactose, and it enhanced the production of short-chain fatty acids and altered the gut microbiota. The findings suggest that the polysaccharide has prebiotic potential and could be used as a functional feed additive in aquaculture.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Oncology
Wei Cheng, Ziwei Cheng, Lingling Weng, Dongwei Xing, Minguang Zhang
Summary: Our research demonstrates that ASP effectively suppresses hypoxia-induced proliferation, migration, invasion, and angiogenesis of HCC cells, partly through regulating HIF-1 alpha/VEGF expression via MAPK and PI3K signaling pathways.
Article
Chemistry, Applied
Maxim S. Kokoulin, Alexandra S. Kuzmich, Lyudmila A. Romanenko, Irina V. Chikalovets
Summary: This study investigates the structure and antiproliferative effect of the capsular polysaccharide from Kangiella japonica KMM 3897 on cancer cells. The carbohydrate polymer was isolated, purified, and its structure was determined through chemical analysis and NMR spectroscopy.
CARBOHYDRATE POLYMERS
(2022)
Article
Biochemistry & Molecular Biology
Dusica Maysinger, Issan Zhang, Pei You Wu, Marten Kagelmacher, Haiming Daniel Luo, Jayachandran N. Kizhakkedathu, Jens Dernedde, Matthias Ballauf, Rainer Haag, Adeola Shobo, Gerhard Multhaup, R. Anne McKinney
Summary: The objective of this study was to investigate the interaction between polyglycerols with sulfate or sialic acid functional groups and high mobility group box 1 (HMGB1). The study aimed to determine if polyglycerols could prevent the loss of morphological plasticity in excitatory neurons in the hippocampus. The results suggest that dendritic and linear polyglycerols can interact with HMGB1 and prevent dendritic spine loss in excitatory neurons.
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Ana S. Luis, Arnaud Basle, Dominic P. Byrne, Gareth S. A. Wright, James A. London, Chunsheng Jin, Niclas G. Karlsson, Gunnar C. Hansson, Patrick A. Eyers, Mirjam Czjzek, Tristan Barbeyron, Edwin A. Yates, Eric C. Martens, Alan Cartmell
Summary: This study uses structural biology to uncover how sulfatases from the human gut microbiota recognize sulfated glycans. The data reveals that carbohydrate sulfatases are highly selective for the glycan component of their substrate.
NATURE CHEMICAL BIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Yu Pei, Shengtao Yang, Zhenbang Xiao, Chunxia Zhou, Pengzhi Hong, Zhong-Ji Qian
Summary: A sulfated polysaccharide (GNP) extracted from Gelidium crinale exhibits strong antioxidant and anti-inflammatory activities, inhibiting inflammatory response induced by LPS and showing potential as a component in pharmaceutical and functional food industries.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Mary Shamya Arokiarajan, Rajasekar Thirunavukkarasu, Jerrine Joseph, Obluchinskaya Ekaterina, Wilson Aruni
Summary: Marine ecosystem associated organisms are a rich source of bioactive compounds, particularly polysaccharides, which have gained significant interest in the biomedical field. Seaweeds are particularly noted for their natural bioactive sulfated polysaccharides, with a wide range of therapeutic applications including antitumor and immunomodulatory properties.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Agricultural Engineering
Yi Han, Meng Zhao, Kehui Ouyang, Si Chen, Yang Zhang, Xin Liu, Qi An, Zitong Zhao, Wenjun Wang
Summary: The sulfation derivative of Cyclocarya paliurus polysaccharides showed stronger antioxidant activity compared to the original polysaccharides. The antioxidant effect may be performed via the Keap1-Nrf2 pathway, with Nrf2 proteins increased and Keap1 proteins decreased in response to polysaccharide stimulation.
INDUSTRIAL CROPS AND PRODUCTS
(2021)
Article
Biochemistry & Molecular Biology
Xue-Wu Chen, Yu-Yun Zheng, Jian-Ming Ouyang
Summary: The study investigated the repair of oxidatively damaged HK-2 cells using different sulfated levels of Undaria pinnatifida polysaccharides (UPPs). UPP2 showed the best cell repair ability and enhanced the endocytosis of crystals, indicating its potential as an agent to inhibit CaOx crystal deposition caused by high oxalate concentration.
Article
Integrative & Complementary Medicine
Lim Seong-Min, Park Hae-Bin, Jin Jun-O
Summary: Astragalus membranaceus polysaccharides, a major component of the root extract, have been found to modulate immune responses by activating dendritic cells and T cells. Studies show that intravenous injection of A. membranaceus polysaccharides in mice and human peripheral blood can enhance immune responses.
CHINESE JOURNAL OF NATURAL MEDICINES
(2021)
Article
Nanoscience & Nanotechnology
Nofar Yehuda, Yury Turkulets, Ilan Shalish, Ariel Kushmaro, Shoshana (Malis) Arad
Summary: The cell-wall sulfated polysaccharide of the red microalga Porphyridium sp. can complex with metal ions to produce novel materials with high antimicrobial activity, especially against Candida albicans. The Cu2O-polysaccharide complex exhibited covalent binding of copper, increased viscosity and conductivity, and showed inhibitory effects against various bacteria and fungi. The complex's antimicrobial properties were attributed to needle-like structures on the surface, indicating potential biotechnological applications.
ACS APPLIED MATERIALS & INTERFACES
(2021)