Article
Biochemistry & Molecular Biology
Taichi Tsuneishi, Masataka Takahashi, Masaki Tsujimura, Keiichi Kojima, Hiroshi Ishikita, Yasuo Takeuchi, Yuki Sudo
Summary: The study demonstrates that the newly synthesized DMP-retinal can be incorporated into AR3, resulting in novel optical properties and significant differences at the molecular level compared to the natural A1-retinal.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Yiyi Chen, Yujie Dong, Jie Yan, Lan Wang, Shirley Yu, Kangwei Jiao, Francois Paquet-Durand
Summary: This study systematically mapped the transcriptional changes that occur in the degenerating mouse retina at the single cell level using single-cell RNA-sequencing. The results highlight the relevance of Ca2+-signaling and metabolic pathways to hereditary photoreceptor degeneration, and suggest that metabolic changes in rd1 mutation may be regulated through the MAPK pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Shun Kubo, Haruka Yamamoto, Naoko Kajimura, Yoshihiro Omori, Yamato Maeda, Taro Chaya, Takahisa Furukawa
Summary: The study reveals that in photoreceptor cells, Samd11 is a component of PRC1 and interacts with Samd7 to establish cell identity, with Samd7 acting as the main regulator and Samd11 as an accessory factor.
SCIENTIFIC REPORTS
(2021)
Article
Biology
Sarita Hebbar, Malte Lehmann, Sarah Behrens, Catrin Haelsig, Weihua Leng, Michaela Yuan, Sylke Winkler, Elisabeth Knust
Summary: Mutations in Drosophila Prp31 gene lead to retinal degeneration, providing insights into the molecular mechanisms underlying human retinitis pigmentosa.
Article
Cell Biology
Alexandra K. Blomfield, Meenakshi Maurya, Kiran Bora, Madeline C. Pavlovich, Felix Yemanyi, Shuo Huang, Zhongjie Fu, Amy E. O'Connell, Jing Chen
Summary: Wnt/beta-catenin signaling is crucial for the development of embryonic eyes. WNT2B is involved in the development of the lens and peripheral regions of the eye. It may play a role in retinal progenitor cell differentiation and the formation of rod photoreceptor cells.
Article
Ophthalmology
Shannon R. Barwick, Haiyan Xiao, David Wolff, Jing Wang, Elizabeth Perry, Brendan Marshall, Sylvia B. Smith
Summary: Retinitis pigmentosa (RP) is a devastating inherited retinal disease that leads to visual impairment and blindness. Currently, there is no cure for RP, highlighting the importance of research into prolonging vision. This study investigated the effects of Sigma 1 receptor (Sig1R) activation in a mouse model of RP and found that it can protect visual function and structure. These results provide a framework for further studies on Sig1R as a potential therapeutic target for retinal degenerative diseases.
EXPERIMENTAL EYE RESEARCH
(2023)
Article
Cell & Tissue Engineering
Elisa Cuevas, Daniel L. Holder, Ashwak H. Alshehri, Julie Treguier, Jorn Lakowski, Jane C. Sowden
Summary: The study utilized CRISPR/Cas9 gene editing to create NRL-deficient embryonic stem cell (ESC) line, which differentiated into retinal organoids. The research found that in NRL-deficient organoids, photoreceptor development exhibited abnormalities, indicating a conserved molecular switch mechanism.
Review
Pharmacology & Pharmacy
Joseph Thomas Ortega, Beata Jastrzebska
Summary: The retina is a multilayer neuronal tissue at the back of the eye that transduces light into neural impulses. Many eye diseases lead to retina degeneration, with RP being a common hereditary disorder related to mutations in rhodopsin. In RP, sustained inflammation exacerbates due to abnormal genetic background, leading to photoreceptor decline.
Article
Multidisciplinary Sciences
Maeva Langouet, Christine Jolicoeur, Awais Javed, Pierre Mattar, Micah D. Gearhart, Stephen P. Daiger, Mette Bertelsen, Lisbeth Tranebjaerg, Nanna D. Rendtorff, Karen Gronskov, Catherine Jespersgaard, Rui Chen, Zixi Sun, Hui Li, Najmeh Alirezaie, Jacek Majewski, Vivian J. Bardwell, Ruifang Sui, Robert K. Koenekoop, Michel Cayouette
Summary: This study reveals the involvement of BCOR in photoreceptor degenerative diseases by interacting with transcription factors CRX and OTX2 to reduce their activation of photoreceptor-specific genes. Mutations in human BCOR are associated with severe early-onset X-linked retinal degeneration, and the expression of BCOR mutants in the mouse retina leads to degeneration with enhanced repressive activity on OTX2.
Review
Biochemistry & Molecular Biology
Meng Zhao, Guang-Hua Peng
Summary: Photoreceptors in the retina are crucial for converting light into electric signals, and their development is regulated by specific genes and proteins. Single-cell sequencing is a promising technology for studying photoreceptor development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Susanne Wiemann, Aisha Yousf, Stephanie C. Joachim, Carolin Peters, Ana M. Mueller-Buehl, Natalie Wagner, Jacqueline Reinhard
Summary: This study aimed to investigate the functional role of the glycoprotein tenascin-C (Tnc) in retinal ischemia, finding increased Tnc levels after ischemia accompanied by diminished rod-photoreceptor degeneration and retinal dysfunction in KO mice. Additionally, KO mice showed lower levels of activated caspase 3(+) cells, suggesting a potential role of Tnc in synaptic remodeling during ischemic retinal degeneration. Increased vesicular glutamate transporter 1 (vGlut1) levels in both ischemic groups indicated impaired glutamatergic signaling and excitotoxicity after ischemia.
FRONTIERS IN NEUROSCIENCE
(2021)
Review
Medicine, General & Internal
Alexandra V. Garafalo, Rebecca Sheplock, Alexander Sumaroka, Alejandro J. Roman, Artur V. Cideciyan, Samuel G. Jacobson
Summary: Inherited retinal diseases (IRDs) encompass cone-rod diseases, which have complex etiologies and can lead to vision loss. Among the causative genes, there is diversity, leading to a variety of disease manifestations, and paving the way for potential therapies.
Article
Biochemical Research Methods
Chisato Inoue, Tamaki Takeuchi, Akira Shiota, Mineo Kondo, Yuji Nshizawa
Summary: In this study, a transgenic rat strain named P347L rat was created by replacing proline with leucine in the rhodopsin protein. Pathological analysis revealed rapid degeneration and loss of the outer nuclear layer in P347L rats before fully established photoreceptor cells. Rapamycin was shown to delay photoreceptor cell degeneration in this RP model.
BIOLOGICAL PROCEDURES ONLINE
(2021)
Article
Cell Biology
Ellen Townes-Anderson, Eva Halasz, Ilene Sugino, Amy L. Davidow, Laura J. Frishman, Luke Fritzky, Fawad A. K. Yousufzai, Marco Zarbin
Summary: Detached retina reattachment may not fully restore vision, due to long-term damage to photoreceptor synapses. This study investigated the effects of reattachment and ROCK inhibition on cone synapses using microscopy and electroretinograms. ROCK inhibition protects against structural abnormalities and improves functional restoration of cone-bipolar neurotransmission. These findings suggest that ROCK inhibitors could enhance gene or stem cell therapies and improve recovery of the injured retina.
Article
Biology
Tylor R. Lewis, Sebastien Phan, Carson M. Castillo, Keun-Young Kim, Kelsey Coppenrath, William Thomas, Ying Hao, Nikolai P. Skiba, Marko E. Horb, Mark H. Ellisman, Vadim Y. Arshavsky, Audrey M. Bernstein
Summary: The initial steps of vision occur in stacked membrane structures called discs located within the outer segment compartment of photoreceptor cells. These discs become enclosed and form deep indentations known as incisures. Using electron microscopy and tomography, it was discovered that incisures only form after complete disc enclosure. The size of the incisures is determined by the ratio of peripherin-2 to rhodopsin, with a higher ratio resulting in larger and more complex incisures.
Article
Ophthalmology
Imane Hammoum, Maha Benlarbi, Ahmed Dellaa, Rim Kahloun, Riadh Messaoud, Soumaya Amara, Rached Azaiz, Ridha Charfeddine, Mohamed Dogui, Moncef Khairallah, Akos Lukats, Rafika Ben Chaouacha-Chekir
EXPERIMENTAL EYE RESEARCH
(2018)
Article
Neurosciences
Agnes Csaki, Viktoria Vereczki, Akos Lukats, Zsolt Boldogkoi, Anna Sebestyen, Zita Puskar, Katalin Koves
NEUROSCIENCE LETTERS
(2018)
Article
Surgery
A. Budai, G. Horvath, L. Tretter, Z. Radak, E. Koltai, Z. Bori, F. Torma, A. Lukats, P. Rohlich, A. Szijarto, A. Fulop
BRITISH JOURNAL OF SURGERY
(2019)
Article
Multidisciplinary Sciences
Ingrid van der Merwe, Akos Lukats, Veronika Blahova, Maria K. Oosthuizen, Nigel C. Bennett, Pavel Nemec
Article
Neurosciences
Josephine Juttner, Arnold Szabo, Brigitte Gross-Scherf, Rei K. Morikawa, Santiago B. Rompani, Peter Hantz, Tamas Szikra, Federico Esposti, Cameron S. Cowan, Arjun Bharioke, Claudia P. Patino-Alvarez, Ozkan Keles, Akos Kusnyerik, Thierry Azoulay, Dominik Hartl, Arnaud R. Krebs, Dirk Schubeler, Rozina I. Hajdu, Akos Lukats, Janos Nemeth, Zoltan Z. Nagy, Kun-Chao Wu, Rong-Han Wu, Lue Xiang, Xiao-Long Fang, Zi-Bing Jin, David Goldblum, Pascal W. Hasler, Hendrik P. N. Scholl, Jacek Krol, Botond Roska
NATURE NEUROSCIENCE
(2019)
Article
Multidisciplinary Sciences
Rozina Hajdu, Lenke K. Laurik, Klaudia Szabo, Bulcsu Dekany, Zsuzsanna Almasi, Anna Enzsoly, Arnold Szabo, Tunas Radovits, Csaba Matyas, Attila Olah, Agoston Szel, Gabor M. Somfai, Csaba David, Akos Lukats
SCIENTIFIC REPORTS
(2019)
Article
Multidisciplinary Sciences
Dasha Nelidova, Rei K. Morikawa, Cameron S. Cowan, Zoltan Raics, David Goldblum, Hendrik P. N. Scholl, Tamas Szikra, Arnold Szabo, Daniel Hillier, Botond Roska
Article
Biochemistry & Molecular Biology
Cameron S. Cowan, Magdalena Renner, Martina De Gennaro, Brigitte Gross-Scherf, David Goldblum, Yanyan Hou, Martin Munz, Tiago M. Rodrigues, Jacek Krol, Tamas Szikra, Rachel Cuttat, Annick Waldt, Panagiotis Papasaikas, Roland Diggelmann, Claudia P. Patino-Alvarez, Patricia Galliker, Stefan E. Spirig, Dinko Pavlinic, Nadine Gerber-Hollbach, Sven Schuierer, Aldin Srdanovic, Marton Balogh, Riccardo Panero, Akos Kusnyerik, Arnold Szabo, Michael B. Stadler, Selim Orgul, Simone Picelli, Pascal W. Hasler, Andreas Hierlemann, Hendrik P. N. Scholl, Guglielmo Roma, Florian Nigsch, Botond Roska
Article
Cell Biology
Viktoria Denes, Karmen Kovacs, Akos Lukats, Adrienn Mester, Gergely Berta, Arnold Szabo, Robert Gabriel
Summary: This study identified retinal ganglion cells (RGCs) as expressing PAC1 receptors and being capable of producing Fgf1, Bmp4, and Gdf3. However, the RGCs lack the ability to release these proteins, potentially suggesting a role for intracrine pathways in regulating RGC development.
EUROPEAN JOURNAL OF HISTOCHEMISTRY
(2022)
Article
Ophthalmology
Anna Enzsoly, Rozina I. Hajdu, Zsolt Turoczi, Iren Szalai, Erika Tatrai, Fanni Palya, Zoltan Z. Nagy, Csaba Matyas, Attila Olah, Tamas Radovits, Klaudia Szabo, Bulcsu Dekany, Arnold Szabo, Akos Kusnyerik, Petra Soltesz, Daniel S. Veres, Aniko Somogyi, Gabor M. Somfai, Akos Lukats
Summary: The study found that an increased number of dual cones in diabetic rats correlated with fT4 levels. The risk of color vision deficiencies was higher in diabetic patients, but the study did not detect any effect of thyroid hormones on the development of color vision deficiencies.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)