期刊
CELL AND TISSUE RESEARCH
卷 355, 期 1, 页码 223-232出版社
SPRINGER
DOI: 10.1007/s00441-013-1723-6
关键词
Bisphenol A; Meiotic chromosomal spread; Meiotic double-strand breaks; Spermatogenesis; Stage of seminiferous epithelium
类别
资金
- National Basic Research Program of China (National 973 Program) [2011CB503700]
- National Natural Science Foundation of China [31170800]
Whether environmental exposure to bisphenol A (BPA) may induce reproductive disorders is still controversial but certain studies have reported that BPA may cause meiotic abnormalities in C. elegans and female mice. However, little is known about the effect of BPA on meiosis in adult males. To determine whether BPA exposure at an environmentally relevant dose could induce meiotic abnormalities in adult male rats, we exposed 9-week-old male Wistar rats to BPA by gavage at 20 mu g/kg body weight (bw)/day for 60 consecutive days. We found that BPA significantly increased the proportion of stage VII seminiferous epithelium and decreased the proportion of stage VIII. Consequently, spermiation was inhibited and spermatogenesis was disrupted. Further investigation revealed that BPA exposure delayed meiosis initiation in the early meiotic stage and induced the accumulation of chromosomal abnormalities and meiotic DNA double-strand breaks (DSBs) in the late meiotic stage. The latter event subsequently activated the phosphatidylinositol 3-kinase-related protein kinase (ATM). Our results suggest that long-term exposure to BPA may lead to continuous meiotic abnormalities and ultimately put mammalian reproductive health at risk.
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