期刊
CELL AND TISSUE RESEARCH
卷 349, 期 3, 页码 717-731出版社
SPRINGER
DOI: 10.1007/s00441-012-1381-0
关键词
Epididymis; Sperm maturation; Gene expression; Lumicrine factors; Small RNAs
类别
资金
- CIHR
The epididymis is responsible for post-testicular sperm maturation, which consists in the acquisition of forward motility and fertilizing ability. This organ is composed of three main anatomical regions - the caput, corpus and cauda epididymidis - which possess distinct gene expression profiles, ensuring different epididymal functions essential to the different steps of sperm maturation. Since many genes display spatially restricted expression in the epididymis, this organ constitutes a model of choice to study the mechanisms that govern region-specific gene expression. Factors such as steroid hormones, lumicrine factors and temperature affect the pattern of gene expression in the epididymis. Recently, the contribution of small RNAs in epididymal gene regulation has been investigated and constitutes a promising avenue for clinical application with regard to male fertility.
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