期刊
CELL AND TISSUE RESEARCH
卷 342, 期 1, 页码 21-30出版社
SPRINGER
DOI: 10.1007/s00441-010-1040-2
关键词
Cochlea; Resident macrophage; Immunohistochemistry; Confocal laser microscopy; Mouse (C57BL/6J; C57Bl/6-Tg)
类别
资金
- National Institute of Deafness and Other Communications Disorders [R01 DC00844, R03 DC008888-02, P30 DC005983]
A large population of perivascular cells was found to be present in the area of the blood-labyrinth barrier in the stria vascularis of normal adult cochlea. The cells were identified as perivascular resident macrophages (PVMs), as they were positive for several macrophage surface molecules including F4/80, CD68, and CD11b. The macrophages, which were closely associated with microvessels and structurally intertwined with endothelial cells and pericytes, constitutively expressed scavenger receptor classes A(1) and B-1 and accumulated blood-borne proteins such as horseradish peroxidase and acetylated low-density lipoprotein. The PVMs were demonstrated to proliferate slowly, as evidenced by the absence of 5-bromo-2-deoxyuridine (BrdU)-positive PVMs at 3-14 days in normal mice injected with BrdU. However, in irradiated mice, the majority of the PVMs turned over via bone-marrow-cell migration within a 10-month time-frame. The existence of PVMs in the vascular wall of the blood-labyrinth barrier might therefore serve as a source for progenitor cells for postnatal vasculogenesis and might contribute to the repair of damaged vessels in the context of a local inflammatory response.
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