Article
Immunology
Jan-Hendrik Schroeder, Gordon Beattie, Jonathan W. W. Lo, Tomasz Zabinski, Nick Powell, Joana F. F. Neves, Richard G. G. Jenner, Graham M. M. Lord
Summary: Significant progress has been made in understanding innate lymphoid cells (ILC) by applying concepts from T cell biology, such as flow cytometry gating strategies and CD90 markers. Surprisingly, a sub-population of ILC in the gut were found to have low or no expression of CD90, contrary to expectations. These CD90-negative and CD90-low CD127(+) ILC were influenced by stimulatory cues and dysbiosis, and could produce IL-13, IFN gamma and IL-17A in steady state and colitis conditions.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Ramon A. Lujan, Sophia M. Vrba, Heather D. Hickman
Summary: Before the adaptive immune response, innate antiviral cells, including conventional natural killer cells (cNK) and tissue-resident ILCs (ILC1s), respond to a wide range of viruses to limit replication and virus-induced pathology. While cNK cells lyse virus-infected cells, ILC1s respond with the production of antiviral cytokines and can even induce an antiviral state in uninfected tissue. Mounting evidence suggests that ILC1s may have enhanced secondary responses to viral infections.
JOURNAL OF MOLECULAR BIOLOGY
(2022)
Review
Immunology
Maiko Naito, Atsushi Kumanogoh
Summary: Since their discovery in 2010, group 2 innate lymphoid cells (ILC2s) have been extensively studied to understand their developmental pathways, activation and regulation mechanisms, and their roles in tissue homeostasis and specific diseases. However, the impact of the surrounding environment on ILC2s functions is still not fully understood. Recent histologic analyses have shown that ILC2s reside in perivascular regions in peripheral tissues and their function is regulated by surrounding cells through various interactions. This review focuses on summarizing the interactions between ILC2s and surrounding cells, aiming to advance the development of novel diagnostic and therapeutic approaches for ILC2-related diseases.
INFLAMMATION AND REGENERATION
(2023)
Article
Allergy
Maryam Ghaedi, Fumio Takei
Summary: Innate lymphoid cells (ILCs) mainly reside at barrier surfaces and play a regulatory role in tissue homeostasis and immunity. They are divided into 3 groups based on similar effector programs to T cells, and their development from lymphoid progenitors in adult mouse bone marrow has been extensively studied.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ying Kong, Han-Dong Li, Dan Wang, Xiaolin Gao, Chunsheng Yang, Minshu Li, Ting Chang, Qiang Liu
Summary: The study found a correlation between the reduction of ILC2 and disease severity in neuromyelitis optica spectrum disorder (NMOSD), and expanding ILC2 could alleviate the pathological conditions.
Review
Immunology
Takahiro Matsuyama, Hiromi Matsuyama, Yoichi Dotake, Koichi Takagi, Kentaro Machida, Hiromasa Inoue
Summary: T helper type 2 cells and group 2 innate lymphoid cells play a crucial role in asthma, particularly in airway eosinophilic inflammation. These cells are activated by cytokines released by airway epithelial cells and produce high levels of type 2 cytokines. ILC2s induce airway inflammation independently of antigens and may contribute to steroid resistance. Biologics targeting these cytokines and/or their receptors have shown promise in reducing asthma exacerbations and improving lung function and quality of life in asthmatic patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Katja J. Jarick, Patrycja M. Topczewska, Manuel O. Jakob, Hiroshi Yano, Mohammad Arifuzzaman, Xuemei Gao, Sotiria Boulekou, Vladislava Stokic-Trtica, Pierre S. Leclere, Alexandra Preusser, Zoe A. Rompe, Anton Stamm, Amy M. Tsou, Coco Chu, Frederik R. Heinrich, Gabriela M. Guerra, Pawel Durek, Andranik Ivanov, Dieter Beule, Sofia Helfrich, Claudia U. Duerr, Anja A. Kuehl, Christina Stehle, Chiara Romagnani, Mir-Farzin Mashreghi, Andreas Diefenbach, David Artis, Christoph S. N. Klose
Summary: This article investigates the role of innate lymphoid cells (ILCs) in protective immunity. Using a mouse model specific to ILCs, researchers found that ILC2s have non-redundant functions during steady state and disease, and they interact with adaptive immune cells to organize the immune system.
Review
Immunology
Laura Mathae, Fumio Takei, Itziar Martinez-Gonzalez
Summary: Group 2 innate lymphoid cells (ILC2s) are present in mucosal and non-mucosal tissues in both mice and humans, and are involved in initiating type 2 inflammation. Recent studies have shown that ILC2s have the ability to circulate between different organs during inflammation and may play roles in mediating multiple type 2 diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Masashi Ikutani, Susumu Nakae
Summary: ILC2s are a type of cells known for their rapid response to parasitic infections and their role in the development of allergic disorders, producing key cytokines. Recent studies have shown that ILC2s play important roles in various physiological processes, and their interactions with IL-33 and eosinophils have attracted researchers' interest.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Takahiro Matsuyama, Kentaro Machida, Keiko Mizuno, Hiromi Matsuyama, Yoichi Dotake, Masahiro Shinmura, Koichi Takagi, Hiromasa Inoue
Summary: Asthma is characterized by chronic airway inflammation. Group 2 innate lymphoid cells (ILC2) play a crucial role in its pathogenesis and are involved in both steroid resistance and the induction of airway eosinophilic inflammation. Studies have shown that ILC2s induce airway inflammation through interactions with cytokines and other mediators from immune and non-immune cells, collaborating with T helper type 2 cells to organize type 2 immune responses. The increased frequencies of ILC2s in the blood and bronchoalveolar lavage fluid of asthma patients, especially in severe asthmatics, contribute to the regulation of immune response in asthma.
Article
Endocrinology & Metabolism
Mingming Liu, Danni Wang, Lin Xu, Yan Pan, Huachen Huang, Minshu Li, Qiang Liu
Summary: Group 2 innate lymphoid cells (ILC2) have a suppressive effect on neuroinflammation and injury following intracerebral hemorrhage (ICH). Depletion of ILC2 exacerbates neurodeficits and brain edema after ICH, accompanied by increased microglia activity and leukocyte infiltration. Conversely, expansion of ILC2 reduces ICH injury, microglia activity, and leukocyte infiltration.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Immunology
Jan-Hendrik Schroeder, Katrin Meissl, Dominika Hromadova, Jonathan W. Lo, Joana F. Neves, Jane K. Howard, Helena Helmby, Nick Powell, Birgit Strobl, Graham M. Lord
Summary: T-bet deficient mice show an increase in ILC3 cellularity but do not have a greater risk of developing spontaneous colitis. T-bet appears to control the number of ILC3 cells, but does not drive a pathogenic role of ILC3 in mice with a conventional specific pathogen-free microbiota.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Dengming Lai, Weiwei Chen, Kai Zhang, Melanie J. Scott, Yuehua Li, Timothy R. Billiar, Mark A. Wilson, Jie Fan
Summary: This study identifies a novel pathway in regulating ILC2p mobilization and expansion during sepsis, and indicates BM as the main source of ILC2 in the lung following sepsis.
MOLECULAR MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Feng Li, Zhou Liang, Haojie Zhong, Xinrong Hu, Ziwen Tang, Changjian Zhu, Jiani Shen, Xu Han, Ruoni Lin, Ruilin Zheng, Ruihan Tang, Huajing Peng, Xunhua Zheng, Chengqiang Mo, Peisong Chen, Xin Wang, Qiong Wen, Jianbo Li, Xi Xia, Hongjian Ye, Yagui Qiu, Jianwen Yu, Dongying Fu, Jiaqi Liu, Rong Wang, Huixin Xie, Yun Guo, Xiaoyan Li, Jinjin Fan, Qinghua Liu, Haiping Mao, Wei Chen, Yi Zhou
Summary: In lupus nephritis (LN), gut-derived group 3 innate lymphoid cells (ILC3s) migrate from the small intestine to the kidney via the CXCR6/CXCL16 axis, contributing to the progression of LN, including spleen and lymph node enlargement, antibody production, and renal injury. In renal ectopic lymphoid structures (ELS), ILC3s induce B cell activation in a Delta-like1 (DLL1)/Notch-dependent manner, accompanied by up-regulation of Deltex1 and MAML1.
Review
Immunology
Laura Matha, Itziar Martinez-Gonzalez, Catherine A. Steer, Fumio Takei
Summary: ILC2s are a type of cells that play critical roles in defending against parasites and allergens, producing large amounts of inflammatory factors upon activation. Studies have revealed novel properties of post-activation ILC2s, such as the generation of immunological memory and activation-induced migration.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Yong Yu, Jason C. H. Tsang, Cui Wang, Simon Clare, Juexuan Wang, Xi Chen, Cordelia Brandt, Leanne Kane, Lia S. Campos, Liming Lu, Gabrielle T. Belz, Andrew N. J. McKenzie, Sarah A. Teichmann, Gordon Dougan, Pentao Liu
Article
Immunology
Yong Yu, Juexuan Wang, Walid Khaled, Shannon Burke, Peng Li, Xiongfeng Chen, Wei Yang, Nancy A. Jenkins, Neal G. Copeland, Shujun Zhang, Pentao Liu
JOURNAL OF EXPERIMENTAL MEDICINE
(2012)
Review
Developmental Biology
Peter J. I. Ellis, Yong Yu, Shujun Zhang
Article
Biotechnology & Applied Microbiology
Jason C. H. Tsang, Yong Yu, Shannon Burke, Florian Buettner, Cui Wang, Aleksandra A. Kolodziejczyk, Sarah A. Teichmann, Liming Lu, Pentao Liu