期刊
CELL
卷 152, 期 4, 页码 671-672出版社
CELL PRESS
DOI: 10.1016/j.cell.2013.01.050
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资金
- NIA NIH HHS [AG039756, R01 AG038664, AG038664, AG028040] Funding Source: Medline
- NIDDK NIH HHS [DK094026] Funding Source: Medline
In this issue, Xiao et al. challenge the notion that cold temperatures promote longevity solely through thermodynamic effects. They show that low temperatures activate a cold-sensitive cation channel, TRPA-1, which triggers a complex signaling pathway in both neurons and nonneuronal cells to extend the lifespan of Caenorhabditis elegans.
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