Article
Engineering, Biomedical
Brian C. Ross, Robert N. Kent III, Michael N. Saunders, Samantha R. Schwartz, Brooke M. Smiley, Sarah E. Hocevar, Shao-Chi Chen, Chengchuan Xiao, Laura A. Williams, Aileen J. Anderson, Brian J. Cummings, Brendon M. Baker, Lonnie D. Shea
Summary: Design parameters of microporous annealed particles (MAPs) tubes with different sizes were investigated for the treatment of spinal cord injury (SCI). It was found that tubes composed of 60-micron beads can effectively reduce scarring, increase immune cell density, and promote functional recovery. These studies highlight the importance of bead size in MAP construction.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Kaiyuan Yang, Jia Yang, Weitao Man, Zhe Meng, Chun-Yi Yang, Zheng Cao, Jun Liu, Kunkoo Kim, Yaosai Liu, Shuhui Yang, Yi Guo, Zhijun He, Chao Ma, Guihuai Wang, Xiumei Wang
Summary: This study developed an aligned fibrin nanofiber hydrogel modified with N-Cadherin-Fc for delivering neural stem cells (NSCs) to the injury site of spinal cord injury (SCI). The hydrogel provided multimodal cues to guide NSC functions and nerve regeneration. The hydrogel carrying exogenous NSCs significantly promoted NSC retention, immunomodulation, neuronal differentiation, and in vivo integration with inherent neurons in a rat SCI model, resulting in neural relay formation and locomotor functional recovery.
ADVANCED FIBER MATERIALS
(2023)
Review
Biotechnology & Applied Microbiology
Zhenshan Lv, Chao Dong, Tianjiao Zhang, Shaokun Zhang
Summary: Traffic accidents and falling objects are the main causes of spinal cord injuries (SCIs), seriously affecting the lives and quality of life of patients. Hydrogels, with their biocompatibility and adjustability, serve as structural scaffolds and slow-release carriers in neural tissue engineering, promoting tissue repair. This review discusses the characteristics and advantages of hydrogels as delivery vehicles in SCI therapy and explores their prospects in clinical research for the treatment of SCI.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Engineering, Environmental
Min Wang, Chenggui Wang, Mi Chen, Meng Luo, Qixin Chen, Bo Lei
Summary: In this study, a multifunctional nanocomposite hydrogel scaffold with spinal cord-biomimetic mechanical and electrical properties was reported, which could significantly improve locomotion recovery, reduce inflammation, promote remyelination and axon regeneration after spinal cord injury.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Neurosciences
Nicholas O. Jensen, Brooke Burris, Lili Zhou, Hunter Yamada, Catrina Reyes, Zachary Pincus, Mayssa H. Mokalled
Summary: Adult zebrafish are capable of anatomical and functional recovery following severe spinal cord injury. Axon growth, glial bridging, and adult neurogenesis are hallmarks of cellular regeneration during spinal cord repair. However, the correlation between these cellular regenerative processes and functional recovery remains to be elucidated.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Review
Biotechnology & Applied Microbiology
Tian-Yang Yuan, Jun Zhang, Tong Yu, Jiu-Ping Wu, Qin-Yi Liu
Summary: Spinal cord injury is a challenging central nervous system injury, and 3D bioprinting technology shows potential in nervous system repair. This review discusses the progress of spinal cord tissue engineering and the applications of 3D bioprinting in spinal cord repair.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Editorial Material
Cell & Tissue Engineering
April M. Craft, Jenna Galloway
Summary: Fang et al. conducted a comprehensive transcriptomic analysis of the cell types in the enthesis, the interface between tendon and bone. They identified a potent Gli1-lineage progenitor with clonogenicity and multipotency, which improved enthesis healing in an adult injury model.
Article
Nanoscience & Nanotechnology
Yi Li, Liangliang Yang, Fei Hu, Ji Xu, Junsong Ye, Shuhua Liu, Lifeng Wang, Ming Zhuo, Bing Ran, Hongyu Zhang, Junming Ye, Jian Xiao
Summary: This study presents a promising bioactive system for the treatment of spinal cord injury (SCI) by immobilizing umbilical cord mesenchymal stem cells (UCMSC) and basic fibroblast growth factor (bFGF) in extracellular matrix (ECM) and heparin-poloxamer (HP). The results show that this system has therapeutic effects in reducing apoptosis and improving mitochondrial function, and it activates PAK1 and SIRT4 to protect against SCI.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Engineering, Biomedical
Xiaoyun Liu, Mingming Hao, Zhongjin Chen, Ting Zhang, Jie Huang, Jianwu Dai, Zhijun Zhang
Summary: 3D bioprinting has been used to fabricate NSC-laden scaffolds for in vivo SCI repair, utilizing a novel bioink with fast gelation and high NSC viability. This method promotes axon regeneration and reduces glial scar deposition, leading to significant locomotor recovery in SCI model rats. It represents a versatile strategy for precise engineering of the central nervous system and other neural tissues for regenerative medicine applications.
Review
Neurosciences
Yu-Ming Fang, Wei-Can Chen, Wan-Jing Zheng, Yu-Shen Yang, Yan Zhang, Xin-Li Chen, Meng-Qin Pei, Shu Lin, He-Fan He
Summary: Spinal cord injury leads to loss of motor and sensory function, but effective treatments are lacking. Reprogramming-based neuronal transdifferentiation shows promise in spinal cord injury repair, but its mechanisms are not well understood. This review analyzes the cellular transdifferentiation mechanisms, discusses different molecular approaches and challenges, and provides new therapeutic ideas.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Review
Cell Biology
Serena Silvestro, Emanuela Mazzon
Summary: Spinal cord injury is a devastating injury to the central nervous system, and current therapies have not been successful. MiRNA plays a crucial role in CNS development and pathological processes after neural injury, making it a promising candidate for SCI therapy.
Review
Neurosciences
Manqi Cai, Liji Chen, Tao Wang, Yinru Liang, Jie Zhao, Xiaomin Zhang, Ziyi Li, Hongfu Wu
Summary: Spinal cord injury (SCI) is a central nervous system disease caused mostly by accidents, leading to unsatisfactory prognosis and long-term negative effects on patients' lives. The use of hydrogel, a biocompatible and degradable three-dimensional structure, shows promise in tissue repair and treatment of SCI by improving the microenvironment at the injury site and facilitating axon reconstruction. The addition of different materials to form composite hydrogels can further enhance their performance. This paper reviews the research progress of hydrogel for SCI and introduces several typical composite hydrogels, aiming to provide reference for the clinical application of hydrogel therapy for SCI.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Engineering, Biomedical
Yuanshan Liu, Zhuangzhuang Zhang, Yajie Zhang, Bingqing Luo, Xingzhu Liu, Yi Cao, Renjun Pei
Summary: Spinal cord injury often leads to severe and permanent disabilities. Tissue engineering with biocompatible hydrogels has shown promise for SCI repair, but achieving stable contact with transected nerve stumps and promoting neural regeneration remains a challenge.
ACTA BIOMATERIALIA
(2023)
Article
Multidisciplinary Sciences
Zoe Mayer, James Kahn, Markus Goetz, Yu Hou, Tobias Beiersdoerfer, Nicolas Blumenroehr, Rebekka Volk, Achim Streit, Frank Schultmann
Summary: TBBR is a multi-channel remote sensing dataset that includes 926 high-resolution images with 6927 manually-provided thermal bridge annotations. It provides five channels per image: three color, one thermographic, and one computationally derived height map channel. The data is pre-split into training and test subsets for object detection and instance segmentation tasks. It follows the FAIR principles and is publicly available on the Zenodo data repository. This work aims to facilitate the adoption of the TBBR dataset by the community.
Article
Biochemistry & Molecular Biology
Ana Ribeiro, Mariana Rebocho da Costa, Carmen de Sena-Tomas, Elsa Charas Rodrigues, Raquel Quiteria, Tiago Macarico, Susana Constantino Rosa Santos, Leonor Saude
Summary: The vascular system repair after spinal cord injury (SCI) is inefficient in mammals, leading to secondary tissue damage and immune imbalance, which limit functional recovery. Unlike mammals, zebrafish can repair the spinal cord and restore motility, but the vascular response to injury was not studied. This study describes the development of the zebrafish spinal cord blood vasculature and its response to injury, demonstrating successful re-vascularization and reinforcing the value of zebrafish as a regenerative model for SCI.