Article
Food Science & Technology
Bo Wang, Caihong Wu, Lianzhi Cui, Hui Wang, Ya Liu, Weiwei Cui
Summary: This study found that ingested aluminium accumulates in the intestine, and the gut microbiota may play a crucial role in protecting against aluminium toxicity. The experiment showed that aluminium treatment resulted in pathological changes in the kidneys, liver, and heart tissues of rats, as well as alterations in the structure and diversity of the gut microbiota.
FOOD SCIENCE & NUTRITION
(2022)
Article
Nutrition & Dietetics
Kirra Borrello, Unhee Lim, Song-Yi Park, Kristine R. Monroe, Gertraud Maskarinec, Carol J. Boushey, Lynne R. Wilkens, Timothy W. Randolph, Loic Le Marchand, Meredith A. Hullar, Johanna W. Lampe
Summary: This study found that racial/ethnic differences in GM composition may be influenced by differences in diet. Overall diet quality and intake of certain foods were found to have significant effects on GM composition, which may contribute to racial/ethnic health disparities.
Article
Pharmacology & Pharmacy
M. Carmen Ruiz-Cantero, Elsa Cortes-Montero, Aakanksha Jain, Angeles Montilla-Garcia, Inmaculada Bravo-Caparros, Jaehoon Shim, Pilar Sanchez-Blazquez, Clifford J. Woolf, Jose M. Baeyens, Enrique J. Cobos
Summary: The sigma-1 receptor interacts with TRPV1 and the μ-opioid receptor, and antagonizing sigma-1 receptor can reduce PGE2- and NGF-induced hyperalgesia by increasing the activity of the μ-opioid receptor. This mechanism is not effective against GDNF-induced hyperalgesia. The sigma-1 antagonism transfers the sigma-1 receptor from TRPV1 to μ-opioid receptor and harnesses endogenous opioids produced by TRPV1+ neurons to reduce hyperalgesia.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Review
Microbiology
Jiongxing Fu, Yan Zheng, Ying Gao, Wanghong Xu
Summary: Dietary fiber intake is closely related to the health of the gut microbiota, and a decrease in dietary fiber intake may contribute to the global epidemic of metabolic disorders such as obesity and type 2 diabetes. The effects of dietary fiber on the gut microbiota are specific to the type, amount, and duration of intake. Understanding the interaction between dietary fiber and the gut microbiota can provide insights for optimal intervention strategies for patients.
Review
Biochemistry & Molecular Biology
Tao Che, Bryan L. Roth
Summary: This article explores the molecular basis of opioid receptor signaling, including the binding of opioids to receptors and the molecular determinants of signaling pathways. Additionally, the synergy between computational biology and medicinal chemistry is mentioned as a means to expedite the discovery of more effective and safer opioid compounds.
Article
Nutrition & Dietetics
Anthony A. Xu, Luke K. Kennedy, Kristi Hoffman, Donna L. White, Fasiha Kanwal, Hashem B. El-Serag, Joseph F. Petrosino, Li Jiao
Summary: This study investigated the impact of dietary fatty acid intake on gut microbiota composition and structure. The results showed that different types of fatty acid intake were associated with significant differences in the β diversity of gut bacteria. Specific bacteria such as Sutterella, Tyzzerella, and Fusobacterium were found to have a significant correlation with fatty acid intake.
Article
Biochemistry & Molecular Biology
Chloe X. Yap, Anjali K. Henders, Gail A. Alvares, David L. A. Wood, Lutz Krause, Gene W. Tyson, Restuadi Restuadi, Leanne Wallace, Tiana McLaren, Narelle K. Hansell, Dominique Cleary, Rachel Grove, Claire Hafekost, Alexis Harun, Helen Holdsworth, Rachel Jellett, Feroza Khan, Lauren P. Lawson, Jodie Leslie, Mira Levis Frenk, Anne Masi, Nisha E. Mathew, Melanie Muniandy, Michaela Nothard, Jessica L. Miller, Lorelle Nunn, Gerald Holtmann, Lachlan T. Strike, Greig I. de Zubicaray, Paul M. Thompson, Katie L. McMahon, Margaret J. Wright, Peter M. Visscher, Paul A. Dawson, Cheryl Dissanayake, Valsamma Eapen, Helen S. Heussler, Allan F. McRae, Andrew J. O. Whitehouse, Naomi R. Wray, Jacob Gratten
Summary: The study found negligible direct associations between ASD diagnosis and the gut microbiome, but suggested that ASD-related restricted interests may be linked to diet, microbial taxonomic diversity, and stool consistency. The dataset was well powered to detect microbiome associations with traits such as age, dietary intake, and stool consistency, cautioning against claims that the microbiome has a driving role in ASD.
Review
Food Science & Technology
Yisha Xie, Qingqing Liu, Wenwen Zhang, Feng Yang, Kangyu Zhao, Xiuping Dong, Sangeeta Prakash, Yongjun Yuan
Summary: This article reviews recent research on 3D food printing, including improving food ink printing performance through different protein sources, using high internal phase emulsion or oleogels as fat replacements and nutrition delivery systems, and incorporating functional active ingredients. It discusses the importance of 3D food printing for improving appetite and dietary intake in the elderly, while also addressing critical obstacles such as energy supplements, nutrition balance, and recipe customization. By combining big data and artificial intelligence technology, personalized and customized geriatric foods based on individual traits can be achieved. This article provides a theoretical basis and development direction for future 3D food printing for the elderly.
Review
Behavioral Sciences
C. Sandoval-Caballero, L. Luarte, Y. Jimenez, C. Jaque, F. Cifuentes, G. A. Arenas, M. Figueroa, J. Jara, P. K. Olszewski, J. A. Teske, C. E. Perez-Leighton
Summary: This study conducted a systematic search and meta-analysis of rodent dose-response studies to evaluate the effects of opioid receptor (OR) agonists and antagonists on feeding behaviors and food intake. The results showed overall orexigenic effects of central MOR agonists and anorexigenic effects of OR antagonists. Additionally, peripheral OR agonists selectively increased the intake of fat-preferred foods, while not affecting the intake of sweet carbohydrate-preferred foods. These findings suggest that OR regulation of intake, motivation, and choice is influenced by food macronutrient composition.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Cell Biology
Lea Decarie-Spain, Clarissa M. Liu, Logan Tierno Lauer, Keshav Subramanian, Alexander G. Bashaw, Molly E. Klug, Isabella H. Gianatiempo, Andrea N. Suarez, Emily E. Noble, Kristen N. Donohue, Alyssa M. Cortella, Joel D. Hahn, Elizabeth A. Davis, Scott E. Kanoski
Summary: Memory of the location of a food or water source is encoded in ventral hippocampus neuron activity and mediated through communication to the lateral septum. This spatial memory is specific to appetitive locations and can be regulated by a specific neural pathway.
Article
Surgery
Mahdieh Golzarand, Karamollah Toolabi, Masoomeh Douraghi, Parvin Mirmiran, Korush Djafarian
Summary: This study aimed to assess the changes in gut microbiota after bariatric surgery and their relationship with postoperative dietary intake. The gut microbiota was determined through 16S rRNA gene sequencing, and dietary intake was evaluated through three-day food records. The results showed that there were significant increases in the abundance of Firmicutes, Bifidobacterium, and Ruminococcus in the sleeve gastrectomy group, while Enterobacteria levels increased in the Roux-en-Y gastric bypass group. However, there were no significant changes in the composition of other gut microbiota over the 6-month monitoring period.
Review
Nutrition & Dietetics
Kirrilly M. Pursey, Janelle Skinner, Mark Leary, Tracy Burrows
Summary: This review examines the association between addictive eating and nutrients, foods, and dietary patterns. The findings suggest that foods high in fat and refined carbohydrates are commonly associated with addictive eating. Individuals with addictive eating tend to have higher intakes of energy, carbohydrates, and fats compared to those without addictive eating. However, due to the heterogeneity among studies, it is challenging to determine if specific foods or dietary patterns facilitate the addictive process. Further research is needed to explore potential associations. In the meantime, personalized dietary advice targeting foods high in fat and refined carbohydrates could be incorporated into current treatment approaches for addictive eating.
Review
Nutrition & Dietetics
Nicholas DiPatrizio
Summary: The gut-brain signaling system, particularly the endocannabinoid system in the upper gastrointestinal tract, plays a crucial role in controlling food intake and the dysregulation of this system is associated with obesity. Direct and indirect interactions between endocannabinoids and vagal afferent neurons are key mechanisms in this control, with a focus on how diet-induced obesity impacts these pathways.
Article
Nutrition & Dietetics
Cara L. Frankenfeld, Meredith A. J. Hullar, Gertraud Maskarinec, Kristine R. Monroe, John A. Shepherd, Adrian A. Franke, Timothy W. Randolph, Lynne R. Wilkens, Carol J. Boushey, Loic Le Marchand, Unhee Lim, Johanna W. Lampe
Summary: By analyzing the data from the study, it was found that objective biomarkers of fruit and vegetable intake, especially carotenoids, were positively associated with gut bacterial composition and diversity in this multiethnic population. This provides supportive evidence that high diet quality, particularly fruit and vegetable intake, influences the human gut microbiome in a favorable way.
JOURNAL OF THE ACADEMY OF NUTRITION AND DIETETICS
(2022)
Review
Endocrinology & Metabolism
Axelle Khouma, Moein Minbashi Moeini, Julie Plamondon, Denis Richard, Alexandre Caron, Natalie Jane Michael
Summary: Histamine, a neuromodulator in the brain, contributes to the regulation of various physiological processes, including energy balance, through histaminergic signaling in the hypothalamus. Two histamine receptors, H1R and H3R, play important roles in key hypothalamic nuclei involved in energy homeostasis. Activation of H1R suppresses food intake, while activation of H3R stimulates appetite. The central histaminergic system is implicated in weight gain induced by atypical antipsychotics and has potential as a therapeutic target for obesity treatment.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medicine, General & Internal
Carolina Gutierrez-Repiso, Ailec Ho-Plagaro, Concepcion Santiago-Fernandez, Sara Garcia-Serrano, Francisca Rodriguez-Pacheco, Sergio Valdes, Lourdes Garrido-Sanchez, Cristina Rodriguez-Diaz, Carlos Lopez-Gomez, Francisco J. Moreno-Ruiz, Guillermo Alcain-Martinez, Amandine Gautier-Stein, Gilles Mithieux, Eduardo Garcia-Fuentes
JOURNAL OF CLINICAL MEDICINE
(2020)
Article
Endocrinology & Metabolism
Maud Soty, Justine Vily-Petit, Ashley Castellanos-Jankiewicz, Omar Guzman-Quevedo, Margaux Raffin, Samantha Clark, Marine Silva, Amandine Gautier-Stein, Daniela Cota, Gilles Mithieux
Summary: Portal glucose infusion through intestinal gluconeogenesis activates a neural signal in the hypothalamic arcuate nucleus, leading to decreased food intake and plasma glucose levels. The activation of STAT3 phosphorylation in response to portal glucose appears to be independent of leptin but dependent on calcitonin gene-related peptide (CGRP), suggesting a key role for CGRP in mediating the metabolic and hunger-modulating effects of IGN.
NEUROENDOCRINOLOGY
(2021)
Review
Endocrinology & Metabolism
Filipe De Vadder, Amelie Joly, Francois Leulier
Summary: This review examines the functional relationships between nutritional status, growth hormones, and gut microbiota, finding that undernutrition can affect the gut microbiota and potentially impact growth by modulating GH and IGF1 levels, while the GH/IGF1 axis may also regulate the gut microbiota.
JOURNAL OF MOLECULAR ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Flore Sinet, Maud Soty, Juliane Zemdegs, Bruno Guiard, Judith Estrada, Gael Malleret, Marine Silva, Gilles Mithieux, Amandine Gautier-Stein
Summary: This study demonstrates that diets enriched in fiber and protein can have beneficial effects on anxiety and depressive-like behaviors, with these effects being dependent on the presence of intestinal gluconeogenesis (IGN). Mice lacking IGN display characteristics of depressive-like disorders, along with associated neurobiological alterations.
NEUROENDOCRINOLOGY
(2021)
Article
Nutrition & Dietetics
Amandine Gautier-Stein, Fabienne Rajas, Gilles Mithieux
Summary: This review explores the beneficial effects of high-protein diets on health through the characterization of intestinal gluconeogenesis (IGN), highlighting the indirect satiety effects initiated via IGN and portal glucose sensing. The mu-opioid-antagonistic properties of protein digests in the portal vein play a key role in the control of satiety, shedding new light on the mechanisms by which protein diets improve whole-body homeostasis.
PROCEEDINGS OF THE NUTRITION SOCIETY
(2021)
Review
Biochemistry & Molecular Biology
Amelie Joly, Francois Leulier, Filipe De Vadder
Summary: The gastrointestinal tract contains the enteric nervous system (ENS), which plays a crucial role in controlling motility, fluid balance, and blood flow in the intestine, as well as interacting with other components such as epithelial and immune cells. Recent studies suggest that the diversification of gut microbiota may be essential for the development and function of ENS, potentially starting during fetal development. While the modulation of ENS physiology by microbiota is well-established, further research is needed to fully understand the contribution of gut microbiota to ENS development and pathology, and to uncover the precise mechanisms of microbiota-ENS communication.
TRENDS IN MICROBIOLOGY
(2021)
Article
Endocrinology & Metabolism
Fabienne Rajas, Renaud Dentin, Alexane Cannella Miliano, Marine Silva, Margaux Raffin, Francoise Levavasseur, Amandine Gautier-Stein, Catherine Postic, Gilles Mithieux
Summary: This study highlights the crucial role of the ChREBP-G6Pase duo in regulating glucose-6 phosphate-related pathways in the liver, with ChREBP activation leading to hepatic lipid accumulation and NAFLD-like pathology in mice lacking G6Pase.
MOLECULAR METABOLISM
(2021)
Article
Endocrinology & Metabolism
Judith Estrada-Meza, Jasmine Videlo, Clara Bron, Cecile Saint-Beat, Marine Silva, Francois Duboeuf, Olivier Peyruchaud, Fabienne Rajas, Gilles Mithieux, Amandine Gautier-Stein
Summary: The neonatal administration of tamoxifen had long-term, sex-dependent effects on energy homeostasis in adult mice, with females showing increased fat mass, food intake, and impaired glucose control, while males had modest improvements in glucose tolerance but decreased lean mass and bone weight. Caution is warranted when using tamoxifen for the development of transgenic mouse models related to energy homeostasis and bone biology.
Article
Multidisciplinary Sciences
Marion Darnaud, Filipe De Vadder, Pascaline Bogeat, Lilia Boucinha, Anne-Laure Bulteau, Andrei Bunescu, Celine Couturier, Ana Delgado, Helene Dugua, Celine Elie, Alban Mathieu, Tereza Novotna, Djomangan Adama Ouattara, Severine Planel, Adrien Saliou, Dagmar Srutkova, Jennifer Yansouni, Baerbel Stecher, Martin Schwarzer, Francois Leulier, Andrea Tamellini
Summary: The authors developed and characterized a mouse microbiota model composed of 15 strains representative of C57BL/6J specific opportunistic- and pathogen-free mice, deriving a standardized gnotobiotic mouse model named GM15. This model recapitulates SOPF or SPF animal phenotypes and shows improved reproducibility across different animal facilities. The GM15 model offers opportunities for research on how the microbiota influences host physiology in health and disease, providing a more stable platform for preclinical studies.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Justine Vily-Petit, Aude Barataud, Carine Zitoun, Amandine Gautier-Stein, Matteo Serino, Gilles Mithieux
Summary: Intestinal gluconeogenesis (IGN), gastric bypass (GBP) and gut microbiota positively regulate glucose homeostasis and diet-induced dysmetabolism. This study found that IGN and GBP have different effects on gut microbiota composition. IGN inactivation increased the abundance of certain bacteria on a normal chow diet and a high-fat/high-sucrose diet, while GBP increased the abundance of other bacteria on these diets. Additionally, IGN and GBP together influenced the abundance of specific bacteria on these diets. The levels of short-chain fatty acids in the fecal and urine metabolome were also affected by GBP and IGN inactivation.
SCIENTIFIC REPORTS
(2022)
Article
Gastroenterology & Hepatology
Amandine Gautier-Stein, Gilles Mithieux
Summary: The intestine, like the liver and kidney, can carry out gluconeogenesis and release glucose into the blood. Intestinal glucose is sensed by the gastrointestinal nervous system, which signals the brain regions controlling energy homeostasis and stress-related behavior. Intestinal gluconeogenesis (IGN) is activated by various mechanisms, particularly in nutritional situations and after gastric bypass surgery in obesity. IGN has metabolic and behavioral benefits, possibly signaling the suitability of previously ingested food for maintaining plasma glucose. These benefits may explain why IGN emerged and was maintained by natural selection in vertebrates.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Nutrition & Dietetics
Claire Bordat, Donato Vairo, Charlotte Cuerq, Charlotte Halimi, Franck Peiretti, Armelle Penhoat, Aurelie Vieille-Marchiset, Teresa Gonzalez, Marie-Caroline Michalski, Marion Nowicki, Noel Peretti, Emmanuelle Reboul
Summary: Abetalipoproteinemia (FHBL-SD1) and chylomicron retention disease (FHBL-SD3) are rare recessive disorders caused by mutations in the MTTP and SAR1B genes, respectively. These mutations lead to defective chylomicron formation and secretion, resulting in lipid and fat-soluble vitamin malabsorption and severe neuro-ophthalmic complications. Current treatment options are not fully effective in normalizing serum vitamin E levels and providing complete ophthalmic protection.
Article
Endocrinology & Metabolism
Amandine Gautier-Stein, Julien Chilloux, Maud Soty, Bernard Thorens, Christophe Place, Carine Zitoun, Adeline Duchampt, Lorine Da Costa, Fabienne Rajas, Christophe Lamaze, Gilles Mithieux
Summary: This study reveals a new pathway of glucose production through Cav1-dependent trafficking of G6PC1 to the plasma membrane, contributing to hepatic glucose production and glucose homeostasis.
MOLECULAR METABOLISM
(2023)
Meeting Abstract
Chemistry, Applied
Julie Etienne, Armelle Penhoat, Marie-Caroline Michalski, Carole Knibbe
JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY
(2021)
Meeting Abstract
Chemistry, Applied
Marie-Caroline Michalski, Chloe Robert, Armelle Penhoat, Nicolas Guillot, Emmanuelle Meugnier, Stephanie Chanon, Emmanuelle Loizon, Aurelie Vieille-Marchiset, Francois Caillet, Magali Monnoye, Hubert Vidal, Philippe Gerard, Carole Vaysse
JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY
(2021)
