期刊
CELL
卷 149, 期 4, 页码 731-733出版社
CELL PRESS
DOI: 10.1016/j.cell.2012.04.014
关键词
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资金
- Danish Council for Independent Research
- Lundbeck Foundation
- Career Development Award from Human Frontier Science Program
- Novo Nordisk Foundation
Drug development for complex diseases is shifting from targeting individual proteins or genes to systems-based attacks targeting dynamic network states. Lee et al. now reveal how the progressive rewiring of a signaling network over time following EGF receptor inhibition leaves triple-negative breast tumors vulnerable to a second, later hit with DNA-damaging drugs, demonstrating that time-and order-dependent drug combinations can be more efficacious in killing cancer cells.
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