☆ 4.8 Editorial Material

Stem Cells and DNA Damage: Persist or Perish?

CELL (2010)

期刊

出版社

CELL PRESS

DOI: 10.1016/j.cell.2010.07.030

关键词

类别

Biochemistry & Molecular Biology Cell Biology

向作者/读者索取更多资源

Protocol

社区支持

Reagent

社区支持

作者

我是这篇论文的作者

点击您的名字以认领此论文并将其添加到您的个人资料中。

主要评分

4.8

评分不足

次要评分

新颖性

重要性

科学严谨性

评价这篇论文

Adapt or perish

Rohan B. H. Williams

Summary: Microbial communities in wastewater treatment plants offer insights into the development and mechanisms of antimicrobial resistance.

ELIFE (2022)

添加到收藏夹

Review Plant Sciences

Molecular mechanisms of reprogramming of differentiated cells into stem cells in the moss Physcomitrium patens

Masaki Ishikawa, Mitsuyasu Hasebe

Summary: This article summarizes the genetic networks regulating cellular reprogramming in P. patens and the role of STEMIN1, and discusses the generality and divergence of the molecular mechanisms underlying cellular reprogramming in land plants and animals.

CURRENT OPINION IN PLANT BIOLOGY (2022)

添加到收藏夹

Review Microbiology

Fungal Priming: Prepare or Perish

Ety Harish, Nir Osherov

Summary: Priming refers to the development of a stronger and more protective response in an organism after exposure to mild stress. This memory of previously encountered stress provides a significant survival advantage in a rapidly changing environment. Priming has been observed in animals, plants, fungi, and bacteria, with diverse mechanisms.

JOURNAL OF FUNGI (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Redox and Epigenetics in Human Pluripotent Stem Cells Differentiation

Sebastiano Giallongo, Daniela Rehakova, Marco Raffaele, Oriana Lo Re, Irena Koutna, Manlio Vinciguerra

Summary: Induced pluripotent stem cells (iPSCs) have great potential in regenerative medicine and therapy, but concerns arise regarding genomic instability due to high oxidative stress. Future research should focus on the impact of redox balance and epigenetic modifications on iPSCs.

ANTIOXIDANTS & REDOX SIGNALING (2021)

添加到收藏夹

Article Engineering, Environmental

Differentiation of DNA or membrane damage of the cells in disinfection by flow cytometry

Ruihua Cao, Qiqi Wan, Xiangqian Xu, Shiqi Tian, Gehui Wu, Jingyi Wang, Tinglin Huang, Gang Wen

Summary: A new method was established in this study to differentiate DNA damage and membrane damage of fungal spores, elucidating the disinfection mechanism during chemical disinfection. The repeatability and applicability of this method were confirmed, and it was further applied to explore the inactivation mechanism during chlorine-based disinfection.

JOURNAL OF HAZARDOUS MATERIALS (2022)

添加到收藏夹

Article Environmental Sciences

Epoxiconazole profoundly alters rat brain and properties of neural stem cells

Hiba Hamdi, Imen Graiet, Salwa Abid-Essefi, Joel Eyer

Summary: This study revealed that oral exposure to EPX caused oxidative stress, lipid peroxidation, protein oxidation, DNA fragmentation, impaired antioxidant enzyme activities, and histological alterations in the brain of adult rats. In embryonic neural stem cells, EPX treatment reduced cell viability, proliferation, induced cell cycle arrest, and disrupted cytoskeleton, ultimately leading to apoptosis. Pretreatment with N-acetylcysteine attenuated the toxic effects of EPX on neural stem cells.

CHEMOSPHERE (2022)

添加到收藏夹

Article Oncology

Targeting radiation-tolerant persister cells as a strategy for inhibiting radioresistance and recurrence in glioblastoma

Jintao Gu, Nan Mu, Bo Jia, Qingdong Guo, Luxiang Pan, Maorong Zhu, Wangqian Zhang, Kuo Zhang, Weina Li, Meng Li, Lichun Wei, Xiaochang Xue, Yingqi Zhang, Wei Zhang

Summary: This study presents a novel preclinical model for radiobiological studies and identifies a radiation-tolerant persister subpopulation that drives radioresistance by activating DNA damage repair and promoting stemness. The NF-kappa B-YY1-miR-103a regulatory axis is essential for the function of the radiation-tolerant persister cells. Furthermore, transferrin-functionalized nanoparticles improve radiosensitivity and provide a significant survival benefit.

NEURO-ONCOLOGY (2022)

添加到收藏夹

Article Cell Biology

Metformin inhibits chronic kidney disease-induced DNA damage and senescence of mesenchymal stem cells

Hyoungnae Kim, Mi Ra Yu, Haekyung Lee, Soon Hyo Kwon, Jin Seok Jeon, Dong Cheol Han, Hyunjin Noh

Summary: Research has shown that MSCs from patients with CKD exhibit reduced proliferation, accelerated senescence, and increased DNA damage compared to healthy MSCs, but these changes were significantly reduced after metformin treatment. Metformin enhances the paracrine action of CKD MSCs, leading to lower expression of inflammatory and fibrotic markers in kidney cells co-cultured with metformin-treated MSCs. Furthermore, metformin-treated CKD MSCs effectively reduce inflammation and fibrosis in diseased kidneys, suggesting a therapeutic benefit in targeting accelerated senescence of CKD MSCs.

AGING CELL (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Why Do Muse Stem Cells Present an Enduring Stress Capacity? Hints from a Comparative Proteome Analysis

Mustafa B. Acar, Domenico Aprile, Serife Ayaz-Guner, Huseyin Guner, Coskun Tez, Giovanni Di Bernardo, Gianfranco Peluso, Servet Ozcan, Umberto Galderisi

Summary: Muse cells, as adult stem cells, exhibit enduring capacity to cope with endogenous and exogenous genotoxic stress and have shown potential for survival in damaged tissues. Proteome and network analysis revealed their enrichment in stress response-related pathways, with key nodes NFKB and CRKL playing crucial roles in this process.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

添加到收藏夹

Article Biology

Direct ionizing radiation and bystander effect in mouse mesenchymal stem cells

Amanda Nogueira-Pedro, Helena Regina Comodo Segreto, Kathryn D. Held, Antonio Francisco Gentil Ferreira Junior, Carolina Carvalho Dias, Araceli Aparecida Hastreiter, Edson Naoto Makiyama, Edgar Julian Paredes-Gamero, Primavera Borelli, Ricardo Ambrosio Fock

Summary: This study aimed to evaluate the direct and bystander responses of mesenchymal stem cells (MSCs) to radiation and characterize their radiobiological properties. The results showed that radiation mainly affected directly irradiated MSCs at higher doses, leading to cell death, cell cycle arrest, upregulation of p21, and alteration of redox status. Micronuclei formation, H2AX phosphorylation, and decreased Akt expression were also induced by radiation, regardless of the dose. Bystander effects from unirradiated MSCs were not observed.

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Dissection of DNA damage and repair pathways in live cells by femtosecond laser microirradiation and free- electron modeling

Michael Schmalz, Xiao- Xuan Liang, Ines Wieser, Caroline Gruschel, Lukas Muskalla, Martin Thomas Stoeckl, Roland Nitschke, Norbert Linz, Alfred Leitenstorfer, Alfred Vogel, Elisa Ferrando-May, Wei Yang

Summary: Understanding and predicting the outcome of light-DNA interaction is crucial for DNA repair and radiotherapy. This study combines laser microirradiation, imaging, and modeling to investigate the damage pathways in live cells. The results show that photochemical damage dominates at 515 nm, while electron-mediated damage dominates at wavelengths ≥620 nm. The study provides a conceptual framework for interpreting the wavelength-dependent DNA damage induced by laser and electron interactions.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2023)

添加到收藏夹

Review Biochemistry & Molecular Biology

Current understanding of genomic stability maintenance in pluripotent stem cells

Ping Zheng

Summary: Pluripotent stem cells have wide applications, but the mechanisms of maintaining genome stability in these cells are not clear.

ACTA BIOCHIMICA ET BIOPHYSICA SINICA (2022)

添加到收藏夹

Review Surgery

Peer-reviewing in Surgical Journals: Revolutionize or Perish?

George D. Chloros, Vasileios P. Giannoudis, Peter V. Giannoudis

Summary: Peer review is the gold standard for ensuring the quality of published science, but it has not evolved in the digital world. Journals are facing a peer review crisis, struggling to recruit reliable reviewers and lacking effective incentives. This is a pressing problem that may impact surgical journals.

ANNALS OF SURGERY (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Spectra and characteristics of somatic mutations induced by ionizing radiation in hematopoietic stem cells

Yukiko Matsuda, Arikuni Uchimura, Yasunari Satoh, Naohiro Kato, Masaaki Toshishige, Junko Kajimura, Kanya Hamasaki, Kengo Yoshida, Tomonori Hayashi, Asao Noda, Osamu Tanabe

Summary: The spectra and frequencies of somatic mutations in mouse long-term hematopoietic stem cells (LT-HSCs) were studied using whole-genome sequencing. Spontaneous and X-ray-induced mutations were identified, with SNVs and small indels being the most common types of mutations. The role of reactive oxygen species in radiation mutagenesis and the presence of microhomology sequences in DNA repair mechanisms were also analyzed. The study also revealed the radiation-specificity of different mutation types, as well as the clonality and dynamics of LT-HSCs after irradiation.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2023)

添加到收藏夹

Article Cell & Tissue Engineering

Sall4 Guides p53-Mediated Enhancer Interference upon DNA Damage in Mouse Embryonic Stem Cells

Lei Wang, Xiaojun Tan, Lu Chen, Sisi Xu, Weiping Huang, Nan Chen, Yizhou Wu, Chunyan Wang, Daqiang Zhou, Mangmang Li

Summary: Research findings show that Sall4 negatively regulates DNA damage-induced apoptosis in mESCs by mediating p53 recognition of repressed target genes. Sall4 depletion compromises p53-mediated repression and promotes activation of pro-apoptotic genes.

STEM CELLS (2022)

添加到收藏夹

Article Hematology

Single-cell RNA-seq reveals developmental plasticity with coexisting oncogenic states and immune evasion programs in ETP-ALL

Praveen Anand, Amy Guillaumet-Adkins, Valeriya Dimitrova, Huiyoung Yun, Yotam Drier, Noori Sotudeh, Anna Rogers, Madhu M. Ouseph, Monica Nair, Sayalee Potdar, Randi Isenhart, Jake A. Kloeber, Tushara Vijaykumar, Leili Niu, Tiffaney Vincent, Guangwu Guo, Julia Frede, Marian H. Harris, Andrew E. Place, Lewis B. Silverman, David T. Teachey, Andrew A. Lane, Daniel J. DeAngelo, Jon C. Aster, Bradley E. Bernstein, Jens G. Lohr, Birgit Knoechel

Summary: By conducting full-length single-cell RNA sequencing, we identified two highly distinct stem-like states in early T-cell progenitor acute lymphoblastic leukemia (ETP-ALL), which differed significantly in terms of cell cycle and oncogenic signaling, as well as dependence on Notch activation and PI3K signaling. Our study revealed complex interactions between signaling programs, cellular plasticity, and immune programs in ETP-ALL, highlighting the multidimensionality of tumor heterogeneity.

BLOOD (2021)

添加到收藏夹

Article Oncology

Sex-Biased ZRSR2 Mutations in Myeloid Malignancies Impair Plasmacytoid Dendritic Cell Activation and Apoptosis

Katsuhiro Togami, Sun Sook Chung, Vikas Madan, Christopher A. G. Booth, Christopher M. Kenyon, Lucia Cabal-Hierro, Justin Taylor, Sunhee S. Kim, Gabriel K. Griffin, Mahmoud Ghandi, Jia Li, Yvonne Y. Li, Fanny Angelot-Delettre, Sabeha Biichle, Michael Seiler, Silvia Buonamici, Scott B. Lovitch, Abner Louissaint, Elizabeth A. Morgan, Fabrice Jardin, Pier Paolo Piccaluga, David M. Weinstock, Peter S. Hammerman, Henry Yang, Marina Konopleva, Naveen Pemmaraju, Francine Garnache-Ottou, Omar Abdel-Wahab, H. Phillip Koeffler, Andrew A. Lane

Summary: Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is an aggressive leukemia primarily occurring in males, and the mutations in X chromosome gene ZRSR2 are associated with impaired dendritic cell function and predisposition to leukemic transformation.

CANCER DISCOVERY (2022)

添加到收藏夹

Article Cell Biology

AMPK-PERK axis represses oxidative metabolism and enhances apoptotic priming of mitochondria in acute myeloid leukemia

Adrien Grenier, Laury Poulain, Johanna Mondesir, Arnaud Jacquel, Claudie Bosc, Lucille Stuani, Sarah Mouche, Clement Larrue, Ambrine Sahal, Rudy Birsen, Victoria Ghesquier, Justine Decroocq, Fetta Mazed, Mireille Lambert, Mamy Andrianteranagna, Benoit Viollet, Patrick Auberger, Andrew A. Lane, Pierre Sujobert, Didier Bouscary, Jean-Emmanuel Sarry, Jerome Tamburini

Summary: AMPK activation in AML cells triggers the unfolded protein response, leading to repression of oxidative phosphorylation, TCA cycle, and pyrimidine biosynthesis, as well as enhanced mitochondrial apoptotic signaling. Combination therapy with the AMPK activator GSK621 and the Bcl-2 inhibitor venetoclax shows synergistic effects, suggesting therapeutic potential in AML.

CELL REPORTS (2022)

添加到收藏夹

Article Dermatology

Shared Clonal Origin of Multiple Histiocytic and Dendritic Neoplasms and Polycythemia Vera, Follicular Lymphoma in 1 Patient

Cecilia Larocca, Vignesh Shanmugam, David Zemmour, Joseph H. H. Antin, Andrew A. A. Lane

AMERICAN JOURNAL OF DERMATOPATHOLOGY (2022)

添加到收藏夹

Article Oncology

Outcomes of antifungal prophylaxis for newly diagnosed AML patients treated with a hypomethylating agent and venetoclax

Evan C. Chen, Yiwen Liu, Courtney E. Harris, Eric S. Winer, Martha Wadleigh, Andrew A. Lane, Rahul S. Vedula, R. Coleman Lindsley, Kevin M. Copson, Anne Charles, Francisco Marty, Donna Neuberg, Daniel J. DeAngelo, Richard M. Stone, Marlise R. Luskin, Nicolas C. Issa, Jacqueline S. Garcia

Summary: The use of antifungal prophylaxis does not appear to provide benefits for newly diagnosed AML patients receiving VEN/HMA treatment, especially in institutions with low incidence of fungal infections.

LEUKEMIA & LYMPHOMA (2022)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Mitochondrial variant enrichment from high-throughput single-cell RNA sequencing resolves clonal populations

Tyler E. Miller, Caleb A. Lareau, Julia A. Verga, Erica A. K. DePasquale, Vincent Liu, Daniel Ssozi, Katalin Sandor, Yajie Yin, Leif S. Ludwig, Chadi A. El Farran, Duncan M. Morgan, Ansuman T. Satpathy, Gabriel K. Griffin, Andrew A. Lane, J. Christopher Love, Bradley E. Bernstein, Vijay G. Sankaran, Peter van Galen

Summary: The combination of single-cell transcriptomics and mitochondrial DNA variant detection is useful for establishing lineage relationships in primary human cells, but current methods are not suitable for analyzing complex tissues. In this study, researchers combined common 3' single-cell RNA-sequencing protocols with mitochondrial transcriptome enrichment to significantly increase coverage and enable high-confidence mutation detection. This method successfully identified skewed immune cell expansions in primary human clonal hematopoiesis.

NATURE BIOTECHNOLOGY (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Targeting CD123 in blastic plasmacytoid dendritic cell neoplasm using allogeneic anti-CD123 CAR T cells

Tianyu Cai, Agnes Gouble, Kathryn L. Black, Anna Skwarska, Ammar S. Naqvi, Deanne Taylor, Ming Zhao, Qi Yuan, Mayumi Sugita, Qi Zhang, Roman Galetto, Stephanie Filipe, Antonio Cavazos, Lina Han, Vinitha Kuruvilla, Helen Ma, Connie Weng, Chang-Gong Liu, Xiuping Liu, Sergej Konoplev, Jun Gu, Guilin Tang, Xiaoping Su, Gheath Al-Atrash, Stefan Ciurea, Sattva S. Neelapu, Andrew A. Lane, Hagop Kantarjian, Monica L. Guzman, Naveen Pemmaraju, Julianne Smith, Andrei Thomas-Tikhonenko, Marina Konopleva

Summary: This study demonstrates that UCART123 has selective anti-tumor activity against CD123-positive BPDCN cells, and exhibits strong efficacy in vitro and in mouse models.

NATURE COMMUNICATIONS (2022)

添加到收藏夹

Article Immunology

Single-Cell Multiomics Reveals Clonal T-Cell Expansions and Exhaustion in Blastic Plasmacytoid Dendritic Cell Neoplasm

Erica A. K. DePasquale, Daniel Ssozi, Marina Ainciburu, Jonathan Good, Jenny Noel, Martin A. Villanueva, Charles P. Couturier, Alex K. Shalek, Sary F. Aranki, Hari R. Mallidi, Gabriel K. Griffin, Andrew A. Lane, Peter van Galen

Summary: The immune system plays a major role in inhibiting cancer progression, and the study of immunoregulatory interactions between malignant cells and T-cells in BPDCN provides valuable insights. By analyzing single-cell transcriptomes, it was observed that T-cells in BPDCN patients upregulate IFNA response and downregulate TNFA pathways, indicating T-cell exhaustion and immune evasion mechanisms in BPDCN.

FRONTIERS IN IMMUNOLOGY (2022)

添加到收藏夹

Review Oncology

CD123 and More: How to Target the Cell Surface of Blastic Plasmacytoid Dendritic Cell Neoplasm

Elodie Bole-Richard, Naveen Pemmaraju, Blandine Cael, Etienne Daguindau, Andrew A. Lane

Summary: Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive leukemia derived from plasmacytoid dendritic cells (pDCs). Recently, the first-in-class CD123-targeting therapy, tagraxofusp, was approved for treatment of BPDCN. Other CD123-targeting strategies are in development, including bispecific antibodies and combination approaches with tagraxofusp and other novel agents. Adoptive T-cell therapy using chimeric antigen receptor (CAR)-modified T cells represents a promising new avenue in immunotherapy. This article discusses novel and innovative therapies in development to target surface molecules in BPDCN and explores potential future treatment options.

CANCERS (2022)

添加到收藏夹

Article Hematology

Peripheral blood CD3+ T-cell gene expression biomarkers correlate with clinical frailty in patients with haematological malignancies

Geoffrey Fell, Ashley E. Rosko, Gregory A. Abel, Clark Dumontier, Kelly J. Higby, Anays Murillo, Donna S. Neuberg, Christin E. Burd, Andrew A. Lane

Summary: Older patients with cancer may benefit from targeted treatment based on their frailty status, but currently there is a lack of quantitative biomarkers for assessing frailty. In this study, researchers identified four gene expressions in T cells that were associated with frailty in patients with haematological malignancies. A regression model based on these gene expressions showed high sensitivity and specificity for identifying robust patients. These findings suggest potential biomarkers for future frailty assessment.

BRITISH JOURNAL OF HAEMATOLOGY (2022)

添加到收藏夹

Article Oncology

Long-Term Benefits of Tagraxofusp for Patients With Blastic Plasmacytoid Dendritic Cell Neoplasm

Naveen Pemmaraju, Kendra L. Sweet, Anthony S. Stein, Eunice S. Wang, David A. Rizzieri, Sumithira Vasu, Todd L. Rosenblat, Christopher L. Brooks, Nassir Habboubi, Tariq Mughal, Hagop Kantarjian, Marina Konopleva, Andrew A. Lane

Summary: In this article, the long-term results of a clinical trial for BPDCN, including treatment-naive and relapsed/refractory patients, were reported. The study showed that TAG monotherapy resulted in high and durable responses in first-line patients with BPDCN, allowing many patients to bridge to stem-cell transplant.

JOURNAL OF CLINICAL ONCOLOGY (2022)

添加到收藏夹

Letter Oncology

Treatment patterns and outcomes of patients with CNS involvement of blastic plasmacytoid dendritic cell neoplasm (BPDCN)

James A. Davis, David A. Rizzieri, Andrew A. Lane, Justin Taylor, Muhammad Salman Faisal, Sumithira Vasu, Deborah Soong, Hong Li, Amanda Herbst, I. Brian Greenwell

LEUKEMIA & LYMPHOMA (2022)

添加到收藏夹

Letter Hematology

Genomics of PDGFR-rearranged hypereosinophilic syndrome

Esther Rheinbay, Meifang Qi, Juliette M. Bouyssou, Andrew J. Oler, Lauren Thumm, Michelle Makiya, Irina Maric, Amy D. Klion, Andrew A. Lane

BLOOD ADVANCES (2023)

添加到收藏夹

Editorial Material Hematology

DDX41: here, there ... and everywhere

Christopher R. Reilly, Andrew A. Lane

Summary: In this study, Cheloor Kovilakam et al conducted a comprehensive population-level analysis of >450,000 adults in the UK Biobank to assess the epidemiological characteristics, clinical features, and malignancy risk associated with germ line pathogenic variants in the DEAD box RNA helicase 41 gene (DDX41-GPV).

BLOOD (2023)

添加到收藏夹

Article Medicine, Research & Experimental

Expansion, persistence, and efficacy of donor memory- like NK cells infused for posttransplant relapse

Roman M. Shapiro, Grace C. Birch, Guangan Hu, Juliana Vergara Cadavid, Sarah Nikiforow, Joanna Baginska, Alaa K. Ali, Mubin Tarannum, Michal Sheffer, Yasmin Z. Abdulhamid, Benedetta Rambaldi, Yohei Arihara, Carol Reynolds, Max S. Halpern, Scott J. Rodig, Nicole Cullen, Jacquelyn O. Wolff, Kathleen L. Pfaff, Andrew A. Lane, R. Coleman Lindsley, Corey S. Cutler, Joseph H. Antin, Vincent T. Ho, John Koreth, Mahasweta Gooptu, Haesook T. Kim, Karl-Johan Malmberg, Catherine J. Wu, Jianzhu Chen, Robert J. Soiffer, Jerome Ritz, Rizwan Romee

JOURNAL OF CLINICAL INVESTIGATION (2022)

添加到收藏夹

暂无数据

Stem Cells and DNA Damage: Persist or Perish?

期刊

出版社

CELL PRESS

关键词

类别

向作者/读者索取更多资源

Protocol

Reagent

作者

我是这篇论文的作者

评论

主要评分

次要评分

新颖性

重要性

科学严谨性

评价这篇论文

推荐

导出引文

分享论文