Review
Oncology
Elizabeth L. Thompson, Jiayi J. Hu, Laura J. Niedernhofer
Summary: This research focuses on advances in melanoma treatment, including mechanisms of drug resistance and the role of senescent cells in resistance and secondary cancer development. Targeting senescent cells in treatment may offer a novel approach for improving clinical outcomes in melanoma.
Review
Biochemistry & Molecular Biology
Nattaphong Rattanavirotkul, Kristina Kirschner, Tamir Chandra
Summary: Senescence is a cellular stress response triggered by diverse stressors and can act as a tumor suppressor mechanism, with the ability to be transmitted to neighboring cells. Recent evidence suggests a more complex scenario for secondary senescence, involving juxtacrine communication between cells, and differences have been noted between primary and secondary senescent endpoints.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Cell Biology
Zhentao Zhang, Gabriella Shayani, Yanping Xu, Ashley Kim, Yurim Hong, Haiyue Feng, Hua Zhu
Summary: Cardiac fibroblasts are a major contributor to cardiac fibrosis during heart repair processes. This study demonstrates that Gata4 plays a role in regulating the senescence of cardiac fibroblasts. Deletion of Gata4 in cardiac fibroblasts induces senescence, while deletion in cardiomyocytes does not.
Article
Dermatology
Mitchell S. Stark, Meghan E. Muse, Drew T. Bergman, Lucas A. Salas, Lisa N. Tom, Antonia Laino, Duncan Lambie, Richard A. Sturm, Helmut Schaider, Brock C. Christensen, Peter H. Soyer
Summary: This study compared the differences between benign and dysplastic melanocytic nevi using genome-wide methylation profiling and identified key epigenetic regulatory mechanisms involved in nevogenesis. It found that benign nevi showed increased genome-scale methylation and methylation of Alu/LINE-1 retrotransposable elements, indicating genomic stability, while dysplastic nevi showed evidence of genomic instability through hypomethylation of Alu/LINE-1. Using dermoscopic classifications, differentially methylated loci were found in reticular/nonspecific patterned nevi but not in globular nevi.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Multidisciplinary Sciences
Toshiyuki Ko, Seitaro Nomura, Shintaro Yamada, Kanna Fujita, Takanori Fujita, Masahiro Satoh, Chio Oka, Manami Katoh, Masamichi Ito, Mikako Katagiri, Tatsuro Sassa, Bo Zhang, Satoshi Hatsuse, Takanobu Yamada, Mutsuo Harada, Haruhiro Toko, Eisuke Amiya, Masaru Hatano, Osamu Kinoshita, Kan Nawata, Hiroyuki Abe, Tetsuo Ushiku, Minoru Ono, Masashi Ikeuchi, Hiroyuki Morita, Hiroyuki Aburatani, Issei Komuro
Summary: This study identifies Htra3 as a critical regulator of cardiac fibrosis and heart failure by maintaining the identity of quiescent cardiac fibroblasts and degrading TGF-beta. These findings provide new insights into the pathogenesis of heart failure and suggest Htra3 as a potential therapeutic target.
NATURE COMMUNICATIONS
(2022)
Article
Cell Biology
Yuting Tang, Fangling Hong, Siyang Ding, Jiashu Yang, Ming Zhang, Yunfei Ma, Que Zheng, Dawei Yang, Yucui Jin, Changyan Ma
Summary: In this study, it was found that the upregulation of long noncoding RNA (lncRNA) IGFBP7-OT and its maternal gene, IGFBP7, in osteoarthritic cartilage were positively correlated. Overexpression of IGFBP7-OT inhibited chondrocyte viability, promoted chondrocyte apoptosis, and reduced extracellular matrix components, while knockdown of IGFBP7-OT had the opposite effects. IGFBP7-OT overexpression promoted cartilage degeneration and aggravated the monosodium iodoacetate-induced osteoarthritis phenotype in vivo. Mechanistic research revealed that IGFBP7-OT promoted osteoarthritis progression by upregulating IGFBP7 expression through inhibiting methylation of the IGFBP7 promoter by suppressing the occupancy of DNMT1 and DNMT3a. The upregulation of IGFBP7-OT in osteoarthritis was partially controlled by METTL3-mediated N6-methyladenosine (m6A) modification.
Article
Biochemistry & Molecular Biology
Zhengyu Piao, Hyun Jung Lee, Byeongmoon Jeong
Summary: This study successfully induced osteoarthritis in a mouse model using a thermogel-based sustained drug release system. The results suggest that thermogels can be a precise tool for developing animal disease models by controlling drug release.
Article
Biochemistry & Molecular Biology
Dongsheng Shang, Tianchu Zhou, Xinying Zhuang, Yanfang Wu, Hanqing Liu, Zhigang Tu
Summary: Simian virus 40 (SV40), a potentially oncogenic virus of monkey origin, has been found to inhibit cellular senescence and accumulations of DNA damage, thus demonstrating its tumorigenic potential.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Valentina Bracun, Bart van Essen, Adriaan A. Voors, Dirk J. van Veldhuisen, Kenneth Dickstein, Faiez Zannad, Marco Metra, Stefan Anker, Nilesh J. Samani, Piotr Ponikowski, Gerasimos Filippatos, John G. F. Cleland, Chim C. Lang, Leong L. Ng, Canxia Shi, Sanne de Wit, Joseph P. About Msallem, Wouter C. Meijers, IJsbrand T. Klip, Peter van der Meer, Rudolf A. de Boer
Summary: IGFBP7 serves as an independent and robust prognostic biomarker in patients with heart failure, associated with cardiac function and immune system regulation.
Article
Biochemistry & Molecular Biology
Olga Lyublinskaya, Julia Kornienko, Julia Ivanova, Natalia Pugovkina, Larisa Alekseenko, Ekaterina Lyublinskaya, Irina Tyuryaeva, Irina Smirnova, Tatiana Grinchuk, Mariia Shorokhova, Anna Krasnenko, Nikolay Plotnikov, Nikolay Nikolsky
Summary: The study revealed that high doses of antioxidants can induce genotoxic stress and premature senescence in stem cells by triggering endoplasmic reticulum stress and unfolded protein response. Molecular analysis confirmed the untimely degradation of cell cycle proteins in response to antioxidant treatment, suggesting potential triggers for cell damage and premature aging.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Priyanka Banerjee, Niyanshi Gaddam, Tej K. Pandita, Sanjukta Chakraborty
Summary: Cellular senescence, driven by various mechanisms and senescence-associated secretory phenotype (SASP), is an important area of research in age-related diseases. The impact of senescence and SASP on different cell types, the immune system, and the vascular system has been widely discussed, but the impact on lymphatic biology and pathological lymphangiogenesis remains underexplored. In this review, the role of senescence on lymphatic pathobiology, its impact on cancer, and potential therapeutic interventions are discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Johannes Lehmann, Roberto Narcisi, Natasja Franceschini, Danai Chatzivasileiou, Cindy G. Boer, Wendy J. L. M. Koevoet, Diana Putavet, Dubravka Drabek, Rien van Haperen, Peter L. J. de Keizer, Gerjo J. V. M. van Osch, Derk ten Berge
Summary: The signaling protein WNT3A can counteract paracrine senescence in human adult mesenchymal stem cells (MSCs). Entry into senescence in a small subpopulation of MSCs triggers a secretome that induces healthy cells into senescence. WNT signals interrupt this cascade by repressing cytokines that mediate senescence induction.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Shuang Zhao, Yufei Tang, Ruohan Wang, Masoud Najafi
Summary: This article focuses on the cell death mechanisms induced by paclitaxel, a chemotherapy drug, in cancer treatment and the resistance of cancer cells to paclitaxel. The study found that paclitaxel can induce apoptosis and mitotic catastrophe, as well as other cell death mechanisms, and it can also lead to drug resistance. The article also discusses the use of combination therapies to overcome drug resistance.
Review
Cell Biology
Jing Yang, Mengmeng Liu, Dongchun Hong, Musheng Zeng, Xing Zhang
Summary: Cellular senescence in cancer presents a dual role, acting as both a preventative measure and a promoter of tumor development. Senescent cells contribute to oncogenesis through their secretory phenotype, both inhibiting tumor growth and creating an environment conducive to tumor progression.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Immunology
Atefe Ghamar Talepoor, Mehrnoosh Doroudchi
Summary: Immune system aging and atherosclerosis share common drivers, such as inflammation and chronic viral infections. Several DNA and RNA viruses are stimulators of both immunosenescence and atherosclerosis. The newly emerged SARS-CoV-2 virus can induce immune aging and atherosclerosis, as well as cause inflammation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pathology
Noah Frydenlund, Dominick A. Leone, Brendon Mitchell, Ossama Abbas, Jagdish Dhingra, Meera Mahalingam
Article
Pathology
Brendon Mitchell, Dominick A. Leone, John K. Feller, Shi Yang, Meera Mahalingam
Article
Pathology
Noah Frydenlund, Meera Mahalingam
Letter
Dermatology
Meera Mahalingam
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2017)
Review
Dermatology
John K. Feller, Meera Mahalingam
AMERICAN JOURNAL OF DERMATOPATHOLOGY
(2013)
Article
Dermatology
Phyu P. Aung, Meenakshi Batrani, Shi Yang, Meera Mahalingam
AMERICAN JOURNAL OF DERMATOPATHOLOGY
(2013)
Review
Dermatology
Ossama Abbas, Meera Mahalingam
AMERICAN JOURNAL OF DERMATOPATHOLOGY
(2013)
Letter
Pathology
Meera Mahalingam, Mai P. Hoang
Article
Dermatology
Asok Biswas, Joanna E. Richards, Joseph Massaro, Meera Mahalingam
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2014)
Article
Dermatology
K. Feller, S. Yang, N. Tung, J. Lee, M. Mahalingam
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2014)
Article
Pathology
Namrata Setia, Ossama Abbas, Yessica Sousa, Jane L. Garb, Meera Mahalingam
Article
Pathology
John K. Feller, Shi Yang, Meera Mahalingam
Article
Biochemistry & Molecular Biology
Minggang Fang, Fen Xia, Meera Mahalingam, Ching-Man Virbasius, Narendra Wajapeyee, Michael R. Green
MOLECULAR AND CELLULAR BIOLOGY
(2013)
Article
Dermatology
Marguerite Sullivan, Rebecca Hartman, Meera Mahalingam
JOURNAL OF CUTANEOUS PATHOLOGY
(2020)
Article
Clinical Neurology
Kevin Yang, Thor D. Stein, Bertrand R. Huber, Emmett A. Sartor, Jacob R. Rachlin, Meera Mahalingam
Summary: This case report describes a patient with primary glioblastoma and malignant melanoma, with evolving pathological diagnoses ultimately confirming the presence of glioblastoma. The patient's cancer history and pathological features suggest a potential association between malignant melanoma and glioblastoma.
