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LUSH shapes up for a starring role in olfaction

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CELL
卷 133, 期 7, 页码 1137-1139

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CELL PRESS
DOI: 10.1016/j.cell.2008.06.010

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In the fruit fly Drosophila, odorant-binding proteins are secreted into the fluid that bathes olfactory neurons. Laughlin et al. (2008) now challenge the assumption that the odorant-binding protein LUSH passively transports its pheromone to a specific olfactory receptor. Instead, LUSH undergoes a conformational change upon pheromone binding that is sufficient for neuronal activation.

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