期刊
JOURNAL OF EXPERIMENTAL BOTANY
卷 66, 期 6, 页码 1607-1616出版社
OXFORD UNIV PRESS
DOI: 10.1093/jxb/erv059
关键词
Effector; lipid modification; lipidation; myristoylation; palmitoylation; plant immunity; plant plasma membrane; plant-pathogen interactions; protein fatty acylation. R-ptotein
资金
- US Department of Agriculture-National Institute of Food and Agriculture [USDA-NIFA 2010-65108-20503]
- Human Frontiers Science Program (HFSP) Long term Fellowship [LT000608/2011-L]
The modification of proteins by the attachment of fatty acids is a targeting tactic involved in mechanisms of both plant immunity and bacterial pathogenesis. The plant plasma membrane (PM) is a key battleground in the war against disease-causing microbes. This membrane is armed with an array of sensor proteins that function as a surveillance system to detect invading pathogens. Several of these sensor proteins are directed to the plasma membrane through the covalent addition of fatty acids, a process termed fatty acylation. Phytopathogens secrete effector proteins into the plant cell to subvert these surveillance mechanisms, rendering the host susceptible to infection. The targeting of effectors to specific locales within plant cells, particularly the internal face of the host PM, is critical for their virulence function. Several bacterial effectors hijack the host fatty acylation machinery to be modified and directed to this contested locale. To find and fight these fatty acylated effectors the plant leverages lipid-modified intracellular sensors. This review provides examples featuring how fatty acylation is a battle tactic used by both combatants in the molecular arms race between plants and pathogens. Also highlighted is the exploitation of a specific form of host-mediated fatty acid modification, which appears to be exclusively employed by phytopathogenic effector proteins.
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