Article
Surgery
Erik Stahlberg, Andreas Stroth, Alexander Haenel, Ulrike Grzyska, Franz Wegner, Malte Sieren, Marco Horn, Jorg Barkhausen, Jan Peter Goltz
Summary: This study compared the retrograde plantar-arch and transpedal-access approaches for revascularization procedures. The transpedal-access approach had significantly higher procedural success, while the plantar-arch approach was significantly affected by calcifications in the pedal-plantar loop and target-lesion. Both techniques showed no significant differences in terms of limb salvage and survival rates.
JOURNAL OF ENDOVASCULAR THERAPY
(2022)
Article
Surgery
Malka Huici-Sanchez, Francisco Javier Marti-Mestre, Carlos Martinez-Rico, Emma Espinar-Garcia, Xavier Jimenez-Guiu, Antonio Romera-Villegas, Ramon Vila-Coll
Summary: Ultrasound-guided retrograde distal access is an effective method that can be used as a bailout method in endovascular procedures where crossing the lesion anterogradely is not possible.
Review
Surgery
Stefanos Giannopoulos, Luis M. Palena, Ehrin J. Armstrong
Summary: Retrograde endovascular treatment for patients with critical limb ischaemia has a high technical success rate of 96% and a low complication rate, making it a safe and effective option when antegrade treatment fails.
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2021)
Article
Surgery
Gurkan Danisan, Omer Faruk Ates, Onur Taydas, Mustafa Ozdemir, Ali Kupeli, Alper Erkin
Summary: The study demonstrates the feasibility, effectiveness, and acceptable safety of the retrograde guidewire-assisted remodeling technique (REGART) in treating occlusive arterial occlusions, particularly when conventional techniques fail. By minimizing the risk of dissection, the target occluded artery can be recanalized while preserving other arterial origins.
JOURNAL OF ENDOVASCULAR THERAPY
(2022)
Review
Cell & Tissue Engineering
Zeinab Shirbaghaee, Mohammad Hassani, Saeed Heidari Keshel, Masoud Soleimani
Summary: This article reviews the immunomodulatory features of mesenchymal stem cells (MSCs) and their potential applications as therapeutic agents in the treatment of critical limb ischemia (CLI). Despite advances in clinical research, MSC therapy is still considered experimental and not recommended for regular clinical use. The article provides recommendations to improve the efficacy of cell therapy for CLI patients.
STEM CELL RESEARCH & THERAPY
(2022)
Review
Engineering, Biomedical
Zheng Xing, Chen Zhao, Siwen Wu, Chunchen Zhang, Haifeng Liu, Yubo Fan
Summary: Therapeutic angiogenesis provides a potential solution for critical limb ischemia by manipulating blood vessel growth in vivo without the need for extra pharmaceutics and surgery. With the rise of interdisciplinary research, regenerative medicine strategies offer new possibilities for treating various clinical diseases.
Article
Surgery
Robert Myers, Bakhtawar Mushtaq, Nicholas Taylor, Hajar Rashid, Danielle M. Pineda
Summary: This study aims to understand the impact of bypass surgery on limb salvage in patients aged >80 years with critical limb ischemia. The study found that there was no significant difference in limb salvage, hospital length of stay, and primary patency between patients aged <80 years and those aged >=80 years. However, further studies are needed to determine the statistical impact on mortality in this population with a larger cohort.
JOURNAL OF VASCULAR SURGERY
(2023)
Article
Medicine, Research & Experimental
Aamal G. El-Waseif, Manar A. Nader, Hatem A. Salem, Sally L. Elshaer
Summary: The study demonstrates that the ROCK inhibitor Fasudil provides vascular protection in an experimentally induced unilateral critical limb ischemia (CLI) model in mice, possibly by restoring antioxidant capacity and inhibiting inflammatory response.
Review
Biochemistry & Molecular Biology
Lucia Beltran-Camacho, Marta Rojas-Torres, Ma Carmen Duran-Ruiz
Summary: Critical limb ischemia is the most severe form of peripheral arterial disease, commonly caused by atherosclerosis leading to progressive blockage of arterial vessels. For patients not suitable for surgical intervention, angiogenic cell therapy has emerged as a promising alternative, showing potential for enhancing revascularization by promoting vessel formation and blood flow recovery.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Surgery
Joel L. Ramirez, Greg J. Zahner, Shipra Arya, S. Marlene Grenon, Warren J. Gasper, Julie Ann Sosa, Michael S. Conte, James C. Iannuzzi
Summary: This study identified an association between depression and nonhome discharge (NHD) after revascularization for CLTI. The presence of depression was linked to an increased risk of NHD, especially in endovascular revascularization cases. There was a higher odds of NHD in men with depression compared to women with depression, suggesting a gender difference in this association.
JOURNAL OF VASCULAR SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Lirong Xu, Yutong Liu, Qianyun Cheng, Yang Shen, Ye Yuan, Xiaolang Jiang, Xu Li, Daqiao Guo, Junhao Jiang, Changpo Lin
Summary: CLI, the most advanced clinical stage of peripheral vascular disease, leads to lower extremity rest pain, ulceration, and gangrene due to insufficient blood and oxygen supply, making effective biomarkers and therapeutic targets crucial. The study confirmed the downregulation of circadian gene Bmal1 in CLI patients, affecting inflammation and angiogenesis. Bmal1 disruption impairs angiogenesis and endothelial cell functions, suggesting its potential as a biomarker and therapeutic target in CLI.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Medicine, General & Internal
Alessia Scatena, Pasquale Petruzzi, Filippo Maioli, Francesca Lucaroni, Cristina Ambrosone, Giorgio Ventoruzzo, Francesco Liistro, Danilo Tacconi, Marianna Di Filippi, Nico Attempati, Leonardo Palombi, Leonardo Ercolini, Leonardo Bolognese
Summary: The study showed that treatment with autologous PBMNC implants in NO-CLI patients with DFUs significantly reduced amputation rate, improved survival, and promoted wound healing. Autologous PBMNC injection may effectively prevent amputations in patients with DFUs.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Medicine, General & Internal
Matilde Zamboni, Massimo Pedriali, Luca Ferretto, Sabrina Scian, Francesca Ghirardini, Riccardo Bozza, Romeo Martini, Sandro Irsara
Summary: The development of chronic vascular wounds is a major issue, especially with the aging population and increasing incidence of underlying diseases. Local injection of peripheral blood mononuclear cells may be a promising cell treatment for wound healing, but more research is needed to establish its clinical efficacy.
Review
Cell & Tissue Engineering
Laura Lozano Navarro, Xueyi Chen, Lady Tatiana Girata Viviescas, Andrea K. Ardila-Roa, Maria L. Luna-Gonzalez, Claudia L. Sossa, Martha L. Arango-Rodriguez
Summary: Peripheral arterial disease affects hundreds of millions of people worldwide and can lead to limb amputation or death. Revascularization is crucial for preventing amputation, but a significant portion of patients are not suitable for traditional surgical treatment, resulting in higher amputation rates. Mesenchymal stem cells have emerged as a promising cell-based therapy for peripheral arterial disease due to their regenerative properties.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Cardiac & Cardiovascular Systems
Lirong Xu, Yutong Liu, Qianyun Cheng, Yang Shen, Ye Yuan, Xiaolang Jiang, Xu Li, Daqiao Guo, Junhao Jiang, Changpo Lin
Summary: CLI, the most advanced stage of peripheral vascular disease, involves downregulation of circadian gene Bmal1 which affects lipid metabolism, inflammation, and angiogenesis. This downregulation impairs angiogenesis and endothelial cell functions, while repressing inflammation and promoting angiogenesis through transcriptional regulation of VEGF. Therefore, Bmal1 may serve as an effective biomarker and therapeutic target in CLI.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Surgery
Zoltan Ruzsa, Adam Csavajda, Istvan Hizoh, Monika Deak, Peter Sotonyi, Olivier F. Bertrand, Tak Kwan, Bela Merkely, Balazs Nemes
Summary: This study compared success and complication rates of radial, femoral, and pedal artery access for treating superficial artery stenosis. Results showed that pedal access had lower X-ray dose and access site complication rates, while femoral artery intervention can be safely performed with lower hospitalization rates.
JOURNAL OF ENDOVASCULAR THERAPY
(2022)
Article
Cardiac & Cardiovascular Systems
Adel Aminian, Gregory A. Sgueglia, Marcus Wiemer, Gabriele Luigi Gasparini, Joelle Kefer, Zoltan Ruzsa, Maarten A. H. van Leeuwen, Bert Vandeloo, Claudiu Ungureanu, Sasko Kedev, Juan F. Iglesias, Gregor Leibundgut, Karim Ratib, Ivo Bernat, Irene Barriocanal, Vladimir Borovicanin, Shigeru Saito
Summary: The DISCO RADIAL trial is a large-scale randomized trial comparing DRA and TRA in patients undergoing coronary angiography or PCI in terms of the incidence of RAO at discharge. The trial is designed as a prospective, multicenter, randomized, controlled study and will assess several important secondary endpoints.
AMERICAN HEART JOURNAL
(2022)
Article
Rheumatology
George Konstantonis, Krishna Singh, Petros P. Sfikakis, Ankush D. Jamthikar, George D. Kitas, Suneet K. Gupta, Luca Saba, Kleio Verrou, Narendra N. Khanna, Zoltan Ruzsa, Aditya M. Sharma, John R. Laird, Amer M. Johri, Manudeep Kalra, Athanasios Protogerou, Jasjit S. Suri
Summary: This study proposes a novel machine learning paradigm for detecting cardiovascular disease in individuals at medium to high cardiovascular risk. By collecting data from a Greek cohort, the study applies different risk factors and machine learning classifiers, and finds that this machine learning paradigm shows strong ability in predicting cardiovascular disease.
RHEUMATOLOGY INTERNATIONAL
(2022)
Article
Cardiac & Cardiovascular Systems
Alexandru Achim, Kornel Kakonyi, Ferenc Nagy, Zoltan Jambrik, Albert Varga, Attila Nemes, Jeffrey Shi Kai Chan, Gabor G. Toth, Zoltan Ruzsa
Summary: This study aimed to assess the predictive value of radial artery calcification (RC) for coronary artery disease. The results showed a significant correlation between radial calcification and coronary calcification, and RC can predict the extent and severity of coronary artery disease.
CARDIOLOGY RESEARCH AND PRACTICE
(2022)
Article
Medicine, General & Internal
Reka Skoda, Attila Nemes, Gyorgy Barczi, Hajnalka Vago, Zoltan Ruzsa, Istvan F. Edes, Attila Olah, Annamaria Kosztin, Elek Dinya, Bela Merkely, David Becker
Summary: This study aimed to assess the impact of diabetes mellitus (DM) on the clinical outcome and survival of patients with myocardial infarction (MI) who underwent percutaneous coronary intervention (PCI). The results showed that diabetic patients had worse short- and long-term survival compared to non-diabetic patients. The presence of DM was found to be more important than the type of MI in affecting survival, while LV and renal functions had a greater impact on survival than DM.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Attila Nemes, Arpad Kormanyos, Zoltan Ruzsa, Alexandru Achim, Nora Ambrus, Csaba Lengyel
Summary: This study aimed to assess the associations between LV rotational parameters and LA volumes throughout the cardiac cycle in healthy adults. The results showed strong associations between basal LV rotation and LA volumes, while no significant associations were found between apical LV rotation and LA volumes. These findings have important implications for understanding cardiac function.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Balazs T. Nemeth, Istvan Hizoh, Fanni Nowotta, Zoltan Ruzsa, Tibor Szuk, Peter Kulyassa, Gabor A. Fulop, Fanni E. Szablics, David Becker, Bela Merkely, Istvan F. Edes
Summary: Through comparing radial compression devices for percutaneous coronary interventions, a cost-effective and potentially green method was found to be non-inferior to dedicated devices in terms of safety, making it a safe and similarly effective alternative.
Review
Biology
Alexandru Achim, Orsolya Agnes Peter, Kornel Kakonyi, Viktor Sasi, Attila Nemes, Calin Homorodean, Agata Stanek, Dan Mircea Olinic, Zoltan Ruzsa
Summary: In an effort to improve transcatheter vascular interventions, radial artery access has moved more distally at the anatomical snuffbox. Ultrasound guidance during puncture may encourage more operators to switch to this approach, as the artery in this location is smaller, more angulated, and more difficult to palpate.
Article
Medicine, General & Internal
Attila Nemes, Arpad Kormanyos, Zoltan Ruzsa, Alexandru Achim, Nora Ambrus, Csaba Lengyel
Summary: This study simultaneously assessed the volume changes of the left atrium (LA) and left ventricle (LV) in healthy individuals and found that LV performance is influenced by factors including LA volume. Increased LA volume is associated with increased LV volume and reduced LV ejection fraction. Moreover, increased LA volume is also associated with increased LV mass.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Alexandru Achim, Orsolya Agnes Peter, Mihai Cocoi, Adela Serban, Stefan Mot, Alexandra Dadarlat-Pop, Attila Nemes, Zoltan Ruzsa
Summary: Atherosclerosis is a complex disease that affects the entire arterial tree, with variations in lipid deposits and plaque composition depending on the location. The clinical manifestations also differ based on the structure and location of the atherosclerotic plaque. This review aims to explore the heterogeneity of atherosclerotic impairment in different arterial districts and examine the current evidence regarding the topographical interrelations of atherosclerosis.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Article
Medicine, General & Internal
Attila Nemes, Arpad Kormanyos, Zoltan Ruzsa, Alexandru Achim, Nora Ambrus, Csaba Lengyel
Summary: This study aimed to evaluate the associations between tricuspid valve (TA) dimensions and right atrial (RA) strains in healthy adults using three-dimensional speckle-tracking echocardiography (3DSTE). The results showed that increased TA areas during any phase of the cardiac cycle did not lead to the deterioration of peak RA strains in longitudinal (LS) and circumferential (CS) directions. However, increased end-diastolic TA area was associated with reduced radial strain (RS) in the RA. Dilation of both end-diastolic and end-systolic TA areas was related to increased RA volumes. Overall, 3DSTE is a suitable method for non-invasive assessment of TA dimensions, RA volumes, and strains.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biology
Attila Nemes, Gergely Racz, Arpad Kormanyos, Zoltan Ruzsa, Alexandru Achim, Csaba Lengyel
Summary: This study investigates the potential relationships between tricuspid annulus (TA) size and its sphincter-like and longitudinal functions in healthy adults. The findings suggest that three-dimensional echocardiography is capable of measuring TA dimensions and functional sphincter-like properties, which are associated with M-mode-derived TAPSE, indicating a sensitive and harmonic TA function in healthy adults without functional tricuspid regurgitation.
Article
Cardiac & Cardiovascular Systems
Ferenc T. Nagy, Dorottya Olajos, Borbala Vattay, Sarolta Borzsak, Melinda Boussoussou, Monika Deak, Milan Vecsey-Nagy, Barbara Sipos, adam L. Jermendy, Gabor G. Toth, Balazs Nemes, Bela Merkely, Tamas Szili-Torok, Zoltan Ruzsa, Balint Szilveszter
Summary: The feasibility of regadenoson stress dynamic perfusion computed tomography (DPCT) in chronic limb-threatening ischemia (CLTI) patients was tested. The combination of coronary computed tomography angiography (CTA) and DPCT proved to be a feasible method for detecting obstructive and functionally significant coronary artery disease (CAD) in CLTI patients, despite the high prevalence of severe coronary artery calcification.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Article
Cardiac & Cardiovascular Systems
Viktor Sasi, Gyula Szanto, Alexandru Achim, Imre Ungi, Albert Varga, Zoltan Ruzsa
Summary: Patients with calcified, fibrotic native coronary vessels and prior suboptimal stenting outcomes are at major risk of stent thrombosis. In this study, the authors investigated a new combination therapy of laser atherectomy and super high-pressure balloon to treat severe under-expansion of stent caused by fibrotic, calcified tissue.
INTERVENTIONAL CARDIOLOGY-REVIEWS RESEARCH RESOURCES
(2023)
Article
Cardiac & Cardiovascular Systems
Alexandru Achim, Kornel Kakonyi, Zoltan Jambrik, Zoltan Ruzsa
Summary: This case report presents a patient, a 29-year-old healthy male volleyball player, who developed acute upper limb ischemia (ULI) after being diagnosed with COVID-19. The repetitive stress on the hands of volleyball players may lead to vascular abnormalities, but acute ULI has not been reported before. The patient underwent various treatments without success before opting for percutaneous large-bore embolectomy.
EUROPEAN HEART JOURNAL-CASE REPORTS
(2022)