Article
Medicine, General & Internal
Francois Godart, Jean Benoit Baudelet, Alexandre Delarue, Anne Sophie Polge, Olivia Domanski, Said Bichali, Ali Houeijeh
Summary: This study reports a single-center experience in transcatheter closure of perimembranous ventricular septal defects (PmVSD) using the Lifetech Konar-multifunctional occluder (MFO). The results demonstrate that MFO is effective and safe for PmVSD closure, including multifenestrated/Gerbode-type defects, with no complications.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Respiratory System
Wenxin Lu, Fengwen Zhang, Taibing Fan, Tianli Zhao, Yu Han, Xiaopeng Hu, Qi Li, Hao Shi, Xiangbin Pan
Summary: This study demonstrated the efficacy and safety of MIPDO method in treating pmVSD patients, with advantages in procedural and postoperative indicators compared to surgical repair. MIPDO method showed non-inferiority to surgical closure in efficacy for both intention-to-treat and per-protocol population, providing easier perioperative recovery, economic benefit, and outcomes.
JOURNAL OF THORACIC DISEASE
(2021)
Article
Cardiac & Cardiovascular Systems
Qiang Chen, Rong Yang, Yu-Qing Lei, Kai-Peng Sun, Hua Cao
Summary: Transthoracic device closure of VSDs significantly improves the quality of life of adult patients in the midterm follow-up, reflected in their physical and psychological fields. However, they are still unable to achieve normal levels of peak exercise ability. Further exploration and interventions are worth considering.
BMC CARDIOVASCULAR DISORDERS
(2021)
Article
Cardiac & Cardiovascular Systems
Iman Naimi, Thomas K. Jones, Zachary Steinberg
Summary: We present a case of severe hemolysis following transcatheter high-velocity shunt occlusion with an Amplatzer device, which was successfully managed by removing the device and reoccluding with a Gore Cardioform occluder.
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2022)
Article
Cardiac & Cardiovascular Systems
Liu Liu Huang, Mai Chen, De Cai Zeng, Chun Xiao Su, Chun Lan Jiang, Bao Shi Zheng, Ji Wu, Shi Kang Li
Summary: Both percutaneous and perventricular ultrasound-guided device closure of PmVSD are effective and safe treatment options, with the percutaneous approach offering less trauma and faster recovery.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Engineering, Biomedical
Gaoyang Guo, Jinpeng Hu, Fan Wang, Daihua Fu, Rifang Luo, Fanjun Zhang, Cheng Hu, Juan Chen, Xiangbin Pan, Li Yang, Yunbing Wang, Xingdong Zhang
Summary: Degradable heart occluders are promising replacements for currently used non-degradable ones, offering a potentially superior approach for repairing congenital VSD without interfering with the normal function of the heart. We developed a fully degradable VSD occluder with excellent shape recovery and secure fixation ability. The occluder provided robust fixation for the first 3 months and was completely absorbed within 12 months. Our degradable occluder showed desired occlusion and no complications in canines during a 24-month follow-up, demonstrating its potential clinical application.
Article
Cardiac & Cardiovascular Systems
Yuichi Matsuzaki, Darren P. Berman, Hirotsugu Kurobe, John M. Kelly, Ryuma Iwaki, Kevin Blum, Shoji Toshihiro, Andrew Harrison, John P. Cheatham, Toshiharu Shinoka
Summary: This study investigated the function and safety of a bioabsorbable ASD occluder system for PFO and/or secundum ASD transcatheter closure using a sheep model. Results showed that the modified 2nd generation BAO can be deployed via minimally invasive percutaneous transcatheter techniques, partially degrades over 1 year, and is replaced by host native tissues.
PEDIATRIC CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Lea Boukaram, Raymond N. Haddad, Linda Daou, Zakhia Saliba
Summary: This study reports the successful closure of a congenital defect in an 18-year-old girl using the MFO device, with immediate and 12-month-follow-up confirming successful outcomes with complete shunt closure and resolution of tricuspid regurgitation.
JOURNAL OF CARDIAC SURGERY
(2021)
Review
Cardiac & Cardiovascular Systems
Sanjiban Ghosh, Aritra Mukherji, Nihar Lalitkumar Pathak, Jayitri Mazumdar, Amitabha Chattopadhyay
Summary: Varied degrees of atrioventricular block can occur after transcatheter closure of perimembranous ventricular septal defects, but it is extremely rare following the use of the Amplatzer duct occluder-II device. Understanding the onset and underlying mechanism of atrioventricular block is crucial for successful management. In a reported case, delayed onset high-grade atrioventricular block after closure of a perimembranous ventricular septal defect using a duct occluder-II device was successfully reverted to sinus rhythm with high dose steroid therapy, which has not been reported in literature before.
PROGRESS IN PEDIATRIC CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Mohammad K. Mojadidi, Preetham Kumar, Ahmed N. Mahmoud, Islam Y. Elgendy, Hilary Shapiro, Brian West, Andrew C. Charles, Heinrich P. Mattle, Sherman Sorensen, Bernhard Meier, Stephen D. Silberstein, Jonathan M. Tobis
Summary: A pooled analysis of individual participant data from two randomized trials using the Amplatzer PFO Occluder showed that percutaneous device closure significantly reduced the mean number of monthly migraine days and attacks, and increased the number of subjects who experienced complete migraine cessation with good safety outcomes.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Multidisciplinary Sciences
Shai Tejman-Yarden, Dor Freidin, Netanel Nagar, Yisrael Parmet, Muhamed Abed, Oliana Vazhgovsky, David Yogev, Dov Ganchrow, Efrat Mazor-Drey, Sumit Chatterji, Roy Beinart, Israel Barbash, Victor Guetta, Orly Goitein
Summary: This study explored the feasibility and accuracy of virtual reality (VR) derived from cardiac computed angiography (CCTA) data in predicting the size of left atrial appendage occlusion (LAAO) devices. The results showed that VR measurement of the maximal ostium diameter had the strongest correlation with the diameter of the inserted device, indicating that VR may provide new imaging possibilities for the evaluation of complex pre-procedural structures.
Article
Cardiac & Cardiovascular Systems
Sisca Natalia Siagian, Radityo Prakoso, Brian Mendel, Zakky Hazami, Valerinna Yogibuana Swastika Putri, Zulfahmi, Damba Dwisepto Aulia Sakti, Ario Soeryo Kuncoro
Summary: This case report highlights the feasibility of closing multiple ventricular septal defects (VSDs) with a single device percutaneously using zero-fluoroscopy technique. A 7-year-old child with multiple muscular VSDs underwent successful closure with an Amplatzer Septal Occluder, leading to improved symptoms and resolution of pulmonary hypertension.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Lusine Abrahamyan, Madeleine Barker, Christoffer Dharma, Douglas S. Lee, Peter C. Austin, Areeba Asghar, Annamalar Muthuppalaniappan, Lee Benson, Mark Osten, Eric M. Horlick
Summary: This study evaluated the real-world outcomes of adult patients undergoing transcatheter PFO closure with the Amplatzer PFO Occluder. The results showed excellent safety and effectiveness outcomes, similar to randomized controlled trials or other long-term cohort studies. New onset atrial fibrillation was one of the most commonly adverse events.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Multidisciplinary Sciences
Shouzheng Wang, Zefu Li, Yunbing Wang, Tianli Zhao, Xuming Mo, Taibing Fan, Jianhua Li, Tao You, Rundi Deng, Wenbin Ouyang, Weiwei Wang, Chuangnian Zhang, Gianfranco Butera, Ziyad M. Hijazi, Kunjing Pang, Da Zhu, Shiliang Jiang, Gejun Zhang, Xiaopeng Hu, Yongquan Xie, Fengwen Zhang, Fang Fang, Jingping Sun, Ping Li, Juan Chen, Zhiling Luo, Xiangbin Pan
Summary: This study investigates the efficacy and safety of a fully bioabsorbable occluder in patients with ventricular septal defects. The results show that the occluder can be successfully implanted and completed the trial without residual shunt. It is a safe and effective alternative to traditional metal occluders.
Article
Medicine, General & Internal
Marc Llagostera-Martin, Hector Cubero-Gallego, Aleksandra Mas-Stachurska, Neus Salvatella, Andrea Sanchez-Carpintero, Helena Tizon-Marcos, Marcos Garcia-Guimaraes, Alicia Calvo-Fernandez, Luis Molina, Beatriz Vaquerizo
Summary: The LAmbre(TM) device shows high success rates in implantation for left atrial appendage closure (LAAC) in a high-risk population, with minimal complications and promising mid-term performance.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
M. Granegger, S. Kung, O. Bollhalder, D. Quandt, C. Scheifele, D. Drozdov, U. Held, A. Callegari, O. Kretschmar, M. Hubler, M. Schweiger, W. Knirsch
Summary: Somatic, vascular, and cardiac parameters demonstrate catch-up growth after Fontan procedure, with factors including timing of surgery, ventricular morphology, and gender influencing outcomes. Despite trends towards normalization, diastolic function of the single ventricle remains altered in this cohort.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Patrick O. Myers, Hitendu Dave, Oliver Kretschmar, Tornike Sologashvili, Raymond Pfister, Rene Pretre
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2020)
Article
Pediatrics
Melanie Ehrler, Isabelle Werninger, Barbara Schnider, Dominique A. Eichelberger, Nadja Naef, Vera Disselhoff, Oliver Kretschmar, Cornelia F. Hagmann, Beatrice Latal, Flavia M. Wehrle
Summary: The study found that the ongoing COVID-19 pandemic significantly impacts the whole family, particularly causing additional distress and concerns in families with children at risk for neurodevelopmental impairments. During the pandemic, these families should receive individualized counseling and assistance from healthcare providers and schools.
Editorial Material
Cardiac & Cardiovascular Systems
Martin Schmiady, Oliver Kretschmar, Rene Pretre, Hitendu Dave
Summary: Atresia of the left main coronary artery is a rare anomaly that can lead to life-threatening emergencies. Surgical revascularization of the affected segment using autologous saphenous vein graft was successfully performed, resulting in the saving of the patient's life.
INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
(2021)
Article
Obstetrics & Gynecology
Laura Hapuoja, Oliver Kretschmar, Valentin Rousson, Hitendu Dave, Nadja Naef, Beatrice Latal
Summary: The study found that while most growth parameters increased from 1 to 10 years, some children with congenital heart disease (CHD) still had weight and head circumference below the norm at age 10. Lower gestational age and longer hospitalization were associated with impaired head circumference or height, while lower socioeconomic status was related to higher BMI and weight at 10 years.
EARLY HUMAN DEVELOPMENT
(2021)
Article
Oncology
Vanessa Sitte, Barbara Burkhardt, Roland Weber, Oliver Kretschmar, Martin Hersberger, Eva Bergstrasser, Martin Christmann
Summary: This study aimed to evaluate sensitive parameters for cardiac damage in childhood cancer survivors. The results showed that strain imaging and new cardiac biomarkers in HFpEF were more sensitive than standard echo and laboratory parameters.
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
(2022)
Article
Pediatrics
Rebecca Spillmann, Susanne Polentarutti, Melanie Ehrler, Oliver Kretschmar, Flavia M. Wehrle, Beatrice Latal
Summary: Children with congenital heart disease (CHD) are at risk for neurodevelopmental deficits, and this study investigated the impact of cognitive deficits on educational outcome and participation in leisure activities. The results showed that children with CHD had lower IQ and executive functions compared to norms, attended regular school and participated in leisure activities less frequently than the general population. These findings emphasized the importance of early detection of cognitive deficits and providing support for cognitive functioning in children with CHD.
PEDIATRIC RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Anna Krokovay, Martin Schweiger, Oliver Kretschmar, Rene Pretre
Summary: Anomalous origin of the left coronary artery from the pulmonary artery is a rare congenital anomaly, which can be corrected by reimplanting it into the aorta through surgery.
INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
A. Krokovay, R. Pretre, O. Kretschmar, W. Knirsch, E. Valsangiacomo Buechel, H. Dave
Summary: This study discussed the surgical reconstruction of non-sclerotic proximal coronary artery stenosis in children using autologous vein grafts, showing good medium- to long-term outcomes. The 100% survival rate and normal coronary artery patency and cardiac function post-reconstruction were observed.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Environmental Sciences
Regina Wespi, Alessia Callegari, Daniel Quandt, Jana Logoteta, Michael von Rhein, Oliver Kretschmar, Walter Knirsch
Summary: PDA stenting is a feasible and safe treatment option for patients with duct-dependent pulmonary perfusion. Interdisciplinary decision-making before the procedure and surgical backup afterwards are necessary. The procedure allows for adequate body and pulmonary vessel growth for subsequent surgical procedures.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Environmental Sciences
Alessia Callegari, Daniel Quandt, Achim Schmitz, Karin Klingel, Christian Balmer, Hitendu Dave, Oliver Kretschmar, Walter Knirsch
Summary: This study assessed the findings and outcomes in children with suspected cardiomyopathy or myocarditis undergoing cardiac catheterization. The study found that invasive hemodynamic data and histological/immunohistological findings provide important information for the clinical diagnosis and management of children with suspected CMP/myocarditis.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Biology
Antonio Amodeo, Milena Stojanovic, Hitendu Dave, Robert Cesnjevar, Alexander Konetzka, Tugba Erdil, Oliver Kretschmar, Martin Schweiger
Summary: This retrospective study evaluated the use and timing of V-A ECMO in pediatric patients and found that ventricular physiology and heart anatomy play important roles in the outcomes of children on ECMO.
Article
Neuroimaging
Melanie Ehrler, Michael von Rhein, Ladina Schlosser, Peter Brugger, Matthias Greutmann, Oliver Kretschmar, Beatrice Latal, Ruth Tuura O'Gorman
Summary: Congenital heart disease (CHD) patients are at risk for neurodevelopmental impairments, including altered motor function. The study found that motor performance was lower in CHD patients compared to controls, especially in those with more complex CHD. The microstructure of the corticospinal tract (CST) is altered in CHD patients and is associated with pure motor impairments, particularly in patients with severe CHD.
NEUROIMAGE-CLINICAL
(2021)
Article
Cardiac & Cardiovascular Systems
Vilius Dranseika, Rene Pretre, Oliver Kretschmar, Hitendu Dave
Summary: The Melody valve is a feasible and reproducible option for mitral valve replacement in infants, with good immediate results and the possibility of later dilatation. The survival rate is relatively high, with stable postoperative echo gradients, and minimal occurrence of serious complications.
ANNALS OF PEDIATRIC CARDIOLOGY
(2021)
Article
Neuroimaging
Melanie Ehrler, Beatrice Latal, Oliver Kretschmar, Michael von Rhein, Ruth O'Gorman Tuura
NEUROIMAGE-CLINICAL
(2020)