Article
Chemistry, Organic
Chengqiang Cao, Yi Yang, Xin Li, Yunxia Liu, Hui Liu, Zengdian Zhao, Lei Chen
Summary: The reaction, catalyzed by palladium, efficiently constructs two new bonds with high yields, while the alkene group is easily functionalized, leading to the formation of products with a unique structure that is difficult to synthesize.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Andrew Whyte, Jonathan Bajohr, Ramon Arora, Alexa Torelli, Mark Lautens
Summary: An enantioselective consecutive cyclization/coupling process catalyzed by palladium was reported in this study. The stereoinduction was achieved through an enantioselective carbopalladation, leading to the generation of an intermediate that promotes a nucleopalladation step. This dual cyclization sequence was compatible with various nucleophiles and aryl iodides, producing numerous bisheterocycles in good yields and high regio- and enantioselectivities.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Sanghyup Seo, Donghyeon Kim, Hyunwoo Kim
Summary: The reductive cross-coupling of terminal alkenes and N-heterocyclic bromides was successfully demonstrated through ligand optimization of Pd and CuH catalysis. The optimized ligands for Pd and CuH catalysis, Briphos and DTB-DPPBz respectively, were further applied to gram-scale production of clathryimine B.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Tobias Wagener, Lukas Lueckemeier, Constantin G. Daniliuc, Frank Glorius
Summary: This study successfully demonstrates the synthesis of sought-after, enantioenriched delta-lactams through an interrupted hydrogenation mechanism using oxazolidinone-substituted pyridines and water.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Physical
Tristan Delcaillau, Hendrik L. Schmitt, Philip Boehm, Eric Falk, Bill Morandi
Summary: The intramolecular carbothiolation of unsaturated hydrocarbons using a palladium-NHC catalyst was reported. The reaction showed excellent tolerance and chemoselectivity, and could be applied to the synthesis of various sulfur-containing compounds.
Review
Chemistry, Multidisciplinary
Arpad Molnar
Summary: This review aims to analyze recent studies on the synthesis of five-membered nitrogen heterocycles using palladium catalysts. The focus is on studies from the last three years. The common feature of these methods is the formation of nitrogen-containing five-membered rings through the ring closing of appropriate starting materials. The selected examples demonstrate that a wide range of products, from small monocycles to condensed multi-ring systems, can be efficiently obtained with high yields and stereoselectivities under mild reaction conditions.
Review
Biochemistry & Molecular Biology
Lucia Veltri, Roberta Amuso, Raffaella Mancuso, Bartolo Gabriele
Summary: This short review highlights the progress in utilizing palladium-catalyzed carbon dioxide for synthesizing valuable organic molecules. The review is organized based on the type of substrate used in the Pd-catalyzed carboxylation process, including olefinic substrates, acetylenic substrates, and other substrates such as aryl halides and triflates.
Article
Chemistry, Physical
Juan Camilo Arango-Daza, Carles Lluna-Galan, Luis Izquierdo-Aranda, Jose R. Cabrero-Antonino, Rosa Adam
Summary: A heterogeneous catalytic system for the acceptorless dehydrogenative condensation between N,N'-disubstituted ureas and 1,2-diols to produce imidazolones was developed. The designed palladium nanoaggregates on an alumina matrix showed good activity and selectivity, with wide applicability and moderate to good yields. Mechanistic studies and characterization were performed, revealing the key factors for the catalyst's activity. Furthermore, a Pd-Zn cooperation effect was described, and bimetallic materials were also designed and characterized properly.
Article
Chemistry, Multidisciplinary
Nihad Salameh, Federica Valentini, Olivier Baudoin, Luigi Vaccaro
Summary: We report a general and efficient enantioselective C-H arylation of aryl bromides using BozPhos as the bisphosphine ligand and SP-NHC-PdII as recoverable heterogeneous catalyst. By exploiting the release and catch mechanism of action, high enantioselectivities were achieved across different substrates containing methyl, cyclopropyl and aryl C-H bonds. The developed catalytic system provides a more sustainable solution for the synthesis of high added-value chiral products through recycling of the precious metal.
Review
Chemistry, Organic
Tamal Ballav, Rajesh Chakrabortty, Aniruddha Das, Suman Ghosh, Venkataraman Ganesh
Summary: This review summarizes the research achievements in the field of synergistic dual catalysis in recent years, highlighting the unique strategies of carbon-carbon and carbon-heteroatom bond formation achieved by combining Pd catalyst with transition metals, Lewis acids, or organocatalysts. The wide applications of these strategies in pharmaceutical and agrochemical industries are also discussed.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Organic
Subhankar Ghosh, Shital K. Chattopadhyay
Summary: In this study, a single metal catalyst and air as the oxidant were used to achieve tandem C-H arylation and C-H amidation of cis-cinnamyl hydroxamates, leading to the regioselective formation of a 3-aryl-2-quinolone ring system. Under identical conditions, the corresponding trans-isomer resulted in a 4-aryl-2-quinolone derivative. The observed complementary regioselectivity during the tandem C-H arylation and C-H amidation of isomeric substrates is unusual and has potential applications.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Ferenc Beke, Janos T. Csenki, Zoltan Novak
Summary: This account article summarizes the synthesis and applications of fluoroalkyl and fluoroalkenyliodonium salts, with a focus on the reagents designed in the author's laboratory in the past decade. Trifluoroethyl(aryl)iodonium salts have been frequently used to build carbon-carbon and carbon-heteroatom bonds through simple nucleophilic substitutions and transition metal catalyzed coupling reactions. Iodonium salts equipped with unsaturated fluorinated function exhibit diverse reactivity and enable the preparation of fluorinated carbo- and heterocyclic molecules through cycloaddition and nucleophilic addition reactions. The presented collection aims to inspire future developments and applications of iodonium reagents in organic synthesis.
Article
Chemistry, Applied
Rene Hommelsheim, Robin van Nahl, Lena M. Hanek, Jas S. Ward, Kari Rissanen, Carsten Bolm
Summary: This study reports a palladium-catalyzed domino reaction that enables the synthesis of 3-amino-substituted 1,2,4-benzothiadiazine 1,1-dioxides at room temperature. The method demonstrates good substrate compatibility and mild reaction conditions.
ADVANCED SYNTHESIS & CATALYSIS
(2023)
Article
Chemistry, Applied
Fernando Martinez-Lara, Anisley Suarez, Noelia Velasco, Samuel Suarez-Pantiga, Roberto Sanz
Summary: The gold-catalyzed transformation of propargylic glycols with thiols results in the formation of alpha-indol-3-yl alpha-((Z)-2-thioalkenyl) ketones through a complex but selective reaction mechanism. This sequence involves regioselective thiolation of indolyl diols followed by the attack of sulfur on the activated alkyne, rather than the indole. The final compounds are obtained in high yields from simple starting materials such as indolyl acyloins, ethynyl magnesium bromide, and thiols.
ADVANCED SYNTHESIS & CATALYSIS
(2022)
Article
Chemistry, Applied
Miguel A. Munoz-Torres, Fernando Martinez-Lara, Marta Solas, Samuel Suarez-Pantiga, Roberto Sanz
Summary: The combination of organolithium chemistry with gold catalysis offers a new synthetic strategy for accessing polysubstituted indoles and carbazoles. This method utilizes ketopyrroles as starting materials and involves a series of reactions to selectively synthesize the desired products.
ADVANCED SYNTHESIS & CATALYSIS
(2022)
Article
Chemistry, Organic
Navjeet Kaur, Neha Ahlawat, Pranshu Bhardwaj, Yamini Verma, Pooja Grewal, Nirmala Kumari Jangid
SYNTHETIC COMMUNICATIONS
(2020)
Review
Polymer Science
Nirmala Kumari Jangid, Sapana Jadoun, Navjeet Kaur
EUROPEAN POLYMER JOURNAL
(2020)
Review
Chemistry, Organic
Navjeet Kaur, Neha Ahlawat, Pranshu Bhardwaj, Yamini Verma, Pooja Grewal, Nirmala Kumari Jangid
SYNTHETIC COMMUNICATIONS
(2020)
Review
Chemistry, Inorganic & Nuclear
Navjeet Kaur, Yamini Verma, Neha Ahlawat, Pooja Grewal, Pranshu Bhardwaj, Nirmala Kumari Jangid
INORGANIC AND NANO-METAL CHEMISTRY
(2020)
Article
Chemistry, Organic
Navjeet Kaur, Neha Ahlawat, Yamini Verma, Pooja Grewal, Pranshu Bhardwaj, Nirmala Kumari Jangid
SYNTHETIC COMMUNICATIONS
(2020)
Review
Chemistry, Inorganic & Nuclear
Navjeet Kaur, Neha Ahlawat, Yamini Verma, Pranshu Bhardwaj, Pooja Grewal, Nirmala Kumari Jangid
INORGANIC AND NANO-METAL CHEMISTRY
(2020)
Review
Polymer Science
Nirmala Kumari Jangid, Sapana Jadoun, Anjali Yadav, Manish Srivastava, Navjeet Kaur
Summary: Polyaniline-TiO2-based photocatalysis shows great potential for environmental remediation by dye degradation, with excellent photocatalytic activity under both ultraviolet light and natural sunlight irradiation.
Review
Chemistry, Organic
Navjeet Kaur, Neha Ahlawat, Yamini Verma, Pooja Grewal, Pranshu Bhardwaj, Nirmala Kumari Jangid
Summary: Heterocyclic compounds are abundant in nature and play important roles in various applications such as pharmaceuticals, agrochemicals, and dyes. Aromatic heterocyclic compounds, in particular, are prevalent in biologically active molecules and are widely utilized in organic synthesis. The synthesis of heterocycles using crown ethers has been a focus in organic chemistry research.
CURRENT ORGANIC CHEMISTRY
(2021)
Review
Chemistry, Organic
Navjeet Kaur, Neha Ahlawat, Yamini Verma, Pooja Grewal, Pranshu Bhardwaj, Nirmala Kumari Jangid
Summary: Metal-mediated formation of heterocycles is an emerging and important strategy in organic chemistry. Silver-assisted cyclic reactions are highly efficient for the synthesis of five-membered fused N-heterocyclic compounds. This review article covers the applications of silver in the preparation of these compounds.
CURRENT ORGANIC CHEMISTRY
(2021)
Review
Chemistry, Organic
Meenu Devi, Shivangi Jaiswal, Jaya Dwivedi, Navjeet Kaur
Summary: This review focuses on the synthesis of pyrimidine derivatives with various activities, encouraging researchers to develop novel, potent, safe, and selective compounds against mutant strains. Development of synthetic protocols is a high priority in medicinal chemistry research.
CURRENT ORGANIC CHEMISTRY
(2021)
Review
Chemistry, Organic
Navjeet Kaur, Pranshu Bhardwaj, Mansi Gupta
Summary: Various diketones and dicarbonyl compounds play significant roles in the synthesis of core heterocyclic compounds and also act as chelating ligands. Organic chemists have focused on the synthesis of nitrogen-containing heterocyclic compounds.
CURRENT ORGANIC CHEMISTRY
(2021)
Review
Chemistry, Organic
Meenu Devi, Shivangi Jaiswal, Sonika Jain, Navjeet Kaur, Jaya Dwivedi
Summary: Nitrogen-containing heterocycles, particularly pyrimidine, have drawn significant attention from chemists due to their diverse biological activities and potential therapeutic applications. Pyrimidine derivatives, with their high degree of structural diversity, exhibit a wide range of therapeutic activities such as anticancer, anti-inflammatory, and anti-HIV properties.
CURRENT ORGANIC SYNTHESIS
(2021)
Review
Chemistry, Multidisciplinary
Navjeet Kaur, Meenu Devi, Pooja Grewal, Neha Ahlawat, Pranshu Bhardwaj, Yamini Verma, Nirmala Kumari Jangid
Summary: Transition metal-catalyzed cycloisomerization reactions have significant advantages in the synthesis of heterocycles, allowing for greater molecular complexity and better functional group compatibility from readily available substrates. The use of copper catalysts for the synthesis of five-membered N-heterocycles is an effective strategy.
JOURNAL OF THE IRANIAN CHEMICAL SOCIETY
(2022)
Review
Chemistry, Organic
Navjeet Kaur, Pooja Grewal, Komal Poonia
Summary: Heterocycles remain popular among researchers for their significant activities in pharmaceuticals. Diketones play a crucial role in synthetic organic chemistry and are used in the synthesis of core heterocyclic compounds. This review article covers the synthesis of O-heterocycles from dicarbonyl compounds.
SYNTHETIC COMMUNICATIONS
(2021)
Review
Chemistry, Organic
Pranshu Bhardwaj, Navjeet Kaur
Summary: In this review, Pd-catalyzed amination and arylation reactions for the construction of various benzodiazepine scaffolds are discussed. Different synthetic strategies, such as C-H arylation, Pd-catalyzed carbonylation, and Buchwald Hartwig coupling, are included. The domino processes as intra- or intermolecular reactions are developed as an eco-friendly and effective tool to synthesize functionalized benzodiazepines. The article primarily focuses on synthesizing a 1,4-benzodiazepine nucleus fused with 5-membered carbo- and heterocycles in the presence of palladium catalysts.
CURRENT ORGANIC CHEMISTRY
(2022)
