Article
Chemistry, Physical
Eduam O. Boeira, Caroline B. Pla, Fabiano S. Rodembusch, Angelica Moro
Summary: In this study, the arylation of Troger's base was achieved through the Suzuki cross-coupling reaction using aqueous micellar catalysis. The developed reaction conditions allowed for the preparation of various Troger's base derivatives with low catalytic loading of Pd(OAc)(2) catalyst and under environmentally friendly aqueous conditions.
Article
Polymer Science
Haniyeh Daneshafruz, Hossein Barani, Hassan Sheibani
Summary: The study utilizes graphene oxide as a stable support for palladium nanoparticles, resulting in a heterogeneous nanocatalyst. The nanocatalyst demonstrates excellent catalytic efficiency through various characterization techniques. It is efficient, cost-effective, and environmentally friendly, maintaining its catalytic activity after multiple uses.
JOURNAL OF INORGANIC AND ORGANOMETALLIC POLYMERS AND MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Brais Bermudez-Puente, Luis A. Adrio, Fatima Lucio-Martinez, Francisco Reigosa, Juan M. Ortigueira, Jose M. Vila
Summary: The treatment of imines a-c with palladium(II) acetate in acetic acid yielded mu-acetate dinuclear complexes 1a-c, which then reacted with halide analogues, and further reacted with nitrogen, phosphorus, and oxygen donor nucleophiles to form new imine palladacycles. The complexes were fully characterized and applied as catalysts in Suzuki-Miyaura coupling reactions.
Article
Chemistry, Physical
Robina Begum, Zahoor H. Farooqi, Jianliang Xiao, Ejaz Ahmed, Ahsan Sharif, Ahmad Irfan
Summary: In this study, Pd nano crystals were loaded into polymer microgels and used as catalysts for reductive transformations of organic compounds. The experiments showed that the catalytic reactions had high conversion rates under mild conditions, and the catalyst exhibited good stability and reusability.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Chemistry, Multidisciplinary
Elad Goren, Mark A. Iron, Yael Diskin-Posner, Alla Falkovich, Liat Avram, Amnon Bar-Shir
Summary: Metal-capped molecular hosts with paramagnetic properties can be used to study host-guest complexes and improve spectral resolution. The paraGEST method reveals different populations of complexes in a solution and allows for the identification of multiple co-existing populations of Ln-beta-CD-guest complexes.
Article
Chemistry, Multidisciplinary
Elad Goren, Mark A. Iron, Yael Diskin-Posner, Alla Falkovich, Liat Avram, Amnon Bar-Shir
Summary: Metal-capped molecular hosts with paramagnetic properties have been shown to be convenient for studying host-guest complexes in supramolecular systems using NMR spectroscopy. The paraGEST method, which utilizes paramagnetic guest exchange saturation transfer, allows for enhanced spectral resolution and the identification of different populations of host-guest complexes. This method is particularly useful for systems containing lanthanide-capped cyclodextrins, as it reveals multiple co-existing populations of complexes with different orientations of the guest molecules.
Article
Biochemistry & Molecular Biology
Kulpavee Jitapunkul, Pisanu Toochinda, Luckhana Lawtrakul
Summary: Stable encapsulation of medically active compounds can lead to longer storage life and facilitate the slow-release mechanism. HPBCD is identified as the best encapsulation agent for plumbagin, forming a stable host-guest complex with promising longer storage life and slow-release potential.
Article
Pharmacology & Pharmacy
Bhupendra Raj Giri, Hyun Seok Yang, Im-Sook Song, Han-Gon Choi, Jung Hyun Cho, Dong Wuk Kim
Summary: This study developed spray-dried amorphous inclusion complexes of methotrexate (MTX) with beta-cyclodextrin derivatives to enhance the drug's solubility, stability, and oral bioavailability in rats. The findings showed significant improvements in pharmacokinetic profiles with DM-beta-CD as the host, indicating a successful oral formulation technique for preventing drug degradation and enhancing pharmacological properties.
Article
Environmental Sciences
Violetta Mohos, Zelma Faisal, Eszter Fliszar-Nyul, Lajos Szente, Miklos Poor
Summary: In this study, it was found that the insoluble beta-cyclodextrin bead polymer (BBP) effectively extracted certain mycotoxins such as citrinin, dihydrocitrinone, sterigmatocystin, zearalanone, alpha-zearalanol, and beta-zearalanol at different pH values. Ochratoxin A was most effectively removed by BBP at pH 3.0. This suggests that BBP could be a suitable mycotoxin binder for decontamination and analytical purposes.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Chemistry, Applied
Sara Payamifar, Foad Kazemi, Babak Kaboudin
Summary: This study introduced a convenient nickel-catalyzed protocol for the Suzuki-Miyaura coupling reaction using a simple mixture of Ni(II) and unfunctionalized beta-cyclodextrin in water. The environmentally friendly and cost-efficient method allows the synthesis of biaryls from arylboronic acids and various aryl halides. The catalyst can be recycled for multiple runs with only a small decrease in catalytic activity.
APPLIED ORGANOMETALLIC CHEMISTRY
(2021)
Article
Chemistry, Applied
Bin Deng, Jing Yang, Mengbi Guo, Rui Yang
Summary: A series of cyclodextrin-based supramolecular polymers were constructed and used as ligands in copper(I)-catalyzed azide alkyne cycloaddition (CuAAC) for the first time. The CD-SP 4 self-assembly showed highly efficient catalytic activity and can be fully recycled, extending the potential applications of cyclodextrin-based supramolecular polymers in green chemical synthesis.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Materials Science, Paper & Wood
Fangfei Liu, Xiong Liu, Qiang Fu
Summary: Metal nanoparticles have been widely used in catalysis due to their excellent activity and selectivity, and sustainable support materials can enhance their efficiency and recyclability. In this study, a cellulose/beta-cyclodextrin hydrogel was utilized as a support to generate nanocomposite hydrogels encapsulating tannic acid-coated metal nanoparticles (Ag, Au, Pd, and Cu) for catalysis. The resulting nanocomposite hydrogels exhibited good catalytic activity and recyclability in various aqueous chemical reactions.
Review
Chemistry, Multidisciplinary
Gaspard Hedouin, Deborah Ogulu, Gaganpreet Kaur, Sachin Handa
Summary: Solvents are a major source of chemical waste, and there is a growing demand for more environmentally friendly alternatives. While water can sometimes be a suitable substitute for organic solvents, its use as a sole solvent is impractical. However, recent advancements in additives have allowed for chemistry in water, including the use of micelles as nanoreactors. Micellar technology has proven to be a sustainable alternative for many reactions, with potential beyond serving as a reaction medium.
CHEMICAL COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Aurelia Malapert, Emmanuelle Reboul, Olivier Dangles, Alain Thiery, N'nabinty Sylla, Valerie Tomao
Summary: A new simple and eco-friendly extraction process has been developed using native beta-cyclodextrin to remove phenolic compounds from olive mill waste water, achieving high extraction efficiency and loading capacity. The study found that the phenols encapsulated in solid beta-cyclodextrin are protected against photodegradation, making it a potential safe-grade food supplement.
Article
Chemistry, Applied
Wenhua Lin, Liping Zhang, Yanping Ma, Tongling Liang, Wen-Hua Sun
Summary: The sterically hindered 2-iminopyridine derivatives and their palladium chlorides complexes efficiently catalyze the Suzuki-Miyaura coupling reaction in aqueous solution, with good substrate scope and reusability for multiple batches. The spontaneous separation of coupling products in the aqueous medium adds to the process's appeal, while the catalytic performance can be significantly influenced by UV irradiation due to the photoisomerization of the catalysts' azo units. Overall, these titled palladium complexes offer a green, sustainable, cost-effective, and convenient method for synthesizing SMC products at a multi-gram scale.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Review
Chemistry, Multidisciplinary
Ting Su, Deyang Zhao, Yantao Wang, Hongying Lu, Rajender S. Varma, Christophe Len
Summary: This Minireview discusses recent advancements in the catalytic oxidation of HMF to 2,5-furandicarboxylic acid (FDCA) and other intermediates using noble, non-noble, and metal-free systems deploying emerging protocols.
Article
Chemistry, Physical
Remi Nguyen, Nicolas Galy, Fatmah Ali Alasmary, Christophe Len
Summary: In this study, glycerol oligomerization for the formation of polyglycerol was successfully carried out under microwave activation using a potassium carbonate catalyst. The effects of temperature, flow rate, and residence time on the reaction were studied, and the main diglycerol and triglycerol regioisomers were quantified. By utilizing successive cyclic mode processes and short distance distillation, the mixture was enriched with glycerol ethers to obtain a mixture consisting of diglycerol, triglycerol, tetraglycerol, and pentaglycerol.
Review
Chemistry, Multidisciplinary
Mohamad Reza Khodadadi, Julien Thiel, Rajender S. Varma, Christophe Len
Summary: Solketal is identified as a promising chemical for oleochemicals, particularly for ketalisation of glycerol. Recent advancements in catalytic ketalisation of glycerol in laboratories involve homogeneous, commercial heterogeneous, and specifically designed heterogeneous catalysts.
JOURNAL OF FLOW CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Ramla Muhammad Kamal, Ahmad Faizal Abdull Razis, Nurul Syafuhah Mohd Sukri, Enoch Kumar Perimal, Hafandi Ahmad, Rollin Patrick, Florence Djedaini-Pilard, Emanuela Mazzon, Sebastien Rigaud
Summary: Vegetable diets, especially Brassica vegetables, have been associated with lower risks of chronic diseases, particularly neurodegenerative diseases (NDDs) and cardiovascular diseases (CVDs). Phytochemicals glucosinolates (GLs) and isothiocyanates (ITCs), mainly found in Cruciferae family, have been recognized as antioxidants contributing to the protective effects on the heart and nervous system. Hydrolytic breakdown products of GLs, such as sulforaphane (SFN), phenylethyl ITC (PEITC), moringin (MG), erucin (ER), and allyl ITC (AITC), have significant effects in mitigating reactive oxidation species (ROS), inflammation, and apoptosis, which are the primary causes of CVDs and NDDs.
Article
Pharmacology & Pharmacy
Sebastien Rigaud, David Mathiron, Tarek Moufawad, David Landy, Florence Djedaini-Pilard, Frederic Marcon
Summary: The study found that it is possible to achieve a high concentration of carvedilol in the presence of gamma CD or RAMEB in aqueous media, with RAMEB showing stronger inclusion complexation and significantly increasing the drug's stability. These results could be a first step in developing a novel oral formulation of carvedilol.
Article
Chemistry, Physical
Fatemeh Rajabi, Mika Sillanpaa, Christophe Len, Rafael Luque
Summary: The study demonstrates the efficient catalytic performance of an ionic solid nanomaterial PMO-Py-IL for the one-pot Biginelli condensation reaction under solvent-free conditions. The catalyst exhibits remarkable stability and reusability, making it a promising candidate for green synthesis.
Article
Chemistry, Physical
Robbie Radjagobalou, Virgile Rouffeteau, Alexia Deleu, Pierre Nabokoff, Janine Cossy, Christophe Len
Summary: A mild and efficient continuous-flow catalytic reductive alkylation method for methanol has been developed, which can produce high yields of O-methyl ethers and tolyl derivatives using a Pd/C catalyst under certain temperature and pressure conditions, providing an effective synthetic route for organic compounds.
MOLECULAR CATALYSIS
(2022)
Article
Chemistry, Multidisciplinary
Anitha Muralidhara, Ed De Jong, Hendrikus (Roy) A. Visser, Gert-Jan M. Gruter, Christophe Len, Jean-Pierre Bertrand, Guy Marlair
Summary: This paper focuses on the safety aspects of the YXY process for the production of furandicarboxylic acid (FDCA) and polyethylene furanoate (PEF). The results indicate that FDCA has a better safety margin than other furanic compounds, while PEF exhibits slightly better energy release and combustion completeness compared to bulk polyester PET.
Article
Chemistry, Multidisciplinary
Aurore Richel, Pedro Maireles-Torres, Christophe Len
Summary: This report outlines recent advances in reducing furfural to high-value chemicals, with a focus on biobased chemicals such as furfuryl alcohol, tetrahydrofurfuryl alcohol, 2-methylfuran, and 2-methyltetrahydrofuran.
CURRENT OPINION IN GREEN AND SUSTAINABLE CHEMISTRY
(2022)
Article
Chemistry, Organic
Xinxin Han, Xin Liu, Christophe Len, Le Liu, Dongdong Wang, Yinbin Zhang, Xin-Hua Duan, Mingyou Hu
Summary: A switchable synthesis method for the preparation of alcohols and ketones containing a CF2-OR scaffold using visible-light promotion is reported. The PDI catalysis method is characterized by its easy operation, broad substrate scopes, and the ability to switch between desired products without the need for transition metal catalysts. The addition or absence of a base plays a key role in controlling the synthesis of the major desired products.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Pouya Ghamari Kargar, Mohammad Mehdi Sadughi, Ashkan Bahadoran, Rahman S. Zabibah, Christophe Len
Summary: Recently, the green synthesis of metal nanoparticles using plant constituents and extracts has gained attention. In this study, Ag NP colloids were synthesized using Stevia plant leaf extracts and their performance as a catalyst was evaluated. The catalytic oxidation reaction carried out in deep eutectic mixtures showed high efficiency and selectivity in synthesizing the target molecule.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2023)
Review
Chemistry, Physical
Wissal Adhami, Aurore Richel, Christophe Len
Summary: The production of biobased furfural has been well-studied for a long time. Recently, the concepts of bioeconomy and circular economy have driven research towards improving production methods and exploring diverse applications. This review focuses on the recent advancements in furfural production from organic feedstocks rich in free sugars and/or polysaccharides.
MOLECULAR CATALYSIS
(2023)
Article
Chemistry, Multidisciplinary
Sabikeh Azimi, Muna S. Merza, Fatemeh Ghasemi, Hasan Ali Dhahi, Farid Baradarbarjastehbaf, Mehdi Moosavi, Pouya Ghamari Kargar, Christophe Len
Summary: In this study, small non-peptide molecules were synthesized to inhibit the major proteinase (Mpro) of SARS-CoV-2. The antiviral potential of imidazoline derivatives as inhibitors of (SARS-CoV-2) Mpro was evaluated using in-silico techniques. The results confirmed that these compounds interacted satisfactorily with the active site of the coronavirus and showed strong interactions with specific residues.
SUSTAINABLE CHEMISTRY AND PHARMACY
(2023)
Article
Chemistry, Organic
Xinxin Han, Xin Liu, Christophe Len, Le Liu, Dongdong Wang, Yinbin Zhang, Xin-Hua Duan, Mingyou Hu
Summary: A switchable synthesis method is developed for the production of alcohols and ketones with a CF2-OR scaffold using visible-light promotion. The PDI catalysis method is characterized by its simplicity, broad substrate scopes, and the ability to switch between desired products without the need for transition metal catalysts. The presence or absence of a base is crucial in controlling the synthesis of the major desired products.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Review
Chemistry, Multidisciplinary
Deyang Zhao, Ting Su, Christophe Len, Rafael Luque, Zhenglong Yang
Summary: This article provides a comprehensive review on the oxidative esterification of 5-Hydroxymethylfurfural (HMF) to furan-2,5-dimethylcarboxylate (FDMC), which is considered as a potential replacement for 2,5-furan dicarboxylic acid (FDCA) in bioplastics synthesis. The recent progress in various catalytic approaches, including the use of noble or non-noble metal catalysts in different reaction environments, is discussed. The continuous flow regime for FDMC preparation is also summarized. Furthermore, the perspective towards industrialization of HMF oxidative esterification to FDMC in a more sustainable, efficient, and economical way is proposed.