Article
Cell Biology
Emir Bozkurt, Heiko Dussmann, Manuela Salvucci, Brenton L. Cavanagh, Sandra Van Schaeybroeck, Daniel B. Longley, Seamus J. Martin, Jochen H. M. Prehn
Summary: The study reveals that TRAIL signaling not only activates apoptosis in colon cancer cells but also induces entosis through TRAIL receptors and the structural presence of caspase-8. The association of TRAIL signaling with cell-in-cell structures is significant in colorectal cancer, especially in the context of patient prognosis. Factors controlling entosis in tumors remain to be elucidated despite the evidence of entosis in cancers.
JOURNAL OF CELL BIOLOGY
(2021)
Article
Cell Biology
Li-hao Zhao, Quan Li, Zhi-Jun Huang, Mi-Xue Sun, Jing-jing Lu, Xiao-hua Zhang, Gang Li, Fang Wu
Summary: NSD2 plays an oncogenic role in CRC by regulating H3K36me2 and the expression of multiple oncogenes, making it a promising therapeutic target.
CELL DEATH & DISEASE
(2021)
Article
Chemistry, Medicinal
Xingchen Liu, Cheng Wang, Shang Li, Lailiang Qu, Fucheng Yin, Dehua Lu, Heng Luo, Xinye Chen, Zhongwen Luo, Ningjie Cui, Xiaobing Wang, Lingyi Kong
Summary: In this study, a potential drug candidate 29e for treating CRC was designed to inhibit tumor growth by targeting PKM2 kinase, demonstrating significant antiproliferative effects in cell experiments and animal models.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Engineering, Biomedical
Euni Cho, Seok-Jun Mun, Minha Jeon, Hyo Keun Kim, Hwira Baek, Yu Seong Ham, Woo Jin Gil, Jin Woong Kim, Chul-Su Yang
Summary: Combination therapy using a liposomal delivery system containing anticancer phytochemicals shows promise for targeted treatment of colorectal cancer.
MATERIALS TODAY BIO
(2023)
Article
Integrative & Complementary Medicine
Juan-ni Zeng, Jin-yu Tan, Li Mo
Summary: This study investigated the therapeutic effect of naringin on colorectal cancer (CRC) and the related mechanism. The results showed that naringin could inhibit cell proliferation and promote apoptosis of CRC cells, as well as suppress cell migration. In vivo experiments also demonstrated its inhibitory effect on tumor growth with good bio-compatibility.
CHINESE JOURNAL OF INTEGRATIVE MEDICINE
(2023)
Article
Oncology
Premila D. Leiphrakpam, Audrey J. Lazenby, Lynette M. Smith, Michael G. Brattain, Chandrakanth Are
Summary: The study revealed a correlation between high stathmin expression and CRC metastasis as well as worse prognosis, along with increased cell proliferation. These findings suggest stathmin as a potential marker for increased risk and treatment in CRC patients.
JOURNAL OF SURGICAL ONCOLOGY
(2021)
Review
Oncology
Emer O'Connell, Ian S. Reynolds, Deborah A. McNamara, John P. Burke, Jochen H. M. Prehn
Summary: Mucinous colorectal cancer is characterized by abundant production of mucin glycoprotein and resistance to cell death. It is estimated to occur in 10-15% of colorectal cancer cases and is associated with a poor prognosis. The mechanisms of resistance to cell death in mucinous colorectal cancer involve altered expression of genes related to chemotherapy metabolism and cell survival signaling.
Article
Multidisciplinary Sciences
Tamuro Hayama, Kotaro Hama, Tsuyoshi Ozawa, Yuko Fujiwara, Keijiro Nozawa, Keiji Matsuda, Kazuaki Yokoyama, Yojiro Hashiguchi, Hiroki Ochiai, Takeyuki Misawa, Takeo Fukagawa
Summary: This study explores the association between sphingolipid metabolism, genetic variations, and clinicopathological factors in colorectal cancer (CRC). By examining the expression levels of genes related to sphingolipid metabolism, the researchers found that CERS4 expression was significantly reduced in CRC with KRAS gene mutation, and high CERS4 expression was more common in colorectal cancer patients with vascular invasion.
SCIENTIFIC REPORTS
(2023)
Article
Pharmacology & Pharmacy
Shican Zhou, Hang Wu, Wenjuan Ning, Xiao Wu, Xiaoxiao Xu, Yuanqiao Ma, Xingwang Li, Junhong Hu, Chenyu Wang, Junpeng Wang
Summary: Ivermectin inhibits colorectal cancer cell growth by promoting ROS-mediated mitochondrial apoptosis pathway and inducing S phase arrest, suggesting its potential as a novel anticancer drug therapy for human colorectal cancer and other cancers.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jinyu Shi, Li Zhou, Hui-Si Huang, Liyuan Peng, Na Xie, Edouard Nice, Li Fu, Cen Jiang, Canhua Huang
Summary: This study reveals that oxiconazole exhibits anti-tumor effect against colorectal cancer (CRC) by inducing autophagy arrest and subsequent apoptosis. Mechanistically, oxiconazole downregulates the antioxidant enzyme peroxiredoxin-2 (PRDX2) to initiate autophagy, leading to growth suppression of CRC cells. The combination of oxiconazole and oxaliplatin achieves an improved anti-tumor effect.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Food Science & Technology
Man Ding, Xuechen Zhang, Jiangying Shi, Kaili Cui, Ruipeng Yang, Fengming Liu, Shuhua Shan, Ghani Israr, Zhuoyu Li
Summary: In this study, quinoa bran was used as the raw material, and active components with anti-colorectal cancer effect were extracted and identified as terpenoids. The results showed that the quinoa bran terpenoids significantly inhibited the proliferation of colorectal cancer cells and repressed tumor growth in mice, indicating great potential for anti-tumor progression.
Article
Oncology
Jeeshan Jiffry, Thongthai Thavornwatanayong, Devika Rao, Elisha J. Fogel, Durvanand Saytoo, Rishika Nahata, Hillary Guzik, Imran Chaudhary, Titto Augustine, Sanjay Goel, Radhashree Maitra
Summary: The study revealed that Pelareorep can enhance its propagation and oncolytic effect in colorectal cancer cells by regulating autophagy-related genes and proteins.
CLINICAL CANCER RESEARCH
(2021)
Article
Cell Biology
Yuying Han, Xiaoliang Gao, Nan Wu, Yirong Jin, He Zhou, Weijie Wang, Hao Liu, Yi Chu, Jiayi Cao, Mingzuo Jiang, Suzhen Yang, Yanting Shi, Xin Xie, Fulin Chen, Ying Han, Wen Qin, Bing Xu, Jie Liang
Summary: Ferroptosis, a regulated cell death induced by iron-dependent lipid peroxidation, is important in tumor development and drug resistance. In this study, we found that LINC00239 is significantly overexpressed in colorectal cancer (CRC) tissues and its high expression predicts poorer survival and prognosis in CRC patients. We also demonstrated that LINC00239 inhibits ferroptosis, decreasing the anti-tumor activity of certain drugs. Importantly, LINC00239 interacts with Keap1 to regulate ferroptosis, suggesting a potential therapeutic strategy for CRC patients with low LINC00239 expression.
CELL DEATH & DISEASE
(2022)
Article
Immunology
Maryam Keshtvarz, Ehsan Rezaei, Jafar Amani, Mohammad Reza Pourmand, Jafar Salimian, Sheila Sarial, Masoumeh Douraghi
Summary: Immunotoxins, a type of targeted therapy, can kill cells using highly potent bacterial, fungal or plant toxins. In this study, a Stx-based immunotoxin was designed and used to selectively induce cytotoxicity and apoptosis in Fn-14-positive cells related to colon and lung cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Medicine, Research & Experimental
Feng Wei, Qing Nian, Maoyuan Zhao, Yueqiang Wen, Yi Yang, Jundong Wang, Zhelin He, Xiaoyan Chen, Xiang Yin, Jian Wang, Xiao Ma, Yu Chen, Peimin Feng, Jinhao Zeng
Summary: Research has found that many natural products can suppress the progression, metastasis, and invasion of colorectal cancer by targeting mitochondria. These natural products inhibit the mitochondrial respiratory chain, increase ROS, and disrupt mitochondrial membrane potential. They also induce cell apoptosis by targeting mitochondria through various apoptotic signaling pathways. Natural products with low toxicity, high efficacy, and multi-targeted properties have great potential for overcoming the challenges of colorectal cancer therapy.
BIOMEDICINE & PHARMACOTHERAPY
(2023)