Article
Biochemistry & Molecular Biology
Emilia P. T. Leitao, Osvaldo S. Ascenso, Tania Santos de Almeida, Ignacio Gonzalez, Inmaculada Hernandez, Jose Quintana, Francisco Estevez, Patricia Rijo
Summary: A series of hydroxylated chalcone derivatives with different substitution patterns were prepared, and it was found that the naphthylchalcone containing a methoxy group in position 6 ' of the A ring exhibited the highest cytotoxicity against human leukaemia cells.
BIOORGANIC CHEMISTRY
(2021)
Article
Chemistry, Medicinal
Dorota Olender, Malgorzata Jozkowiak, Hanna Piotrowska-Kempisty, Katarzyna Sowa-Kasprzak, Lucjusz Zaprutko, Izabela Muszalska-Kolos, Ewa Baranowska-Wojcik, Dominik Szwajgier
Summary: The study aimed to design and synthesize a series of curcuminoid chalcone-NSAID hybrid derivatives and evaluate their biological activity and stability. The results showed that some curcuminoid chalcone derivatives exhibited promising neuroprotective activity and could be used effectively for sonodynamic therapy. Additionally, these hybrid compounds were found to be unstable in acidic and neutral environments, with extreme instability in acidic conditions.
Article
Chemistry, Inorganic & Nuclear
Harshal Dabhane, Suresh Ghotekar, Manohar Zate, Sagar Kute, Ghanshyam Jadhav, Vijay Medhane
Summary: Nanotechnology offers a method for synthesizing nanoparticles, while green plant extract synthesis methods have been successfully applied to overcome environmental issues. The study demonstrates a simple, efficient, inexpensive, and environmentally friendly approach to produce magnesium oxide nanoparticles.
INORGANIC CHEMISTRY COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Laurene Minsat, Cedric Peyrot, Fanny Brunissen, Jean-Hugues Renault, Florent Allais
Summary: A series of phloretin analogs were synthesized through a green method, showing potential higher activity than phloretin itself, with some molecules demonstrating lower EC50 values than phloretin.
Review
Chemistry, Organic
Yogesh Murti, Devender Pathak, Kamla Pathak
Summary: Flavonoids are a diverse family of aromatic compounds in nature with reported biological activities, making them potential targets for nutraceuticals and pharmaceuticals. Green Chemistry advancements have enabled eco-friendly synthesis of chalcones, a precursor to flavonoids, reducing hazards to human health and the environment. Bulk production of various flavonoids using green chemistry techniques has been successfully achieved in the pharmaceutical field.
CURRENT ORGANIC CHEMISTRY
(2021)
Review
Chemistry, Medicinal
Rui Pereira, Artur M. S. Silva, Daniela Ribeiro, Vera L. M. Silva, Eduarda Fernandes
Summary: This review article provides an overview of the chemical structure, chemical properties, and synthesis methods of bis-chalcones. It also emphasizes the anti-inflammatory activity of bis-chalcones and their mechanisms of action.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Organic
Anju K. Sasidharan, Jomon Mathew, Ammathnadu S. Achalkumar, Manoj Mathews
Summary: This study focuses on the synthesis and liquid crystalline properties of low molecular weight bis-chalcone compounds derived from acetone, cyclopentanone, and cyclohexanone cores. The results show that compounds with octyloxy chains at the para position on either side of the dibenzylidine ring exhibit liquid crystalline behavior, while acetone-based compounds do not. The structure-liquid crystalline property relationship is explained through structural analysis and calculations. A preliminary study on the fluorescence property of a selected compound is also conducted.
CURRENT ORGANIC SYNTHESIS
(2022)
Article
Chemistry, Medicinal
Daniel Insuasty, Stephanie Garcia, Rodrigo Abonia, Braulio Insuasty, Jairo Quiroga, Manuel Nogueras, Justo Cobo, Gabriela L. Borosky, Kenneth K. Laali
Summary: A series of quinoline-based compounds were synthesized and evaluated for their cytotoxic activity against cancer cells, with two compounds showing promising anticancer effects with lower GI(50) values than reference drugs. Docking studies revealed strong binding energies in proteins involved in key carcinogenic pathways.
ARCHIV DER PHARMAZIE
(2021)
Article
Chemistry, Multidisciplinary
M. Fatih Polat, Derya Aktas Anil, Gizem Ozkemahli, Burcin Turkmenoglu, Ceylan Hepokur, Serdar Burmaoglu, Oztekin Algul
Summary: A novel series of trimethoxy chalcones with CF3 or F substituents at different positions of ring B were designed and synthesized. These compounds were characterized using IR, NMR spectral data, and elemental analyses. Their cytotoxicity against A549, HEPG2, MCF7, and L929 cells was evaluated, and compound 13 showed the highest activity and induced cell cycle arrest at the G0/G1 phase in MCF7 cells. The apoptotic mechanisms of compound 13 involving Bax, Bcl-2, and p53 were also investigated, along with their effects on human EGFR and VEGFR-2 receptors.
Article
Energy & Fuels
Ping An, Jian Shi, Yuxin Wang, Zizhen Yan, Jiaxiang Hou, Guangwen Xu, Haiming Yu, Lei Shi
Summary: Various strongly basic ionic liquids were synthesized using hydroxyethoxy anion from ethylene glycol. The alkalinity of these liquids was equivalent to sodium methoxide and they exhibited good catalytic performance in transesterification reactions. By comparing with reported catalysts, the reaction mechanism was deduced and the activation energies were determined. A new catalyst circulation process without introducing impurities was proposed and verified.
Article
Chemistry, Organic
Svetlana A. Popova, Evgeniya V. Pavlova, Irina Yu. Chukicheva
Summary: In this study, a series of new methoxychalcone derivatives with an isobornyl fragment in ring A were synthesized via the Claisen-Schmidt condensation of O-allylated 2,4-dihydroxy-5-isobornylacetophenone with different methoxybenzaldehydes.
Article
Chemistry, Medicinal
Bathelemy Ngameni, Kamdoum Cedric, Armelle T. Mbaveng, Musa Erdogan, Ingrid Simo, Victor Kuete, Arif Dastan
Summary: A new series of O-substituted chalcone derivatives with different substituents were designed, synthesized, and characterized, showing promising cytotoxic effects against leukemia and colon adenocarcinoma cells in preliminary cytotoxicity tests.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2021)
Article
Biochemistry & Molecular Biology
Miraj Fatima, Samina Aslam, Ansa Madeeha Zafar, Ali Irfan, Misbahul Ain Khan, Muhammad Ashraf, Shah Faisal, Sobia Noreen, Gamal A. Shazly, Bakht Ramin Shah, Yousef A. Bin Jardan
Summary: This research focuses on the synthesis of furan chalcone compounds and their potential for inhibiting bacterial urease enzyme. The results show that these compounds exhibit promising urease inhibition activity, with 1-phenyl-3-[5-(2,5-dichlorophenyl)-2-furyl]-2-propen-1-one and 1-phenyl-3-[5-(2'-chlorophenyl)-2-furyl] -2-propen-1-one displaying the highest activity.
Article
Chemistry, Physical
Hamza Annath, Jinesh C. Manayil, Jillian Thompson, Andrew C. Marr, Robert Raja
Summary: A comparative study of catalytic active sites in amorphous and crystalline aluminophosphates and their iron-containing analogues revealed that secondary porosity generated via soft templating and large mesopores significantly improve mass-transport and conversion of carbonyls. The active acidic sites play a crucial role in activating carbonyl groups and enhancing catalytic performance. Amorphous aluminophosphate (5) showed promising potential in industrial and pharmaceutical applications, outperforming hierarchical porous FeAlPO-5.
APPLIED CATALYSIS A-GENERAL
(2021)
Article
Biochemistry & Molecular Biology
Arminas Urbonavicius, Graziana Fortunato, Emilija Ambrazaityte, Elena Plytninkiene, Aurimas Bieliauskas, Vaida Milisiunaite, Renzo Luisi, Egle Arbaciauskiene, Sonata Krikstolaityte, Algirdas Sackus
Summary: An efficient synthetic route to diverse pyrazole-based chalcones from 1-phenyl-1H-pyrazol-3-ols with a formyl or acetyl group at the C4 position is described. Isomeric chalcones were further reacted to form 3,5-disubstituted 1,2-oxazoles via regioselective reaction with N-hydroxy-4-toluenesulfonamide. The novel compounds were characterized by in-depth NMR spectroscopy analysis.
