Review
Biochemistry & Molecular Biology
Eugenia Gkaliagkousi, Antonios Lazaridis, Soner Dogan, Emil Fraenkel, Bilge Guvenc Tuna, Ioana Mozos, Milica Vukicevic, Ozlem Yalcin, Kristina Gopcevic
Summary: Vascular aging, characterized by structural and functional changes in the vascular wall, is a significant marker of aging and is closely associated with cardiovascular mortality and age-related vascular pathologies. Understanding the molecular mechanisms involved in vascular aging could provide new insights into the complex biology of this irreversible process and guide future interventions to improve longevity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Yue Wang, Hong-feng Jiang, Hai-ming Dang, Meng-ru Liu, Xin-yan Liu, Yang Yu, Jiang Xie, Xiao-jun Zhan, Hui-na Zhang, Xiao-fan Wu
Summary: The study found that the selective beta 3 adrenergic receptor agonist mirabegron can protect against chronic intermittent hypoxia-induced atherosclerosis by reducing oxidative stress, providing a promising therapeutic strategy for preventing atherosclerosis.
CARDIOVASCULAR DRUGS AND THERAPY
(2022)
Review
Pharmacology & Pharmacy
Alexandra Ekman Ryding
Summary: Researchers working with startup Atrogi AB have developed a novel approach to target the 82 adrenergic receptors in diabetes, potentially paving the way for a new class of medications to address this common disease.
DRUG DISCOVERY TODAY
(2021)
Review
Biochemistry & Molecular Biology
Hongxing Zhang, Mengqiao Cui, Jun-Li Cao, Ming-Hu Han
Summary: This review article discusses the role of norepinephrine in the neurobiology of major depressive disorder (MDD) and highlights the beta-adrenergic receptor subtypes based on recent preclinical and clinical studies. It introduces a new therapeutic approach involving the beta-3 adrenergic receptor to enhance stress resilience and achieve antidepressant efficacy, which is conceptually different from traditional treatments that focus on reversing pathological alterations.
Article
Multidisciplinary Sciences
Xiaoyi Raymond Gao, Marion Chiariglione, Alexander J. Arch
Summary: This study identified novel rare-variant genes associated with intraocular pressure (IOP) and glaucoma, demonstrating the importance of including rare variants in gene discovery. Additionally, the study highlighted potential therapeutic targets for glaucoma, with some of the genes already being drug targets for clinical treatment or in clinical trials. The study also showed the significant association of a rare-variant polygenic risk score with glaucoma in independent participants.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Paola Matarrese, Sonia Maccari, Barbara Ascione, Rosa Vona, Vanessa Vezzi, Tonino Stati, Maria Cristina Gro, Giuseppe Marano, Caterina Ambrosio, Paola Molinari
Summary: This study found that beta-AR stimulation affects the proliferative activity of B16F10 cells by regulating cAMP levels. Additionally, alpha 2-AR agonists can inhibit cell proliferation, which is disrupted by the inhibitory effect of beta-AR agonists on alpha 2-AR. These findings suggest that the crosstalk between beta-AR and alpha 2-AR signaling pathways plays an important role in regulating melanoma proliferation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Minhyung Kim, Daniel T. Fisher, Paul N. Bogner, Umesh Sharma, Han Yu, Joseph J. Skitzki, Elizabeth A. Repasky
Summary: This study demonstrates that a safe beta(2)-adrenergic receptor agonist, terbutaline, can be used to mimic the natural immune suppression and reduce the dose of toxic immunosuppressive drugs required for vascularized composite tissue allotransplantation. This strategy shows promise for reducing the morbidity and mortality associated with the current immunosuppressive therapies.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Neurosciences
Danique R. Hutten, Jens H. J. Bos, Stijn de Vos, Eelko Hak
Summary: This retrospective inception cohort study found that exposure to non-selective beta AR antagonists may increase the risk of developing Alzheimer's disease in older adults, while exposure to selective beta 2AR agonists may decrease the risk.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Agriculture, Dairy & Animal Science
Jinhee H. Hwang, Michael E. Spurlock, John C. Kube, Xiang Z. Li, Stephen B. Smith
Summary: The study revealed that lubabegron fumarate is highly selective for the beta(3)-adrenergic receptor subtype and has minimal agonistic activity at the beta(2)-adrenergic receptor. Differences in mRNA expression levels of beta(1)-, beta(2)-, and beta(3)-AR were observed between subcutaneous and intramuscular adipose tissues. The response to beta-adrenergic ligands, especially agonists for the beta(1)- and beta(3)-receptor subtypes, was found to be lower in intramuscular adipose tissue compared to subcutaneous adipose tissue.
JOURNAL OF ANIMAL SCIENCE
(2021)
Article
Anesthesiology
Larissa Staurengo-Ferrari, Paul G. Green, Dioneia Araldi, Luiz F. Ferrari, Christine Miaskowski, Jon D. Levine
Summary: This study found that stress has a significant impact on oxaliplatin-induced neuropathic pain, with clear gender differences in the role of the two major neuroendocrine stress axes. The findings demonstrate the importance of the neuroendocrine stress axes in CIPN and highlight the sexually dimorphic nature of the condition.
Article
Cell Biology
Jin-Sook Kwon, Eric W. Barr, J. Kurt Chuprun, Walter J. Koch
Summary: Stimulation of alpha- or beta-adrenergic receptors in mice led to changes in the content of circulating blood EVs, with differential expression patterns of miRs. Pathway analysis revealed common and distinct pathways affected by PE and ISO treatment, indicating regulation of specific pathways by alpha- or beta-AR agonists. This study suggests that chronic sympathetic nervous system activation in heart failure may alter the content of EVs secreted from the heart and other organs, potentially impacting pathological remodeling.
Review
Substance Abuse
Paul Vanderkam, Marcello Solinas, Isabelle Ingrand, Nicolas Doux, Soghra Ebrahimighavam, Nematollah Jaafari, Claire Lafay-Chebassier
Summary: The study found that alpha-2 agonists significantly increased smoking cessation rates, while beta-blockers had no significant effect on smoking cessation. Additionally, alpha-1 antagonists were effective in reducing alcohol consumption but did not impact abstinence or heavy drinking days.
Article
Biochemistry & Molecular Biology
Ruxu Zhai, Erika L. Varner, Ajay Rao, Sunil Karhadkar, Antonio Di Carlo, Nathaniel W. Snyder, Priscila Y. Sato
Summary: GRK2 is upregulated in heart failure and cardiac disease models, which reduces mitochondrial respiratory function and responses to beta-AR activation. Upregulation of GRK2 promotes palmitate-induced cell death and impairs ISO-mediated mitochondrial function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Wahiba Sifeddine, Saadia Ba-M'hamed, Marc Landry, Mohamed Bennis
Summary: This study investigated the effects of atomoxetine on ADHD-like symptoms and pain hypersensitivity. The results showed that chronic administration of atomoxetine significantly alleviated ADHD symptoms and attenuated pain responses, likely mediated by alpha- and beta-adrenergic and D2/D3 dopaminergic receptors. These findings suggest potential new indications for atomoxetine.
PHARMACOLOGICAL REPORTS
(2023)
Article
Pathology
Ryota Masuzaki, Kevin C. Ray, Joseph Roland, Roy Zent, Youngmin A. Lee, Seth J. Karp
Summary: The liver's diverse functions rely on a unique and complex microstructure, which is disrupted in fibrosis and cirrhosis. Integrin beta 1 plays a crucial role in maintaining liver architecture and regulating TGF-beta 1 secretion. Disrupting the interaction between hepatocytes and their extracellular matrix is sufficient to drive fibrosis.
AMERICAN JOURNAL OF PATHOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Feyza Alyu, Yusuf Olgar, Sinan Degirmenci, Belma Turan, Yusuf Ozturk
Summary: The study demonstrated the toxic effects of sibutramine on cardiovascular system, showing alterations in intracellular Ca2+, H+, and ROS levels, as well as the mechanical activity of isolated hearts. Acute sibutramine applications induced concentration-dependent changes in action potentials and potassium channel currents, leading to negative alterations in contractility and cardiac parameters. These findings have implications for clinical approaches and drug design studies.
CARDIOVASCULAR TOXICOLOGY
(2021)
Review
Cell Biology
Belma Turan, Erkan Tuncay
Summary: Mitochondria play a crucial role in maintaining cellular Zn2+ homeostasis and signaling in cardiomyocytes, affecting ROS production and redistribution of Zn2+ transporters under pathological conditions. Understanding the role of mitochondria in regulating Zn2+ levels may highlight the importance of new mitochondria-targeting agents for preventing and treating cardiovascular dysfunction in humans.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Correction
Cell Biology
Belma Turan, Erkan Tuncay
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Cardiac & Cardiovascular Systems
Hilmi Burak Kandilci, Mark A. Richards, Marjorie Fournier, Gul Simsek, Yu Jin Chung, Samira Lakhal-Littleton, Pawel Swietach
Summary: Fully-activated Na+/H+ exchanger-1 (NHE1) plays a crucial role in cardiomyocytes, and its activation is limited by metabolic resources, with hypoxia inhibiting NHE1 activity. The exchange of Na+ ions for H+ ions by NHE1 is energetically costly, and inhibition of NHE1 under anoxic conditions is associated with phosphorylation changes in specific tyrosine residues. Studies in vitro and in vivo support the hypothesis that NHE1 responds to oxygen levels, potentially redirecting ATP for contraction in the heart.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Diana Bou-Teen, Nina Kaludercic, David Weissman, Belma Turan, Christoph Maack, Fabio Di Lisa, Marisol Ruiz-Meana
Summary: Excessive mitochondrial ROS production is linked to aging-related heart pathologies, but also serves as a fundamental function in orchestrating signaling pathways that have cardioprotective effects. Mitochondria in cardiac myocytes are abundant and specialized in subcellular populations, with interactions with other organelles influencing their function.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Cell Biology
Yusuf Olgar, Aysegul Durak, Sinan Degirmenci, Erkan Tuncay, Deniz Billur, Semir Ozdemir, Belma Turan
Summary: The study showed that treatment with Tica reversed alterations in ventricular cardiomyocytes from MetS rats, affecting sarcolemmal ion-channel activities, cytosolic Ca2+ levels, and mitochondria structure and function, while also preventing ER stress and mitochondrial dysfunction.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Cell Biology
Deniz Billur, Yusuf Olgar, Belma Turan
Summary: This study demonstrated a correlation between long-QT and connexin 43 (Cx43) status and localization in elderly rats, showing the important role of insulin resistance (I-R), ischemia-reperfusion, aging, and heart dysfunction. Alterations in Cx43 protein level and localizations in aging heart were found to lead to abnormal ventricular repolarization in I-R heart.
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
(2022)
Article
Cell Biology
Hilmi Burak Kandilci, Gul Simsek, Tugba Zirapli, Mustafa Celebier
Summary: Iron deficiency is closely associated with mitochondrial dysfunction in heart failure patients. Iron plays a role as a structural component in mitochondria and also as a cofactor for the degradation of hypoxia inducible factor. This study used HL-1 cells to investigate the effects of iron depletion on mitochondrial function and reveal the mechanisms leading to cardiac failure.
Article
Cell Biology
Belma Turan, Aysegul Durak, Yusuf Olgar, Erkan Tuncay
Summary: Recent studies suggest that hyperglycemia has a lesser contribution to cardiovascular disease (CVD) compared to impaired glucose tolerance. Glucose intolerance appears to be the biggest risk factor for CVD in individuals with insulin resistance. Abnormal insulin signaling is linked to heart dysfunction in diabetics, as well as cardiac insulin resistance in age-related heart failure (HF). Furthermore, HF is associated with generalized insulin resistance. Clinical outcomes and experimental data show that antihyperglycemic drugs have beneficial effects on the cardiovascular system beyond their ability to lower blood glucose levels, including direct effects on the myocardium. New-class drugs like glucagon-like peptide 1 receptor agonists (GLP-1Ra) and sodium-glucose cotransport 2 inhibitors (SGLT2i) can improve cardiac health. However, there are still many unanswered questions about their therapeutic effects on cardiomyocytes in heart failure, despite various cellular-level studies. Comparative studies on SGLT2i versus GLP-1Ra in patients with and without CVD, as well as with or without hyperglycemia, are also important areas of research.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Aysegul Durak, Belma Turan
Summary: This study demonstrates that the GLP-1R agonist liraglutide has cardioprotective effects in aging hearts by improving cardiovascular dysfunction, blood pressure, and oxidative stress parameters. It also normalizes ion channel and Ca2+ regulation in cardiomyocytes. Furthermore, liraglutide promotes mitochondrial function, reduces ROS and RNS levels, and inhibits oxidative stress-induced injury via the IRS1-eNOS-PKG pathway.
JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Cell Biology
Erkan Tuncay, Ivan Gando, Jian-Yi Huo, Gautham Yepuri, Natalie Sampler, Belma Turan, Hua-Qian Yang, Ravichandran Ramasamy, William A. Coetzee
Summary: Sirtuins are beneficial NAD+-dependent deacetylases that play roles in various human health conditions. In this study, researchers investigated the regulation of ATP-sensitive K+ (KATP) channels by sirtuins. They found that increasing NAD+ levels and activating sirtuins led to an increase in KATP channel current and surface expression. This finding has implications for cardiac protection against ischemic damage.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Article
Cell Biology
Irem Aktay, Ceylan Verda Bitirim, Yusuf Olgar, Aysegul Durak, Erkan Tuncay, Deniz Billur, Kamil Can Akcali, Belma Turan
Summary: A study found that the magnolia bark extract MAHOC has a protective effect against doxorubicin-induced heart dysfunction, improving heart function, myocardial structure, and redox regulation. The results suggest that MAHOC may serve as a beneficial adjunct to conventional therapies in chronic heart diseases.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Erkan Tuncay, Irem Aktay, Belma Turan
Summary: This study demonstrates the important regulatory role of high expression of ZnT7-OE in cardiomyocytes on [Zn2+]i, [Zn2+]Mit, and [Ca2+]Mit, affecting mitochondrial function in part through histone modification.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Deniz Billur, Yusuf Olgar, Aysegul Durak, Ayse Hande Yozgat, Simge Unay, Erkan Tuncay, Belma Turan
Summary: Cardiac conduction abnormalities in metabolic syndrome (MetS) involve a complex interplay between cardiomyocytes and nonmyocytes. This study reveals that early-stage MetS hearts undergo significant electrical and structural changes, characterized by short QT intervals on electrocardiograms. These changes are influenced by factors such as increased intercellular interactions between nonmyocytes and cardiomyocytes, as well as altered expression and localization of connexin 43. The findings provide valuable insights into the mechanisms underlying cardiac remodeling in MetS and highlight the importance of nonmyocyte cells in electrical conduction.
CELL BIOCHEMISTRY AND FUNCTION
(2023)
Meeting Abstract
Pharmacology & Pharmacy
Gul Simsek, Hilmi Burak Kandilci
BRITISH JOURNAL OF PHARMACOLOGY
(2023)