Review
Nutrition & Dietetics
Li Cai, Gaoming Wang, Peijun Zhang, Xinyi Hu, Hao Zhang, Fan Wang, Yeqing Tong
Summary: Inflammatory responses are highly associated with the progression of various lung diseases, and vitamin D has the potential to modulate immune functions and induce inflammatory responses, making it a potential adjunctive therapy for the prevention and treatment of lung diseases. This paper reviews the role of vitamin D in tuberculosis and suggests its potential as a safe adjunctive therapy, providing motivation for further research and clinical applications.
FRONTIERS IN NUTRITION
(2022)
Article
Geriatrics & Gerontology
Y. Zhang, Y. Li, J. Liu, X. Wei, N. Tan, J. Zhang, Wei Wang, Yong Wang
Summary: This meta-analysis found no significant effects of vitamin D or calcium supplementation on all-cause mortality, cardiovascular mortality, MACEs, and myocardial infarction among community-dwelling adults.
JOURNAL OF NUTRITION HEALTH & AGING
(2021)
Review
Nutrition & Dietetics
Stephanie Marie Cruz-Pierard, Teresa Nestares, Francisco J. Amaro-Gahete
Summary: Vitamin D supplementation has a protective effect in the prevention and treatment of CRC, while calcium intake shows contradictory effects and further studies are needed to understand its relevance in patients with CRC.
Article
Public, Environmental & Occupational Health
Narges Zandieh, Mohsen Rezaei Hemami, Ali Darvishi, Seyed Mohammad Hasheminejad, Zahra Abdollahi, Maryam Zarei, Ramin Heshmat
Summary: The study found that vitamin D supplementation is cost-effective in preventing cardiovascular diseases in adolescents, with lower costs compared to CVD treatments. Therefore, implementing a vitamin D supplementation program can help reduce the risk of CVD in adulthood from an economic perspective.
Article
Nutrition & Dietetics
Man Hung, Wendy C. Birmingham, Monica Ocampo, Amir Mohajeri
Summary: Cardiovascular diseases (CVD) are the leading cause of death in the United States. This study aimed to determine the association between reported CVD and serum 25-hydroxyvitamin D [25(OH)D]. Using data from the National Health and Nutrition Examination Survey, the study found that deficiency and insufficiency of 25(OH)D were associated with CVD, while adequacy of 25(OH)D was not. Healthcare professionals may consider vitamin D supplementation to improve cardiovascular health in adults for CVD prevention.
Article
Endocrinology & Metabolism
Fei-Long Wei, Tian Li, Quan-You Gao, Yuli Huang, Cheng-Pei Zhou, Wen Wang, Ji-Xian Qian
Summary: This study concluded that daily doses of 700 IU to 2000 IU of supplemental vitamin D were associated with a lower risk of falls among ambulatory and institutionalized older adults. High-dose vitamin D was effective in preventing falls, while low-dose vitamin D showed no significant effect. The preventive effect of vitamin D on falls was influenced by supplemental calcium, concentration, and frequency.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Pharmacology & Pharmacy
Laszlo Horvath, Sara Mirani, Michael Magdy Fahmy Girgis, Szilvia Racz, Ildiko Bacskay, Harjit Pal Bhattoa, Bela E. Toth
Summary: This study aimed to examine the vitD status of patients, explore the relationship between vitD deficiency and certain diseases, assess seasonality and trends, and reveal the indirect impact of the COVID-19 pandemic on vitD(3) supplementation at the population level. The results showed that 20% of all patients had hypovitaminosis D and males had higher odds for hypovitaminosis or vitD deficiency. VitD consumption exhibited seasonality, with higher consumption in autumn and winter. The findings highlight the importance of vitD(3) supplementation for at-risk groups and health education promoting vitamin D-3 supplementation.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Zsuzsanna Putz, Dora Tordai, Noemi Hajdu, Orsolya Erzsebet Vagi, Miklos Kempler, Magdolna Bekeffy, Anna Erzsebet Korei, Ildiko Istenes, Viktor Horvath, Anca Pantea Stoian, Manfredi Rizzo, Nikolaos Papanas, Peter Kempler
Summary: This review summarizes the role of vitamin D in diabetic neuropathy and the latest data on its treatment. Studies suggest that vitamin D deficiency is associated with peripheral neuropathy, diabetic foot ulcers, and cardiac autonomic neuropathy in diabetes. Vitamin D supplementation may be an effective adjunctive therapy for neuropathic pain and can potentially slow down the progression of neural damage.
CLINICAL THERAPEUTICS
(2022)
Review
Nutrition & Dietetics
Ana Palanca, Francisco Javier Ampudia-Blasco, Jose T. Real
Summary: Thyroid cancer is increasing in incidence and vitamin D may have a role in its prevention. However, the exact role of vitamin D in thyroid cancer development is controversial. Some studies suggest elevated serum vitamin D levels have a protective role, while others show no inverse relationship with the occurrence of thyroid cancer. Circulating vitamin D concentration is inversely correlated with disease aggressiveness and poor prognosis.
Article
Nutrition & Dietetics
Jiahao Meng, Xi Li, Weijie Liu, Yifan Xiao, Hang Tang, Yumei Wu, Yilin Xiong, Shuguang Gao
Summary: Vitamin D supplementation may have some beneficial impact on the prevention and treatment of SARS-CoV-2 infection, particularly in patients with vitamin D deficiency. However, further studies are needed to confirm these findings.
CLINICAL NUTRITION
(2023)
Article
Multidisciplinary Sciences
Ganesh Jevalikar, Ambrish Mithal, Anshu Singh, Rutuja Sharma, Khalid J. Farooqui, Shama Mahendru, Arun Dewan, Sandeep Budhiraja
Summary: The study found that there was no significant difference in clinical outcomes or mortality between COVID-19 hospitalized patients with Vitamin D deficiency (VDD) and those without VDD, and serum 25-OHD levels did not correlate with inflammatory markers. Treatment with cholecalciferol for VDD did not impact outcomes.
SCIENTIFIC REPORTS
(2021)
Article
Nutrition & Dietetics
Yuxiong Chen, Siqin Feng, Zhen'ge Chang, Yakun Zhao, Yanbo Liu, Jia Fu, Yijie Liu, Siqi Tang, Yitao Han, Shuyang Zhang, Zhongjie Fan
Summary: This study examined the association between serum vitamin D levels and mortality in patients with nonalcoholic fatty liver disease (NAFLD), finding that higher levels of 25(OH)D were independently associated with reduced risk of all-cause and cardiovascular deaths.
Article
Nutrition & Dietetics
Verena Theiler-Schwetz, Christian Trummer, Martin R. Grubler, Martin H. Keppel, Armin Zittermann, Andreas Tomaschitz, Spyridon N. Karras, Winfried Marz, Stefan Pilz, Stephanie Gangler
Summary: This post hoc analysis investigated the effects of vitamin D on blood pressure and found that vitamin D supplementation did not have an antihypertensive effect in individuals with vitamin D deficiency. However, there was a significant association between achieved 25(OH)D concentrations and blood pressure.
Review
Biochemistry & Molecular Biology
Zsuzsanna Nemeth, Attila Patonai, Laura Simon-Szabo, Istvan Takacs
Summary: The prevention and control of non-communicable diseases, especially in the aging population, is crucial for healthcare sustainability. Adequate lifestyle changes and regulation of vitamin D and SIRT1 play a significant role in reducing mortality and improving quality of life.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
M. Lombardo, A. Vigezzi, G. Ietto, C. Franchi, V Iori, F. Masci, A. Scorza, S. Macchi, D. Iovino, C. Parise, G. Carcano
Summary: Patients with melanoma have lower VDSL levels compared to the healthy population, which may be linked to the risk of developing melanoma. Research showed a correlation between low VDSL and thick tumor depth and high mitotic rate in melanoma cases.
SCIENTIFIC REPORTS
(2021)
Review
Geriatrics & Gerontology
Lorna Caulfield, Philip Heslop, Katherine E. Walesby, Deepa Sumukadas, Avan A. Sayer, Miles D. Witham
Summary: The current evidence does not support the use of ACE inhibitors or angiotensin receptor blockers as a single intervention to improve physical performance in older people, based on a systematic review and meta-analysis of randomized controlled trials.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2021)
Article
Geriatrics & Gerontology
William J. Doherty, Thomas A. Stubbs, Andrew Chaplin, Mike R. Reed, Avan A. Sayer, Miles D. Witham, Antony K. Sorial
Summary: The study assessed the Nottingham Hip Fracture Score (NHFS) for prediction of mortality, physical function, length of stay, and postoperative complications, finding that NHFS performed consistently well in predicting functional outcomes, moderately in predicting mortality, but less well in predicting length of stay and complications.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2021)
Editorial Material
Geriatrics & Gerontology
Miles D. Witham, Adam L. Gordon, Emily J. Henderson, Rowan H. Harwood
Article
Urology & Nephrology
Elaine Rutherford, Sheila Ireland, Kenneth Mangion, Graham A. Stewart, Mark S. MacGregor, Giles Roditi, Rosemary Woodward, Stephen J. Gandy, J. Graeme Houston, Alan G. Jardine, Petra Rauchhaus, Miles D. Witham, Patrick B. Mark, Allan D. Struthers
Summary: In hemodialysis patients, 12 months of treatment with allopurinol did not regress LVMI. Allopurinol also showed no significant effects on blood pressure, flow-mediated dilation, augmentation indices, or pulse wave velocity.
KIDNEY INTERNATIONAL REPORTS
(2021)
Review
Health Care Sciences & Services
Rumana Newlands, Eilidh Duncan, Justin Presseau, Shaun Treweek, Louisa Lawrie, Peter Bower, Jim Elliott, Jill Francis, Graeme MacLennan, Margaret Ogden, Mary Wells, Miles D. Witham, Bridget Young, Katie Gillies
Summary: This study is the first to explore trial participants' accounts of trial retention informed by behavioral science. The findings will serve as a guiding framework when designing trials to limit barriers and enhance enablers of retention within clinical trials.
JOURNAL OF CLINICAL EPIDEMIOLOGY
(2021)
Editorial Material
Medicine, General & Internal
Mark J. Bolland, Alison Avenell, Karen Smith, Miles D. Witham, Andrew Grey
BMJ-BRITISH MEDICAL JOURNAL
(2021)
Article
Surgery
Jennifer S. Lees, Alastair J. Rankin, Keith A. Gillis, Luke Y. Zhu, Kenneth Mangion, Elaine Rutherford, Giles H. Roditi, Miles D. Witham, Donna Chantler, Maurizio Panarelli, Alan G. Jardine, Patrick B. Mark
Summary: In this study, vitamin K supplementation did not reduce vascular stiffness or calcification in KTR over 1 year. Improving vascular health in KTR is likely to require a multifaceted approach.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Medicine, General & Internal
Alisha N. Wade, Collin F. Payne, Lisa Berkman, Angela Chang, F. Xavier Gomez-Olive, Chodziwadziwa Kabudula, Kathleen Kahn, Joshua A. Salomon, Stephen Tollman, Miles Witham, Justine Davies
Summary: This study investigated the relationship between multimorbidity and mortality in an older, rural black South African population, finding that multimorbidity was associated with greater risk of death. HIV multimorbidity in men also showed an increased risk of death compared to non-HIV multimorbidity. Adjusting for frailty slightly attenuated the associations between multimorbidity and mortality risk in women, while slightly increasing the associations between HIV multimorbidity and mortality risk.
Review
Rehabilitation
Gavin Wylie, Thilo Kroll, Miles D. Witham, Jacqui Morris
Summary: This scoping review examined interventions to increase physical activity levels in older care home residents. The results showed that current interventions mainly focused on individual resident level factors, with little consideration for broader social and environmental aspects. The interventions were not fully described and lacked a clear theoretical foundation. Future interventions should address contextual care home factors and provide clear descriptions according to intervention description guidelines.
DISABILITY AND REHABILITATION
(2023)
Review
Geriatrics & Gerontology
Miles D. D. Witham, Antoneta Granic, Ewan Pearson, Sian M. M. Robinson, Avan A. A. Sayer
Summary: Sarcopenia, the age-related loss of muscle strength and mass, has common mechanisms with accelerated ageing seen in diabetes mellitus. Drugs used to treat type 2 diabetes mellitus may have relevance to the prevention and treatment of sarcopenia. Cellular and animal models suggest potential beneficial effects of diabetes drugs on skeletal muscle function, particularly metformin and SGLT2 inhibitors. Intervention studies are needed to investigate the balance of benefit and risk in older individuals with sarcopenia.
Article
Geriatrics & Gerontology
Thomas A. Stubbs, William J. Doherty, Andrew Chaplin, Sarah Langford, Mike R. Reed, Avan A. Sayer, Miles D. Witham, Antony K. Sorial
Summary: This study assessed the ability of pre-fracture mobility to predict post-operative outcomes in hip fracture patients. Patients with worse mobility had higher mortality, longer length of hospital stay, higher likelihood of living in a care home, and higher likelihood of complications. Including mobility assessment in risk scores can improve casemix adjustment and prognostication following hip fracture.
EUROPEAN GERIATRIC MEDICINE
(2023)
Letter
Cell Biology
Miles D. Witham, Rachel Cooper, Kelly A. Bowden A. Davies, Sandra Ortega-Martorell, Claire E. Stewart, Avan A. Sayer
Article
Medicine, General & Internal
Katherine J. Rennie, Miles Witham, Penny Bradley, Andrew Clegg, Stephen Connolly, Helen C. Hancock, Shaun Hiu, Leanne Marsay, Claire McDonald, Laura Robertson, Laura Simms, Alison J. Steel, Claire J. Steves, Bryony Storey, James Wason, Nina Wilson, Thomas von Zglinicki, Avan A. P. Sayer
Summary: This trial aims to investigate whether metformin can improve physical performance in older people with sarcopenia and physical frailty. Participants will receive oral treatment for 4 months and measurements will be taken at the end of the follow-up period. The results will be shared with relevant teams and the scientific community.
Article
Geriatrics & Gerontology
R. M. Dodds, P. Heslop, J. Jaffar, K. Davies, J. M. Noble, F. E. Shaw, M. D. Witham, A. A. Sayer
Summary: This study successfully implemented the Newcastle SarcScreen as part of outpatient care for older people. The assessment revealed a high prevalence of probable sarcopenia and the frailty phenotype in all age groups.
EUROPEAN GERIATRIC MEDICINE
(2022)
Article
Geriatrics & Gerontology
George Smith, Alison Avenell, Margaret M. Band, Geeta Hampson, Edmund J. Lamb, Roberta C. Littleford, Paul McNamee, Roy L. Soiza, Deepa Sumukadas, Miles D. Witham
Summary: Our study found that biochemical markers associated with chronic kidney disease did not consistently correlate with baseline physical performance or changes in physical performance over time in older patients. Targeting improvements in renal biochemistry may not be an effective way to improve physical function and frailty in this population.
EUROPEAN GERIATRIC MEDICINE
(2021)
