Review
Medicine, Research & Experimental
Xiafeng Peng, Shixin Wang, Hongwu Chen, Minglong Chen
Summary: Ischemic heart disease (IHD) is a prevalent cardiovascular disease characterized by the formation, progression and rupture of atherosclerotic plaque. Notch1 signaling plays a significant role in IHD development, including endothelial cells, vascular smooth muscle cells, and macrophages. This review also highlights the effects of Notch1 signaling on various remodeling stages of IHD and its potential in enhancing treatment efficacy for patients with IHD.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2023)
Review
Neurosciences
Shashank Vishwanath Adhikarla, Niraj Kumar Jha, Vineet Kumar Goswami, Ankur Sharma, Anuradha Bhardwaj, Abhijit Dey, Chiara Villa, Yatender Kumar, Saurabh Kumar Jha
Summary: Toll-like receptors (TLRs) are a special class of proteins that connect the innate immune system to the adaptive immune system, with 10 different TLRs identified in human beings. They are found in the central nervous system, breaking the belief of the brain's immune privilege due to the blood-brain barrier. TLRs play roles in producing proinflammatory agents and participating in neuronal cell death, with potential implications in neurodegenerative diseases like Parkinson's disease and Alzheimer's disease.
Article
Clinical Neurology
Wenbo Zhao, Derek J. Hausenloy, David C. Hess, Derek M. Yellon, Xunming Ji
Summary: Remote ischemic conditioning (RIC) has shown variable results in the treatment of cerebrovascular and cardiovascular disease. While milestone studies suggest limited roles for RIC in cardiovascular disease patients, recent large trials found promising results in cerebrovascular disease patients. This article discusses important clinical trials of RIC in cardio-cerebrovascular disease and highlights the challenges of clinical translation. It proposes several promising research directions that should be investigated before RIC can be applied in clinical practice.
Article
Pharmacology & Pharmacy
Asma Mohammed Alyahya
Summary: This article discusses the role of adipokines in cardiovascular disease and its related risk factors, finding that progranulin has both protective and inflammatory effects.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Wei Guo, Ximin Fan, Bradley R. Lewis, Matthew P. Johnson, Charanjit S. Rihal, Amir Lerman, Joerg Herrmann
Summary: This study found that cancer patients have a higher risk of stent thrombosis and myocardial infarction after PCI compared to noncancer patients, especially in the first year post-PCI. The dual antiplatelet therapy score is predictive of thrombotic and ischemic events in both groups, indicating the importance of this score in decision-making for antiplatelet therapy.
JACC-CARDIOVASCULAR INTERVENTIONS
(2021)
Review
Pharmacology & Pharmacy
Na An, Guoxia Zhang, Yingjian Li, Chao Yuan, Fan Yang, Lijing Zhang, Yonghong Gao, Yanwei Xing
Summary: This article summarizes the mechanisms of action of berberine (BBR) in the prevention and treatment of cardiovascular diseases (CVDs). Research has shown that BBR has various pharmacological effects, such as lowering blood sugar, reducing lipid levels, and exerting antioxidant activities. It can protect the myocardium and has therapeutic effects on coronary atherosclerosis, myocardial ischemia/reperfusion, arrhythmias, and heart failure.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Immunology
Zhiyang Li, Yan Ding, Yudong Peng, Jian Yu, Chengliang Pan, Yifan Cai, Qian Dong, Yucheng Zhong, Ruirui Zhu, Kunwu Yu, Qiutang Zeng
Summary: Macrophages play a crucial role in inflammation, heart protection, and tissue repair after myocardial ischemia and myocardial infarction. IL-38 can regulate macrophage inflammatory response, promote differentiation of M1 macrophages into M2 macrophages, and improve myocardial ischemia and ventricular remodeling.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Erij Messadi
Summary: Ischemic heart disease, particularly myocardial infarction, is a major cause of death worldwide. Snake venoms contain biologically active proteins and peptides that have potential therapeutic applications for treating ischemic heart disease and related conditions. This review discusses the mechanisms of action and therapeutic targets of snake venom toxins, as well as the current status of snake venom-derived drugs in clinical development.
Article
Cardiac & Cardiovascular Systems
Paul C. Tang, Jonathan W. Haft, Ienglam Lei, Zhong Wang, Y. Eugene Chen, Ashraf Abou El Ela, Xiaoting Wu, Bertram Pitt, Keith D. Aaronson, Francis D. Pagani
Summary: Compared to non-O donor hearts, transplantation with O donor hearts with ischemic time 4 hours or more leads to worse survival, with higher rates of primary graft dysfunction and chronic rejection.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Matthew A. Cavender, Robert A. Harrington, Gregg W. Stone, Ph Gabriel Steg, C. Michael Gibson, Christian W. Hamm, Matthew J. Price, Renato D. Lopes, Sergio Leonardi, Efthymios N. Deliargyris, Jayne Prats, Kenneth W. Mahaffey, Harvey D. White, Deepak L. Bhatt
Summary: In the CHAMPION PHOENIX trial, cangrelor demonstrated efficacy in reducing early events, which predominantly occurred within 2 hours of randomization. Cangrelor showed significant advantages over clopidogrel in reducing the primary composite endpoint and the secondary endpoint. Early bleeding events were infrequent and similar between cangrelor and clopidogrel.
CIRCULATION-CARDIOVASCULAR INTERVENTIONS
(2022)
Article
Immunology
Atefe Ghamar Talepoor, Banafsheh Rastegari, Mehdi Kalani, Mehrnoosh Doroudchi
Summary: The study found that Eritoran has an inhibitory effect on the production of cytokines induced by LPS, with a more significant effect on the inflammatory responses of PBMCs from patients with atherosclerosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Engineering, Biomedical
Xi Li, Wei Ou, Maodi Xie, Jing Yang, Qian Li, Tao Li
Summary: Myocardial ischemic/reperfusion injury is a global cardiovascular disease with high mortality and morbidity. Antioxidant therapy holds great promise against this condition. Nanoplatform-mediated drug delivery has significant advantages in myocardial ischemic therapy.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Biochemistry & Molecular Biology
Aydin Huseynov, Julius Reinhardt, Leonard Chandra, Daniel Duerschmied, Harald F. Langer
Summary: Platelets are crucial in cardiovascular disease and can be targeted for treatment. In addition to their role in thrombosis, platelets also play a role in vascular inflammation, tissue remodeling, and healing of vascular and tissue lesions. This review focuses on the functions and interactions of platelets and their potential relevance to translation and clinical application. The role of platelets in the development of atherosclerosis and therapeutic options for its prevention are discussed, as well as novel approaches to inhibit platelet function and the use of platelets in regenerative medicine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Annalisa Bosi, Davide Banfi, Michela Bistoletti, Lucia Martina Catizzone, Anna Maria Chiaravalli, Paola Moretto, Elisabetta Moro, Evgenia Karousou, Manuela Viola, Maria Cecilia Giron, Francesca Crema, Carlo Rossetti, Giorgio Binelli, Alberto Passi, Davide Vigetti, Cristina Giaroni, Andreina Baj
Summary: Intestinal ischemia and reperfusion injury leads to the overgrowth of harmful bacteria, increased neutrophil infiltration, upregulation of bacterial target receptors TLR2 and TLR4, and induction of a pro-inflammatory state. However, the activation of TLR2 and TLR4 may provide temporary benefits to the neuronal pathways underlying peristalsis.
Review
Chemistry, Medicinal
Syarifah Aisyah Syed Abd Halim, Norhashima Abd Rashid, Choy Ker Woon, Nahdia Afiifah Abdul Jalil
Summary: This scoping review summarizes the effects of natural products targeting PI3K/AKT in MIRI. The review identifies various natural compounds that reduce MIRI by regulating the PI3K/AKT signaling pathway. 14 research publications meeting the inclusion and exclusion criteria were shortlisted, demonstrating that natural products effectively improve cardiac functions through antioxidant regulation and apoptosis modulation. This review provides evidence supporting the potential of natural products in treating MIRI due to their diverse biological activities and drug-like properties.
