C-peptide replacement therapy as an emerging strategy for preventing diabetic vasculopathy

A review of anti-VEGF agents for proliferative diabetic retinopathy

(2014) P Osaadon et al.   EYE

Prevention of VEGF-mediated microvascular permeability by C-peptide in diabetic mice

(2013) Y.-C. Lim et al.   CARDIOVASCULAR RESEARCH

C-Peptide Activates AMPK  and Prevents ROS-Mediated Mitochondrial Fission and Endothelial Apoptosis in Diabetes

(2013) M. P. Bhatt et al.   DIABETES

SIRT1, p66Shc, and Set7/9 in Vascular Hyperglycemic Memory: Bringing All the Strands Together

(2013) F. Paneni et al.   DIABETES

Impact of C-Peptide Preservation on Metabolic and Clinical Outcomes in the Diabetes Control and Complications Trial

(2013) J. M. Lachin et al.   DIABETES

The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study at 30 Years: Summary and Future Directions: Figure 1

(2013) Rose A. Gubitosi-Klug et al.   DIABETES CARE

Can C-peptide mediated anti-inflammatory effects retard the development of microvascular complications of type 1 diabetes?

(2013) Patrizia Luppi et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

The clinical utility of C-peptide measurement in the care of patients with diabetes

(2013) A. G. Jones et al.   DIABETIC MEDICINE

C-Peptide: A Molecule Balancing Insulin States in Secretion and Diabetes-associated Depository Conditions

(2013) M. Landreh et al.   HORMONE AND METABOLIC RESEARCH

AMPK, insulin resistance, and the metabolic syndrome

(2013) Neil B. Ruderman et al.   JOURNAL OF CLINICAL INVESTIGATION

Evidence for an interaction between proinsulin C-peptide and GPR146

(2013) Gina L C Yosten et al.   JOURNAL OF ENDOCRINOLOGY

Nitric oxide regulates cardiac intracellular Na+ and Ca2+ by modulating Na/K ATPase via PKCε and phospholemman-dependent mechanism

(2013) Davor Pavlovic et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

In VivoQuantitative Visualization Analysis of the Effect of C-Peptide on Glomerular Hyperfiltration in Diabetic Rats by Using Multiphoton Microscopy

(2013) Hiroshi Nakamoto et al.   MICROCIRCULATION

Mechanisms of Diabetic Complications

(2013) Josephine M. Forbes et al.   PHYSIOLOGICAL REVIEWS

The Clinical Potential of C-Peptide Replacement in Type 1 Diabetes

(2012) J. Wahren et al.   DIABETES

C-Peptide Prevents Hyperglycemia-Induced Endothelial Apoptosis Through Inhibition of Reactive Oxygen Species–Mediated Transglutaminase 2 Activation

(2012) Mahendra Prasad Bhatt et al.   DIABETES

Insulin-Induced Generation of Reactive Oxygen Species and Uncoupling of Nitric Oxide Synthase Underlie the Cerebrovascular Insulin Resistance in Obese Rats

(2012) Prasad VG Katakam et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

C-peptide, a novel inhibitor of lung inflammation following hemorrhagic shock

(2011) Ranjit S. Chima et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

C-peptide reduces high-glucose-induced apoptosis of endothelial cells and decreases NAD(P)H-oxidase reactive oxygen species generation in human aortic endothelial cells

(2011) V. Cifarelli et al.   DIABETOLOGIA

Diabetic neuropathy: cellular mechanisms as therapeutic targets

(2011) Andrea M. Vincent et al.   Nature Reviews Neurology

Beneficial effects of C-peptide on renal morphology in diabetic rats

(2010) W. Sun et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

C-Peptide as a Therapeutic Tool in Diabetic Nephropathy

(2010) Claire E. Hills et al.   AMERICAN JOURNAL OF NEPHROLOGY

Role of GTPases in control of microvascular permeability

(2010) V. Spindler et al.   CARDIOVASCULAR RESEARCH

Oxidative Stress and Diabetic Complications

(2010) Ferdinando Giacco et al.   CIRCULATION RESEARCH

Proinsulin C-peptide prevents type-1 diabetes-induced decrease of renal Na+-K+-ATPase α1-subunit in rats

(2010) Lina Nordquist et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Cellular mechanisms by which proinsulin C-peptide prevents insulin-induced neointima formation in human saphenous vein

(2010) R. S. Mughal et al.   DIABETOLOGIA

Proinsulin C-Peptide Antagonizes the Profibrotic Effects of TGF-β1 via Up-Regulation of Retinoic Acid and HGF-Related Signaling Pathways

(2010) Claire E. Hills et al.   MOLECULAR ENDOCRINOLOGY

Epigenetic phenomena linked to diabetic complications

(2010) Luciano Pirola et al.   Nature Reviews Endocrinology

Cellular and physiological effects of C-peptide

(2009) Claire E. Hills et al.   CLINICAL SCIENCE

C-peptide is internalised in human endothelial and vascular smooth muscle cells via early endosomes

(2009) P. Luppi et al.   DIABETOLOGIA

The Regulation of Vascular Endothelial Growth Factor-induced Microvascular Permeability Requires Rac and Reactive Oxygen Species

(2009) Elizabeth Monaghan-Benson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proinsulin C-peptide Regulates Ribosomal RNA Expression

(2009) Emma Lindahl et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Therapies for hyperglycaemia-induced diabetic complications: from animal models to clinical trials

(2009) Nigel A. Calcutt et al.   NATURE REVIEWS DRUG DISCOVERY

Human proinsulin C-peptide reduces high glucose-induced proliferation and NF-κB activation in vascular smooth muscle cells

(2008) Vincenza Cifarelli et al.   ATHEROSCLEROSIS

Treatment of Type 2 Diabetes With Combined Therapy: What are the pros and cons?

(2008) M. Massi-Benedetti et al.   DIABETES CARE

Human C-peptide antagonises high glucose-induced endothelial dysfunction through the nuclear factor-κB pathway

(2008) P. Luppi et al.   DIABETOLOGIA

C-Peptide and Its C-Terminal Fragments Improve Erythrocyte Deformability in Type 1 Diabetes Patients

(2008) Thomas Hach et al.   Experimental Diabetes Research

The “Metabolic Memory”: Is More Than Just Tight Glucose Control Necessary to Prevent Diabetic Complications?

(2008) Antonio Ceriello et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Insulin exhibits short-term anti-inflammatory but long-term proinflammatory effects in vitro

(2008) Yasumasa Iwasaki et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Effects of Intensive Glucose Lowering in Type 2 Diabetes

(2008)   NEW ENGLAND JOURNAL OF MEDICINE

C-peptide as a Mediator of Lesion Development in Early Diabetes—A Novel Hypothesis

(2008) Nikolaus Marx   TRENDS IN CARDIOVASCULAR MEDICINE

Enhanced susceptibility to infections in a diabetic wound healing model

(2008) Tobias Hirsch et al.   BMC Surgery