HDL and cholesterol handling in the brain

Ageing and Parkinson's disease: Why is advancing age the biggest risk factor?

(2014) Amy Reeve et al.   AGEING RESEARCH REVIEWS

Low-Density Lipoprotein Receptor–Related Protein-1

(2014) Dudley K. Strickland et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Phospholipid transfer protein (PLTP) deficiency impaired blood–brain barrier integrity by increasing cerebrovascular oxidative stress

(2014) Ting Zhou et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Reduced glucocerebrosidase is associated with increased α-synuclein in sporadic Parkinson’s disease

(2014) Karen E. Murphy et al.   BRAIN

High-Density Lipoproteins and Cerebrovascular Integrity in Alzheimer’s Disease

(2014) Sophie Stukas et al.   Cell Metabolism

Mendelian Disorders of High-Density Lipoprotein Metabolism

(2014) Federico Oldoni et al.   CIRCULATION RESEARCH

Lipid dysfunction and pathogenesis of multiple system atrophy

(2014) Jonathan M Bleasel et al.   Acta Neuropathologica Communications

Glucocerebrosidase mutations and the pathogenesis of Parkinson disease

(2013) Michelle S. Beavan et al.   ANNALS OF MEDICINE

ABCA8 stimulates sphingomyelin production in oligodendrocytes

(2013) Woojin Scott Kim et al.   BIOCHEMICAL JOURNAL

Tricarboxylic acid cycle-sustained oxidative phosphorylation in isolated myelin vesicles

(2013) Silvia Ravera et al.   BIOCHIMIE

Huntingtonʼs disease and Huntingtonʼs disease-like syndromes

(2013) Felix Gövert et al.   CURRENT OPINION IN NEUROLOGY

Targeting ApoE4/ApoE receptor LRP1 in Alzheimer's disease

(2013) Henna Martiskainen et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Phospholipid Transfer Protein Is Expressed in Cerebrovascular Endothelial Cells and Involved in High Density Lipoprotein Biogenesis and Remodeling at the Blood-Brain Barrier

(2013) Anil Paul Chirackal Manavalan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Low Density Lipoprotein Receptor-related Protein 1 (LRP1) ModulatesN-Methyl-d-aspartate (NMDA) Receptor-dependent Intracellular Signaling and NMDA-induced Regulation of Postsynaptic Protein Complexes

(2013) Chikako Nakajima et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Choroid Plexus and Cerebrospinal Fluid: Emerging Roles in Development, Disease, and Therapy

(2013) M. K. Lehtinen et al.   JOURNAL OF NEUROSCIENCE

Advances in the genetics of Parkinson disease

(2013) Joanne Trinh et al.   Nature Reviews Neurology

Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

(2013) Chia-Chen Liu et al.   Nature Reviews Neurology

Plasma 24S-hydroxycholesterol correlation with markers of Huntington disease progression

(2013) Valerio Leoni et al.   NEUROBIOLOGY OF DISEASE

Lifelong Expression of Apolipoprotein D in the Human Brainstem: Correlation with Reduced Age-Related Neurodegeneration

(2013) Ana Navarro et al.   PLoS One

ApoE influences amyloid-  (A ) clearance despite minimal apoE/A  association in physiological conditions

(2013) P. B. Verghese et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Membrane-bound α-synuclein interacts with glucocerebrosidase and inhibits enzyme activity

(2012) Thai Leong Yap et al.   MOLECULAR GENETICS AND METABOLISM

Low-density lipoprotein receptor overexpression enhances the rate of brain-to-blood A  clearance in a mouse model of  -amyloidosis

(2012) J. M. Castellano et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic lecithin:cholesterol acyltransferase deficiency and cardiovascular disease

(2011) Laura Calabresi et al.   ATHEROSCLEROSIS

Lipid Metabolism and Glial Lipoproteins in the Central Nervous System

(2011) Hideki Hayashi   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Gaucher Disease Glucocerebrosidase and α-Synuclein Form a Bidirectional Pathogenic Loop in Synucleinopathies

(2011) Joseph R. Mazzulli et al.   CELL

Serum lipid profiles are associated with disability and MRI outcomes in multiple sclerosis

(2011) Bianca Weinstock-Guttman et al.   Journal of Neuroinflammation

Peroxisome-Proliferator-Activated Receptor Gamma Coactivator 1   Contributes to Dysmyelination in Experimental Models of Huntington's Disease

(2011) Z. Xiang et al.   JOURNAL OF NEUROSCIENCE

Apolipoprotein E in Alzheimer's disease and other neurological disorders

(2011) Philip B Verghese et al.   LANCET NEUROLOGY

Aggregation of α-synuclein in brain samples from subjects with glucocerebrosidase mutations

(2011) Jae Hyuk Choi et al.   MOLECULAR GENETICS AND METABOLISM

Positive correlation between elevated plasma cholesterol levels and cognitive impairments in LDL receptor knockout mice: relevance of cortico-cerebral mitochondrial dysfunction and oxidative stress

(2011) J. de Oliveira et al.   NEUROSCIENCE

Whole body cholesterol metabolism is impaired in Huntington's disease

(2011) V. Leoni et al.   NEUROSCIENCE LETTERS

Cholesterol metabolism in neurons and astrocytes

(2011) Frank W. Pfrieger et al.   PROGRESS IN LIPID RESEARCH

Prevalence of Metabolic Syndrome and Metabolic Abnormalities in Schizophrenia and Related Disorders—A Systematic Review and Meta-Analysis

(2011) Alex J. Mitchell et al.   SCHIZOPHRENIA BULLETIN

Human apoE Isoforms Differentially Regulate Brain Amyloid-  Peptide Clearance

(2011) J. M. Castellano et al.   Science Translational Medicine

Glucocerebrosidase is present in α-synuclein inclusions in Lewy body disorders

(2010) Ozlem Goker-Alpan et al.   ACTA NEUROPATHOLOGICA

Association of Higher Levels of High-Density Lipoprotein Cholesterol in Elderly Individuals and Lower Risk of Late-Onset Alzheimer Disease

(2010) Christiane Reitz et al.   ARCHIVES OF NEUROLOGY

Formation and function of apolipoprotein E-containing lipoproteins in the nervous system

(2010) Jean E. Vance et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Association of a Functional Polymorphism in the Cholesteryl Ester Transfer Protein (CETP) Gene With Memory Decline and Incidence of Dementia

(2010) Amy E. Sanders   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Apolipoprotein A-I Deficiency Increases Cerebral Amyloid Angiopathy and Cognitive Deficits in APP/PS1ΔE9 Mice

(2010) Iliya Lefterov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuronal LRP1 Knockout in Adult Mice Leads to Impaired Brain Lipid Metabolism and Progressive, Age-Dependent Synapse Loss and Neurodegeneration

(2010) Q. Liu et al.   JOURNAL OF NEUROSCIENCE

Quantification of Cholesterol-Metabolizing P450s CYP27A1 and CYP46A1 in Neural Tissues Reveals a Lack of Enzyme−Product Correlations in Human Retina but Not Human Brain

(2010) Wei-Li Liao et al.   JOURNAL OF PROTEOME RESEARCH

Blood lipids, homocysteine, stress factors, and vitamins in clinically stable multiple sclerosis patients

(2010) Giuseppe Salemi et al.   Lipids in Health and Disease

Review: Sporadic cerebral amyloid angiopathy

(2010) J. Attems et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Scavenger receptor class B type I (SR-BI) regulates perivascular macrophages and modifies amyloid pathology in an Alzheimer mouse model

(2010) K. Thanopoulou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Greasing the wheels of Aβ clearance in Alzheimer's Disease: The role of lipids and apolipoprotein E

(2009) Jianjia Fan et al.   BIOFACTORS

Central nervous system: cholesterol turnover, brain development and neurodegeneration

(2009) John M. Dietschy   BIOLOGICAL CHEMISTRY

Brain α-synuclein accumulation in multiple system atrophy, Parkinson's disease and progressive supranuclear palsy: a comparative investigation

(2009) Junchao Tong et al.   BRAIN

Wild-type but not mutant huntingtin modulates the transcriptional activity of liver X receptors

(2009) M Futter et al.   JOURNAL OF MEDICAL GENETICS

Oxysterols and neurodegenerative diseases

(2009) Ingemar Björkhem et al.   MOLECULAR ASPECTS OF MEDICINE

Alpha-synuclein-glucocerebrosidase interactions in pharmacological Gaucher models: A biological link between Gaucher disease and parkinsonism

(2009) Amy B. Manning-Boğ et al.   NEUROTOXICOLOGY

Low HDL Cholesterol Is a Risk Factor for Deficit and Decline in Memory in Midlife

(2008) Archana Singh-Manoux et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Smith–Lemli–Opitz syndrome: pathogenesis, diagnosis and management

(2008) Forbes D Porter   EUROPEAN JOURNAL OF HUMAN GENETICS

Mechanisms of neurodegeneration in Huntington’s disease

(2008) Joana M. Gil et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Gaucher disease: mutation and polymorphism spectrum in the glucocerebrosidase gene (GBA)

(2008) Kathleen S. Hruska et al.   HUMAN MUTATION

LCAT synthesized by primary astrocytes esterifies cholesterol on glia-derived lipoproteins

(2008) Veronica Hirsch-Reinshagen et al.   JOURNAL OF LIPID RESEARCH

Role of ATP-binding cassette transporters in brain lipid transport and neurological disease

(2008) Woojin Scott Kim et al.   JOURNAL OF NEUROCHEMISTRY

Paraoxonase 1 activity in different types of multiple sclerosis

(2008) A Jamroz-Wisniewska et al.   Multiple Sclerosis Journal

The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders

(2008) Berislav V. Zlokovic   NEURON

Mutations in the very low-density lipoprotein receptor VLDLR cause cerebellar hypoplasia and quadrupedal locomotion in humans

(2008) T. Ozcelik et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Low HDL cholesterol associates with major depression in a sample with a 7-year history of depressive symptoms

(2008) Soili M. Lehto et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Low plasma total cholesterol in patients with Huntington’s disease and first-degree relatives

(2007) Manolis Markianos et al.   MOLECULAR GENETICS AND METABOLISM