Article
Cardiac & Cardiovascular Systems
Antonija Sakic, Chiraz Chaabane, Noona Ambartsumian, Jorg Klingelhofer, Sylvain Lemeille, Brenda R. Kwak, Mariam Grigorian, Marie-Luce Bochaton-Piallat
Summary: This study investigates the role of extracellular S100A4 in the phenotypic transition of smooth muscle cells during atherosclerosis. The findings suggest that neutralization of extracellular S100A4 promotes the stabilization of atherosclerotic plaques and could potentially be a new target to influence plaque evolution.
CARDIOVASCULAR RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Joao Carlos Ribeiro-Silva, Patricia Nolasco, Jose Eduardo Krieger, Ayumi Aurea Miyakawa
Summary: Vascular aging is characterized by the fragmentation of elastic fibers and collagen deposition, leading to reduced distensibility and increased stiffness in the blood vessels. Research shows that aging promotes changes in smooth muscle cell phenotypes, ultimately resulting in mechanical impairment of aging arteries. Understanding the role of ECM changes during aging may help in developing new strategies to prevent or delay arterial aging and cardiovascular diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Tong Li, Baofu Wang, Hao Ding, Shiqi Chen, Weiting Cheng, Yang Li, Xiaoxiao Wu, Lei Wang, Yangyang Jiang, Ziwen Lu, Yu Teng, Sha Su, Xiaowan Han, Mingjing Zhao
Summary: Atherosclerosis (AS)-related diseases are the leading cause of death in clinical patients. Vascular smooth muscle cells (VSMCs) play a crucial role in AS, and intercellular communication through extracellular vesicles (EVs) is important in the pathophysiology of AS.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Hematology
Sebastian F. Mause, Elisabeth Ritzel, Annika Deck, Felix Vogt, Elisa A. Liehn
Summary: EPCs stimulate proliferation and migration of SMCs and increase their neointimal accumulation following vascular injury. Furthermore, EPCs context-dependently modify the SMC phenotype with protection from the transformative effect of cholesterol when a direct cell-cell contact is established.
THROMBOSIS AND HAEMOSTASIS
(2022)
Review
Cell Biology
Manish Jain, Anil K. Chauhan
Summary: Integrins play a crucial role in modulating the functional properties of smooth muscle cells and their implications in vascular pathology.
Article
Physiology
Hanaa Abdelazim, Laura Beth Payne, Kyle Nolan, Karan Paralkar, Vanessa Bradley, Ronak Kanodia, Rosalie Gude, Rachael Ward, Aboozar Monavarfeshani, Michael A. Fox, John C. Chappell
Summary: This study provides new insights into the heterogeneity of pericytes (PCs) and the presence of medial cells within the microvessel wall, highlighting the importance of the vascular perivascular matrix and extracellular matrix (ECM) characteristics as criteria for identifying PCs.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Peripheral Vascular Disease
Harri Elamaa, Mika Kaakinen, Marjut Natynki, Zoltan Szabo, Veli-Pekka Ronkainen, Ville Aijala, Joni M. Maki, Risto Kerkela, Johanna Myllyharju, Lauri Eklund
Summary: The study suggests that inducible deletion of PHD2 in endothelial cells can lead to progressive lung disease, while deletion in arterial smooth muscle cells results in elevated right ventricular pressure without alterations in vascular tone regulators. Mechanistically, PHD2 inhibition in smooth muscle cells involves actin polymerization-related tension development via activated cofilin.
Article
Hematology
Huan Yang, Ting Zhou, Amelia Stranz, Elise DeRoo, Bo Liu
Summary: A study using single-cell RNA sequencing on mouse AAA tissues revealed 12 distinct populations of 8 cell types. The percentages of each population and gene expression were compared between sham and AAA tissue, showing that populations within major cell types such as smooth muscle cells, fibroblasts, and macrophages may contribute differently to AAA pathogenesis.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Immunology
Sonia I. Vlaicu, Alexandru Tatomir, Matthew Fosbrink, Vinh Nguyen, Dallas Boodhoo, Cornelia Cudrici, Tudor C. Badea, Violeta Rus, Horea Rus
Summary: In this study, the involvement of RGC-32 in cell proliferation and cell cycle activation in endothelial cells and smooth muscle cells in atherosclerosis was investigated. Overexpression of RGC-32 enhanced the cell cycle activation and proliferation induced by C5b-9, while silencing of RGC-32 inhibited this activation.
CLINICAL IMMUNOLOGY
(2022)
Review
Cell Biology
Arianna Parnigoni, Manuela Viola, Evgenia Karousou, Simona Rovera, Cristina Giaroni, Alberto Passi, Davide Vigetti
Summary: Hyaluronic acid (HA) plays a crucial role in blood vessel structure, cell dedifferentiation, and immune cell recruitment.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Food Science & Technology
Yan-Yan Zheng, Hao-Zhe Zhu, Zhong-Yuan Wu, Wen-Juan Song, Chang-Bo Tang, Chun-Bao Li, Shi-Jie Ding, Guang-Hong Zhou
Summary: Adding smooth muscle cells to cultured meat models significantly improves meat texture, increases collagen content and hardness, indicating that smooth muscle cells play a key role in improving the quality of cultured meat.
FOOD RESEARCH INTERNATIONAL
(2021)
Review
Physiology
Jean-Paul Richalet, Florence Jeny, Patrice Callard, Jean-Francois Bernaudin
Summary: The pathophysiology of high-altitude pulmonary edema is thought to be the result of exacerbated hypoxic pulmonary vasoconstriction. In this review, the authors focus on the cellular mechanisms in the pulmonary acinus that respond to hypoxia, leading to the accumulation of fluid in the alveoli. These mechanisms include damage to the fluid reabsorption capacity of alveolar epithelial cells, increased permeability of endothelial and epithelial cells, activation of inflammation by alveolar macrophages, disruption of extracellular matrix architecture and tight junctions, and induced pulmonary vasoconstriction. The complex intercellular network of the alveolar-capillary barrier is affected by acute hypoxia in all its components, resulting in rapid water accumulation in the alveoli.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2023)
Article
Hematology
Chen Zhang, Yanming Li, Abhijit Chakraborty, Yang Li, Kimberly R. Rebello, Pingping Ren, Wei Luo, Lin Zhang, Hong S. Lu, Lisa A. Cassis, Joseph S. Coselli, Alan Daugherty, Scott A. LeMaire, Ying H. Shen
Summary: This study reveals that aortic cells adapt to stress by modifying their functions, leading to a protective adaptive response against aortic aneurysm and dissection (AAD). The adaptive response involves upregulation of genes related to wound healing, elastin and collagen production, proliferation, migration, cytoskeleton organization, cell-matrix focal adhesion, and PI3K-PKB/Akt and TGF-beta signaling. YAP is identified as an important transcription complex driving the expression of these genes and plays a role in mechanical signal transduction.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Cell Biology
Alen Faiz, Louise M. Harkness, Gavin Tjin, Victor Bernal, Peter Horvatovich, Alan James, John G. Elliot, Janette K. Burgess, Anthony W. Ashton
Summary: The study found that the ECM deposited by asthmatic and non-asthmatic ASM cells under non-stimulated conditions had similar composition and angiogenic potential, both capable of regulating the behavior of endothelial cells. This suggests that the dysregulation of airway ECM in asthma is driven by even low levels of inflammation, emphasizing the need for more effective anti-inflammatory therapies to maintain airway ECM and regulate aberrant angiogenesis.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Food Science & Technology
Yan-Yan Zheng, Yu Chen, Hao-Zhe Zhu, Chun-Bao Li, Wen-Juan Song, Shi-Jie Ding, Guang-Hong Zhou
Summary: Using peanut wire-drawing protein as a scaffold material can promote cell adhesion and proliferation in cultured meat, producing higher quality muscle tissue. This technology provides an innovative pathway for the industrialized production of cultured meat.
FOOD RESEARCH INTERNATIONAL
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Marie-Luce Bochaton-Piallat, Magnus Back
CARDIOVASCULAR RESEARCH
(2018)
Review
Cardiac & Cardiovascular Systems
Andrea Caporali, Magnus Back, Mat J. Daemen, Imo E. Hoefer, Elizabeth A. Jones, Esther Lutgens, Christian M. Matter, Marie-Luce Bochaton-Piallat, Arndt F. Siekmann, Judith C. Sluimer, Sabine Steffens, Jose Tunon, Cecile Vindis, Jolanda J. Wentzel, Seppo Yla-Herttuala, Paul C. Evans
CARDIOVASCULAR RESEARCH
(2018)
Review
Cardiac & Cardiovascular Systems
Jose Tunon, Lina Badimon, Marie-Luce Bochaton-Piallat, Bertrand Cariou, Mat J. Daemen, Jesus Egido, Paul C. Evans, Imo E. Hoefer, Daniel F. J. Ketelhuth, Esther Lutgens, Christian M. Matter, Claudia Monaco, Sabine Steffens, Erik Stroes, Cecile Vindis, Christian Weber, Magnus Back
CARDIOVASCULAR RESEARCH
(2019)
Article
Multidisciplinary Sciences
Yves Lecarpentier, Vincent Kindler, Marie-Luce Bochaton-Piallat, Antonija Sakic, Victor Claes, Jean-Louis Hebert, Alexandre Vallee, Olivier Schussler
Article
Genetics & Heredity
C. Barazzone-Argiroffo, J. Lascano Maillard, I Vidal, M. L. Bochaton-Piallat, S. Blaskovic, Y. Donati, B. E. Wildhaber, A-L Rougemont, C. Delacourt, I Ruchonnet-Metrailler
ORPHANET JOURNAL OF RARE DISEASES
(2019)
Review
Cardiac & Cardiovascular Systems
Yvonne Alexander, Elena Osto, Arno Schmidt-Trucksass, Michael Shechter, Danijela Trifunovic, Dirk J. Duncker, Victor Aboyans, Magnus Back, Lina Badimon, Francesco Cosentino, Marco De Carlo, Maria Dorobantu, David G. Harrison, Tomasz J. Guzik, Imo Hoefer, Paul D. Morris, Giuseppe D. Norata, Rosa Suades, Stefano Taddei, Gemma Vilahur, Johannes Waltenberger, Christian Weber, Fiona Wilkinson, Marie-Luce Bochaton-Piallat, Paul C. Evans
Summary: Endothelial cells play a crucial role in cardiovascular health, and dysfunction can be caused by cardiovascular risk factors but restored once stimuli are removed. There are various methods to measure endothelial function, with each having its pros and cons. It is recommended to adopt a consensus methodology like flow-mediated dilatation and establish reference values for different populations. Future studies should explore the integration of endothelial function measurements with patient-specific epigenetic data and other biomarkers.
CARDIOVASCULAR RESEARCH
(2021)
Review
Cardiac & Cardiovascular Systems
Paul C. Evans, G. Ed Rainger, Justin C. Mason, Tomasz J. Guzik, Elena Osto, Zania Stamataki, Desley Neil, Imo E. Hoefer, Maria Fragiadaki, Johannes Waltenberger, Christian Weber, Marie-Luce Bochaton-Piallat, Magnus Back
CARDIOVASCULAR RESEARCH
(2020)
Article
Cardiac & Cardiovascular Systems
Malgorzata Furmanik, Martijn Chatrou, Rick van Gorp, Asim Akbulut, Brecht Willems, Harald Schmidt, Guillaume van Eys, Marie-Luce Bochaton-Piallat, Diane Proudfoot, Erik Biessen, Ulf Hedin, Ljubica Perisic, Barend Mees, Catherine Shanahan, Chris Reutelingsperger, Leon Schurgers
CIRCULATION RESEARCH
(2020)
Article
Medical Laboratory Technology
Emmanuel Somm, Sophie A. Montandon, Ursula Loizides-Mangold, Nadia Gaia, Vladimir Lazarevic, Claudio De Vito, Elodie Perroud, Marie-Luce Bochaton-Piallat, Charna Dibner, Jacques Schrenzel, Francois R. Jornayvaz
Summary: The study shows that the GLP-1 receptor agonist liraglutide can prevent the accumulation of C16 and C24 ceramides/sphingomyelins species, alleviate inflammation, and inhibit the initiation of fibrosis in the liver of MCD-diet-fed mice. Additionally, liraglutide influences the composition of gut microbiota induced by the MCD-diet.
TRANSLATIONAL RESEARCH
(2021)
Article
Cell Biology
Yves Lecarpentier, Vincent Kindler, Xenophon Krokidis, Marie-Luce Bochaton-Piallat, Victor Claes, Jean-Louis Hebert, Alexandre Vallee, Olivier Schussler
Article
Physiology
Sandrine Morel, Sabine Schilling, Mannekomba R. Diagbouga, Matteo Delucchi, Marie-Luce Bochaton-Piallat, Sylvain Lemeille, Sven Hirsch, Brenda R. Kwak
Summary: The study found that under both low and supra-high aneurysmal WSS conditions, endothelial cells adapt by changing their morphology to a more spherical shape, with differential regulation in gene expression and cell structure.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Menno P. J. de Winther, Magnus Back, Paul Evans, Delphine Gomez, Isabel Goncalves, Helle F. Jorgensen, Rory R. Koenen, Esther Lutgens, Giuseppe Danilo Norata, Elena Osto, Lea Dib, Michael Simons, Konstantinos Stellos, Seppo Yla-Herttuala, Holger Winkels, Marie-Luce Bochaton-Piallat, Claudia Monaco
Summary: The advent of single-cell biology has opened up new possibilities for understanding human biological processes and diagnosing, monitoring, and treating diseases, including cardiovascular disease (CVD). By analyzing CVD samples at the single-cell level, new cell communities that play a role in disease development can be identified, leading to new therapeutic strategies. This review focuses on the single-cell analysis of atherosclerotic plaques, highlighting the current understanding of cellular subpopulations and their heterogeneity and plasticity in relation to clinically relevant features. The clinical impact of single-cell technologies in CVD patient care is emphasized, calling for multidisciplinary and international collaborative efforts.
EUROPEAN HEART JOURNAL
(2023)
Article
Pharmacology & Pharmacy
Tamara Melnik, Ksenia Kapitanova, Laurent Vinet, Marie-Luce Bochaton-Piallat, Olivier Jordan, Florence Delie
Summary: This study aimed to encapsulate a high payload of atorvastatin (ATV) to prevent intimal hyperplasia (IH) in vascular bypass grafts and evaluate its impact on synthetic smooth muscle cells (SMCs) involved in IH progression. Poly(lactic-co-glycolic acid) microparticles (MPs) were formulated with different drug loadings and tested for ATV release, sterilization, and effects on SMCs. The results showed sustained ATV release from 10% and 20% ATV-loaded MPs for 90 days. The ATV-loaded MPs reversed the synthetic phenotype of SMCs and attenuated their migratory and proliferative capacities.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Antonija Sakic, Chiraz Chaabane, Noona Ambartsumian, Jorg Klingelhofer, Sylvain Lemeille, Brenda R. Kwak, Mariam Grigorian, Marie-Luce Bochaton-Piallat
Summary: This study investigates the role of extracellular S100A4 in the phenotypic transition of smooth muscle cells during atherosclerosis. The findings suggest that neutralization of extracellular S100A4 promotes the stabilization of atherosclerotic plaques and could potentially be a new target to influence plaque evolution.
CARDIOVASCULAR RESEARCH
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
A. Sakic, C. Chaabane, N. Ambartsumian, J. Klingelhofer, S. Lemeille, B. Kwak, M. Grigorian, M. -L. Bochaton-Piallat