Article
Cell Biology
Feifei Wang, Yafan Han, Wanyue Sang, Lu Wang, Xiaoyan Liang, Liang Wang, Qiang Xing, Yankai Guo, Jianghua Zhang, Ling Zhang, Tuerhong Zukela, Jiasuoer Xiaokereti, Yanmei Lu, Xianhui Zhou, Baopeng Tang, Yaodong Li
Summary: Congenital long QT syndrome is a hereditary cardiovascular disorder characterized by prolonged QT interval. This study demonstrates the effectiveness of using patient-specific iPSCs to identify potential cures and alternative therapies for long QT syndrome patients who do not respond well to conventional treatments. Verapamil and lidocaine show promise as therapeutic agents in reducing symptoms and improving the quality of life for these patients.
Review
Pharmacology & Pharmacy
Emanuele Micaglio, Emanuela T. Locati, Michelle M. Monasky, Federico Romani, Francesca Heilbron, Carlo Pappone
Summary: ADRs are significant causes of morbidity and mortality, involving various drugs and organs. Genetic predisposition towards ADRs is a growing focus for preventive measures and safe therapeutic use of common drugs.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Ethan Hau Yin Lam, Fengqing Yu, Sabrina Zhu, Zongjie Wang
Summary: In the past decade, personalized medicine has made significant progress in addressing patient-specific disease complexities and developing individualized treatment strategies. The emergence of 3D bioprinting has provided novel opportunities for personalized medicine, although current bioprinted constructs have limitations in achieving anatomically realistic organs with mature biological functions. This review discusses the principles and realizations of bioprinting, focusing on techniques such as extrusion printing and digital light processing (DLP). It also explores the applications of bioprinted constructs in regenerative medicine and drug discovery. Despite the challenges, bioprinting shows promise as an empowering technology to overcome critical obstacles in personalized medicine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Abdulsalam A. Alqahtani, Mohammed Muqtader Ahmed, Abdul Aleem Mohammed, Javed Ahmad
Summary: The current healthcare system is limited by the concept of one size fits all, resulting in varied responses and adverse reactions in patients. Personalized medicine (PM) offers customized therapy for individual patients, potentially revolutionizing the healthcare system. 3D printing techniques can be used to design PM in metabolic syndrome, delivering the desired dose and drug release profile for optimal efficacy and safety.
Article
Cardiac & Cardiovascular Systems
Li Feng, Jianhua Zhang, ChangHwan Lee, Gina Kim, Fang Liu, Andrew J. Petersen, Evi Lim, Corey L. Anderson, Kate M. Orland, Gail A. Robertson, Lee L. Eckhardt, Craig T. January, Timothy J. Kamp
Summary: This study investigated the pathogenesis of the hERG1-H70R variant in long QT syndrome type 2 using patient-specific iPSC-CMs, revealing a mechanism involving impaired trafficking of hERG1a and maintained expression of hERG1b leading to subunit imbalance and reduced I-Kr.
CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Elisa Giacomelli, Luca Sala, Dorien Ward-van Oostwaard, Milena Bellin
Summary: Wild-type and LQT1 hiPSCs were differentiated into various cell types to create 3D cardiac microtissues, successfully recapitulating the typical features of LQTS. The use of a 96-well multi-electrode array proved effective in detecting electrical changes in the 3D tissues.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Physiology
Luca Sala, Vladislav Leonov, Manuela Mura, Federica Giannetti, Aleksandr Khudiakov, Alessandra Moretti, Lia Crotti, Massimiliano Gnecchi, Peter J. Schwartz
Summary: During the early stages of the COVID-19 pandemic, the use of drug repurposing to find compounds for improving the prognosis of symptomatic patients was common. Hydroxychloroquine (HCQ) was one of the first drugs used for COVID-19 treatment, but its effectiveness is debated and it may cause electrocardiographic abnormalities. By studying human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs), researchers found that HCQ had proarrhythmic effects and could potentially distinguish symptomatic from asymptomatic mutation carriers.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Medicine, Research & Experimental
Justin Davis, Ahmad Chouman, Jeffery Creech, Andre Monteiro da Rocha, Daniela Ponce-Balbuena, Eric N. Jimenez Vazquez, Ruthann Nichols, Andrey Lozhkin, Nageswara R. Madamanchi, Katherine F. Campbell, Todd J. Herron
Summary: A model of ischemic heart disease was successfully created using human induced pluripotent stem cell-derived cardiomyocytes, exhibiting many characteristics similar to ischemic cardiomyocytes. This provides a new opportunity for the study of human ischemic heart disease.
Article
Oncology
Zhichao Li, Haibo Xu, Lei Yu, Jia Wang, Qian Meng, Hongbing Mei, Zhiming Cai, Wei Chen, Weiren Huang
Summary: This research established an effective three-dimensional culture system for generating kidney cancer organoids and successfully generated 33 organoid lines from different subtypes of kidney cancer. These organoids preserved the histological architecture, mutational landscape, and transcriptional profile of the parental tumor tissues, and revealed inter- and intra-tumoral heterogeneity. Additionally, the organoids can be used for drug screening and evaluating the efficacy of immunotherapy.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Review
Chemistry, Analytical
Yuqiao Liu, Junmin Li, Shenghao Xiao, Yanhui Liu, Mingxia Bai, Lixiu Gong, Jiaqian Zhao, Dajing Chen
Summary: Precision medicine is essential for optimizing drug dosage and minimizing toxicity. Wearable sensors offer real-time and continuous drug monitoring, enabling personalized medicine and reducing healthcare costs.
Article
Biochemistry & Molecular Biology
Liang Yang, Guanghui Xie, Yuguang Wang, Jian Li, Bin Zheng, Jinmiao Zhu, Xinsong Yuan, Qian Hong, Zengchun Ma, Yue Gao
Summary: This study investigated the metabolic behavior of aconitum alkaloids in Fu Zi of different concentrations and the effects of aconitine on healthy individuals and LQTS patients. The results showed that the concentrations of aconitum alkaloids increased with the dosage, and aconitine had significant effects on cell amplitude and action potential duration.
Review
Biochemistry & Molecular Biology
Noor A. A. Nahid, Julie A. A. Johnson
Summary: CYP2D6 pharmacogenetics and phenoconversion are crucial for ensuring drug safety and efficacy, but their implementation in clinical practice faces challenges.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Alexa M. Pinsky, Xiaozhi Gao, Sahej Bains, Changsung John Kim, Julien Louradour, Katja E. Odening, David J. Tester, John R. Giudicessi, Michael J. Ackerman
Summary: This study evaluated the arrhythmic risk of the progestin-based oral contraceptive Depo in a patient-specific induced pluripotent stem cell-derived cardiomyocyte (iPSC-CM) model of Long QT syndrome type 2 (LQT2). The results demonstrated that Depo can induce ventricular fibrillation in LQT2 patients, highlighting the potential proarrhythmic effect of progestin-based contraceptives.
Article
Endocrinology & Metabolism
Natsuki Miyake, Takashi Nagai, Hidetaka Suga, Satoko Osuka, Takatoshi Kasai, Mayu Sakakibara, Mika Soen, Hajime Ozaki, Tsutomu Miwata, Tomoyoshi Asano, Mayuko Kano, Ayako Muraoka, Natsuki Nakanishi, Tomoko Nakamura, Maki Goto, Yoshinori Yasuda, Yohei Kawaguchi, Takashi Miyata, Tomoko Kobayashi, Mariko Sugiyama, Takeshi Onoue, Daisuke Hagiwara, Shintaro Iwama, Akira Iwase, Naoko Inoshita, Hiroshi Arima, Hiroaki Kajiyama
Summary: This study successfully generated PRL-producing cells from human iPSCs and confirmed their endocrine functions. The generated cells showed similar secretory responsiveness as human pituitary cells in vivo. This model could be used in various studies such as drug discovery, prediction of side effects, and elucidation of tumorigenic mechanisms. Furthermore, it may contribute to the development of regenerative medicine for the pituitary gland.
Article
Cardiac & Cardiovascular Systems
Caroline Davydoff, Antoine Andorin, Damien Minois, Marine Arnaud, Mathilde Minier, Frederic Sacher, Raphael Martins, Nicolas Clementy, Jean Baptiste Gourraud, Vincent Probst
Summary: The incidence of cardiac arrhythmic events (CAEs) during sports practice in patients diagnosed with long QT syndrome (LQTS) is low, especially after good compliance with beta-blocker therapy.
Letter
Cardiac & Cardiovascular Systems
Kenji Yodogawa, Yuhi Fujimoto, Kanako Hagiwara, Eiichiro Oka, Hiroshi Hayashi, Hiroshige Murata, Teppei Yamamoto, Yu-Ki Iwasaki, Wataru Shimizu
Letter
Cardiac & Cardiovascular Systems
Kenji Yodogawa, Yuhi Fujimoto, Kanako Hagiwara, Eiichiro Oka, Hiroshi Hayashi, Hiroshige Murata, Teppei Yamamoto, Yu-Ki Iwasaki, Wataru Shimizu
Article
Cardiac & Cardiovascular Systems
Toyonobu Tsuda, Takeshi Kato, Keisuke Usuda, Takashi Kusayama, Soichiro Usui, Kenji Sakata, Kenshi Hayashi, Masa-aki Kawashiri, Masakazu Yamagishi, Masayuki Takamura, Takayuki Otsuka, Shinya Suzuki, Akio Hirata, Masato Murakami, Mitsuru Takami, Masaomi Kimura, Hidehira Fukaya, Shiro Nakahara, Wataru Shimizu, Yu-ki Iwasaki, Hiroshi Hayashi, Tomoo Harada, Ikutaro Nakajima, Ken Okumura, Junjiroh Koyama, Michifumi Tokuda, Teiichi Yamane, Yukihiko Momiyama, Kojiro Tanimoto, Kyoko Soejima, Noriko Nonoguchi, Koichiro Ejima, Nobuhisa Hagiwara, Masahide Harada, Kazumasa Sonoda, Masaru Inoue, Koji Kumagai, Hidemori Hayashi, Kazuhiro Satomi, Yoshinao Yazaki, Yuji Watari, Masaru Arai, Ryuta Watanabe, Katsuaki Yokoyama, Naoya Matsumoto, Koichi Nagashima, Yasuo Okumura
Summary: A recent randomized trial showed that catheter ablation for atrial fibrillation (AF) in heart failure patients with reduced ejection fraction (EF) can reduce the risk of death or heart failure. However, the effectiveness of catheter ablation for AF in heart failure patients with mid-range or preserved EF remains uncertain.
CIRCULATION JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Tomofumi Nakamura, Takeshi Aiba, Wataru Shimizu, Tetsushi Furukawa, Tetsuo Sasano
Summary: In this study, an artificial intelligence model was developed to predict previous or future ventricular fibrillation episodes from Brugada syndrome ECGs. The model achieved high accuracy and F1 score in ECG evaluation and showed good performance in predicting the presence of ventricular fibrillation.
CIRCULATION JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Teresa Trenkwalder, Mark Lachmann, Lukas Stolz, Vera Fortmeier, Hector Alfonso Alvarez Covarrubias, Elena Rippen, Friederike Schuermann, Antonia Presch, Moritz von Scheidt, Celine Ruff, Amelie Hesse, Muhammed Gercek, N. Patrick Mayr, Ilka Ott, Tibor Schuster, Gerhard Harmsen, Shinsuke Yuasa, Sebastian Kufner, Petra Hoppmann, Christian Kupatt, Heribert Schunkert, Adnan Kastrati, Karl-Ludwig Laugwitz, Volker Rudolph, Michael Joner, Joerg Hausleiter, Erion Xhepa
Summary: This study aims to capture the cardiopulmonary complexity of patients with mitral regurgitation (MR) using a machine-learning (ML)-based phenotyping approach. The study found considerable heterogeneity in cardiac damage among MR patients depending on underlying factors and comorbidities. The ML model identified four phenotypes and correlated them with 5-year outcomes.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Tomofumi Sawatani, Akihiro Shirakabe, Hirotake Okazaki, Masato Matsushita, Yusaku Shibata, Shota Shigihara, Suguru Nishigoori, Nozomi Sasamoto, Kazutaka Kiuchi, Nobuaki Kobayashi, Wataru Shimizu, Kuniya Asai
Summary: This study found that BNP and NT-proBNP levels change over time during hospitalization for AHF, with BNP significantly decreasing on Days 2-5 and Before-discharge, while NT-proBNP remains unchanged. The research also revealed that a high NT-proBNP/BNP ratio on Day 2-5 is associated with poorer prognosis, even if BNP levels adequately decrease.
INTERNATIONAL HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Jun Nakata, Keita Saku, Takuya Nishikawa, Tokuhiro Kimura, Hideto Sangen, Kazuhiro Asano, Kosuke Kadooka, Yusuke Hosokawa, Shuhei Tara, Wataru Shimizu, Takeshi Yamamoto, Kuniya Asai
Summary: A 77-year-old female presented with loss of consciousness, hypotension, and bradycardia. She had elevated Trop-T and lactate levels, indicating an infero-posterior ST elevation myocardial infarction. Echocardiography revealed a reduced left ventricular ejection fraction, abnormal wall motion in the infero-posterior region, hyperkinetic apical movement, and severe mitral regurgitation. Coronary angiography showed a hypoplastic right coronary artery, total thrombotic occlusion of the dominant left circumflex artery, and 75% stenosis in the left anterior descending artery. Hemodynamic improvement and reduction of acute ischemic mitral regurgitation were achieved with the use of Impella 2.5 and successful percutaneous coronary intervention with stents. The patient underwent staged PCI to the left anterior descending artery and was discharged after completion.
INTERNATIONAL HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Hideto Sangen, Takeshi Yamamoto, Shuhei Tara, Tokuhiro Kimura, Noritomo Narita, Kenta Onodera, Keishi Suzuki, Junya Matsuda, Kosuke Kadooka, Kenta Takahashi, Toshinori Ko, Hiroshi Hayashi, Jun Nakata, Yusuke Hosokawa, Koichi Akutsu, Hitoshi Takano, Tomohiko Masuno, Shoji Yokobori, Hiroyuki Yokota, Wataru Shimizu, Kuniya Asai
Summary: Patients with life-threatening acute myocardial infarction (AMI) are transferred to either emergency medical care center (EMCC) or cardiovascular intensive care unit (CICU). The EMCC group had more severe disease, longer door-to-reperfusion time, and higher in-hospital mortality rates, especially from non-cardiac causes, compared to the CICU group. Additionally, the EMCC group had a significantly higher 1-year post-discharge mortality rate than the CICU group.
INTERNATIONAL HEART JOURNAL
(2023)
Article
Clinical Neurology
Masayuki Shiozawa, Masatoshi Koga, Hiroshi Inoue, Takeshi Yamashita, Masahiro Yasaka, Shinya Suzuki, Masaharu Akao, Hirotsugu Atarashi, Takanori Ikeda, Ken Okumura, Yukihiro Koretsune, Wataru Shimizu, Hiroyuki Tsutsui, Atsushi Hirayama, Jin Nakahara, Satoshi Teramukai, Tetsuya Kimura, Yoshiyuki Morishima, Atsushi Takita, Takenori Yamaguchi, Kazunori Toyoda
Summary: This study aimed to compare the incidence of intracranial hemorrhage (ICH) and ischemic stroke in elderly patients with nonvalvular atrial fibrillation (NVAF) taking direct oral anticoagulants (DOACs) versus warfarin in a real-world setting. The results showed that patients on DOACs had lower risks of ischemic stroke, ICH, and subdural/epidural hemorrhage compared to those on warfarin.
INTERNATIONAL JOURNAL OF STROKE
(2023)
Article
Cardiac & Cardiovascular Systems
Daisaku Nakatani, Tomoharu Dohi, Shungo Hikoso, Atsushi Tanaka, Mamoru Nanasato, Wataru Shimizu, Koichi Node, Yasushi Sakata
Summary: There were limited clinical studies on the relationship between SGLT2 inhibitors and hematopoiesis in patients with diabetes and heart failure. In the CANDLE trial, 226 patients were studied, and it was found that canagliflozin was associated with increased hematocrit and hemoglobin levels compared to glimepiride. In conclusion, canagliflozin improved hematologic parameters in patients with diabetes and heart failure.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Yu Yoshida, Keiko Uchida, Kazuki Kodo, Reina Ishizaki-Asami, Jun Maeda, Yoshinori Katsumata, Shinsuke Yuasa, Keiichi Fukuda, Kenjiro Kosaki, Yusuke Watanabe, Osamu Nakagawa, Hiroyuki Yamagishi
Summary: This study used next-generation sequencing to analyze the genes of a familial case with complex congenital heart disease (CHD). Two rare variants in the NODAL and TBX20 genes were identified and found to affect downstream signaling pathways involved in heart development. These findings suggest that loss-of-function mutations in NODAL and TBX20 may contribute to the etiology of complex CHD associated with single ventricle defects in this family.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Yasuo Terauchi, Hiroshi Inoue, Takeshi Yamashita, Masaharu Akao, Hirotsugu Atarashi, Takanori Ikeda, Yukihiro Koretsune, Ken Okumura, Shinya Suzuki, Hiroyuki Tsutsui, Kazunori Toyoda, Atsushi Hirayama, Masahiro Yasaka, Takenori Yamaguchi, Satoshi Teramukai, Tetsuya Kimura, Yoshiyuki Morishima, Atsushi Takita, Wataru Shimizu
Summary: This sub-analysis of the ANAFIE Registry investigated 2-year outcomes and oral anticoagulant use stratified by glycated hemoglobin (HbA1c) levels among Japanese patients aged ≥ 75 years with non-valvular atrial fibrillation (NVAF) with and without clinical diagnosis of diabetes mellitus (DM). The results showed that only HbA1c ≥ 8.0% was associated with increased all-cause death and net clinical outcome risks, while the event risks did not increase in other HbA1c subgroups.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Peripheral Vascular Disease
Kazuomi Kario, Naoyuki Hasebe, Ken Okumura, Takeshi Yamashita, Masaharu Akao, Hirotsugu Atarashi, Takanori Ikeda, Yukihiro Koretsune, Wataru Shimizu, Shinya Suzuki, Hiroyuki Tsutsui, Kazunori Toyoda, Atsushi Hirayama, Masahiro Yasaka, Takenori Yamaguchi, Satoshi Teramukai, Tetsuya Kimura, Yoshiyuki Morishima, Atsushi Takita, Hiroshi Inoue
Summary: This sub-cohort study aimed to estimate the incidence of clinical outcomes in elderly Japanese patients with non-valvular atrial fibrillation (NVAF) and high home systolic blood pressure (H-SBP) receiving anticoagulant therapy. The results showed that in warfarin-treated patients, the incidence of cardiovascular events was higher in those with H-SBP ≥ 145 mmHg compared to those with H-SBP < 125 mmHg. In the DOAC group, there was also a tendency for increased cardiovascular events at H-SBP ≥ 145 mmHg. Therefore, strict blood pressure control is necessary in elderly NVAF patients receiving anticoagulant therapy.
HYPERTENSION RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Michio Ogano, Yu-ki Iwasaki, Taiji Okada, Jun Tanabe, Wataru Shimizu, Kuniya Asai
Summary: This study aimed to identify the preferred left ventricular (LV) lead position for upgrading conventional right ventricular (RV) apical pacing to cardiac resynchronization therapy (CRT). The results showed that the QRS duration decreased and the left ventricular dP/dt(max) increased at the LV anterolateral site compared to the posterolateral site during biventricular pacing compared with RV apical pacing. Therefore, the LV anterolateral site is the preferred LV lead position for upgrading RV apical pacing to CRT.
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Shun Hashimoto, Hiroki Kitakata, Shun Kohsaka, Daisuke Fujisawa, Yasuyuki Shiraishi, Naomi Nakano, Otoya Sekine, Yoshikazu Kishino, Yoshinori Katsumata, Shinsuke Yuasa, Keiichi Fukuda, Takashi Kohno
Summary: Understanding patient perspectives and the association with patient-physician communication is crucial for improving multidisciplinary education programs and adherence to self-care in heart failure patients. This study found that patients had high confidence in most self-care behaviors, except for low-salt diet, regular exercise, and flu vaccination. The quality of patient-physician communication was also found to be associated with patient confidence.
JOURNAL OF CARDIOLOGY
(2023)
