Article
Cardiac & Cardiovascular Systems
Ting-Ting Zhang, Qing-Qing Lei, Jie He, Xin Guan, Xin Zhang, Ying Huang, Zi-Yue Zhou, Rui-Xin Fan, Ting Wang, Chen-Xi Li, Jin-Yan Shang, Zhuo-Miao Lin, Wan-Li Peng, Li-Kai Xia, Yu-Ling He, Chuan-Ying Hong, Jing-Song Ou, Rui-Ping Pang, Xiao-Ping Fan, Hui Huang, Jia-Guo Zhou
Summary: This study reveals that Best3 mutation, which mainly acts in blood vessels, leads to aortic dissection by regulating the degradation of MEKK2/3, controlling smooth muscle cell phenotypic switch, and maintaining the structural integrity of the aorta. This provides a new therapeutic target for the treatment of aortic dissection.
Article
Cardiac & Cardiovascular Systems
Jingrui Chen, Peng Xia, Yuening Liu, Clark Kogan, Zhaokang Cheng
Summary: Ablation of Rbl2 leads to increased apoptosis of cardiomyocytes and exacerbates myocardial ischemia/reperfusion injury. Mechanistically, the loss of Rbl2 enhances the expression of Bnip3 and upregulates the transcriptional activator E2F1. In vitro experiments demonstrate that depletion of Rbl2 enhances H2O2-induced mitochondrial damage and apoptosis.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Multidisciplinary Sciences
Rafael Kramann
Summary: Myocardial infarction, also known as heart attack, is one of the deadliest diseases worldwide. Analyzing the changes in human tissue after a heart attack, both spatially and at the single-cell level, provides valuable insights into disease mechanisms and serves as a resource for therapeutic discoveries.
Article
Medicine, General & Internal
Mansoor Zafar, Mariya Farooq, Ahmed Abousamra, Andrew Marshall, Mark Whitehead
Summary: An 84-year-old man was admitted with urinary tract infection and chest discomfort, responded well to initial treatment but later developed acute severe abdominal pain which was found to be due to acute posterior myocardial infarction, severe metabolic acidosis, and acute small bowel ischemia. Despite the urgent need for surgical intervention, his severe frailty led to conservative management, ultimately resulting in palliative care and his death.
Article
Radiology, Nuclear Medicine & Medical Imaging
Theo Pezel, Philippe Garot, Marine Kinnel, Thierry Unterseeh, Thomas Hovasse, Stephane Champagne, Solenn Toupin, Francesca Sanguineti, Jerome Garot
Summary: Silent ischaemia and unrecognized MI were found to be independent predictors of major adverse cardiovascular events (MACE) in asymptomatic individuals with multiple risk factors and without known coronary artery disease (CAD), indicating their good long-term prognostic value. These stress CMR parameters have incremental long-term prognostic value over traditional risk factors for predicting MACE.
EUROPEAN RADIOLOGY
(2021)
Article
Food Science & Technology
Caterina Peggion, Fiorella Tonello
Summary: Snake venom phospholipases A2 (PLA2s) have similar sequences and structures to mammalian PLA2s, but exhibit distinct toxic properties. Analysis revealed differences in short linear motifs (SLiMs) between snake venom and mammalian PLA2s, potentially leading to the formation of toxic protein-membrane complexes.
Editorial Material
Anesthesiology
Andrew Owen, Creed M. Stary, Eric R. Gross
Summary: Perioperative organ injury is a common and significant complication in the approximately 240 million individuals who undergo surgery worldwide each year. Ischaemic preconditioning, a technique that reduces organ injury in experimental models, has faced challenges when translated to clinical practice. However, utilizing isolated preconditioned exosomes, secreted vesicles containing cell-survival mediators, offers a potential solution to overcome these hurdles and prevent perioperative organ injury.
BRITISH JOURNAL OF ANAESTHESIA
(2023)
Article
Cardiac & Cardiovascular Systems
Max Lenz, Attila Kiss, Patrick Haider, Manuel Salzmann, Mira Brekalo, Konstantin A. A. Krychtiuk, Ouafa Hamza, Kurt Huber, Christian Hengstenberg, Bruno K. K. Podesser, Johann Wojta, Philipp J. J. Hohensinner, Walter S. S. Speidl
Summary: Ischaemia-reperfusion injury (IRI) is a challenging issue in acute cardiac care, and subsequent heart failure is a severe long-term consequence. In this study, they aimed to investigate the involvement of Toll-like receptor 9 (TLR9) in neutrophil activation and chemotaxis, which may be a target for modulating IRI. The results showed that inhibition of TLR9 led to increased neutrophil infiltration and tissue damage.
Article
Biochemistry & Molecular Biology
Laura Otero-Ortega, Elisa Alonso-Lopez, Maria Perez-Mato, Fernando Laso-Garcia, Mari Carmen Gomez-de Frutos, Luke Diekhorst, Maria Laura Garcia-Bermejo, Elisa Conde-Moreno, Blanca Fuentes, Maria Alonso de Lecinana, Eduardo Armada, Lorena Buiza-Palomino, Exuperio Diez-Tejedor, Maria Gutierrez-Fernandez
Summary: The study analyzed the content of circulating EVs in patients with IS and MI, finding common proteins and miRNAs as well as differences between the two groups. The research suggests a relationship between circulating EV content and the patient's disease state, with certain proteins and miRNAs participating in both diseases while others are specific to IS patients.
Article
Cardiac & Cardiovascular Systems
Eleder Cachorro, Mario Guenscht, Mario Schubert, Mirna S. Sadek, Johanna Siegert, Fabian Dutt, Carla Bauermeister, Susann Quickert, Henrik Berning, Felix Nowakowski, Simon Laemmle, Rebecca Firneburg, Xiaojing Luo, Stephan R. Kuenzel, Erik Klapproth, Peter Mirtschink, Manuel Mayr, Matthias Dewenter, Christiane Vettel, Jordi Heijman, Kristina Lorenz, Kaomei Guan, Ali El-Armouche, Michael Wagner, Susanne Kaemmerer
Summary: This study focuses on the cardioprotective effect of CNP and its antiarrhythmic properties through PDE2 stimulation. The results show that CNP has strong antiarrhythmic effects by reducing cAMP levels and decreasing Ca2+ handling proteins phosphorylation. These effects were confirmed in human iPSC-derived cardiomyocytes, indicating the potential of CNP-PDE2 axis as a novel target for future antiarrhythmic strategies.
CIRCULATION RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Leigh A. Bradley, Alexander Young, Hongbin Li, Helen O. Billcheck, Matthew J. Wolf
Summary: The study found that rare but cycling adult cardiomyocytes contribute to myocardial function after myocardial infarction, suggesting they may have physiological relevance.
CIRCULATION RESEARCH
(2021)
Correction
Biochemistry & Molecular Biology
R. J. Sullivan, K. Flaherty
Summary: A correction to the paper has been published.
Article
Mathematical & Computational Biology
Eryk Kropiwnicki, John E. Evangelista, Daniel J. Stein, Daniel J. B. Clarke, Alexander Lachmann, Maxim Kuleshov, Minji Jeon, Kathleen M. Jagodnik, Avi Ma'ayan
Summary: By analyzing the molecular and structural similarities of drugs and small molecules, machine learning techniques can help identify drug repurposing opportunities and predict potential side effects. Databases and search engines provide rich knowledge in the field of pharmacology, supporting applications in systems pharmacology.
DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION
(2021)
Article
Biochemical Research Methods
Qiong Wu, Tianzhou Ma, Qingzhi Liu, Donald K. Milton, Yuan Zhang, Shuo Chen
Summary: The study introduces a new computational package for extracting interconnected communities from gene co-expression networks, providing a more flexible approach to understanding gene regulatory mechanisms. By developing efficient algorithms and leveraging advanced graph norm shrinkage, the method demonstrates significant advantages in simulation studies. The approach is validated by applying it to RNA-seq data from a cancer study, identifying key biological pathways related to tumor cells' immune evasion mechanisms.
Article
Cardiac & Cardiovascular Systems
Wahiba Dhahri, Tamilla Sadikov Valdman, Dan Wilkinson, Elizabeth Pereira, Eylul Ceylan, Naaz Andharia, Beiping Qiang, Hassan Masoudpour, Fanny Wulkan, Elya Quesnel, Wenlei Jiang, Shunsuke Funakoshi, Amine Mazine, M. Juliana Gomez-Garcia, Neda Latifi, Yidi Jiang, Ella Huszti, Craig A. Simmons, Gordon Keller, Michael A. Laflamme
Summary: The study showed that culturing hPSC-CMs on PDMS-lined roller bottles and transplanting these cells into a guinea pig model of myocardial infarction resulted in better structural and functional outcomes compared to conventional immature hPSC-CM populations. The PDMS-matured hPSC-CMs exhibited increased cardiac gene expression and more mature properties in vitro, and the intracardiac grafts formed with these cells showed enhanced structure and alignment, better electromechanical integration, and improved contractile function. This study provides practical methods for the scaled generation of mature hPSC-CMs and highlights the importance of using more mature cardiomyocytes for cardiac regeneration.